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The map label for this gene is cobC [H]

Identifier: 51893062

GI number: 51893062

Start: 2067612

End: 2068175

Strand: Reverse

Name: cobC [H]

Synonym: STH1924

Alternate gene names: 51893062

Gene position: 2068175-2067612 (Counterclockwise)

Preceding gene: 51893063

Following gene: 51893061

Centisome position: 57.99

GC content: 75.0

Gene sequence:

>564_bases
GTGCGCCACGGCGCGACGGCTGCCAACGCGGAAGGGCGGTACGTCGGCTGGGAGGAGCACCCGCTCAGCGCAGACGGGCT
CGCTCAGGCGGAAGCGGCTGCGCGTTACCTGAGCCGGTTTCGGCTCACCGGCATGCGCACCAGCGACCTCATGCGGTGCC
GCCAGACCGCCGAGCGGATCGGGAGGGCCACGGGGCTCACGCCCGCGCCCGACCCAAGGCTGCGGGAACTGAACTTCGGG
CGCTTCTCCGGCCTGACGTACGAGGAGATCGCCCGGCAGTGGCCCGAGGAGCTCGCCGCCTGGCTGGCCGACCCGGAACA
CGCGCCGCCCCCGGGCGGGGAGAGCCTGGCGTCGCTGCGGAGCCGGGCCCTGGCCGCCCTGCCCCGGCAGGACGGGGCCG
TCGTGGTCACACACGGCGGTGTGATCCGCACGGTGCTTGCCCACCTGACCGGCAGGGGACTCTGGGACTGGCGGGTTCCT
CCCGGCGCCGTGGTCCTGCTCCGGTGGGACGGCGAGCGGGCCGTGGATGAGCCGCGGGTCTGGCGGCCGGAAGCGGGGGA
ATGA

Upstream 100 bases:

>100_bases
TGCGGCTTGCTGTGCGCACCCGGCCAGAGAACCGGCGGCTGATCGCCCTGCTGCGCAGCATCCTGGAGGAGGAGGCGCCG
TGACCTGCACCCTCTTCCTG

Downstream 100 bases:

>100_bases
CGGGCACAACGGCGTGCCCGAACGGGCGGTGATCCGGTGCGGCGGCGCAACGGGGCGCCTGCCGCACCAGAGGCACAACG
AGGTGCCGCGCTGCGGGTAC

Product: phosphoglycerate mutase variant

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRHGATAANAEGRYVGWEEHPLSADGLAQAEAAARYLSRFRLTGMRTSDLMRCRQTAERIGRATGLTPAPDPRLRELNFG
RFSGLTYEEIARQWPEELAAWLADPEHAPPPGGESLASLRSRALAALPRQDGAVVVTHGGVIRTVLAHLTGRGLWDWRVP
PGAVVLLRWDGERAVDEPRVWRPEAGE

Sequences:

>Translated_187_residues
MRHGATAANAEGRYVGWEEHPLSADGLAQAEAAARYLSRFRLTGMRTSDLMRCRQTAERIGRATGLTPAPDPRLRELNFG
RFSGLTYEEIARQWPEELAAWLADPEHAPPPGGESLASLRSRALAALPRQDGAVVVTHGGVIRTVLAHLTGRGLWDWRVP
PGAVVLLRWDGERAVDEPRVWRPEAGE
>Mature_187_residues
MRHGATAANAEGRYVGWEEHPLSADGLAQAEAAARYLSRFRLTGMRTSDLMRCRQTAERIGRATGLTPAPDPRLRELNFG
RFSGLTYEEIARQWPEELAAWLADPEHAPPPGGESLASLRSRALAALPRQDGAVVVTHGGVIRTVLAHLTGRGLWDWRVP
PGAVVLLRWDGERAVDEPRVWRPEAGE

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=172, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI1790856, Length=166, Percent_Identity=34.9397590361446, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993390, Length=174, Percent_Identity=32.183908045977, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510917, Length=174, Percent_Identity=32.183908045977, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25145314, Length=164, Percent_Identity=34.1463414634146, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 20587; Mature: 20587

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHGATAANAEGRYVGWEEHPLSADGLAQAEAAARYLSRFRLTGMRTSDLMRCRQTAERI
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GRATGLTPAPDPRLRELNFGRFSGLTYEEIARQWPEELAAWLADPEHAPPPGGESLASLR
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
SRALAALPRQDGAVVVTHGGVIRTVLAHLTGRGLWDWRVPPGAVVLLRWDGERAVDEPRV
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEECCCCCCEEEEEEECCCCCCCCCCC
WRPEAGE
CCCCCCC
>Mature Secondary Structure
MRHGATAANAEGRYVGWEEHPLSADGLAQAEAAARYLSRFRLTGMRTSDLMRCRQTAERI
CCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GRATGLTPAPDPRLRELNFGRFSGLTYEEIARQWPEELAAWLADPEHAPPPGGESLASLR
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
SRALAALPRQDGAVVVTHGGVIRTVLAHLTGRGLWDWRVPPGAVVLLRWDGERAVDEPRV
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEECCCCCCEEEEEEECCCCCCCCCCC
WRPEAGE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]