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The map label for this gene is hisD

Identifier: 51893975

GI number: 51893975

Start: 3057209

End: 3058528

Strand: Reverse

Name: hisD

Synonym: STH2837

Alternate gene names: 51893975

Gene position: 3058528-3057209 (Counterclockwise)

Preceding gene: 51893976

Following gene: 51893974

Centisome position: 85.77

GC content: 72.73

Gene sequence:

>1320_bases
ATGTTGAAGGTATGGGAGCCGCAGGCTTTCCTGGAGTTCCTGAACCGGCGCCGCACCGAGTTCTACCCGGAGATCGAGGC
GCAGGTGCGCGCCATCCTGGAGCGGGTGCGCCGGGAGGGAGACGGGGCGCTGTACGCCTTCACCCGGCAGTTCGACGGCG
CCGACCTGGAGGCCACGGGCCTGCGGGTGACCGAGGCCGAGTACCGGGAGGCCGAGGCCGCGGTGAGCGCGGCGTTTCGC
GCCGCCCTGCAGGTGGCCGTCGAGAACATCGCCGCCTTCCACCGGCCGCAGGTGCCCACCTCCTGGTTCACGACCCGGCC
GGACGGCACCATCGTGGGCCAGCGGGTCACCCCGGTGGACCGGGCGGGGGTGTACGTGCCCGGCGGGTCGGCACCGCTCT
TCTCCTGCCTGCTGATGACCGCCATCCCCGCGGTGGTTGCCGGGGTCCCGGAGGTGATCGTCTGCACCCCGCCGGACCGG
AATGGCCGGATCGACCCGCACATGCTGGTGGCCGCCAGGGCTGCGGGGGTCAAGGACGTGTACAAGGTGGGCGGCGCGCA
GGCCATCGGGGCCATGGCCTATGGCACGGCCACGGTGCCCCGGGTCGACAAGATCGCCGGCCCGGGCAACTACTACGTGA
CCCTGGCCAAGAAGCTGGTCTTCGGCCCCGTCGGCATCGACATGCTGGCCGGGCCGACGGAGGTGATGGCCGTCGACGAC
GGCAGCGTCGATGCGGAGTGGCTGGCGGCCGACCTGCTGAGCCAGGCCGAACACCCCAACGGCATGGTGATCCTGGTGAC
CACGGCCGGGCCGGAGCGCATCGCGGCCGTCGGCGCGGCGATGGCGCGGCACACCGCCGCCCTGCCCCGGGCGGAGACCA
TCCGCCGGTCGGTGGCGGAGTTGGGCGCGGCCCTGGCGGTGGACACGCTGGAGGAGGCCGCGGACCTGGTCAACGCTGTC
GGGCCCGAGCATCTGGAGGTGGGCGTGGCCGACCCCTGGGCGTTCCTGCCGCTGGTGCGGCACGCCGGCTCCATCTTCCT
GGGCCGCTGGACGCCGGAGGCGATGGGCGACTACATCGCCGGGCCGTCCAACGTGATCCCCACCGAGGGCACGGCCCGGT
ATGCGTCGCCGGTATGCGTGGAGACGTTCATCAAGCGCTCGGCGGTGACCTGTTACAGCGAGGCCGCCTTCCGCGCCCAG
GCGCCTCACGCCGTGCGGCTGGCGCTCACCGAGGACCTGCTGGCCCACGCGGCGTCGATGCAGATCCGGCTGGCGAAGCC
GGACGGGGAGAGCCCATCGGAGGGGAGGGAAGCCGGATGA

Upstream 100 bases:

>100_bases
GGATCGGCCCGATGGTCCAGCGGCTCCGCGAGCTGGTGAGCCGGCGCGCGGTGGCCGCAAACGCCTAGCCTGCGGCCGTA
TCGTCAAGGAGGAGATCGAG

Downstream 100 bases:

>100_bases
CGGACTGCAGTCGGAATGAGACGGGCGCACTGGCGGAGCGGGTCGGACAGGTGGCCCGGAAGACCCGGGAGACCGACATC
GCCGTCACGTGGCGTCTCGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLKVWEPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTEAEYREAEAAVSAAFR
AALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVYVPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDR
NGRIDPHMLVAARAAGVKDVYKVGGAQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPVGIDMLAGPTEVMAVDD
GSVDAEWLAADLLSQAEHPNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAELGAALAVDTLEEAADLVNAV
GPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAGPSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQ
APHAVRLALTEDLLAHAASMQIRLAKPDGESPSEGREAG

Sequences:

>Translated_439_residues
MLKVWEPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTEAEYREAEAAVSAAFR
AALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVYVPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDR
NGRIDPHMLVAARAAGVKDVYKVGGAQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPVGIDMLAGPTEVMAVDD
GSVDAEWLAADLLSQAEHPNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAELGAALAVDTLEEAADLVNAV
GPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAGPSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQ
APHAVRLALTEDLLAHAASMQIRLAKPDGESPSEGREAG
>Mature_439_residues
MLKVWEPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTEAEYREAEAAVSAAFR
AALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVYVPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDR
NGRIDPHMLVAARAAGVKDVYKVGGAQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPVGIDMLAGPTEVMAVDD
GSVDAEWLAADLLSQAEHPNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAELGAALAVDTLEEAADLVNAV
GPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAGPSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQ
APHAVRLALTEDLLAHAASMQIRLAKPDGESPSEGREAG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=40.4938271604938, Blast_Score=266, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319819, Length=421, Percent_Identity=36.104513064133, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_SYMTH (Q67KH6)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076666.1
- ProteinModelPortal:   Q67KH6
- SMR:   Q67KH6
- GeneID:   2979878
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2837
- NMPDR:   fig|292459.1.peg.2712
- HOGENOM:   HBG329596
- OMA:   TEWEVEK
- BioCyc:   STHE292459:STH2837-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46629; Mature: 46629

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 323-323 ACT_SITE 324-324 BINDING 125-125 BINDING 187-187 BINDING 210-210 BINDING 233-233 BINDING 255-255 BINDING 258-258 BINDING 324-324 BINDING 357-357 BINDING 411-411 BINDING 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVWEPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATG
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECC
LRVTEAEYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVD
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCC
RAGVYVPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDV
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHH
YKVGGAQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPVGIDMLAGPTEVMAVDD
HHCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEHHHHHCCCCHHHHCCCCEEEEECC
GSVDAEWLAADLLSQAEHPNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAE
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGAALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIA
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHCC
GPSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASM
CCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHC
QIRLAKPDGESPSEGREAG
EEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLKVWEPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATG
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECC
LRVTEAEYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVD
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCC
RAGVYVPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDV
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHH
YKVGGAQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPVGIDMLAGPTEVMAVDD
HHCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEHHHHHCCCCHHHHCCCCEEEEECC
GSVDAEWLAADLLSQAEHPNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAE
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGAALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIA
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHCC
GPSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASM
CCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHC
QIRLAKPDGESPSEGREAG
EEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA