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The map label for this gene is purQ

Identifier: 51893994

GI number: 51893994

Start: 3079542

End: 3080249

Strand: Reverse

Name: purQ

Synonym: STH2856

Alternate gene names: 51893994

Gene position: 3080249-3079542 (Counterclockwise)

Preceding gene: 51893995

Following gene: 51893993

Centisome position: 86.37

GC content: 68.64

Gene sequence:

>708_bases
ATGCGGTTCGGGATTCTCGTCTTTCCGGGCACCAACTGTGAGATGGAGACCTTCTACGTCCTGCGGGAGGTCGTCGGGGT
GCAGGCCGACTACGTCTGGCACGAGGCAAGGGATCTCACACCCTACGACGCCGTGGTCATTCCCGGCGGCTTCACCTATG
GCGACCGGGTGCGCAGCGGAGCCCTCGCCTGCCGCGCCCCGGTGATGGAGGCGGTGGCCGAGTTTGCGGCTCGGGGCGGG
CTGGTGCTGGGCATCTGCAACGGCTTCCAGATCCTCACCGAGGCGGGCCTCCTGCCCGGCGGTTTCCGGCCCAACGCCCA
CGGGCGTTACCGGTGCGGATGGAGCCGCGTGCGGGTGGAGAACGCGGCCACCCCGTTCACCCTGGCGTGCAGGCCGGGCC
AGGTGCTGAAGATCCCCGTGAGCCACGGGATGGGCAACTACCAGGCCGATCCTGACACGCTGCGTGCCCTGAGCGAGAAC
CAGCAGGTCCTGTTCCGCTACTGCACGCCGGAGGGGGCGGTTACCCCCGGGGCCAACCCCAACGGATCGGCGGAGAACAT
TGCCGGGATCGTGAACCGGACCGGCAACGTCGCCGGCGTGATGCCCCACCCCGAGCGGGCGACGGAGCAGGTTCTGGGTT
CTGCCGACGGGCGCCTTCTGTTTGCGTCCATGGTGCAACACCTGACGGGGAGGGTCATCCGTGTCTGA

Upstream 100 bases:

>100_bases
GCTGCGCAAGGTGCTGGCGGAGACCGCTGCCGGCGCGGGCGGGGGCCGGCGATAGACGGAGCTGACGGAAGCGCGGGCTG
GCGCAGAGGAGGCGGGGGCC

Downstream 100 bases:

>100_bases
GATGCAGCAGCCCTGGAGTCTGGTGGGTCTCACGGAGGCGGAGTACCGCCGGGTGGTGGAGATCCTGGGGCGGGAGCCGA
ACCCCACCGAACTGCACATG

Product: phosphoribosylformylglycinamidine synthase

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRFGILVFPGTNCEMETFYVLREVVGVQADYVWHEARDLTPYDAVVIPGGFTYGDRVRSGALACRAPVMEAVAEFAARGG
LVLGICNGFQILTEAGLLPGGFRPNAHGRYRCGWSRVRVENAATPFTLACRPGQVLKIPVSHGMGNYQADPDTLRALSEN
QQVLFRYCTPEGAVTPGANPNGSAENIAGIVNRTGNVAGVMPHPERATEQVLGSADGRLLFASMVQHLTGRVIRV

Sequences:

>Translated_235_residues
MRFGILVFPGTNCEMETFYVLREVVGVQADYVWHEARDLTPYDAVVIPGGFTYGDRVRSGALACRAPVMEAVAEFAARGG
LVLGICNGFQILTEAGLLPGGFRPNAHGRYRCGWSRVRVENAATPFTLACRPGQVLKIPVSHGMGNYQADPDTLRALSEN
QQVLFRYCTPEGAVTPGANPNGSAENIAGIVNRTGNVAGVMPHPERATEQVLGSADGRLLFASMVQHLTGRVIRV
>Mature_235_residues
MRFGILVFPGTNCEMETFYVLREVVGVQADYVWHEARDLTPYDAVVIPGGFTYGDRVRSGALACRAPVMEAVAEFAARGG
LVLGICNGFQILTEAGLLPGGFRPNAHGRYRCGWSRVRVENAATPFTLACRPGQVLKIPVSHGMGNYQADPDTLRALSEN
QQVLFRYCTPEGAVTPGANPNGSAENIAGIVNRTGNVAGVMPHPERATEQVLGSADGRLLFASMVQHLTGRVIRV

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=191, Percent_Identity=34.0314136125654, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582111, Length=232, Percent_Identity=28.0172413793103, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24582109, Length=232, Percent_Identity=28.0172413793103, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17137292, Length=232, Percent_Identity=28.0172413793103, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_SYMTH (Q67KF7)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076685.1
- ProteinModelPortal:   Q67KF7
- SMR:   Q67KF7
- GeneID:   2979755
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2856
- NMPDR:   fig|292459.1.peg.2731
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- BioCyc:   STHE292459:STH2856-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR010075
- InterPro:   IPR002818
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF01965 DJ-1_PfpI

EC number: =6.3.5.3

Molecular weight: Translated: 25288; Mature: 25288

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 203-203 ACT_SITE 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFGILVFPGTNCEMETFYVLREVVGVQADYVWHEARDLTPYDAVVIPGGFTYGDRVRSG
CCEEEEEECCCCCCHHHHHHHHHHHCCCHHHEEHHCCCCCCCCEEEECCCCCCHHHHHCC
ALACRAPVMEAVAEFAARGGLVLGICNGFQILTEAGLLPGGFRPNAHGRYRCGWSRVRVE
CHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEECCCEEEEEC
NAATPFTLACRPGQVLKIPVSHGMGNYQADPDTLRALSENQQVLFRYCTPEGAVTPGANP
CCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
NGSAENIAGIVNRTGNVAGVMPHPERATEQVLGSADGRLLFASMVQHLTGRVIRV
CCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEECC
>Mature Secondary Structure
MRFGILVFPGTNCEMETFYVLREVVGVQADYVWHEARDLTPYDAVVIPGGFTYGDRVRSG
CCEEEEEECCCCCCHHHHHHHHHHHCCCHHHEEHHCCCCCCCCEEEECCCCCCHHHHHCC
ALACRAPVMEAVAEFAARGGLVLGICNGFQILTEAGLLPGGFRPNAHGRYRCGWSRVRVE
CHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEECCCEEEEEC
NAATPFTLACRPGQVLKIPVSHGMGNYQADPDTLRALSENQQVLFRYCTPEGAVTPGANP
CCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
NGSAENIAGIVNRTGNVAGVMPHPERATEQVLGSADGRLLFASMVQHLTGRVIRV
CCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA