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The map label for this gene is hisB

Identifier: 51893974

GI number: 51893974

Start: 3056586

End: 3057212

Strand: Reverse

Name: hisB

Synonym: STH2836

Alternate gene names: 51893974

Gene position: 3057212-3056586 (Counterclockwise)

Preceding gene: 51893975

Following gene: 51893973

Centisome position: 85.73

GC content: 69.22

Gene sequence:

>627_bases
ATGACGGACTGCAGTCGGAATGAGACGGGCGCACTGGCGGAGCGGGTCGGACAGGTGGCCCGGAAGACCCGGGAGACCGA
CATCGCCGTCACGTGGCGTCTCGACGGGGCGGGACGGGCGGATGTCGACACCGGTGTGCCGTTCTTCGACCACATGCTGG
ACCAGATCGCCCGCCACAGCCTCACCGATCTCACGGCCCGGGCGGTGGGCGACCTGGAGATCGACGCGCACCACACGGTG
GAGGACACCGGCATCGCCCTGGGGCAGGCCCTGCGCCGCGCCCTGGGCGACGGCCGCTCCATCCGCCGGTACGGCTCGGC
CTTTGTCCCCTTTGACGAGACGCTGGCCTTCGCCGCGGTGGACGTCAGCGGCCGTCCCTACCTGGTCTTTGACGCCGCGC
TGCCGGCGCAGAAGGTAGGTAACTTCGACACCGAACTGGCCGAGGAGTTCTTCCGCGCCCTGGCCATGAATGCCGGCATC
ACCCTGCATCTGAAGGTCCACTACGGCCGGAACACCCACCACATGATCGAGGGTCTGTTCAAGGCTTTCGCCCGGGCCCT
CGGCGATGCCGTGGCGCGGGATCCCCGGGTCCTGGGGGTCCCCTCCACCAAGGGGGCCCTGTTCTGA

Upstream 100 bases:

>100_bases
GGCTGGCGCTCACCGAGGACCTGCTGGCCCACGCGGCGTCGATGCAGATCCGGCTGGCGAAGCCGGACGGGGAGAGCCCA
TCGGAGGGGAGGGAAGCCGG

Downstream 100 bases:

>100_bases
TGGCCCGGATCGTCATCGTGGACTACGGGATGGGCAACCTCGCCAGCGTCCGGAACGCCCTGCGGGCGGTGGGCTTCGAG
GCGGCGGTGAGCGACGACCC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTDCSRNETGALAERVGQVARKTRETDIAVTWRLDGAGRADVDTGVPFFDHMLDQIARHSLTDLTARAVGDLEIDAHHTV
EDTGIALGQALRRALGDGRSIRRYGSAFVPFDETLAFAAVDVSGRPYLVFDAALPAQKVGNFDTELAEEFFRALAMNAGI
TLHLKVHYGRNTHHMIEGLFKAFARALGDAVARDPRVLGVPSTKGALF

Sequences:

>Translated_208_residues
MTDCSRNETGALAERVGQVARKTRETDIAVTWRLDGAGRADVDTGVPFFDHMLDQIARHSLTDLTARAVGDLEIDAHHTV
EDTGIALGQALRRALGDGRSIRRYGSAFVPFDETLAFAAVDVSGRPYLVFDAALPAQKVGNFDTELAEEFFRALAMNAGI
TLHLKVHYGRNTHHMIEGLFKAFARALGDAVARDPRVLGVPSTKGALF
>Mature_207_residues
TDCSRNETGALAERVGQVARKTRETDIAVTWRLDGAGRADVDTGVPFFDHMLDQIARHSLTDLTARAVGDLEIDAHHTVE
DTGIALGQALRRALGDGRSIRRYGSAFVPFDETLAFAAVDVSGRPYLVFDAALPAQKVGNFDTELAEEFFRALAMNAGIT
LHLKVHYGRNTHHMIEGLFKAFARALGDAVARDPRVLGVPSTKGALF

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=51.530612244898, Blast_Score=184, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=39.3665158371041, Blast_Score=151, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SYMTH (Q67KH7)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076665.1
- ProteinModelPortal:   Q67KH7
- SMR:   Q67KH7
- GeneID:   2980061
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2836
- NMPDR:   fig|292459.1.peg.2711
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- BioCyc:   STHE292459:STH2836-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22605; Mature: 22474

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDCSRNETGALAERVGQVARKTRETDIAVTWRLDGAGRADVDTGVPFFDHMLDQIARHS
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
LTDLTARAVGDLEIDAHHTVEDTGIALGQALRRALGDGRSIRRYGSAFVPFDETLAFAAV
HHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHEEEEE
DVSGRPYLVFDAALPAQKVGNFDTELAEEFFRALAMNAGITLHLKVHYGRNTHHMIEGLF
ECCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHH
KAFARALGDAVARDPRVLGVPSTKGALF
HHHHHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TDCSRNETGALAERVGQVARKTRETDIAVTWRLDGAGRADVDTGVPFFDHMLDQIARHS
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
LTDLTARAVGDLEIDAHHTVEDTGIALGQALRRALGDGRSIRRYGSAFVPFDETLAFAAV
HHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHEEEEE
DVSGRPYLVFDAALPAQKVGNFDTELAEEFFRALAMNAGITLHLKVHYGRNTHHMIEGLF
ECCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHH
KAFARALGDAVARDPRVLGVPSTKGALF
HHHHHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA