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The map label for this gene is ubiH

Identifier: 51597494

GI number: 51597494

Start: 3745990

End: 3747168

Strand: Reverse

Name: ubiH

Synonym: YPTB3184

Alternate gene names: 51597494

Gene position: 3747168-3745990 (Counterclockwise)

Preceding gene: 51597495

Following gene: 51597493

Centisome position: 78.98

GC content: 55.22

Gene sequence:

>1179_bases
ATGAGTGTGATAATTGTTGGTGGTGGAATGGCGGGGGTAACTCTGGCACTGGCCATTTCATCCCTTACTCACGGGCAGGT
GCCCGTTGCACTGGTTGAGGCGCAACAACCCAATGACCGGCAACATCCGGGCTTTGATGCCAGAGCGATTGCGCTGGCGC
AGGGGACTTGCCAGCAGTTGGCGCGCATTGGTGCCTGGTCGGCATTGGCCGATTGTGCCACGGCCATTGATCATGTTCAT
GTCAGTGATCGCGGTCATTCTGGTTTTGTTAATTTGCGGGCTGAAGATTACGGTGTACCGGCGCTGGGGCATGTTCTCGA
GCTACATGATGCTGGTGAACGGCTCTTTGCCTTGCTGATGAAAGCTCCGGGGGTGACGCTGCATTGTCCGGCCAAAGTGG
TTGATGTGGTTCGTACCGCTGAATCCGCCCGTGTGACGTTGGATGACGGGCAACAACTGGCGGCAAAATTGCTGGTGGCC
GCAGACGGTTCTCACTCGGCATTAGCCCAATCCTGCGCTATCCAATGGCAGCGACAGGATTACCAACAGGTTGCGATTAT
TGCGAATATCACCACCTCCGAGCTACCGAATGGCCGTGCTTTTGAGCGTTTTACCCGCAATGGGCCATTAGCTTTACTGC
CGATGTCTCAGGGGCGCAGTTCTTTGGTTTGGTGCCATGCGAAGCATGATCAACAACAGATCGATAGCTGGGATGACGCG
CGTTTTTTGGCAGAGCTACAGCAAGCCTTTGGTTGGCGGTTGGGGAAAATGCTTCAGGCGGGTAAACGCCACAGCTACCC
ATTACAGTTACTGACTGCGTCACGTCATATCAGCCACCGCCTGGCGTTGGTGGGGAATGCGGCACAAACCTTACATCCGA
TAGCCGGTCAGGGGTTTAATCTTGGCCTGCGGGATGTGATGTCACTGGCTGAAACCCTTGCAGAGGCTGCGGCCATGGGG
AATGATCTCGGTGACTATACCGTTCTTAGCCACTATCAGCAGCGGCGTCAGCAGGATCAACAGGCGACTATTGGCGTTAC
TGATGGTTTGATCCGTTTGTTTGCGAATCGCTATGGGCCGTTAGTCGCAGGGCGGAATTTGGCGCTGATGGCCATGGAAC
AGATGCCCACAATACGTGATACTTTTGCCCGGCGTACATTGGGCTGGGTCGAGCGCTAA

Upstream 100 bases:

>100_bases
GGTTAAAGACCCTGATGACATTGAAGCATTGATGGCATTGAATCATTGATGGTATTGAAATACTGATGGTATTGAAACAC
AGATGGCAGCGAGATAACTG

Downstream 100 bases:

>100_bases
CTCAATAGACTCATCGGGATTAACGCGCCTCATCGTTGAGGTTTACCCTATGGGGTGGCACAAATGCTGTTCAAATCGTT
CCCGACCAATTTGCTTCTCG

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSVIIVGGGMAGVTLALAISSLTHGQVPVALVEAQQPNDRQHPGFDARAIALAQGTCQQLARIGAWSALADCATAIDHVH
VSDRGHSGFVNLRAEDYGVPALGHVLELHDAGERLFALLMKAPGVTLHCPAKVVDVVRTAESARVTLDDGQQLAAKLLVA
ADGSHSALAQSCAIQWQRQDYQQVAIIANITTSELPNGRAFERFTRNGPLALLPMSQGRSSLVWCHAKHDQQQIDSWDDA
RFLAELQQAFGWRLGKMLQAGKRHSYPLQLLTASRHISHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAAAMG
NDLGDYTVLSHYQQRRQQDQQATIGVTDGLIRLFANRYGPLVAGRNLALMAMEQMPTIRDTFARRTLGWVER

Sequences:

>Translated_392_residues
MSVIIVGGGMAGVTLALAISSLTHGQVPVALVEAQQPNDRQHPGFDARAIALAQGTCQQLARIGAWSALADCATAIDHVH
VSDRGHSGFVNLRAEDYGVPALGHVLELHDAGERLFALLMKAPGVTLHCPAKVVDVVRTAESARVTLDDGQQLAAKLLVA
ADGSHSALAQSCAIQWQRQDYQQVAIIANITTSELPNGRAFERFTRNGPLALLPMSQGRSSLVWCHAKHDQQQIDSWDDA
RFLAELQQAFGWRLGKMLQAGKRHSYPLQLLTASRHISHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAAAMG
NDLGDYTVLSHYQQRRQQDQQATIGVTDGLIRLFANRYGPLVAGRNLALMAMEQMPTIRDTFARRTLGWVER
>Mature_391_residues
SVIIVGGGMAGVTLALAISSLTHGQVPVALVEAQQPNDRQHPGFDARAIALAQGTCQQLARIGAWSALADCATAIDHVHV
SDRGHSGFVNLRAEDYGVPALGHVLELHDAGERLFALLMKAPGVTLHCPAKVVDVVRTAESARVTLDDGQQLAAKLLVAA
DGSHSALAQSCAIQWQRQDYQQVAIIANITTSELPNGRAFERFTRNGPLALLPMSQGRSSLVWCHAKHDQQQIDSWDDAR
FLAELQQAFGWRLGKMLQAGKRHSYPLQLLTASRHISHRLALVGNAAQTLHPIAGQGFNLGLRDVMSLAETLAEAAAMGN
DLGDYTVLSHYQQRRQQDQQATIGVTDGLIRLFANRYGPLVAGRNLALMAMEQMPTIRDTFARRTLGWVER

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=384, Percent_Identity=29.4270833333333, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI32967307, Length=373, Percent_Identity=30.8310991957105, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=66.0714285714286, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1786883, Length=396, Percent_Identity=30.8080808080808, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1789273, Length=392, Percent_Identity=30.3571428571429, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25146631, Length=425, Percent_Identity=26.8235294117647, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321694, Length=456, Percent_Identity=24.780701754386, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI19920760, Length=420, Percent_Identity=25.2380952380952, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 42497; Mature: 42366

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIIVGGGMAGVTLALAISSLTHGQVPVALVEAQQPNDRQHPGFDARAIALAQGTCQQL
CEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ARIGAWSALADCATAIDHVHVSDRGHSGFVNLRAEDYGVPALGHVLELHDAGERLFALLM
HHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPAKVVDVVRTAESARVTLDDGQQLAAKLLVAADGSHSALAQSCAIQWQRQD
HCCCCEEECHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
YQQVAIIANITTSELPNGRAFERFTRNGPLALLPMSQGRSSLVWCHAKHDQQQIDSWDDA
CEEEEEEEECHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHCCCCHHH
RFLAELQQAFGWRLGKMLQAGKRHSYPLQLLTASRHISHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAETLAEAAAMGNDLGDYTVLSHYQQRRQQDQQATIGVTDGLIRLFANRYGP
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
LVAGRNLALMAMEQMPTIRDTFARRTLGWVER
EEECCCEEEEEHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVIIVGGGMAGVTLALAISSLTHGQVPVALVEAQQPNDRQHPGFDARAIALAQGTCQQL
EEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ARIGAWSALADCATAIDHVHVSDRGHSGFVNLRAEDYGVPALGHVLELHDAGERLFALLM
HHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
KAPGVTLHCPAKVVDVVRTAESARVTLDDGQQLAAKLLVAADGSHSALAQSCAIQWQRQD
HCCCCEEECHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
YQQVAIIANITTSELPNGRAFERFTRNGPLALLPMSQGRSSLVWCHAKHDQQQIDSWDDA
CEEEEEEEECHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHCCCCHHH
RFLAELQQAFGWRLGKMLQAGKRHSYPLQLLTASRHISHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
LGLRDVMSLAETLAEAAAMGNDLGDYTVLSHYQQRRQQDQQATIGVTDGLIRLFANRYGP
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
LVAGRNLALMAMEQMPTIRDTFARRTLGWVER
EEECCCEEEEEHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]