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The map label for this gene is cobD [H]

Identifier: 51893063

GI number: 51893063

Start: 2068193

End: 2069212

Strand: Reverse

Name: cobD [H]

Synonym: STH1925

Alternate gene names: 51893063

Gene position: 2069212-2068193 (Counterclockwise)

Preceding gene: 51893064

Following gene: 51893062

Centisome position: 58.02

GC content: 73.04

Gene sequence:

>1020_bases
GTGGCGCGGGCCCGCTGGGGCGAGCCGCCAGGGGGTTTCTGCGACTTCAGCGCCAACATCAACCCGCTGGGCCCGCCCGC
GGGCGCGGTGGCCGCGGCGCAGGCGGCCCTAGCCGGAATCGCGCACTACCCCGAGCCATTCGCCCGCCGGCTGCGGGCCG
CCCTGGCCCGGCGTCACCAGGTGGACGAGTCGATGGTGCTGGTGGGAAACGGCGCGGCGGAGGTGCTGTACCTGCTGCTC
CGCCTGGCGTCAGGCTTCCGGGTGGCACTGCCCGAACCCGGCTTTGCGGAGTACGCGCGCGCCGCCCGGGCTGCAGGGGC
CGAGCTGCTGCCCGTCGCGCACGACCGCACCGATCCGCCGCCCCAGCTGGGGCGGGGGGACTGGTGGATCATCTGCAACC
CCCACAATCCCACCGGCCACCTGTTCACGCCGGAGCAGCTCCTGCGGGCGGCGGAGCGGACGGAGGCGACCCTGCTCATC
GACGAGGCCTTCATCGACCTCACAGCCGCGGGCGAGGCCGGCTCCGTGATCGCCCGTGTGCCCCACCGCTGCAACCTGGT
CGTGGTGCGGTCGCTCACGAAGTTTTTCGCCCTGCCCGGACTGCGGGTCGGGTATGCGGTGGCCCCGCGCTGGATGGTGG
CCGAGTTGGACGCGGCGCGCGACCCCTGGAGCGTGAACAGTCTGGCGCAGGCCGCTGCGCTCGCGGCCCTGAGCGATGAG
GCCTACGCCGCCCGCACCCGGCACTGGGTGGCCGTGGAACGGGCCTATCTCGCCGAGCAGCTGGCGAGCCTGCCGGGGTT
TATCGTCTATCCGCCATCTGCCAACTTCGTGCTGGTGCGGGCGCCGCTGCCCGCCCACGAGATCCAGCGGCGGCTGGGAC
CCCGGGGTGTGCTGATACGCGACTGCCGCTCCTTTGCCGGGCTGACGGAGCATCACATGCGGCTTGCTGTGCGCACCCGG
CCAGAGAACCGGCGGCTGATCGCCCTGCTGCGCAGCATCCTGGAGGAGGAGGCGCCGTGA

Upstream 100 bases:

>100_bases
GAGCCTTGTGCGAGCTGGCGGAACTGGCGGCGATCGCCTGCTTCGCTCTGCAGACAGGGAGGTGGACAGGATGATGACCC
TGCACGGCGGCGACCTGGCT

Downstream 100 bases:

>100_bases
CCTGCACCCTCTTCCTGGTGCGCCACGGCGCGACGGCTGCCAACGCGGAAGGGCGGTACGTCGGCTGGGAGGAGCACCCG
CTCAGCGCAGACGGGCTCGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MARARWGEPPGGFCDFSANINPLGPPAGAVAAAQAALAGIAHYPEPFARRLRAALARRHQVDESMVLVGNGAAEVLYLLL
RLASGFRVALPEPGFAEYARAARAAGAELLPVAHDRTDPPPQLGRGDWWIICNPHNPTGHLFTPEQLLRAAERTEATLLI
DEAFIDLTAAGEAGSVIARVPHRCNLVVVRSLTKFFALPGLRVGYAVAPRWMVAELDAARDPWSVNSLAQAAALAALSDE
AYAARTRHWVAVERAYLAEQLASLPGFIVYPPSANFVLVRAPLPAHEIQRRLGPRGVLIRDCRSFAGLTEHHMRLAVRTR
PENRRLIALLRSILEEEAP

Sequences:

>Translated_339_residues
MARARWGEPPGGFCDFSANINPLGPPAGAVAAAQAALAGIAHYPEPFARRLRAALARRHQVDESMVLVGNGAAEVLYLLL
RLASGFRVALPEPGFAEYARAARAAGAELLPVAHDRTDPPPQLGRGDWWIICNPHNPTGHLFTPEQLLRAAERTEATLLI
DEAFIDLTAAGEAGSVIARVPHRCNLVVVRSLTKFFALPGLRVGYAVAPRWMVAELDAARDPWSVNSLAQAAALAALSDE
AYAARTRHWVAVERAYLAEQLASLPGFIVYPPSANFVLVRAPLPAHEIQRRLGPRGVLIRDCRSFAGLTEHHMRLAVRTR
PENRRLIALLRSILEEEAP
>Mature_338_residues
ARARWGEPPGGFCDFSANINPLGPPAGAVAAAQAALAGIAHYPEPFARRLRAALARRHQVDESMVLVGNGAAEVLYLLLR
LASGFRVALPEPGFAEYARAARAAGAELLPVAHDRTDPPPQLGRGDWWIICNPHNPTGHLFTPEQLLRAAERTEATLLID
EAFIDLTAAGEAGSVIARVPHRCNLVVVRSLTKFFALPGLRVGYAVAPRWMVAELDAARDPWSVNSLAQAAALAALSDEA
YAARTRHWVAVERAYLAEQLASLPGFIVYPPSANFVLVRAPLPAHEIQRRLGPRGVLIRDCRSFAGLTEHHMRLAVRTRP
ENRRLIALLRSILEEEAP

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=343, Percent_Identity=28.2798833819242, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36849; Mature: 36718

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARARWGEPPGGFCDFSANINPLGPPAGAVAAAQAALAGIAHYPEPFARRLRAALARRHQ
CCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
VDESMVLVGNGAAEVLYLLLRLASGFRVALPEPGFAEYARAARAAGAELLPVAHDRTDPP
CCCCEEEEECCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
PQLGRGDWWIICNPHNPTGHLFTPEQLLRAAERTEATLLIDEAFIDLTAAGEAGSVIARV
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHEEEEECCCCCCHHHHC
PHRCNLVVVRSLTKFFALPGLRVGYAVAPRWMVAELDAARDPWSVNSLAQAAALAALSDE
CCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHEEEHHCCCCCCCHHHHHHHHHHHHHCCH
AYAARTRHWVAVERAYLAEQLASLPGFIVYPPSANFVLVRAPLPAHEIQRRLGPRGVLIR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHHHHCCCCCHHH
DCRSFAGLTEHHMRLAVRTRPENRRLIALLRSILEEEAP
HHHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARARWGEPPGGFCDFSANINPLGPPAGAVAAAQAALAGIAHYPEPFARRLRAALARRHQ
CCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
VDESMVLVGNGAAEVLYLLLRLASGFRVALPEPGFAEYARAARAAGAELLPVAHDRTDPP
CCCCEEEEECCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
PQLGRGDWWIICNPHNPTGHLFTPEQLLRAAERTEATLLIDEAFIDLTAAGEAGSVIARV
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHEEEEECCCCCCHHHHC
PHRCNLVVVRSLTKFFALPGLRVGYAVAPRWMVAELDAARDPWSVNSLAQAAALAALSDE
CCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHEEEHHCCCCCCCHHHHHHHHHHHHHCCH
AYAARTRHWVAVERAYLAEQLASLPGFIVYPPSANFVLVRAPLPAHEIQRRLGPRGVLIR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHHHHHCCCCCHHH
DCRSFAGLTEHHMRLAVRTRPENRRLIALLRSILEEEAP
HHHHHCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]