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The map label for this gene is ipaH3 [H]

Identifier: 51597601

GI number: 51597601

Start: 3920994

End: 3922820

Strand: Direct

Name: ipaH3 [H]

Synonym: YPTB3301

Alternate gene names: 51597601

Gene position: 3920994-3922820 (Clockwise)

Preceding gene: 51597589

Following gene: 51597602

Centisome position: 82.64

GC content: 48.39

Gene sequence:

>1827_bases
ATGAATCTATCAAATATAACCTCGAACGTGTCAATGCCGAACATAGGACCAGACCATGAAATCCATGCTGACCGGGCAGC
AGCAACAGCCTTAACTCCGGCTGACTATCATGCAATATGGGAACAGTGGGAAAGCGAGGCGATACCGGGTGCTAACGAAC
AGCGGGACCAGGCAGTAGCAAGAATGAAAGAGTGTCTGGAAAACAATGCTGAGCGCCTCGAACTCAATAGGCTTGGTTTG
ACCTCATTACCCGAAATATGGCCCACCTCGCTGTCCTCTTTAGATTTAAGCGACAATGTACTCACACAATTCCCCCAAAA
TTTGCCCGAGGGTTTGGATTATTTGAATGTTTCCAGCAATCGTCGGTTACAAGAATGGCCAGATTCGCTCCCTTCATCTC
TGAAAGACCTTTGTATCACAAGTTGTGGCTTCACTACGCTGGGAAGTTTACCGCCTAATCTGCAAGATTTGAGAGCGAAT
CATAATCAGATAAACACGCTACCCGAGACGTGGCCCGCCTCGCTGTTACTTTTAGATTTATGCCAAAACGCACTCACACA
ATTCCCCCAAAATTTACCCGAAGGGATGGAGGATTTAACTCTTTCATACAATCGTCAGTTACAACAAGGCACAAGCTCAC
TCCCCTCGTCGCTAAAATTCCTCGATATCGTACGCTGTGGATTCACTGAGCTTTCTGAAGCCATAACCAGTTTACCTATA
ACGTGTCAAATTAATATGGGACAGCGGGGGAGTTCGGGATATACCCATCTTATTCCTGAAAATGTACGTGAGCTACTGCT
GGATCGGGAGATGGATCGGCAGGTATGGATGGAGTTGGGGCCGTATATACTGCGGGCGCGGGAGCGGGAGGTACTGCTGG
CACAAGAAGCCCAGCAGGAACGTCCATCCCCTACTATTAACAATCTCAGTGACGTCATTGCCACCTGGCTACCCGCGGAG
CAACAAGACAAACTGGCAGGAAATTGGGCAACCATTGAGCAGGAAGACAATGCCCCCGCATTTAGCGCTTTTTTGAACCG
TTTGGCCGATACCGTCAGTGCGAAAGAAAATCCAGAGTTTATACTGCAAGTCGCCATCTGGCTGGCTCAACTGGCTGGTT
CACCTGCGCTACGTGAGCAGACCTTTCTTATCGCTCAGGAAGCAAGCGCGACCTGTGAAGACCGCATTACCTTGACGTAT
AACGATATGCAAAAGGCAGTCATGCTCCATGAGGTCGAAAAGGGACAATATGACACGCAATTACCTGAACTGATGGCGCG
TGGCCGGGAGATGTTCCGTCTGGAACAACTTGAGAATATTGCCCGCGAAAAAGTAAAAATACTAAAAACACTGAATGTAC
ATTCAGTCGACGACATCGAAGTCTATCTTGCCTATCAGGTTAAACTACGTGAGTCCTTAGAACTTTTCTCAGTAAGCAAA
GAAATGCGCTTCTTTGGCGTATCGCATGTGACAACAGACGATTTACTGAGCGCAGAAGCCAGGGTGAAAACTGCGGAAAA
CCACGATTTCCCGCGCTGGCTATCACAATGGTCCCCGTGGAAAAGCGTGGTGCAACGTATTGAGCCTGAACGTTATGCTG
CTGCGTTCGAAAAACAGTACCACGCACTGGAGAATATTTACCCAGATAAACTGGCGGCTGAATTGGCCGCCAACGGGATG
GCGGGCGATGTGGATGCCAACCGCATTGTCGGCAAAAGAATCAACGATGAGATAATGGGGAAGATCGATATGGCCCTGAC
TCATGAGGTTCTCTCTGCCAAAGGAGCCATCTCCTTATTAGATAGTCAGTGGATGGAATATATCTAA

