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The map label for this gene is tktB [C]

Identifier: 51893449

GI number: 51893449

Start: 2495121

End: 2495942

Strand: Reverse

Name: tktB [C]

Synonym: STH2311

Alternate gene names: 51893449

Gene position: 2495942-2495121 (Counterclockwise)

Preceding gene: 51893450

Following gene: 51893448

Centisome position: 69.99

GC content: 73.6

Gene sequence:

>822_bases
GTGACTGCGCCGGACGTTCCGCTGCTCACCGAGATCGCGAAGCGCATCCGCGTCCACGTGATCCGCACCGTCCTGCGCCT
GGGGAGCGGCCACCTGGGCGGGTCGCTGTCTGCGGCCGAAATCCTCAGCGTACTCTATTTCCACACGCTGCGCATCCGGC
CGGAGGAGCCGGACTGGCCTGGGCGCGACCGGTTCATCCTGTCCAAGGGCCACGCTGCGCTGGCCTACTACGCCGCCCTG
GCGGAGCGGGGTTACTTCCCGCCGGACGAGCTGGCCGGCTTCGGCGCCCTGGGGTCGCGGCTGCAGGGACACCCCGACAT
GCGCCGGACGCCCGGGGTCGACATGTCCACCGGATCCCTGGGCCAGGGGCTCTCGGCCGGCGTAGGCATGGCCCTGGCCG
CCCGCATCCGGGGGGAGGGCTGGCGGACGTACGTCCTGCTGGGGGACGGCGAGATCCAGGAGGGCCAGGTGTGGGAGGCG
GCGATGCTGGCCGGCGAGCTGCGCCTGACCGGGCTGACGGCGATCCTGGACTTCAACCGGCTGTCCCAGACCCGCTCCAC
CACCGGTGCACACCCGCCCGACCTGCTGCCCGGCCGCTGGCGGGGGTTCGGCTGGGAGGTGCGGGAGGTGGACGGACACG
ACGTCTCCGCCCTCGCGGCCGCCCTGGACCGGCCGGCGGACGGGCGGCCTCTGCTGGTGGTGGCCCACACCGTGAAGGGG
CGCGGGGTCTCCTTCATGGAGGGGCGGCCGGAGTGGCACTCGCACCCGCTGACCCGGGAGCAGGCTGAGCAGGCCCTCGC
GGAACTGGGGGTGAGACCGTGA

Upstream 100 bases:

>100_bases
GGAGGCGCTGCACACCGCCGCCGACGTGGCGGAAGTGCTCCGGCTGATCCGGTCGGTCTCGGCGCCCCCGTCGGAACCCG
GCGAAGGGGAGGTGACCTAG

Downstream 100 bases:

>100_bases
CGGTGGCGATGCGGGACGCGTACGGCGAGGCTCTGGCGCAACTGGGCGGGCTGCGGCCCGACGTGGTGGTGCTGGACGCG
GACCTGGGCAACTCGGTCCG

Product: transketolase N-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTAPDVPLLTEIAKRIRVHVIRTVLRLGSGHLGGSLSAAEILSVLYFHTLRIRPEEPDWPGRDRFILSKGHAALAYYAAL
AERGYFPPDELAGFGALGSRLQGHPDMRRTPGVDMSTGSLGQGLSAGVGMALAARIRGEGWRTYVLLGDGEIQEGQVWEA
AMLAGELRLTGLTAILDFNRLSQTRSTTGAHPPDLLPGRWRGFGWEVREVDGHDVSALAAALDRPADGRPLLVVAHTVKG
RGVSFMEGRPEWHSHPLTREQAEQALAELGVRP

Sequences:

>Translated_273_residues
MTAPDVPLLTEIAKRIRVHVIRTVLRLGSGHLGGSLSAAEILSVLYFHTLRIRPEEPDWPGRDRFILSKGHAALAYYAAL
AERGYFPPDELAGFGALGSRLQGHPDMRRTPGVDMSTGSLGQGLSAGVGMALAARIRGEGWRTYVLLGDGEIQEGQVWEA
AMLAGELRLTGLTAILDFNRLSQTRSTTGAHPPDLLPGRWRGFGWEVREVDGHDVSALAAALDRPADGRPLLVVAHTVKG
RGVSFMEGRPEWHSHPLTREQAEQALAELGVRP
>Mature_272_residues
TAPDVPLLTEIAKRIRVHVIRTVLRLGSGHLGGSLSAAEILSVLYFHTLRIRPEEPDWPGRDRFILSKGHAALAYYAALA
ERGYFPPDELAGFGALGSRLQGHPDMRRTPGVDMSTGSLGQGLSAGVGMALAARIRGEGWRTYVLLGDGEIQEGQVWEAA
MLAGELRLTGLTAILDFNRLSQTRSTTGAHPPDLLPGRWRGFGWEVREVDGHDVSALAAALDRPADGRPLLVVAHTVKGR
GVSFMEGRPEWHSHPLTREQAEQALAELGVRP

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=262, Percent_Identity=42.7480916030534, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4507521, Length=262, Percent_Identity=42.7480916030534, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=41.7293233082707, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI225637459, Length=259, Percent_Identity=33.2046332046332, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI225637461, Length=259, Percent_Identity=32.8185328185328, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI225637463, Length=225, Percent_Identity=32.4444444444444, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1788808, Length=274, Percent_Identity=36.8613138686131, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI48994911, Length=272, Percent_Identity=35.2941176470588, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539652, Length=252, Percent_Identity=39.2857142857143, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6325331, Length=284, Percent_Identity=37.3239436619718, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319593, Length=273, Percent_Identity=32.967032967033, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI45551847, Length=264, Percent_Identity=41.6666666666667, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI45550715, Length=264, Percent_Identity=41.6666666666667, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24666278, Length=270, Percent_Identity=38.5185185185185, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24645119, Length=225, Percent_Identity=42.6666666666667, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29595; Mature: 29464

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPDVPLLTEIAKRIRVHVIRTVLRLGSGHLGGSLSAAEILSVLYFHTLRIRPEEPDWP
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCC
GRDRFILSKGHAALAYYAALAERGYFPPDELAGFGALGSRLQGHPDMRRTPGVDMSTGSL
CCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCC
GQGLSAGVGMALAARIRGEGWRTYVLLGDGEIQEGQVWEAAMLAGELRLTGLTAILDFNR
CCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSQTRSTTGAHPPDLLPGRWRGFGWEVREVDGHDVSALAAALDRPADGRPLLVVAHTVKG
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEECCC
RGVSFMEGRPEWHSHPLTREQAEQALAELGVRP
CCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAPDVPLLTEIAKRIRVHVIRTVLRLGSGHLGGSLSAAEILSVLYFHTLRIRPEEPDWP
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCC
GRDRFILSKGHAALAYYAALAERGYFPPDELAGFGALGSRLQGHPDMRRTPGVDMSTGSL
CCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCC
GQGLSAGVGMALAARIRGEGWRTYVLLGDGEIQEGQVWEAAMLAGELRLTGLTAILDFNR
CCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSQTRSTTGAHPPDLLPGRWRGFGWEVREVDGHDVSALAAALDRPADGRPLLVVAHTVKG
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEECCC
RGVSFMEGRPEWHSHPLTREQAEQALAELGVRP
CCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]