Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 51893259

GI number: 51893259

Start: 2263190

End: 2265142

Strand: Reverse

Name: tkt [H]

Synonym: STH2121

Alternate gene names: 51893259

Gene position: 2265142-2263190 (Counterclockwise)

Preceding gene: 51893260

Following gene: 51893254

Centisome position: 63.52

GC content: 70.1

Gene sequence:

>1953_bases
GTGGAGAAGGCCAAGTCCGGTCACCCCGGGGCTCCGATGGGATGCGCCGACATGGCCTTCGTGCTTTGGACCCAGTTCCT
GCGCTTCGACCCGGAGAATCCGGAGTGGCCCAATCGCGACCGCTTCATCCTCTCCAACGGTCACGGCTCCATGTTGCTGT
ACTCCCTGCTGCACCTGTCCGGCTACGACCTGGACATGGAGCAGATCCAGTCCTTCCGGCAGTGGGGCAGCCGGACGCCC
GGTCACCCCGAGTACGGCCACACCCCCGGCGTGGAAGTGACGACCGGTCCCCTGGGCCAGGGCATCGCCCACGCGGTGGG
GATGGCGGCGGCCGCCGAGATGCTGGCCGCCCGGGTGAACACCGACGACTTCCGGCCCGTTGACCACTACATCTACGGCA
TCTGCGGGGACGGCGACCTGATGGAAGGGGTCGTGGCCGAGGCCGCCGCGCTGGCGGGCCAGTGGAAGCTCGGCCGGCTG
ATCTTCCTGTACGACGACAACGAGATCTCCATCGAGGGCAACACCGACATCGCTTTCTCGGAGGACGTGGCGAAGCGGTT
CGAGTCCTACGGCTGGCACGTCGACCGGTGCGACGGCCACGACCACCTGGCGATCGCGGCGGCCATCGAGCGGGCGCGGG
CGGTCACCGACAAGCCCTCGCTGATCATCTGCCGGACGGTCCTCGGCCACGGCTCGCCCAACAAGGCCGGCAAGGCCGTC
GCCCACGGGGCGCCGCTGGGGCCGGAGGAGACCCGGCTGACCAAGGAGGCCCTGGGCTGGCCGCAGGAGCCCGCCTTCTA
CGTGCCCGACGAGGTGCGGCAGTTCTTCGCGGAACTGAAGGCGGAGAAGCAGGCGGAGGCCCGCCGCTGGCAGGAGCAGT
TTGACGCCTGGCGGCAGGCCAACCCCGAGAAGGCGCAGCTCTGGGACCAGCACAAGAACCTCATGGTCCCCGCCGATCTG
GACGCCCAGCTGGTGGAGGCGGCGAGGAGCGAGAAGCCGCTGGCCACCCGCAAGTACTCCGAGATGGTCATCCAGCGGGC
GGCGGCCCTGGTCCCCAGCCTGGTGGGCGGCTCGGCCGACCTGGCGGAGTCCAACCTGACCACCATCAAGGGCGGCGGCG
ACGTCGGCCCGGCGTGCCGGATCGATGAGTACGACTTCTCCTGGTCCGGGCGCAACTTCCATTTCGGCGTGCGGGAGCAC
GCGATGGGCTCCATCGTCAACGGAGTGGTGCTCTACGGCGGCTTCCGGGCCTACGGCGCGACCTTCCTGGTCTTCTCCGA
CTACATGCGCCCGCCGATCCGCCTGGCGGCGCTGATGCAGGTGCCGTCGATCTTCGTCTTCACCCACGACTCCTTCTTCC
TGGGCGAGGACGGCCCGACGCACCAGCCGGTGGAGCACCTCTGGTCGCTGCGGATGATCCCGCACGTCACCGTGTTCCGG
CCTGCCGACGGCCTGGAGACGGCCATGGCCTGGGCCTACGCCCTCATGGAGGCGAAGGAGCCGACGATCCTGGCCCTCAC
CCGGCAGAACGTGCCGCATCTGGAGCGGCCGGCGGGCTTTGCGATCCGTGACGTGTGGAAGGGCGGCTACGTGGTCTCTG
ACGCCGCGAACCCGGTCGCGACGCTGATCGCCACCGGCTCGGAGGTGGGGCTGGCCGTCGAGGCGCAGAAGCTTCTGGCC
GAGCGGGGGATCGCCGTCCGGGTGGTCTCGATGCCCTCGGTGGAGCTCTTCCTGCGCCAGCCCCGGGAGTATCAGGAGCA
GGTCCTGGTGGGCCGGCTGGCCGCCATCGAGGCGGGCCGGACCGACGGCTGGTACCGGATCATCGGCCGGGACGGCCTGG
CCATCGGCCACGAGGATTTCGGTGCCTCCGCCCCCGCCGGCGTCCTGGCGGAGAAGTTCGGGTTCACCCCGGCGCAGGTC
GCGGCGCGGGTGGTGGAGTGGCTCGAGGGGTAG

Upstream 100 bases:

>100_bases
TCCAGGTAAGGAGGTTTTCTTCACCGTGCGAGTTGCCAGTCTGAACCCGCAATTGCGCCAGAACGTTGTCAACACCATCA
AGATGCTCGCGGTGGACGCG

Downstream 100 bases:

>100_bases
CGCGTTAAGATGCCCTGGGCAGCGGGGCTCGGCGCCCAGGCCGCCCCTGAAGAGATATGGGCTCCTCGGCAGACGGGCGT
GCTCGCTGCGCCCGCGCCGT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MEKAKSGHPGAPMGCADMAFVLWTQFLRFDPENPEWPNRDRFILSNGHGSMLLYSLLHLSGYDLDMEQIQSFRQWGSRTP
GHPEYGHTPGVEVTTGPLGQGIAHAVGMAAAAEMLAARVNTDDFRPVDHYIYGICGDGDLMEGVVAEAAALAGQWKLGRL
IFLYDDNEISIEGNTDIAFSEDVAKRFESYGWHVDRCDGHDHLAIAAAIERARAVTDKPSLIICRTVLGHGSPNKAGKAV
AHGAPLGPEETRLTKEALGWPQEPAFYVPDEVRQFFAELKAEKQAEARRWQEQFDAWRQANPEKAQLWDQHKNLMVPADL
DAQLVEAARSEKPLATRKYSEMVIQRAAALVPSLVGGSADLAESNLTTIKGGGDVGPACRIDEYDFSWSGRNFHFGVREH
AMGSIVNGVVLYGGFRAYGATFLVFSDYMRPPIRLAALMQVPSIFVFTHDSFFLGEDGPTHQPVEHLWSLRMIPHVTVFR
PADGLETAMAWAYALMEAKEPTILALTRQNVPHLERPAGFAIRDVWKGGYVVSDAANPVATLIATGSEVGLAVEAQKLLA
ERGIAVRVVSMPSVELFLRQPREYQEQVLVGRLAAIEAGRTDGWYRIIGRDGLAIGHEDFGASAPAGVLAEKFGFTPAQV
AARVVEWLEG

Sequences:

>Translated_650_residues
MEKAKSGHPGAPMGCADMAFVLWTQFLRFDPENPEWPNRDRFILSNGHGSMLLYSLLHLSGYDLDMEQIQSFRQWGSRTP
GHPEYGHTPGVEVTTGPLGQGIAHAVGMAAAAEMLAARVNTDDFRPVDHYIYGICGDGDLMEGVVAEAAALAGQWKLGRL
IFLYDDNEISIEGNTDIAFSEDVAKRFESYGWHVDRCDGHDHLAIAAAIERARAVTDKPSLIICRTVLGHGSPNKAGKAV
AHGAPLGPEETRLTKEALGWPQEPAFYVPDEVRQFFAELKAEKQAEARRWQEQFDAWRQANPEKAQLWDQHKNLMVPADL
DAQLVEAARSEKPLATRKYSEMVIQRAAALVPSLVGGSADLAESNLTTIKGGGDVGPACRIDEYDFSWSGRNFHFGVREH
AMGSIVNGVVLYGGFRAYGATFLVFSDYMRPPIRLAALMQVPSIFVFTHDSFFLGEDGPTHQPVEHLWSLRMIPHVTVFR
PADGLETAMAWAYALMEAKEPTILALTRQNVPHLERPAGFAIRDVWKGGYVVSDAANPVATLIATGSEVGLAVEAQKLLA
ERGIAVRVVSMPSVELFLRQPREYQEQVLVGRLAAIEAGRTDGWYRIIGRDGLAIGHEDFGASAPAGVLAEKFGFTPAQV
AARVVEWLEG
>Mature_650_residues
MEKAKSGHPGAPMGCADMAFVLWTQFLRFDPENPEWPNRDRFILSNGHGSMLLYSLLHLSGYDLDMEQIQSFRQWGSRTP
GHPEYGHTPGVEVTTGPLGQGIAHAVGMAAAAEMLAARVNTDDFRPVDHYIYGICGDGDLMEGVVAEAAALAGQWKLGRL
IFLYDDNEISIEGNTDIAFSEDVAKRFESYGWHVDRCDGHDHLAIAAAIERARAVTDKPSLIICRTVLGHGSPNKAGKAV
AHGAPLGPEETRLTKEALGWPQEPAFYVPDEVRQFFAELKAEKQAEARRWQEQFDAWRQANPEKAQLWDQHKNLMVPADL
DAQLVEAARSEKPLATRKYSEMVIQRAAALVPSLVGGSADLAESNLTTIKGGGDVGPACRIDEYDFSWSGRNFHFGVREH
AMGSIVNGVVLYGGFRAYGATFLVFSDYMRPPIRLAALMQVPSIFVFTHDSFFLGEDGPTHQPVEHLWSLRMIPHVTVFR
PADGLETAMAWAYALMEAKEPTILALTRQNVPHLERPAGFAIRDVWKGGYVVSDAANPVATLIATGSEVGLAVEAQKLLA
ERGIAVRVVSMPSVELFLRQPREYQEQVLVGRLAAIEAGRTDGWYRIIGRDGLAIGHEDFGASAPAGVLAEKFGFTPAQV
AARVVEWLEG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=629, Percent_Identity=24.8012718600954, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4507521, Length=629, Percent_Identity=24.8012718600954, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI133778974, Length=245, Percent_Identity=31.4285714285714, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI225637459, Length=573, Percent_Identity=22.5130890052356, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI225637463, Length=557, Percent_Identity=22.4416517055655, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=557, Percent_Identity=22.4416517055655, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI48994911, Length=659, Percent_Identity=49.9241274658574, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1788808, Length=653, Percent_Identity=48.698315467075, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=252, Percent_Identity=32.9365079365079, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325331, Length=649, Percent_Identity=46.3790446841294, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319593, Length=651, Percent_Identity=43.1643625192012, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24645119, Length=652, Percent_Identity=26.0736196319018, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45551847, Length=263, Percent_Identity=32.319391634981, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550715, Length=263, Percent_Identity=32.319391634981, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24666278, Length=250, Percent_Identity=32.8, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71309; Mature: 71309

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAKSGHPGAPMGCADMAFVLWTQFLRFDPENPEWPNRDRFILSNGHGSMLLYSLLHLS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHC
GYDLDMEQIQSFRQWGSRTPGHPEYGHTPGVEVTTGPLGQGIAHAVGMAAAAEMLAARVN
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
TDDFRPVDHYIYGICGDGDLMEGVVAEAAALAGQWKLGRLIFLYDDNEISIEGNTDIAFS
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCEEEC
EDVAKRFESYGWHVDRCDGHDHLAIAAAIERARAVTDKPSLIICRTVLGHGSPNKAGKAV
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCHH
AHGAPLGPEETRLTKEALGWPQEPAFYVPDEVRQFFAELKAEKQAEARRWQEQFDAWRQA
HCCCCCCCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPEKAQLWDQHKNLMVPADLDAQLVEAARSEKPLATRKYSEMVIQRAAALVPSLVGGSAD
CCHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
LAESNLTTIKGGGDVGPACRIDEYDFSWSGRNFHFGVREHAMGSIVNGVVLYGGFRAYGA
HCCCCCEEEECCCCCCCCCEECCCCCCCCCCCEECCHHHHHHHHHHHHHHEECCHHHHCE
TFLVFSDYMRPPIRLAALMQVPSIFVFTHDSFFLGEDGPTHQPVEHLWSLRMIPHVTVFR
EEEEEHHHCCCHHHHHHHHHCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHCCCEEEEC
PADGLETAMAWAYALMEAKEPTILALTRQNVPHLERPAGFAIRDVWKGGYVVSDAANPVA
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCE
TLIATGSEVGLAVEAQKLLAERGIAVRVVSMPSVELFLRQPREYQEQVLVGRLAAIEAGR
EEEECCCCCCEEHHHHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHCCC
TDGWYRIIGRDGLAIGHEDFGASAPAGVLAEKFGFTPAQVAARVVEWLEG
CCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKAKSGHPGAPMGCADMAFVLWTQFLRFDPENPEWPNRDRFILSNGHGSMLLYSLLHLS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHC
GYDLDMEQIQSFRQWGSRTPGHPEYGHTPGVEVTTGPLGQGIAHAVGMAAAAEMLAARVN
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
TDDFRPVDHYIYGICGDGDLMEGVVAEAAALAGQWKLGRLIFLYDDNEISIEGNTDIAFS
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCEEEC
EDVAKRFESYGWHVDRCDGHDHLAIAAAIERARAVTDKPSLIICRTVLGHGSPNKAGKAV
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCHH
AHGAPLGPEETRLTKEALGWPQEPAFYVPDEVRQFFAELKAEKQAEARRWQEQFDAWRQA
HCCCCCCCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPEKAQLWDQHKNLMVPADLDAQLVEAARSEKPLATRKYSEMVIQRAAALVPSLVGGSAD
CCHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
LAESNLTTIKGGGDVGPACRIDEYDFSWSGRNFHFGVREHAMGSIVNGVVLYGGFRAYGA
HCCCCCEEEECCCCCCCCCEECCCCCCCCCCCEECCHHHHHHHHHHHHHHEECCHHHHCE
TFLVFSDYMRPPIRLAALMQVPSIFVFTHDSFFLGEDGPTHQPVEHLWSLRMIPHVTVFR
EEEEEHHHCCCHHHHHHHHHCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHCCCEEEEC
PADGLETAMAWAYALMEAKEPTILALTRQNVPHLERPAGFAIRDVWKGGYVVSDAANPVA
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCE
TLIATGSEVGLAVEAQKLLAERGIAVRVVSMPSVELFLRQPREYQEQVLVGRLAAIEAGR
EEEECCCCCCEEHHHHHHHHHCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHCCC
TDGWYRIIGRDGLAIGHEDFGASAPAGVLAEKFGFTPAQVAARVVEWLEG
CCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]