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The map label for this gene is hisA

Identifier: 51893972

GI number: 51893972

Start: 3055232

End: 3055912

Strand: Reverse

Name: hisA

Synonym: STH2834

Alternate gene names: 51893972

Gene position: 3055912-3055232 (Counterclockwise)

Preceding gene: 51893973

Following gene: 51893971

Centisome position: 85.69

GC content: 74.89

Gene sequence:

>681_bases
ATGGACGAGGCCACGGTCTATGGGGTGGACCCGGTCCGGATCGCGGCTCGCTGGGCGGAGGCCGGCGCCCGCTGGATCCA
CGTGGTGGACCTGGACGGCGCGCTCCGGGGCCGGCCGCAGAACGCCGCCGCGGTGCGGGCCATCGTGGAGGCGCTGCGCC
AGAGGCACCCCGGCGTGCGGGTGCAGCTGGGCGGCGGGCTGCGCACCCTGGAGGCGCTGGAGGCCGCCCTGGCGCTGGGG
GTCTCCCGGGCGATCATCGGCACCTCGGCCCTCGAAGGCGACGTGGCGGCCCGTGCGGTGGCGCGTTTCGGCCCGGACCG
GGTCGCCGTCTCCATCGACGCGCGCGGCGGCTTCGTGGCCGCGCGCGGCTGGGTGGAGGTGACCCGGGTCCGGGCCGTGG
ACCTGGCCGTGCGGATGCGGGAGGTCGGGGTGCGGACGGTCGTCTACACCGATATCGCCACCGACGGCATGCTCACCGGC
CCCAACTTTGCCGAACTGGAGATGATGGGCCGGACCGGCCTCGATGTCATCGCCAGCGGGGGGATCTCCTCGCTGGAGGA
CATCCGGCGGCTCACGGAGATCCCCGGCGTGGCCGGGGCCATCATCGGCAGGGCGCTCTACACCGGCGCGGTGGACCTGG
CGGAGGCCCTGTCGCTCTGCGGAGAGACCCGTGACACGTGA

Upstream 100 bases:

>100_bases
TCCGGATGCTGGCCAACTGGGGGAGAATGGTATGCGACTTGATCTCTACCCGGCCATCGACCTGAAGGACGGCCAGGTGG
TGCGGCTCCGGCAGGGGCGC

Downstream 100 bases:

>100_bases
TAAGGAGGCGCTGGCACCATGCCCCTCGCGAAGCGCATCATCCCGTGCCTGGATATCCGGGACGGGCGGGTGGTGAAGAA
CGTCCAGTTCCACCTGAACA

Product: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALG
VSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTG
PNFAELEMMGRTGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT

Sequences:

>Translated_226_residues
MDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALG
VSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTG
PNFAELEMMGRTGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT
>Mature_226_residues
MDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALG
VSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTG
PNFAELEMMGRTGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=220, Percent_Identity=33.1818181818182, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SYMTH (Q67KH9)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076663.1
- ProteinModelPortal:   Q67KH9
- GeneID:   2980060
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2834
- NMPDR:   fig|292459.1.peg.2709
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- BioCyc:   STHE292459:STH2834-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 23722; Mature: 23722

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVR
CCCCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
VQLGGGLRTLEALEAALALGVSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVA
EEECCCHHHHHHHHHHHHHHHHHHHHHCHHHCHHHHHHHHHHCCCCEEEEEEECCCCEEE
ARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTGPNFAELEMMGRTGLDVIASG
ECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCHHHHEECCCCCCHHHCCC
GISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVR
CCCCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
VQLGGGLRTLEALEAALALGVSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVA
EEECCCHHHHHHHHHHHHHHHHHHHHHCHHHCHHHHHHHHHHCCCCEEEEEEECCCCEEE
ARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTGPNFAELEMMGRTGLDVIASG
ECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCHHHHEECCCCCCHHHCCC
GISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA