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The map label for this gene is purL

Identifier: 51893993

GI number: 51893993

Start: 3077213

End: 3079549

Strand: Reverse

Name: purL

Synonym: STH2855

Alternate gene names: 51893993

Gene position: 3079549-3077213 (Counterclockwise)

Preceding gene: 51893994

Following gene: 51893992

Centisome position: 86.36

GC content: 71.89

Gene sequence:

>2337_bases
GTGTCTGAGATGCAGCAGCCCTGGAGTCTGGTGGGTCTCACGGAGGCGGAGTACCGCCGGGTGGTGGAGATCCTGGGGCG
GGAGCCGAACCCCACCGAACTGCACATGTTCGGCGTGATGTGGTCCGAACACTGCGCGTACAAGCACTCGAAGGCCGCGC
TGCGGCGGCTTCCCACCCGCGGCGAGCACGTATTGCAGGGGCCGGGCGAGAACGCCGGCGTCGTCCGGATCGACGACGAC
CTGGCCGTGGCCTTCAAGCTCGAGTCCCACAACCACCCCTCCTTCGTGGACCCCTTCAATGGCGCGGCCACGGGCGTGGG
GGGCATCCTGCGGGACGTCTTCACCATGGGCGCCCGCCCGGTGGCGACCCTGAACTCCCTGCGCTTCGGCCCGCTGGACG
AGCCCAAGCAGCGGGAACTGCTCAGGGGTGTGGTGGCCGGCATCGGCCATTACGGCAACACGGTGGGCGTGCCCTGCATC
GGCGGGGAGGTCTACTTCGACGAGTCCTACCGGGGCAACTGCCTGGTCAACGCCATGTGCATCGGCATCCTCCGGCCGGA
CCGCATCCACCGGGGCATCGCCGCCGGCCCGGGCAACGCCATCATGGTGGTGGGCAACCCGACCGGTCGGGACGGCATCC
ACGCCGCGTCGCTGCTGGCCTCGGCCGAGTTCAGCGGCAGCGAGGCGGAGGCGGCGCTGCCCACGGTGCCCGTGGGCGAC
CCCTTCGCCGAGAAGATGCTGATGGAGGCCTGCCTGGAACTGTTCGAGACCGACGCGGTGGTGGGTATCCAGGACATGGG
CGCCGCCGGCCTCATCTCCTCGTCCTCGGAGATGGCAGCCCGGGGCGGCGTGGGCGTGGAGCTGGACGTGCGCAAGGTGC
CGGCCCGGGAGGAGGGCATGGAGCCCTGGGAGTTCCTCCTCTCCGAGTCACAGGAGCGGATGCTCGTCTGCGTGAAGAAG
GGGCGGGAGGCCGAGGTCGAGGCGATCTGCCGGAAGTGGGGCGTGGGCTGCGCCGTGATCGGCCGGGTGACCGACGACGG
CATGGTGCGGGTGCTGGACGACGGGCGAGTCGTGGCCGAGGTGCCGGCCAGGGCGCTTGCCGAAGCGCCGGTCTACCACC
CGGCCAAGGCCGAGCCCGCCTACCTGGCGGAGCTGCGGGCCTTCGACTGGTCCCGGCTGCCCGAGCCGGAGGATTGGAAT
GAGACGCTGCTCCGGCTGCTGGGCTCGCCCAACATCGGCGCGCGGGCCTGGATCTACGAGCAGTTCGACCACATGGTGCA
GGCGGGTACCGTCCTGGGGCCCGGCGGAGACGCCGGGGTCATCCGGCTCGGCGCGGCCGTCGCGCCGGGGGCGCACGGCC
TCACCCGGCAGCCGCCGGGGGAGGGCCTGCCCGGCCGGTCCGGCCAGGCGGGGCCCCCGAAGGGCATCGCCGCCTCAGTG
GACTGCAACGGCCGCTACGTCTACCTGAACCCCCGGCGGGGCACCGCCATCGCCGTGGCGGAGGCGGCCCGCAACTGCGT
GGTCACCGGCGCCCGGCCCGTGGCCATCACCAACAACTGCAACTTCGGCAACCCCGAGAAGCCGGAGATCTTCTGGACCT
TCGACGAGGCCATCACCGGCATGGCCGAGGCCTGCGAGGCGCTGGGCACACCCGTGACCGGCGGCAACGTCTCCTTCTAC
AACGAGACCAGCGGGGAGGCCATTCACCCGACCCCGACCATCGGCATGATCGCGGTGCACGAGAACCTGGACCGGCTGAC
CACCCCGGGCTTCAAGCAGGTGGGTGACGTGATCCTCCTGCTGGGCGAGACCCGGGACGAGCTGGGCGGCTCCGAGTACG
CCAGGCTGATCCACGGCGTGCTGGCCGGCGACGCCCCGGCCCTGGACCTCGCCTTCGAGAAGCGGCTGCAGGACGTGGTG
CTGCGGGCGATCCACGAGGGGCTGGTGACCGCCGCCCACGACGTGGCGGAGGGCGGCCTCGCGGTCGCCCTGGCGGAGAT
GGCCATCGCCGCCGCGGAGCCGTCCCTGGGCTGCCAGGTGAGCATCTTCCTCGGCGAGGGCCGGGTAGACGGCCAGCTCT
TCGGCGAGTCCCAGTCCCGCATCCTGGTCACGGCCACCCGGGAGCAGGTGGGGCGGCTGCAGGCCCTCCTGATGGTGGAG
CAGATCCCCTTCCGGGTGCTGGGCGACGTGACCGCCGACGGCCGGTTCCGGCTGGCCGCGCTGGCTCCGGGCAGCGGGTC
GGCCCACGTCTACCGGCGTCAGGAGCTGATCGACCTGCCGGTCGCGGACCTGGTGCGTGCGCACAAGGAGGCGATCCCCA
GGTGGATGGACGCGTGA

