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The map label for this gene is slrP [H]

Identifier: 51597602

GI number: 51597602

Start: 3923045

End: 3924922

Strand: Direct

Name: slrP [H]

Synonym: YPTB3302

Alternate gene names: 51597602

Gene position: 3923045-3924922 (Clockwise)

Preceding gene: 51597601

Following gene: 51597605

Centisome position: 82.68

GC content: 46.11

Gene sequence:

>1878_bases
ATGAATCTATCAAATATAACCTCGCACATGTCAATGCCGAACATAGGACCAGACCATGAAATCCATGCTGACCGGGCAGC
AGCAACAACCTTAACTTCGGCTGACTATCATGCAATATGGGAAAAGTGGGCAAGCGAGGCAATACCGGGTGCTAACGAAC
AGCGGGACCAGGCAGTAGCAAGAATGAAAGAGTGTTTGGAAAACAATGCCGATAGACTCAATCTACATAACCTTGATTTG
ACGTCATTGCCAGATACCCTACCACCTTGTAACGAACTGGAGATATCGAACAATAACATCACTGAGTTGCCTACTTTGCC
AAACAACCTGCAAAGGTTGATGGCAATCTGTAATCAACTGCGTACATTACCCGATACATTACCTGAACATCTATTATCTC
TATATGTGGCCTCGAATAAACTCGAACGGCTCCCCGAGAACCTGCCAGAGAGTCTCTATAGATTAAATGTTTGCGATAAT
CCGTCACTGCAATTCCCAAACAACTGGCCTTCGAATCTGATGTATCTTAACATTGCAGACTGTGAATTAACTGAACTGCC
TACACTGCCGAACACCTTGACAGAACTGTCTGCGGATTTTAATCAACTGCGTACATTGCCCGATACATTGCCGATATCGC
TGTTAAGGTTAAGTGTAACCAGTAATCAACTCACACAACTCCCCGAGACATTGCCCGCCTCTCTGTCATTTTTAATGGTA
TTGGGCAATAGTCTCACCGCACTACCGGAAAATTTACCTAGTAGCTTAAGCTGTATCGGCGCTGAATATAATCAATTTTC
CCAACTTCCCGATCTAGCACGTCTGCCCCAAAACTGCGAATTTCTCTTGGAAGGTAACCCTCTTTCTGCCAGCACGCTGT
TGGCACTACAGCATCTCCGTACTAACCCGTATTATCAGGGGCCACAGATTATCTGCCGCGAATTAGACGATCTCCCCCCT
GCGAGTCTCAGTAATATTGTTGCCATCTGGTTGGTTCCCGAACAACAAAACACGTTGGCAGGAGATTGGGCAAATATCGA
GACAGAAGCTAACTCAGCTGCTTTTAGCGTTTTTCTTCACCGTTTGGCTACCACTAAAAACACAGAAAACATCCCTGAAT
TTAAACAACAAATTGCAGCATGGTTGTTGCAACTGGCTGGCTCACCGACTCTACGTGAGCAGACCTTTCTTATCGCTCAG
GAAGCAAGCGCGACCTGTGAAGACCGCATTACCTTGACCTATAACGATATGCAAAAGGCAGTCATGCTCCATGAGGTCGA
AAAGGGACAATATGACACGCAATTACCTGAACTGATGGCGCGTGGCCGGGAGATGTTCCGTCTGGAACAACTTGAGAATA
TTGCCCGCGAAAAAGTAAAAATACTAAAAACACTGAATGTACATTCTGTCGACGACATCGAAGTCTATCTTGCCTATCAG
GTTAAACTACGTGAGTCCTTAGAACTTTTCTCAGTAAGCAAAGAAATGCGCTTCTTTGGCGTATCGCATGTGACAGAAGA
CGATTTACTGAGCGCAGAAAAGAGGGTGAAAACCACGGAAAACCACGATTTCCCGCGCTGGCTATCACAATGGTCCCCAT
GGAAAAGCGTGGTGCAACGTATTGATCCTGAAAGTTATGCTGCTGCGGTCGAAAAGCAGTACCACGCACTGGAGAATATT
TACCCAGATAAACTGGCGGCTGAATTGGCCGCCAACGGGATGACGGGCGATGTGGATGCCAACCGCATTGTCGGCAAAAG
AATCAACGATGAGCTCATGGGGGAGATCGATATAGCCCTGACTCATGAGGTTCTCTCTGCCAAAGGAGCCTCCTCCTTAT
TAGATAAACTGTGGATGGAATCTCTAATCTCGCCTTAA

Upstream 100 bases:

>100_bases
CCAGTAAGCTGAAAATACCAGTAGTAGACCTTATGCATCCCCTGTTATTTATCAGCCAAAATAACGCCTCTAAGACTTAT
TAAGGGAGCGGTTTAATACA

Downstream 100 bases:

>100_bases
TACTGCACGGCCCGTTATGCCATAAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGTTGATCACCACCATGTCGTT
AGTGGCTAATTACCTGACGA

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MNLSNITSHMSMPNIGPDHEIHADRAAATTLTSADYHAIWEKWASEAIPGANEQRDQAVARMKECLENNADRLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVASNKLERLPENLPESLYRLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELSADFNQLRTLPDTLPISLLRLSVTSNQLTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCEFLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIDPESYAAAVEKQYHALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDIALTHEVLSAKGASSLLDKLWMESLISP

Sequences:

>Translated_625_residues
MNLSNITSHMSMPNIGPDHEIHADRAAATTLTSADYHAIWEKWASEAIPGANEQRDQAVARMKECLENNADRLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVASNKLERLPENLPESLYRLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELSADFNQLRTLPDTLPISLLRLSVTSNQLTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCEFLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIDPESYAAAVEKQYHALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDIALTHEVLSAKGASSLLDKLWMESLISP
>Mature_625_residues
MNLSNITSHMSMPNIGPDHEIHADRAAATTLTSADYHAIWEKWASEAIPGANEQRDQAVARMKECLENNADRLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVASNKLERLPENLPESLYRLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELSADFNQLRTLPDTLPISLLRLSVTSNQLTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCEFLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIDPESYAAAVEKQYHALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDIALTHEVLSAKGASSLLDKLWMESLISP

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 70221; Mature: 70221

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSHMSMPNIGPDHEIHADRAAATTLTSADYHAIWEKWASEAIPGANEQRDQAVA
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
RMKECLENNADRLNLHNLDLTSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQL
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RTLPDTLPEHLLSLYVASNKLERLPENLPESLYRLNVCDNPSLQFPNNWPSNLMYLNIAD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECC
CELTELPTLPNTLTELSADFNQLRTLPDTLPISLLRLSVTSNQLTQLPETLPASLSFLMV
CCHHCCCCCCHHHHHHHHHHHHHHCCCCHHCHHHHHEECCHHHHHHHHHHHHHHHHHHHH
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCEFLLEGNPLSASTLLALQHLR
HCCCHHHHHHCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHH
TNPYYQGPQIICRELDDLPPASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLH
CCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
RLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQEASATCEDRITLTYNDMQKA
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCEEEEHHHHHHH
VMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IDPESYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDIAL
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHH
THEVLSAKGASSLLDKLWMESLISP
HHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLSNITSHMSMPNIGPDHEIHADRAAATTLTSADYHAIWEKWASEAIPGANEQRDQAVA
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
RMKECLENNADRLNLHNLDLTSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQL
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RTLPDTLPEHLLSLYVASNKLERLPENLPESLYRLNVCDNPSLQFPNNWPSNLMYLNIAD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECC
CELTELPTLPNTLTELSADFNQLRTLPDTLPISLLRLSVTSNQLTQLPETLPASLSFLMV
CCHHCCCCCCHHHHHHHHHHHHHHCCCCHHCHHHHHEECCHHHHHHHHHHHHHHHHHHHH
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCEFLLEGNPLSASTLLALQHLR
HCCCHHHHHHCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHH
TNPYYQGPQIICRELDDLPPASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLH
CCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
RLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQEASATCEDRITLTYNDMQKA
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCEEEEHHHHHHH
VMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IDPESYAAAVEKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDELMGEIDIAL
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHH
THEVLSAKGASSLLDKLWMESLISP
HHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]