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The map label for this gene is pepP

Identifier: 51597495

GI number: 51597495

Start: 3747220

End: 3748533

Strand: Reverse

Name: pepP

Synonym: YPTB3185

Alternate gene names: 51597495

Gene position: 3748533-3747220 (Counterclockwise)

Preceding gene: 51597496

Following gene: 51597494

Centisome position: 79.01

GC content: 51.52

Gene sequence:

>1314_bases
ATGACTCAGCAAGAATACCAGAACCGCCGTCAGGCACTGTTGGCGAAAATGGCCCCTGGCAGTGCTGCTATTATTTTTGC
CGCACCAGAAGCCACACGCAGTGCAGACTCTGAATATCCTTATCGGCAGAATAGTGATTTTAGCTATCTGACGGGCTTCA
ACGAGCCAGAAGCGGTGTTGATTCTGGTTAAAAGCGATGAGACTCATAACCACAGCGTGCTGTTTAACCGGGTTCGGGAT
TTAACCGCTGAGATCTGGTTTGGTCGTCGGTTAGGGCAAGAGGCCGCCCCCACGAAACTGGCAGTAGATCGCGCATTACC
TTTCGATGAAATCAACGAGCAGCTCTATTTGCTGCTTAATCGCCTGGATGTGATTTATCACGCTCAAGGGCAATATGCTT
ACGCAGATAATATTGTTTTTGCTGCACTGGAAAAATTACGTCATGGTTTTCGTAAAAATCTCCGAGCGCCAGCCACGTTA
ACCGATTGGCGGCCTTGGTTGCATGAAATGCGTCTGTTTAAATCAGCCGAAGAGATCGCCGTGCTGCGCCGCGCCGGTGA
AATCAGCGCACTGGCCCATACCCGTGCGATGGAAAAATGCCGCCCCGGTATGTTTGAATATCAATTGGAAGGGGAAATTC
TGCATGAATTTACCCGCCATGGCGCGCGTTATCCAGCGTACAACACCATCGTTGGTGGGGGTGAAAACGGCTGCATTTTG
CACTACACCGAGAATGAGTGTGAGCTGCGGGACGGGGATTTGGTCCTTATCGACGCGGGTTGTGAATACCGTGGCTATGC
CGGTGATATCACTCGCACTTTCCCGGTAAATGGCAAATTTACCCCCGCTCAGCGGGCGGTTTATGACATCGTTCTGGCGG
CTATCAATAAATCGCTGACGTTGTTCCGCCCCGGTACCAGCATCCGTGAGGTCACGGAAGAGGTGGTACGGATCATGGTC
GTCGGTTTGGTGGAGTTGGGTATTCTGAAAGGTGATATCGAACAGTTAATCGCTGAACAAGCCCATCGGCCATTCTTTAT
GCATGGCCTAAGCCACTGGCTGGGGATGGATGTCCATGACGTCGGCGATTACGGTAGCAGTGACCGTGGCCGTATCCTTG
AACCGGGCATGGTATTAACCGTGGAACCGGGCTTGTACATTGCCCCAGATGCCGATGTCCCGCCGCAATACCGGGGCATT
GGTATTCGTATTGAAGATGACATTGTGATTACCGCCACGGGTAACGAAAACTTGACCGCGAGCGTGGTTAAAGACCCTGA
TGACATTGAAGCATTGATGGCATTGAATCATTGA

Upstream 100 bases:

>100_bases
GACACTGCATTGATTTTGAACAATGGGCTGATTTTATCAATTGGCAAGTGTGGTGAAGTGAGTTTCAGGTGATGCAAACC
GGATATTTCAGGAGAAGGTC

Downstream 100 bases:

>100_bases
TGGTATTGAAATACTGATGGTATTGAAACACAGATGGCAGCGAGATAACTGATGAGTGTGATAATTGTTGGTGGTGGAAT
GGCGGGGGTAACTCTGGCAC

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTQQEYQNRRQALLAKMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTGFNEPEAVLILVKSDETHNHSVLFNRVRD
LTAEIWFGRRLGQEAAPTKLAVDRALPFDEINEQLYLLLNRLDVIYHAQGQYAYADNIVFAALEKLRHGFRKNLRAPATL
TDWRPWLHEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCIL
HYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLTLFRPGTSIREVTEEVVRIMV
VGLVELGILKGDIEQLIAEQAHRPFFMHGLSHWLGMDVHDVGDYGSSDRGRILEPGMVLTVEPGLYIAPDADVPPQYRGI
GIRIEDDIVITATGNENLTASVVKDPDDIEALMALNH

Sequences:

>Translated_437_residues
MTQQEYQNRRQALLAKMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTGFNEPEAVLILVKSDETHNHSVLFNRVRD
LTAEIWFGRRLGQEAAPTKLAVDRALPFDEINEQLYLLLNRLDVIYHAQGQYAYADNIVFAALEKLRHGFRKNLRAPATL
TDWRPWLHEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCIL
HYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLTLFRPGTSIREVTEEVVRIMV
VGLVELGILKGDIEQLIAEQAHRPFFMHGLSHWLGMDVHDVGDYGSSDRGRILEPGMVLTVEPGLYIAPDADVPPQYRGI
GIRIEDDIVITATGNENLTASVVKDPDDIEALMALNH
>Mature_436_residues
TQQEYQNRRQALLAKMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTGFNEPEAVLILVKSDETHNHSVLFNRVRDL
TAEIWFGRRLGQEAAPTKLAVDRALPFDEINEQLYLLLNRLDVIYHAQGQYAYADNIVFAALEKLRHGFRKNLRAPATLT
DWRPWLHEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCILH
YTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLTLFRPGTSIREVTEEVVRIMVV
GLVELGILKGDIEQLIAEQAHRPFFMHGLSHWLGMDVHDVGDYGSSDRGRILEPGMVLTVEPGLYIAPDADVPPQYRGIG
IRIEDDIVITATGNENLTASVVKDPDDIEALMALNH

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=448, Percent_Identity=32.8125, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI149589008, Length=450, Percent_Identity=32.6666666666667, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=37.6623376623377, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI260593663, Length=342, Percent_Identity=33.0409356725146, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1789275, Length=433, Percent_Identity=82.2170900692841, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=31.8493150684932, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=30.1960784313725, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=470, Percent_Identity=31.7021276595745, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=373, Percent_Identity=28.1501340482574, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=441, Percent_Identity=32.4263038548753, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321118, Length=451, Percent_Identity=29.2682926829268, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI19920384, Length=416, Percent_Identity=37.2596153846154, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21357079, Length=451, Percent_Identity=34.3680709534368, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49058; Mature: 48927

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQEYQNRRQALLAKMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTGFNEPEAVL
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEE
ILVKSDETHNHSVLFNRVRDLTAEIWFGRRLGQEAAPTKLAVDRALPFDEINEQLYLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHH
RLDVIYHAQGQYAYADNIVFAALEKLRHGFRKNLRAPATLTDWRPWLHEMRLFKSAEEIA
HHHEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCIL
HHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCCEEECCCCCEEE
HYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLT
EEECCCCEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
LFRPGTSIREVTEEVVRIMVVGLVELGILKGDIEQLIAEQAHRPFFMHGLSHWLGMDVHD
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
VGDYGSSDRGRILEPGMVLTVEPGLYIAPDADVPPQYRGIGIRIEDDIVITATGNENLTA
CCCCCCCCCCCEECCCEEEEECCCEEECCCCCCCCCCCEEEEEEECCEEEEEECCCCEEE
SVVKDPDDIEALMALNH
EEECCCHHHHHHHHCCC
>Mature Secondary Structure 
TQQEYQNRRQALLAKMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTGFNEPEAVL
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEE
ILVKSDETHNHSVLFNRVRDLTAEIWFGRRLGQEAAPTKLAVDRALPFDEINEQLYLLLN
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHH
RLDVIYHAQGQYAYADNIVFAALEKLRHGFRKNLRAPATLTDWRPWLHEMRLFKSAEEIA
HHHEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCIL
HHHHCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCCCCCCEEECCCCCEEE
HYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLT
EEECCCCEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEE
LFRPGTSIREVTEEVVRIMVVGLVELGILKGDIEQLIAEQAHRPFFMHGLSHWLGMDVHD
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
VGDYGSSDRGRILEPGMVLTVEPGLYIAPDADVPPQYRGIGIRIEDDIVITATGNENLTA
CCCCCCCCCCCEECCCEEEEECCCEEECCCCCCCCCCCEEEEEEECCEEEEEECCCCEEE
SVVKDPDDIEALMALNH
EEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]