Upstream 100 bases:

>100_bases
CAATGAGTTAAAAATACCAGTAGTAGACCTTATCTACCCCCTGTTATTTATCAGCCAAAATAACACCTCTAAGACTGATT
AAGGGAGCGATTTTAATACA

Downstream 100 bases:

>100_bases
TCTCGCCTTAATACTGCACGGCCCGCTATGCCATAAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGTTGATTGGT
CATTTTTCTCCCGCCACACC

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MNLSNITSNVSMPNIGPDHEIHADRAAATALTPADYHAIWEQWESEAIPGANEQRDQAVARMKECLENNAERLELNRLGL
TSLPEIWPTSLSSLDLSDNVLTQFPQNLPEGLDYLNVSSNRRLQEWPDSLPSSLKDLCITSCGFTTLGSLPPNLQDLRAN
HNQINTLPETWPASLLLLDLCQNALTQFPQNLPEGMEDLTLSYNRQLQQGTSSLPSSLKFLDIVRCGFTELSEAITSLPI
TCQINMGQRGSSGYTHLIPENVRELLLDREMDRQVWMELGPYILRAREREVLLAQEAQQERPSPTINNLSDVIATWLPAE
QQDKLAGNWATIEQEDNAPAFSAFLNRLADTVSAKENPEFILQVAIWLAQLAGSPALREQTFLIAQEASATCEDRITLTY
NDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQVKLRESLELFSVSK
EMRFFGVSHVTTDDLLSAEARVKTAENHDFPRWLSQWSPWKSVVQRIEPERYAAAFEKQYHALENIYPDKLAAELAANGM
AGDVDANRIVGKRINDEIMGKIDMALTHEVLSAKGAISLLDSQWMEYI

Sequences:

>Translated_608_residues
MNLSNITSNVSMPNIGPDHEIHADRAAATALTPADYHAIWEQWESEAIPGANEQRDQAVARMKECLENNAERLELNRLGL
TSLPEIWPTSLSSLDLSDNVLTQFPQNLPEGLDYLNVSSNRRLQEWPDSLPSSLKDLCITSCGFTTLGSLPPNLQDLRAN
HNQINTLPETWPASLLLLDLCQNALTQFPQNLPEGMEDLTLSYNRQLQQGTSSLPSSLKFLDIVRCGFTELSEAITSLPI
TCQINMGQRGSSGYTHLIPENVRELLLDREMDRQVWMELGPYILRAREREVLLAQEAQQERPSPTINNLSDVIATWLPAE
QQDKLAGNWATIEQEDNAPAFSAFLNRLADTVSAKENPEFILQVAIWLAQLAGSPALREQTFLIAQEASATCEDRITLTY
NDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQVKLRESLELFSVSK
EMRFFGVSHVTTDDLLSAEARVKTAENHDFPRWLSQWSPWKSVVQRIEPERYAAAFEKQYHALENIYPDKLAAELAANGM
AGDVDANRIVGKRINDEIMGKIDMALTHEVLSAKGAISLLDSQWMEYI
>Mature_608_residues
MNLSNITSNVSMPNIGPDHEIHADRAAATALTPADYHAIWEQWESEAIPGANEQRDQAVARMKECLENNAERLELNRLGL
TSLPEIWPTSLSSLDLSDNVLTQFPQNLPEGLDYLNVSSNRRLQEWPDSLPSSLKDLCITSCGFTTLGSLPPNLQDLRAN
HNQINTLPETWPASLLLLDLCQNALTQFPQNLPEGMEDLTLSYNRQLQQGTSSLPSSLKFLDIVRCGFTELSEAITSLPI
TCQINMGQRGSSGYTHLIPENVRELLLDREMDRQVWMELGPYILRAREREVLLAQEAQQERPSPTINNLSDVIATWLPAE
QQDKLAGNWATIEQEDNAPAFSAFLNRLADTVSAKENPEFILQVAIWLAQLAGSPALREQTFLIAQEASATCEDRITLTY
NDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQVKLRESLELFSVSK
EMRFFGVSHVTTDDLLSAEARVKTAENHDFPRWLSQWSPWKSVVQRIEPERYAAAFEKQYHALENIYPDKLAAELAANGM
AGDVDANRIVGKRINDEIMGKIDMALTHEVLSAKGAISLLDSQWMEYI

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Synthesizes a 'Lys-48'-linked ubiquitin chain, which requir

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 9 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 68600; Mature: 68600

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSNVSMPNIGPDHEIHADRAAATALTPADYHAIWEQWESEAIPGANEQRDQAVA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
RMKECLENNAERLELNRLGLTSLPEIWPTSLSSLDLSDNVLTQFPQNLPEGLDYLNVSSN
HHHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCC
RRLQEWPDSLPSSLKDLCITSCGFTTLGSLPPNLQDLRANHNQINTLPETWPASLLLLDL
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHCCCHHCCCCCCHHHHHHHHHHH
CQNALTQFPQNLPEGMEDLTLSYNRQLQQGTSSLPSSLKFLDIVRCGFTELSEAITSLPI
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
TCQINMGQRGSSGYTHLIPENVRELLLDREMDRQVWMELGPYILRAREREVLLAQEAQQE
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPSPTINNLSDVIATWLPAEQQDKLAGNWATIEQEDNAPAFSAFLNRLADTVSAKENPEF
CCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHH
ILQVAIWLAQLAGSPALREQTFLIAQEASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQ
HHHHHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHH
LPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQVKLRESLELFSVSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
EMRFFGVSHVTTDDLLSAEARVKTAENHDFPRWLSQWSPWKSVVQRIEPERYAAAFEKQY
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHH
HALENIYPDKLAAELAANGMAGDVDANRIVGKRINDEIMGKIDMALTHEVLSAKGAISLL
HHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHH
DSQWMEYI
HHHHHHCC
>Mature Secondary Structure
MNLSNITSNVSMPNIGPDHEIHADRAAATALTPADYHAIWEQWESEAIPGANEQRDQAVA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
RMKECLENNAERLELNRLGLTSLPEIWPTSLSSLDLSDNVLTQFPQNLPEGLDYLNVSSN
HHHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCC
RRLQEWPDSLPSSLKDLCITSCGFTTLGSLPPNLQDLRANHNQINTLPETWPASLLLLDL
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHCCCHHCCCCCCHHHHHHHHHHH
CQNALTQFPQNLPEGMEDLTLSYNRQLQQGTSSLPSSLKFLDIVRCGFTELSEAITSLPI
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCC
TCQINMGQRGSSGYTHLIPENVRELLLDREMDRQVWMELGPYILRAREREVLLAQEAQQE
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPSPTINNLSDVIATWLPAEQQDKLAGNWATIEQEDNAPAFSAFLNRLADTVSAKENPEF
CCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHH
ILQVAIWLAQLAGSPALREQTFLIAQEASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQ
HHHHHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHH
LPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQVKLRESLELFSVSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
EMRFFGVSHVTTDDLLSAEARVKTAENHDFPRWLSQWSPWKSVVQRIEPERYAAAFEKQY
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHH
HALENIYPDKLAAELAANGMAGDVDANRIVGKRINDEIMGKIDMALTHEVLSAKGAISLL
HHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHH
DSQWMEYI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12384590 [H]