Upstream 100 bases:

>100_bases
ATGCCCCACCCCGAGCGGGCGACGGAGCAGGTTCTGGGTTCTGCCGACGGGCGCCTTCTGTTTGCGTCCATGGTGCAACA
CCTGACGGGGAGGGTCATCC

Downstream 100 bases:

>100_bases
TCCGGCCCGGTGACCCGACCCTGGCCCTGGCCCTGCAGCCCTACCTGGGCGGGTGGCCGACCAACCCGGACAAGGGCCCG
GCGGACGAGTGCGGCGTCTT

Product: phosphoribosylformylglycinamidine synthetase

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MSEMQQPWSLVGLTEAEYRRVVEILGREPNPTELHMFGVMWSEHCAYKHSKAALRRLPTRGEHVLQGPGENAGVVRIDDD
LAVAFKLESHNHPSFVDPFNGAATGVGGILRDVFTMGARPVATLNSLRFGPLDEPKQRELLRGVVAGIGHYGNTVGVPCI
GGEVYFDESYRGNCLVNAMCIGILRPDRIHRGIAAGPGNAIMVVGNPTGRDGIHAASLLASAEFSGSEAEAALPTVPVGD
PFAEKMLMEACLELFETDAVVGIQDMGAAGLISSSSEMAARGGVGVELDVRKVPAREEGMEPWEFLLSESQERMLVCVKK
GREAEVEAICRKWGVGCAVIGRVTDDGMVRVLDDGRVVAEVPARALAEAPVYHPAKAEPAYLAELRAFDWSRLPEPEDWN
ETLLRLLGSPNIGARAWIYEQFDHMVQAGTVLGPGGDAGVIRLGAAVAPGAHGLTRQPPGEGLPGRSGQAGPPKGIAASV
DCNGRYVYLNPRRGTAIAVAEAARNCVVTGARPVAITNNCNFGNPEKPEIFWTFDEAITGMAEACEALGTPVTGGNVSFY
NETSGEAIHPTPTIGMIAVHENLDRLTTPGFKQVGDVILLLGETRDELGGSEYARLIHGVLAGDAPALDLAFEKRLQDVV
LRAIHEGLVTAAHDVAEGGLAVALAEMAIAAAEPSLGCQVSIFLGEGRVDGQLFGESQSRILVTATREQVGRLQALLMVE
QIPFRVLGDVTADGRFRLAALAPGSGSAHVYRRQELIDLPVADLVRAHKEAIPRWMDA

Sequences:

