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The map label for this gene is degP [H]

Identifier: 50843744

GI number: 50843744

Start: 2506148

End: 2507587

Strand: Reverse

Name: degP [H]

Synonym: PPA2307

Alternate gene names: 50843744

Gene position: 2507587-2506148 (Counterclockwise)

Preceding gene: 50843745

Following gene: 50843742

Centisome position: 97.94

GC content: 59.03

Gene sequence:

>1440_bases
ATGGGATCGTGGACACTGGAAGTCATGAGTGAGTCGACGAATGGTCCCCAAGAGCCTCGTGAACCTAATTCTTTCCCGCG
TGCTAGCGCCGAGGGCGGATATTCCTCGCACTCTGAGGATGCCCGTCAGGGCTGGGCACAGGAGTCATATTGGTCGCACA
GTGACGATACCCGGTCTAGTTCGGGAGATTCGCCGACTACCCAACGGCAGCCGTGGGAATCATCTGAACAGCCCACTGCT
ATTGATCCGAACCTTGGTAACAAAAATGCCGGCTCGCCGCAGCCCTCGTCTCGATCGGGCCGCAAGGGTTTCCGAGGCGG
GACTATTGTCCTTGCTGCGCTGCTAGCCGCGGCCGTGGGTGGAGTCTCAGGTGGTCTTGTCGATCGTTCCTTGACAAAAA
ATGACACTCCTGCCGTGGCCACAAAGTCTGCCGCCCCGAATACCGTTACCAAGGTTGTTCAGGGATCGTCATCTGCTCCG
GACTGGACGGCCACTGCCTCCGCCATCTCGAACTCGGTGGTCTCTATCACCGTGACGACCGGCAATGGGGGCGGCGAGGG
GTCCGGTGTCGTCGTCGATTCCAACGGCGACATCGTCACCAACAATCACGTCGTCTCTGACGCCGCATCCGGCGGTCAAC
TGACGGTATCTATGGGCAACAAGACGTATGACGCCAAGGTGGTGGGTAGTGATCCATCAACTGACCTGGCTGTCATCCGG
GTAACGAATCCGCCCGAATCCATGAAGCCGATGAGGTTCGCCAATTCCAGCAAGCTGACCGTCGGTGCCCCGGTCATGGC
TGTTGGTAACCCGCTAGGACTGTCCGGATCGGTGACGACCGGCATCATTAGCGCTCTTAACCGCCCGGTCACGACCATGA
GCCGCGATGACTCAGATGACGTGTTGGGGTCATATGATTCCTCGTCGGGGGTCGTCGTCACCAATGCCATCCAGACCAGC
GCCGCGATTAACCCAGGCAATTCCGGGGGTGCGCTGGTCAATGCCAATGGTGAACTCGTCGGCATCAACTCCTCAATCGC
CAGTTTGCCGTCGGCGGACCGCTCCCAGTCGGGCAATATCGGCATCGGGTTCGCCATCCCATCGAATTTGGCCAAGTCGG
TTGCCGACCAGATCATCCGGACCGGCAAGGTCACTCACGCTTTCCTAGGCATCTCGGTTCGTGACGCGGCTGCAGTTAAG
GCTGGTGTCAAGGTTCGGGGTGCCGGAATCGCGACGGTCATTCCGAGTTCGGCTGCCGGCAAGGCCGGTTTGCGCCGAGG
CGACGTCATCACCAGGATTGACGACACTGATATCGCCTCGGGGGAGTCTTTAGTAGGTCTTATTCGTTCGTTCAAAGCTG
GGCAGAAGGCGAAAATCAGTTATATCCGTGGTTCCCAGGAGGGGACGGTTGACGTGACAATGGGCACGGCGAAGGCTTGA

Upstream 100 bases:

>100_bases
CCTGACCATGGTCGGATGGGGTTGGCCGGTCGCGTGCCACTACAGCGTCGTTCCCTCTCCGCCGACAGCATGTTTCCCTC
GGCGATCGGGTGAACACTTG

Downstream 100 bases:

>100_bases
TTTTGGCAGTAACACAGCCAACTCTCCGCAGCCGATGTGCTGCGGAGAGTTCGAATTTCTACCTGCGCTCTCACATGAGG
TCGAGGACCGCTCGGGCAGT

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MGSWTLEVMSESTNGPQEPREPNSFPRASAEGGYSSHSEDARQGWAQESYWSHSDDTRSSSGDSPTTQRQPWESSEQPTA
IDPNLGNKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVGGVSGGLVDRSLTKNDTPAVATKSAAPNTVTKVVQGSSSAP
DWTATASAISNSVVSITVTTGNGGGEGSGVVVDSNGDIVTNNHVVSDAASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIR
VTNPPESMKPMRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDDVLGSYDSSSGVVVTNAIQTS
AAINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNIGIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVK
AGVKVRGAGIATVIPSSAAGKAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKISYIRGSQEGTVDVTMGTAKA

Sequences:

>Translated_479_residues
MGSWTLEVMSESTNGPQEPREPNSFPRASAEGGYSSHSEDARQGWAQESYWSHSDDTRSSSGDSPTTQRQPWESSEQPTA
IDPNLGNKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVGGVSGGLVDRSLTKNDTPAVATKSAAPNTVTKVVQGSSSAP
DWTATASAISNSVVSITVTTGNGGGEGSGVVVDSNGDIVTNNHVVSDAASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIR
VTNPPESMKPMRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDDVLGSYDSSSGVVVTNAIQTS
AAINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNIGIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVK
AGVKVRGAGIATVIPSSAAGKAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKISYIRGSQEGTVDVTMGTAKA
>Mature_478_residues
GSWTLEVMSESTNGPQEPREPNSFPRASAEGGYSSHSEDARQGWAQESYWSHSDDTRSSSGDSPTTQRQPWESSEQPTAI
DPNLGNKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVGGVSGGLVDRSLTKNDTPAVATKSAAPNTVTKVVQGSSSAPD
WTATASAISNSVVSITVTTGNGGGEGSGVVVDSNGDIVTNNHVVSDAASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIRV
TNPPESMKPMRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDDVLGSYDSSSGVVVTNAIQTSA
AINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNIGIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVKA
GVKVRGAGIATVIPSSAAGKAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKISYIRGSQEGTVDVTMGTAKA

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=271, Percent_Identity=32.1033210332103, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4506141, Length=279, Percent_Identity=32.258064516129, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI7019477, Length=307, Percent_Identity=30.9446254071661, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI24308541, Length=275, Percent_Identity=30.5454545454545, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786356, Length=294, Percent_Identity=40.1360544217687, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789629, Length=297, Percent_Identity=37.7104377104377, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789630, Length=295, Percent_Identity=34.2372881355932, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646839, Length=384, Percent_Identity=28.6458333333333, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48385; Mature: 48254

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSWTLEVMSESTNGPQEPREPNSFPRASAEGGYSSHSEDARQGWAQESYWSHSDDTRSS
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCCCCC
SGDSPTTQRQPWESSEQPTAIDPNLGNKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVG
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GVSGGLVDRSLTKNDTPAVATKSAAPNTVTKVVQGSSSAPDWTATASAISNSVVSITVTT
CCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEE
GNGGGEGSGVVVDSNGDIVTNNHVVSDAASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIR
CCCCCCCCEEEEECCCCEEECCEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCEEEEE
VTNPPESMKPMRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDD
ECCCCCCCCCCEECCCCCEEECCCCEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCC
VLGSYDSSSGVVVTNAIQTSAAINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECCCCEEEECCHHHHCCCCCCCCCCCE
GIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVKAGVKVRGAGIATVIPSSAAG
EEEECCHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHCCCEEECCCEEEECCCCCCC
KAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKISYIRGSQEGTVDVTMGTAKA
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
>Mature Secondary Structure 
GSWTLEVMSESTNGPQEPREPNSFPRASAEGGYSSHSEDARQGWAQESYWSHSDDTRSS
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCCCCC
SGDSPTTQRQPWESSEQPTAIDPNLGNKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVG
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GVSGGLVDRSLTKNDTPAVATKSAAPNTVTKVVQGSSSAPDWTATASAISNSVVSITVTT
CCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEE
GNGGGEGSGVVVDSNGDIVTNNHVVSDAASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIR
CCCCCCCCEEEEECCCCEEECCEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCEEEEE
VTNPPESMKPMRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDD
ECCCCCCCCCCEECCCCCEEECCCCEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCC
VLGSYDSSSGVVVTNAIQTSAAINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECCCCEEEECCHHHHCCCCCCCCCCCE
GIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVKAGVKVRGAGIATVIPSSAAG
EEEECCHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHCCCEEECCCEEEECCCCCCC
KAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKISYIRGSQEGTVDVTMGTAKA
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]