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The map label for this gene is dxs [C]

Identifier: 51893448

GI number: 51893448

Start: 2494186

End: 2495124

Strand: Reverse

Name: dxs [C]

Synonym: STH2310

Alternate gene names: 51893448

Gene position: 2495124-2494186 (Counterclockwise)

Preceding gene: 51893449

Following gene: 51893447

Centisome position: 69.97

GC content: 74.76

Gene sequence:

>939_bases
GTGACGGTGGCGATGCGGGACGCGTACGGCGAGGCTCTGGCGCAACTGGGCGGGCTGCGGCCCGACGTGGTGGTGCTGGA
CGCGGACCTGGGCAACTCGGTCCGGTGCGACGGCTTCGGCCGGCTCTATTCCGATCGGTACATCCAGGTGGGCATCGCCG
AGCAGAACATGGTGGGCGTCGCCGCGGGGCTGGCGGCCTGCGGCCTGGTGCCGGTGGTCAACAGCTTCGCCGCCTTCGCC
GTCTGCCGGGCCCTGGACCAGATCCGGGTCTCCGTCTGCCAGACCGGCCTGCCGGTGAAGGTGGTCGGTTCCTACAGCGG
GCTCGCGGTCTCCAAGGGGGGCAGTACCCACGCCTCGGTGGAGGACATCGCCGTCATGCGGGCGCTGCCGGGCATGACCG
TGATCGTGCCGGGGGATGCGGAGGAGGCCGCCCAGGTCACCCGCATGCTGCCGGACATCCCCGGCCCCGTGTACCTGCGG
CTCTACCGGAACGCCGTGCCGCCGGTGGTCCCCGCGGGGTACCGGTTCCGGCCCGGGAAGGCGGTCCTGCTCCGGCCGGG
GACTGACGTGGCCATCGTCAGCACCGGCACGATGACGGCCCGGGCGCTGGAGGCTGCCGGTCGGCTGGCCGGGCGGGGCG
TGGGCGCCGCGGTGCTCCACGTGCCGACGGTCAAGCCGCTGGACGAGGAGGCCGTGGTGGACGTCGCCGCCCGCTGCCGG
GCGGTGGTGACGGCCGAGGAGCACAGCGTCATCGGCGGCCTCGGGGCCGCGGTGGCCGAGTGTCTCGGCGAGCGGCACCC
GATGCCCGTCCACCGGGTCGGCGTGCCGGACCGCTTCGGCGAGTCCGGCCCCGACGACGAGCTGCTGGCCCACCTGGGCG
TGGACGAAGCGGCGATCGAGCGGCGGGTCCTGGCCGCTCTGGGGGAGGGCGGGGGCTGA

Upstream 100 bases:

>100_bases
GGCGCGGGGTCTCCTTCATGGAGGGGCGGCCGGAGTGGCACTCGCACCCGCTGACCCGGGAGCAGGCTGAGCAGGCCCTC
GCGGAACTGGGGGTGAGACC

Downstream 100 bases:

>100_bases
CGGAGGCGGCTGCCGCATGGGGTGAAGTTCGGAAGCCTGATGGCAGAAGGCATACACCTTTCGGAGGTGCAGGGGATGAA
GATCCTGGCCGTGTGCGGGA

Product: transketolase C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTVAMRDAYGEALAQLGGLRPDVVVLDADLGNSVRCDGFGRLYSDRYIQVGIAEQNMVGVAAGLAACGLVPVVNSFAAFA
VCRALDQIRVSVCQTGLPVKVVGSYSGLAVSKGGSTHASVEDIAVMRALPGMTVIVPGDAEEAAQVTRMLPDIPGPVYLR
LYRNAVPPVVPAGYRFRPGKAVLLRPGTDVAIVSTGTMTARALEAAGRLAGRGVGAAVLHVPTVKPLDEEAVVDVAARCR
AVVTAEEHSVIGGLGAAVAECLGERHPMPVHRVGVPDRFGESGPDDELLAHLGVDEAAIERRVLAALGEGGG

Sequences:

>Translated_312_residues
MTVAMRDAYGEALAQLGGLRPDVVVLDADLGNSVRCDGFGRLYSDRYIQVGIAEQNMVGVAAGLAACGLVPVVNSFAAFA
VCRALDQIRVSVCQTGLPVKVVGSYSGLAVSKGGSTHASVEDIAVMRALPGMTVIVPGDAEEAAQVTRMLPDIPGPVYLR
LYRNAVPPVVPAGYRFRPGKAVLLRPGTDVAIVSTGTMTARALEAAGRLAGRGVGAAVLHVPTVKPLDEEAVVDVAARCR
AVVTAEEHSVIGGLGAAVAECLGERHPMPVHRVGVPDRFGESGPDDELLAHLGVDEAAIERRVLAALGEGGG
>Mature_311_residues
TVAMRDAYGEALAQLGGLRPDVVVLDADLGNSVRCDGFGRLYSDRYIQVGIAEQNMVGVAAGLAACGLVPVVNSFAAFAV
CRALDQIRVSVCQTGLPVKVVGSYSGLAVSKGGSTHASVEDIAVMRALPGMTVIVPGDAEEAAQVTRMLPDIPGPVYLRL
YRNAVPPVVPAGYRFRPGKAVLLRPGTDVAIVSTGTMTARALEAAGRLAGRGVGAAVLHVPTVKPLDEEAVVDVAARCRA
VVTAEEHSVIGGLGAAVAECLGERHPMPVHRVGVPDRFGESGPDDELLAHLGVDEAAIERRVLAALGEGGG

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=305, Percent_Identity=32.7868852459016, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI4507521, Length=305, Percent_Identity=32.7868852459016, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI225637463, Length=302, Percent_Identity=33.112582781457, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI225637459, Length=302, Percent_Identity=33.112582781457, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI225637461, Length=302, Percent_Identity=33.112582781457, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI133778974, Length=312, Percent_Identity=31.0897435897436, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786622, Length=272, Percent_Identity=35.6617647058824, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1788808, Length=331, Percent_Identity=26.5861027190332, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=310, Percent_Identity=35.1612903225806, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17538422, Length=281, Percent_Identity=27.0462633451957, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325331, Length=265, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=303, Percent_Identity=24.7524752475248, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319593, Length=246, Percent_Identity=25.2032520325203, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551847, Length=320, Percent_Identity=34.375, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45550715, Length=320, Percent_Identity=34.375, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645119, Length=320, Percent_Identity=34.375, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24666278, Length=314, Percent_Identity=32.8025477707006, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21358145, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650940, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32141; Mature: 32010

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAMRDAYGEALAQLGGLRPDVVVLDADLGNSVRCDGFGRLYSDRYIQVGIAEQNMVGV
CEEEEHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCHHHCCCCEEEEEECCCCHHHH
AAGLAACGLVPVVNSFAAFAVCRALDQIRVSVCQTGLPVKVVGSYSGLAVSKGGSTHASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHH
EDIAVMRALPGMTVIVPGDAEEAAQVTRMLPDIPGPVYLRLYRNAVPPVVPAGYRFRPGK
HHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEECCCC
AVLLRPGTDVAIVSTGTMTARALEAAGRLAGRGVGAAVLHVPTVKPLDEEAVVDVAARCR
EEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
AVVTAEEHSVIGGLGAAVAECLGERHPMPVHRVGVPDRFGESGPDDELLAHLGVDEAAIE
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCCCCHHHHHHCCCCHHHHH
RRVLAALGEGGG
HHHHHHHCCCCC
>Mature Secondary Structure 
TVAMRDAYGEALAQLGGLRPDVVVLDADLGNSVRCDGFGRLYSDRYIQVGIAEQNMVGV
EEEEHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCHHHCCCCEEEEEECCCCHHHH
AAGLAACGLVPVVNSFAAFAVCRALDQIRVSVCQTGLPVKVVGSYSGLAVSKGGSTHASV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHH
EDIAVMRALPGMTVIVPGDAEEAAQVTRMLPDIPGPVYLRLYRNAVPPVVPAGYRFRPGK
HHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEECCCC
AVLLRPGTDVAIVSTGTMTARALEAAGRLAGRGVGAAVLHVPTVKPLDEEAVVDVAARCR
EEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
AVVTAEEHSVIGGLGAAVAECLGERHPMPVHRVGVPDRFGESGPDDELLAHLGVDEAAIE
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCCCCHHHHHHCCCCHHHHH
RRVLAALGEGGG
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]