>Translated_778_residues
MSEMQQPWSLVGLTEAEYRRVVEILGREPNPTELHMFGVMWSEHCAYKHSKAALRRLPTRGEHVLQGPGENAGVVRIDDD
LAVAFKLESHNHPSFVDPFNGAATGVGGILRDVFTMGARPVATLNSLRFGPLDEPKQRELLRGVVAGIGHYGNTVGVPCI
GGEVYFDESYRGNCLVNAMCIGILRPDRIHRGIAAGPGNAIMVVGNPTGRDGIHAASLLASAEFSGSEAEAALPTVPVGD
PFAEKMLMEACLELFETDAVVGIQDMGAAGLISSSSEMAARGGVGVELDVRKVPAREEGMEPWEFLLSESQERMLVCVKK
GREAEVEAICRKWGVGCAVIGRVTDDGMVRVLDDGRVVAEVPARALAEAPVYHPAKAEPAYLAELRAFDWSRLPEPEDWN
ETLLRLLGSPNIGARAWIYEQFDHMVQAGTVLGPGGDAGVIRLGAAVAPGAHGLTRQPPGEGLPGRSGQAGPPKGIAASV
DCNGRYVYLNPRRGTAIAVAEAARNCVVTGARPVAITNNCNFGNPEKPEIFWTFDEAITGMAEACEALGTPVTGGNVSFY
NETSGEAIHPTPTIGMIAVHENLDRLTTPGFKQVGDVILLLGETRDELGGSEYARLIHGVLAGDAPALDLAFEKRLQDVV
LRAIHEGLVTAAHDVAEGGLAVALAEMAIAAAEPSLGCQVSIFLGEGRVDGQLFGESQSRILVTATREQVGRLQALLMVE
QIPFRVLGDVTADGRFRLAALAPGSGSAHVYRRQELIDLPVADLVRAHKEAIPRWMDA
>Mature_777_residues
SEMQQPWSLVGLTEAEYRRVVEILGREPNPTELHMFGVMWSEHCAYKHSKAALRRLPTRGEHVLQGPGENAGVVRIDDDL
AVAFKLESHNHPSFVDPFNGAATGVGGILRDVFTMGARPVATLNSLRFGPLDEPKQRELLRGVVAGIGHYGNTVGVPCIG
GEVYFDESYRGNCLVNAMCIGILRPDRIHRGIAAGPGNAIMVVGNPTGRDGIHAASLLASAEFSGSEAEAALPTVPVGDP
FAEKMLMEACLELFETDAVVGIQDMGAAGLISSSSEMAARGGVGVELDVRKVPAREEGMEPWEFLLSESQERMLVCVKKG
REAEVEAICRKWGVGCAVIGRVTDDGMVRVLDDGRVVAEVPARALAEAPVYHPAKAEPAYLAELRAFDWSRLPEPEDWNE
TLLRLLGSPNIGARAWIYEQFDHMVQAGTVLGPGGDAGVIRLGAAVAPGAHGLTRQPPGEGLPGRSGQAGPPKGIAASVD
CNGRYVYLNPRRGTAIAVAEAARNCVVTGARPVAITNNCNFGNPEKPEIFWTFDEAITGMAEACEALGTPVTGGNVSFYN
ETSGEAIHPTPTIGMIAVHENLDRLTTPGFKQVGDVILLLGETRDELGGSEYARLIHGVLAGDAPALDLAFEKRLQDVVL
RAIHEGLVTAAHDVAEGGLAVALAEMAIAAAEPSLGCQVSIFLGEGRVDGQLFGESQSRILVTATREQVGRLQALLMVEQ
IPFRVLGDVTADGRFRLAALAPGSGSAHVYRRQELIDLPVADLVRAHKEAIPRWMDA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=667, Percent_Identity=23.3883058470765, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI48994899, Length=400, Percent_Identity=28.25, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=650, Percent_Identity=22.6153846153846, Blast_Score=86, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=777, Percent_Identity=24.1956241956242, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24582111, Length=662, Percent_Identity=25.5287009063444, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582109, Length=662, Percent_Identity=25.5287009063444, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137292, Length=662, Percent_Identity=25.5287009063444, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_SYMTH (Q67KF8)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076684.1
- ProteinModelPortal:   Q67KF8
- SMR:   Q67KF8
- GeneID:   2979754
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2855
- NMPDR:   fig|292459.1.peg.2730
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- BioCyc:   STHE292459:STH2855-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 82897; Mature: 82766

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMQQPWSLVGLTEAEYRRVVEILGREPNPTELHMFGVMWSEHCAYKHSKAALRRLPTR
CCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
GEHVLQGPGENAGVVRIDDDLAVAFKLESHNHPSFVDPFNGAATGVGGILRDVFTMGARP
CCCEECCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VATLNSLRFGPLDEPKQRELLRGVVAGIGHYGNTVGVPCIGGEVYFDESYRGNCLVNAMC
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCCEEEEEHE
IGILRPDRIHRGIAAGPGNAIMVVGNPTGRDGIHAASLLASAEFSGSEAEAALPTVPVGD
EECCCHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PFAEKMLMEACLELFETDAVVGIQDMGAAGLISSSSEMAARGGVGVELDVRKVPAREEGM
HHHHHHHHHHHHHHHHCCCEEEHHHCCCCCEECCCHHHHHCCCCCEEEEHEECCCHHCCC
EPWEFLLSESQERMLVCVKKGREAEVEAICRKWGVGCAVIGRVTDDGMVRVLDDGRVVAE
CHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEC
VPARALAEAPVYHPAKAEPAYLAELRAFDWSRLPEPEDWNETLLRLLGSPNIGARAWIYE
CCHHHHHCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
QFDHMVQAGTVLGPGGDAGVIRLGAAVAPGAHGLTRQPPGEGLPGRSGQAGPPKGIAASV
HHHHHHHCCCEECCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
DCNGRYVYLNPRRGTAIAVAEAARNCVVTGARPVAITNNCNFGNPEKPEIFWTFDEAITG
ECCCEEEEEECCCCCEEEEEHHHCCEEEECCCEEEEECCCCCCCCCCCEEEEEHHHHHHH
MAEACEALGTPVTGGNVSFYNETSGEAIHPTPTIGMIAVHENLDRLTTPGFKQVGDVILL
HHHHHHHHCCCCCCCCEEEEECCCCCEECCCCCEEEEEEECCHHHHCCCCHHHHCCEEEE
LGETRDELGGSEYARLIHGVLAGDAPALDLAFEKRLQDVVLRAIHEGLVTAAHDVAEGGL
ECCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AVALAEMAIAAAEPSLGCQVSIFLGEGRVDGQLFGESQSRILVTATREQVGRLQALLMVE
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHH
QIPFRVLGDVTADGRFRLAALAPGSGSAHVYRRQELIDLPVADLVRAHKEAIPRWMDA
HCCHHEECCCCCCCCEEEEEECCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEMQQPWSLVGLTEAEYRRVVEILGREPNPTELHMFGVMWSEHCAYKHSKAALRRLPTR
CCCCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
GEHVLQGPGENAGVVRIDDDLAVAFKLESHNHPSFVDPFNGAATGVGGILRDVFTMGARP
CCCEECCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VATLNSLRFGPLDEPKQRELLRGVVAGIGHYGNTVGVPCIGGEVYFDESYRGNCLVNAMC
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCCEEEEEHE
IGILRPDRIHRGIAAGPGNAIMVVGNPTGRDGIHAASLLASAEFSGSEAEAALPTVPVGD
EECCCHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PFAEKMLMEACLELFETDAVVGIQDMGAAGLISSSSEMAARGGVGVELDVRKVPAREEGM
HHHHHHHHHHHHHHHHCCCEEEHHHCCCCCEECCCHHHHHCCCCCEEEEHEECCCHHCCC
EPWEFLLSESQERMLVCVKKGREAEVEAICRKWGVGCAVIGRVTDDGMVRVLDDGRVVAE
CHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEC
VPARALAEAPVYHPAKAEPAYLAELRAFDWSRLPEPEDWNETLLRLLGSPNIGARAWIYE
CCHHHHHCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
QFDHMVQAGTVLGPGGDAGVIRLGAAVAPGAHGLTRQPPGEGLPGRSGQAGPPKGIAASV
HHHHHHHCCCEECCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
DCNGRYVYLNPRRGTAIAVAEAARNCVVTGARPVAITNNCNFGNPEKPEIFWTFDEAITG
ECCCEEEEEECCCCCEEEEEHHHCCEEEECCCEEEEECCCCCCCCCCCEEEEEHHHHHHH
MAEACEALGTPVTGGNVSFYNETSGEAIHPTPTIGMIAVHENLDRLTTPGFKQVGDVILL
HHHHHHHHCCCCCCCCEEEEECCCCCEECCCCCEEEEEEECCHHHHCCCCHHHHCCEEEE
LGETRDELGGSEYARLIHGVLAGDAPALDLAFEKRLQDVVLRAIHEGLVTAAHDVAEGGL
ECCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AVALAEMAIAAAEPSLGCQVSIFLGEGRVDGQLFGESQSRILVTATREQVGRLQALLMVE
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHH
QIPFRVLGDVTADGRFRLAALAPGSGSAHVYRRQELIDLPVADLVRAHKEAIPRWMDA
HCCHHEECCCCCCCCEEEEEECCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA