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The map label for this gene is proA

Identifier: 51893677

GI number: 51893677

Start: 2723149

End: 2724426

Strand: Reverse

Name: proA

Synonym: STH2539

Alternate gene names: 51893677

Gene position: 2724426-2723149 (Counterclockwise)

Preceding gene: 51893678

Following gene: 51893676

Centisome position: 76.4

GC content: 74.8

Gene sequence:

>1278_bases
GTGGATGTGCGGAGCATGGCCCGGCAGGCCCGGGCGGCCCAGCGGCAACTGGAGCTGACGTCGCCGGAGGAGCGCAACGC
GGCCCTGGAGGCGATCGCACGGGCCCTGGAGGCGCGGGCCGGGCAGATTGTGGCGGCCAACCGCGCGGACCTGGCCGCCG
CGGAGGAGGCCGGCCTGCCCGGTCCCATGATCGCCCGGCTGCGCCTGGACGAGGGGAAGCTGGCGGGGGTGATCCGCGGC
GTGCGGGCGGTGGCCGAGCTGCCGGACCCGCTGGCGGTGGAGCCCCAGGCGTGGATCCGGCCCAACGGGCTGCGCATCCA
GCGGGTGCGGGTGCCCCTGGGGGTCGTCGGCATCATCTACGAGTCCCGCCCCGGTGTGACGGTGGACGCGGCCGTCCTCT
GCCTGAAGGCGGGCAACGCCGTGCTGCTGAAGGGCGGCAAGGAGGCGGCCCGGTCCAACGCGGCCCTGGGCGAGGCGATG
GCAGCCGGCCTGCAGGAGGTGGGGCTTCCGGTGGAGCTGGCGCAGGTGCTGCCCTCGACCCGGGAGGCGGCGCAGGAGCT
GATGGCGGCCCGGAGCCTGGTGGACGTGCTGATCCCCCGGGGCGGCGCCGGCCTGATCCGCGCGACGGTGGAGCAGTCGC
AGGTGCCGGTGATCGAGACGGGCACCGGCGTCTGCCACGTGTACGTCCATAGGGCGGCCGACCTCGCGATGGCCCGGGAG
ATCGTCCTCAACGCCAAGTGCTCCAACCCTGCGGTGTGCAACGCAGCCGAGACCCTGCTGGTGGATCGGGAGGTGGCCGC
GCCTTTCCTGGCCGAGGCCGGCCCGGCGCTGCTGGCCGCCGGGGTGCGGCTGCGGGCCTGCCCGGAGGCTCTGGCGATCC
TGCAGGAGACGGCCCGCCCGGACCTCGCCGGGGCCGGCCCGGCGGCCGTGGAACCCGCCACCGAGGAGGACTGGGCGGCC
GAGTACCTGGACCTCTGTCTGGCCGTGAAGGTCGTCTCGGGTCTGGACGAGGCGCTGGCGCACATCGCCCGGTACGGCAC
CGGCCACTCCGAGGCCATCGTCACCGGCGACGCCGGGGCGGCCGACCGCTTCCTGCGGTCCGTGGACGCGGCGGCCGTGT
ACCACAACGCCTCGACCCGGTTCACCGACGGGGGGGAGTTCGGCTTCGGCGCCGAGATCGGGATCTCCACCCAGAAGCTG
CACGCCCGGGGGCCGATGGGGCTCGCCGAACTGACGACGTACAAGTACGTGGTGCTCGGCAACGGCCAGGTGCGGTGA

Upstream 100 bases:

>100_bases
GATCCCGATGGTGCTGGCCTGCGGCGAGCGGCCCGACGTCCTCAGGCAGATCCTGGCCGGTGAGGAGATCGGCACACTCT
TCAGTCGGGAGGGGTAGACG

Downstream 100 bases:

>100_bases
TCGATCGCGAACCGCGATCATGACCCTGAGAGAATTCAATCAGCTTGTGTGGAACGACGTTCCCGCTGGTGGAACGGCCT
GTGGTAGAATGGGGGCGAGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDVRSMARQARAAQRQLELTSPEERNAALEAIARALEARAGQIVAANRADLAAAEEAGLPGPMIARLRLDEGKLAGVIRG
VRAVAELPDPLAVEPQAWIRPNGLRIQRVRVPLGVVGIIYESRPGVTVDAAVLCLKAGNAVLLKGGKEAARSNAALGEAM
AAGLQEVGLPVELAQVLPSTREAAQELMAARSLVDVLIPRGGAGLIRATVEQSQVPVIETGTGVCHVYVHRAADLAMARE
IVLNAKCSNPAVCNAAETLLVDREVAAPFLAEAGPALLAAGVRLRACPEALAILQETARPDLAGAGPAAVEPATEEDWAA
EYLDLCLAVKVVSGLDEALAHIARYGTGHSEAIVTGDAGAADRFLRSVDAAAVYHNASTRFTDGGEFGFGAEIGISTQKL
HARGPMGLAELTTYKYVVLGNGQVR

Sequences:

>Translated_425_residues
MDVRSMARQARAAQRQLELTSPEERNAALEAIARALEARAGQIVAANRADLAAAEEAGLPGPMIARLRLDEGKLAGVIRG
VRAVAELPDPLAVEPQAWIRPNGLRIQRVRVPLGVVGIIYESRPGVTVDAAVLCLKAGNAVLLKGGKEAARSNAALGEAM
AAGLQEVGLPVELAQVLPSTREAAQELMAARSLVDVLIPRGGAGLIRATVEQSQVPVIETGTGVCHVYVHRAADLAMARE
IVLNAKCSNPAVCNAAETLLVDREVAAPFLAEAGPALLAAGVRLRACPEALAILQETARPDLAGAGPAAVEPATEEDWAA
EYLDLCLAVKVVSGLDEALAHIARYGTGHSEAIVTGDAGAADRFLRSVDAAAVYHNASTRFTDGGEFGFGAEIGISTQKL
HARGPMGLAELTTYKYVVLGNGQVR
>Mature_425_residues
MDVRSMARQARAAQRQLELTSPEERNAALEAIARALEARAGQIVAANRADLAAAEEAGLPGPMIARLRLDEGKLAGVIRG
VRAVAELPDPLAVEPQAWIRPNGLRIQRVRVPLGVVGIIYESRPGVTVDAAVLCLKAGNAVLLKGGKEAARSNAALGEAM
AAGLQEVGLPVELAQVLPSTREAAQELMAARSLVDVLIPRGGAGLIRATVEQSQVPVIETGTGVCHVYVHRAADLAMARE
IVLNAKCSNPAVCNAAETLLVDREVAAPFLAEAGPALLAAGVRLRACPEALAILQETARPDLAGAGPAAVEPATEEDWAA
EYLDLCLAVKVVSGLDEALAHIARYGTGHSEAIVTGDAGAADRFLRSVDAAAVYHNASTRFTDGGEFGFGAEIGISTQKL
HARGPMGLAELTTYKYVVLGNGQVR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=426, Percent_Identity=36.3849765258216, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI21361368, Length=426, Percent_Identity=36.3849765258216, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=424, Percent_Identity=46.2264150943396, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17569969, Length=425, Percent_Identity=37.8823529411765, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17569967, Length=425, Percent_Identity=37.8823529411765, Blast_Score=284, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6324899, Length=437, Percent_Identity=37.070938215103, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21357643, Length=426, Percent_Identity=39.906103286385, Blast_Score=278, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_SYMTH (Q67LC2)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076368.1
- ProteinModelPortal:   Q67LC2
- SMR:   Q67LC2
- GeneID:   2979493
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2539
- NMPDR:   fig|292459.1.peg.2429
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- BioCyc:   STHE292459:STH2539-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44252; Mature: 44252

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRSMARQARAAQRQLELTSPEERNAALEAIARALEARAGQIVAANRADLAAAEEAGLP
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCC
GPMIARLRLDEGKLAGVIRGVRAVAELPDPLAVEPQAWIRPNGLRIQRVRVPLGVVGIIY
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCEEEEEEEE
ESRPGVTVDAAVLCLKAGNAVLLKGGKEAARSNAALGEAMAAGLQEVGLPVELAQVLPST
ECCCCCCHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCH
REAAQELMAARSLVDVLIPRGGAGLIRATVEQSQVPVIETGTGVCHVYVHRAADLAMARE
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHCCCCEEECCCCEEEEEEHHHHHHHHHHH
IVLNAKCSNPAVCNAAETLLVDREVAAPFLAEAGPALLAAGVRLRACPEALAILQETARP
HHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCCC
DLAGAGPAAVEPATEEDWAAEYLDLCLAVKVVSGLDEALAHIARYGTGHSEAIVTGDAGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCH
ADRFLRSVDAAAVYHNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLAELTTYKYVVLG
HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCEEEEEEEC
NGQVR
CCCCC
>Mature Secondary Structure
MDVRSMARQARAAQRQLELTSPEERNAALEAIARALEARAGQIVAANRADLAAAEEAGLP
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCC
GPMIARLRLDEGKLAGVIRGVRAVAELPDPLAVEPQAWIRPNGLRIQRVRVPLGVVGIIY
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCEEEEEEEE
ESRPGVTVDAAVLCLKAGNAVLLKGGKEAARSNAALGEAMAAGLQEVGLPVELAQVLPST
ECCCCCCHHHHHHEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCH
REAAQELMAARSLVDVLIPRGGAGLIRATVEQSQVPVIETGTGVCHVYVHRAADLAMARE
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHCCCCEEECCCCEEEEEEHHHHHHHHHHH
IVLNAKCSNPAVCNAAETLLVDREVAAPFLAEAGPALLAAGVRLRACPEALAILQETARP
HHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCCC
DLAGAGPAAVEPATEEDWAAEYLDLCLAVKVVSGLDEALAHIARYGTGHSEAIVTGDAGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCH
ADRFLRSVDAAAVYHNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLAELTTYKYVVLG
HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCEEEEEEEC
NGQVR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA