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The map label for this gene is hisG

Identifier: 51893976

GI number: 51893976

Start: 3058561

End: 3059226

Strand: Reverse

Name: hisG

Synonym: STH2838

Alternate gene names: 51893976

Gene position: 3059226-3058561 (Counterclockwise)

Preceding gene: 51893977

Following gene: 51893975

Centisome position: 85.79

GC content: 70.42

Gene sequence:

>666_bases
ATGTCGCCGATCACGATCGCCCTGCCCAAAGGCCGCCCGTACGCCGCGACGGTCCGCTTTCTCCGGGAGGCGGGTCTGGC
CGGGCCGGAGCTGGAGCCCGAGGAGGGGCGGAGCCTTTACGTCGAGTGCCCGGCGCAGGGCACGCGCTTCATCATCGCCC
GCGACTCGGACGTTCCCACCTATGTGGAGTACGGGGCCGCGGACCTGGGGATCGTCGGCAAGAACGTGCTCATGGAGCTG
GAGCCCCAGGTCTACGAACTGCTGGACCTGGGCTACAGCCAGTGCCGCTTCGTGCTGGCGGCGCCTGCGGGGGTGGACCC
CCGGCAGCTCCTGAGCGGCCGCTCCCGGCAGCGGGTGGCGACCAAGTACCCGCGCATGACGGAGGCGTACTTCAACAGCC
GGGGCCTGCAGGTCGAGACGATCTTCCTGCACGGCTCCATCGAGGTGGCCCCCAAGGTGGGGCTGGCGGACCTGATCGTC
GACATCGTGGAGACCGGCCGCACCCTGCGGGAGAACAACCTGGTCGTGGTGGAGGAACTGTGGACCTCGTCCATGCGGCT
GATCGCCAATCGCGCCGCGTACCGGCTCCGGGCCGAGCGGATCGGCCCGATGGTCCAGCGGCTCCGCGAGCTGGTGAGCC
GGCGCGCGGTGGCCGCAAACGCCTAG

Upstream 100 bases:

>100_bases
ACTAGCCGTTGCAGGCGCCGGGCAGCGGGGCTCGGCGCCGCAGGCCCCGGGGCCCCGGCACCCCGGCACCCATGAAGTCT
TCCAGGAGGGAACTGCATTC

Downstream 100 bases:

>100_bases
CCTGCGGCCGTATCGTCAAGGAGGAGATCGAGATGTTGAAGGTATGGGAGCCGCAGGCTTTCCTGGAGTTCCTGAACCGG
CGCCGCACCGAGTTCTACCC

Product: ATP-phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSPITIALPKGRPYAATVRFLREAGLAGPELEPEEGRSLYVECPAQGTRFIIARDSDVPTYVEYGAADLGIVGKNVLMEL
EPQVYELLDLGYSQCRFVLAAPAGVDPRQLLSGRSRQRVATKYPRMTEAYFNSRGLQVETIFLHGSIEVAPKVGLADLIV
DIVETGRTLRENNLVVVEELWTSSMRLIANRAAYRLRAERIGPMVQRLRELVSRRAVAANA

Sequences:

>Translated_221_residues
MSPITIALPKGRPYAATVRFLREAGLAGPELEPEEGRSLYVECPAQGTRFIIARDSDVPTYVEYGAADLGIVGKNVLMEL
EPQVYELLDLGYSQCRFVLAAPAGVDPRQLLSGRSRQRVATKYPRMTEAYFNSRGLQVETIFLHGSIEVAPKVGLADLIV
DIVETGRTLRENNLVVVEELWTSSMRLIANRAAYRLRAERIGPMVQRLRELVSRRAVAANA
>Mature_220_residues
SPITIALPKGRPYAATVRFLREAGLAGPELEPEEGRSLYVECPAQGTRFIIARDSDVPTYVEYGAADLGIVGKNVLMELE
PQVYELLDLGYSQCRFVLAAPAGVDPRQLLSGRSRQRVATKYPRMTEAYFNSRGLQVETIFLHGSIEVAPKVGLADLIVD
IVETGRTLRENNLVVVEELWTSSMRLIANRAAYRLRAERIGPMVQRLRELVSRRAVAANA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=172, Percent_Identity=36.046511627907, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=29.2929292929293, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SYMTH (Q67KH5)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076667.1
- ProteinModelPortal:   Q67KH5
- SMR:   Q67KH5
- GeneID:   2979861
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2838
- NMPDR:   fig|292459.1.peg.2713
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- BioCyc:   STHE292459:STH2838-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24516; Mature: 24384

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPITIALPKGRPYAATVRFLREAGLAGPELEPEEGRSLYVECPAQGTRFIIARDSDVPT
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCH
YVEYGAADLGIVGKNVLMELEPQVYELLDLGYSQCRFVLAAPAGVDPRQLLSGRSRQRVA
HHHCCCCCCCHHCCHHHEECCHHHHHHHHCCHHHEEEEEECCCCCCHHHHHCCCCHHHHH
TKYPRMTEAYFNSRGLQVETIFLHGSIEVAPKVGLADLIVDIVETGRTLRENNLVVVEEL
HHCCCHHHHHHCCCCCEEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCEEEEHHH
WTSSMRLIANRAAYRLRAERIGPMVQRLRELVSRRAVAANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPITIALPKGRPYAATVRFLREAGLAGPELEPEEGRSLYVECPAQGTRFIIARDSDVPT
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCH
YVEYGAADLGIVGKNVLMELEPQVYELLDLGYSQCRFVLAAPAGVDPRQLLSGRSRQRVA
HHHCCCCCCCHHCCHHHEECCHHHHHHHHCCHHHEEEEEECCCCCCHHHHHCCCCHHHHH
TKYPRMTEAYFNSRGLQVETIFLHGSIEVAPKVGLADLIVDIVETGRTLRENNLVVVEEL
HHCCCHHHHHHCCCCCEEEEEEEECCEEECCCCCHHHHHHHHHHCCCEECCCCEEEEHHH
WTSSMRLIANRAAYRLRAERIGPMVQRLRELVSRRAVAANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA