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The map label for this gene is purC [H]

Identifier: 51893995

GI number: 51893995

Start: 3080295

End: 3081194

Strand: Reverse

Name: purC [H]

Synonym: STH2857

Alternate gene names: 51893995

Gene position: 3081194-3080295 (Counterclockwise)

Preceding gene: 51893996

Following gene: 51893994

Centisome position: 86.4

GC content: 71.78

Gene sequence:

>900_bases
GTGCCGGACCCGGGCCTCCGGCGGCTGCACCGGGGGAAGGTGCGGGAGATGTTCGAGCTGGACGCGGACCGGCTCCTCAT
GGTGGCCACCGACCGGCTCTCCGCCTTCGACGTCGTCTTTCCGCAGGGCATCCCCGGCAAGGGCCGGGTGCTGACCCAGC
TCAGCGCGCTCTGGTTCGGGGCGACCCGGCATATCGTCGCCAACCACCTTGTCAGCGACGACCTCGGCGGCCTGGGCCTG
CCCGGGGACGTCCGGCGTCTCCTGGAGGGCCGGTCGCTGGTGGTGCGCCGGGCCCGCCGCATCGACGTCGAGTGCGTGGT
GCGGGGGTACCTGGCCGGATCGGGCTGGAAGGAGTACCAGGCCTCCGGCACGGTTTGCGGGATACCCCTCCCGGCGGGGC
TCAGGCTCTCCAGCCGGCTGCCGGAGCCCATCTTCACGCCGGCCCTGAAGAACGACCGGGGCCATGACGAGAACGTGCCG
GAGGCGGAGGTGCGCAGGCGGCTGGGCGACGCGGTGACCGACTTCATCAAGGAGAAGTCGCTGGCCCTCTACCGTTACGC
TGCGGGCGTGGCGGAGAAGGCGGGGATGATCCTGGCGGACACCAAGTTCGAGTTCGGCTTCGTCGGCGACGAGATCGTGC
TGATCGACGAGGCCTTTACCCCGGACTCCAGCCGGTACTGGCCGGCCGACCGGTACCGGGAGGGGGAGCCGGTGGACAGC
CTGGACAAGCAGCCGGTGCGGGACTGGGCGGAACGGACGGGCTGGAACAAGCAGCCGCCGGCTCCGGAGCTGCCCGGGGA
ACTGATCGAGGAGACCGCCCGCCGGTATGCGGATGTGCTCGACCGGCTGCGCAAGGTGCTGGCGGAGACCGCTGCCGGCG
CGGGCGGGGGCCGGCGATAG

Upstream 100 bases:

>100_bases
ATGCAGGTGATGAACCCGCTGGAGTGCCGACTGGGATCGGAGGACATGAAGGAGGTCTTAGCGCTCCTGGGGGGTGCGTA
ACATGGACGTCTTGCTGACG

Downstream 100 bases:

>100_bases
ACGGAGCTGACGGAAGCGCGGGCTGGCGCAGAGGAGGCGGGGGCCATGCGGTTCGGGATTCTCGTCTTTCCGGGCACCAA
CTGTGAGATGGAGACCTTCT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MPDPGLRRLHRGKVREMFELDADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHIVANHLVSDDLGGLGL
PGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTVCGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVP
EAEVRRRLGDAVTDFIKEKSLALYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDS
LDKQPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRLRKVLAETAAGAGGGRR

Sequences:

>Translated_299_residues
MPDPGLRRLHRGKVREMFELDADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHIVANHLVSDDLGGLGL
PGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTVCGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVP
EAEVRRRLGDAVTDFIKEKSLALYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDS
LDKQPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRLRKVLAETAAGAGGGRR
>Mature_298_residues
PDPGLRRLHRGKVREMFELDADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHIVANHLVSDDLGGLGLP
GDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTVCGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPE
AEVRRRLGDAVTDFIKEKSLALYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDSL
DKQPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRLRKVLAETAAGAGGGRR

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=244, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319326, Length=284, Percent_Identity=42.2535211267606, Blast_Score=221, Evalue=1e-58,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33168; Mature: 33037

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPGLRRLHRGKVREMFELDADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFG
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHEECCCCCCCCCHHHHHHHHHHHH
ATRHIVANHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQ
HHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
ASGTVCGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPEAEVRRRLGDAVTDFIKEKS
CCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LALYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDS
HHHHHHHHHHHHHCCEEEEECCEEECCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCC
LDKQPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRLRKVLAETAAGAGGGRR
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PDPGLRRLHRGKVREMFELDADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFG
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHEECCCCCCCCCHHHHHHHHHHHH
ATRHIVANHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQ
HHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
ASGTVCGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPEAEVRRRLGDAVTDFIKEKS
CCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LALYRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDS
HHHHHHHHHHHHHCCEEEEECCEEECCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCC
LDKQPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRLRKVLAETAAGAGGGRR
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA