| Definition | Propionibacterium acnes KPA171202, complete genome. |
|---|---|
| Accession | NC_006085 |
| Length | 2,560,265 |
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The map label for this gene is nrdA [H]
Identifier: 50843559
GI number: 50843559
Start: 2294877
End: 2297447
Strand: Direct
Name: nrdA [H]
Synonym: PPA2121
Alternate gene names: 50843559
Gene position: 2294877-2297447 (Clockwise)
Preceding gene: 50843558
Following gene: 50843560
Centisome position: 89.63
GC content: 62.5
Gene sequence:
>2571_bases ATGAGCGCCGACCCCATTTCGACCATCCGCGTCCGCAAGCGTGACGGGTCTTTAGCCCCCTACGACGGCAACGAAGTCGC TGCCTCGATCATGGACTCGGCCCGCGGCCTTGACGACGCCGTCGCCCGGGCAACCCTGCTGCAGGCAGAGGTGGAGATCA CCCTCTTTGACGGGATGACCACCGACGCCCTCGACGAAGCCGTCATTCAGGTGGCCCTAGGCAACGCTAAGGACGATCCG GCCTTTGACACTATCGCCAGCCGGATCGCCGTCAAGAAGCTCTACAAAGAGGTCTTTGGCGACACCCATGACGATCTAGG TGACGTCGACCCCGAGAGGGTGCAGGATCTGCACCGCAACTATTTCCCGCGCACGATCGCCAAGCTTGTCGCCGATGGTC ACCTTGACGAGCGTCTGGGACGAGATTTCGACCTCGAGACGCTTGCAGCTGCCCTCGACCCCACTCGTGACGACCTCATC GGGTTCATGGGCGTGCGCACCATGATCAACCGTTATCTCTTGCGCACTCCCGATAAGCAGGCTTTGGAGGTACCGCAGTA CTTCTGGATGCGCGTCGCGATGGGGCTGAGCCTCACTGAGGACGATCCCACTTCCTCGGCGCTGGCCCTTTACGACTCCA TGAGCAACCTGCGCCACCTGGCCGCTGGATCCACCCTTGTCAATGCGGGGACGCCATCGGCTCAGCTATCTAACTGCTTC GTCATGCGCACTGAGGACAATCTGGAGCACATCGCCCAGACGATCCGCGACGTCATGTGGATCACCAAGGGCACCGGCGG CATTGGGTTGTCGATGTCGGATCTTCGCTGCGAGGGATCCCCGATCCGCTCAGATAACACTGCATCAACTGGGCCGATCC CCTTCATACACACCTTTGACTCCACACTGCGTGCGGTCTCTCGGGGAGGCAAGAAGCTCGGCGCCTTGTGCTTCTACCTG GAGAACTGGCACATGGACTTCCCGCAGTTCCTCGACCTGCGGCAGAACTCCGGTGACCCGTACCGACGCACCCGCACCGC CGACACTGCGGTGTGGATCTCCGACGAGTTCATGAAGCGTGTCGCCAAAGACGAGGACTGGTACCTCTTCGATCCCGCCG AAACCCCGGATCTCACCGAGCTTACCGGATCGGACTTCTCCAAGCGTTACGCCCAGTATGTCGAGCAGGCGGAAGCTGGC AAGATCAAGCGCTTTCGGCGCACTACTGCCCGCGAGCAATTCCGAGCCATCTTGGTGAGCCTACAGACGACGTCGCACCC ATGGCTGACGTGGAAAGATAGCATCAATACTCGCGCGTTGAACAGCAATACCGGGACGATCCACTCGTCAAACCTATGCA CCGAAATCTGCCTGCCACAGGACCGCGACCACACCGCGGTGTGCAACCTCGCCTCGGTGAACTTGGCGGCGCACCTCGCC GGCCCGCGTGGCAAGCGTCGTCTGGATTGGGACCAGTTGGCCGCCACCACCCGGCTGGCGGTACGTCATCTCGACAACCT TGTCGACATCACCGCCTCTGCAGTACCACAGGCTCAGCGCTCCAACGAGGAAAACCGCGCAATTGGTCTAGGCGTCATGG GTCTGACGGATATGCTCGAGCAGATTCGAGTCCCCTACGACTCCCCGGATGCGTGCGAGATCGTCGACCGGGTCGTTGAG TTCATCAGTTGGCACGCTATCGACACCTCGGCCGACCTGGCCGCCGAACGTGGGGCGTACCCAATGTTCGAAGGGTCGGG GTGGTCACGCGGGATGGTTCCCGTGGACACTTTGGCCGTCCTCGAGCGCGACCGTGGCATCCCTGTCGACGTCGACCGGA CGACGCGGATGGACTGGGACGCGCTGCGCGCCAAGGTGCGCACTGGGATGCGCAATGCCACCTTGATGGCGATCGCTCCG ACGGCGTCGATCGGCCTCATCGCGGGCACAACGCCCGGCCTGGATCCGCAGTTCTCCCAGATGTTCTCCCGAACCACCTC GGCCGGGAAGTTCCTCGAGGTTAATCGCAATCTCGTGGCGGACCTCAAGGATCTGGGCCTGTGGGAGACGATCCGCGAGG AATTGCTGCGTCGTCAGGGTGATCCCAGCGAGATTGAGGCAATTCCGGCGCCCTTGCGTCGTCTTTACCGCACCTCCTTC ACCCTGGACCCGATGGCCTACCTCAACGTGGCCGCTCGGGCGCAGAAGTGGGTGGATCAGGCCATTAGCCGCAACATCTA CCTGGCCTCGCGGTCGGTCGGTGACATGGAGGACCTCTACACCGCAGCTTGGCGAATGGGTGTCAAAACGACGTACTACC TGCACATGCTGCCTCGCCACACCGCCGAGCAGTCGACGGTGGCCGTTAACAAGGCCGCCGGGCGTCGGAACGGCCCACGT CGCGGATTCGCCACTGCGGTGCGTCGGGCCTCAGGTGCCGCGACGATCAGGAAACCGGTTACCGAAACGCTCAATGCGAG CGTGGAGCCCGTCGTCTCCCTCGACCTTATCGACGGCGCCTCCTGCCCTGTTGACCCCCAGGAGCGCCAACAGTGCGAGT CCTGCCAGTGA
Upstream 100 bases:
>100_bases TTCGCGATCTCGCGGGAAGTATCGCAGCGTTCAGGGGGACCACTGTCCCTGCCGCATTCCGCCCGGTCGCGTGCCCACGG CATCGCACGGAGGAATTGCA
Downstream 100 bases:
>100_bases TTGACCATACTGCCCGCTGAAAGCGAGAACACCGATGATCCTTGGTTCTGGAATCCAAGAGGGGCTGCTACTCAAGCCCG TCACCTACTCCTGGGCGTAC
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 856; Mature: 855
Protein sequence:
>856_residues MSADPISTIRVRKRDGSLAPYDGNEVAASIMDSARGLDDAVARATLLQAEVEITLFDGMTTDALDEAVIQVALGNAKDDP AFDTIASRIAVKKLYKEVFGDTHDDLGDVDPERVQDLHRNYFPRTIAKLVADGHLDERLGRDFDLETLAAALDPTRDDLI GFMGVRTMINRYLLRTPDKQALEVPQYFWMRVAMGLSLTEDDPTSSALALYDSMSNLRHLAAGSTLVNAGTPSAQLSNCF VMRTEDNLEHIAQTIRDVMWITKGTGGIGLSMSDLRCEGSPIRSDNTASTGPIPFIHTFDSTLRAVSRGGKKLGALCFYL ENWHMDFPQFLDLRQNSGDPYRRTRTADTAVWISDEFMKRVAKDEDWYLFDPAETPDLTELTGSDFSKRYAQYVEQAEAG KIKRFRRTTAREQFRAILVSLQTTSHPWLTWKDSINTRALNSNTGTIHSSNLCTEICLPQDRDHTAVCNLASVNLAAHLA GPRGKRRLDWDQLAATTRLAVRHLDNLVDITASAVPQAQRSNEENRAIGLGVMGLTDMLEQIRVPYDSPDACEIVDRVVE FISWHAIDTSADLAAERGAYPMFEGSGWSRGMVPVDTLAVLERDRGIPVDVDRTTRMDWDALRAKVRTGMRNATLMAIAP TASIGLIAGTTPGLDPQFSQMFSRTTSAGKFLEVNRNLVADLKDLGLWETIREELLRRQGDPSEIEAIPAPLRRLYRTSF TLDPMAYLNVAARAQKWVDQAISRNIYLASRSVGDMEDLYTAAWRMGVKTTYYLHMLPRHTAEQSTVAVNKAAGRRNGPR RGFATAVRRASGAATIRKPVTETLNASVEPVVSLDLIDGASCPVDPQERQQCESCQ
Sequences:
>Translated_856_residues MSADPISTIRVRKRDGSLAPYDGNEVAASIMDSARGLDDAVARATLLQAEVEITLFDGMTTDALDEAVIQVALGNAKDDP AFDTIASRIAVKKLYKEVFGDTHDDLGDVDPERVQDLHRNYFPRTIAKLVADGHLDERLGRDFDLETLAAALDPTRDDLI GFMGVRTMINRYLLRTPDKQALEVPQYFWMRVAMGLSLTEDDPTSSALALYDSMSNLRHLAAGSTLVNAGTPSAQLSNCF VMRTEDNLEHIAQTIRDVMWITKGTGGIGLSMSDLRCEGSPIRSDNTASTGPIPFIHTFDSTLRAVSRGGKKLGALCFYL ENWHMDFPQFLDLRQNSGDPYRRTRTADTAVWISDEFMKRVAKDEDWYLFDPAETPDLTELTGSDFSKRYAQYVEQAEAG KIKRFRRTTAREQFRAILVSLQTTSHPWLTWKDSINTRALNSNTGTIHSSNLCTEICLPQDRDHTAVCNLASVNLAAHLA GPRGKRRLDWDQLAATTRLAVRHLDNLVDITASAVPQAQRSNEENRAIGLGVMGLTDMLEQIRVPYDSPDACEIVDRVVE FISWHAIDTSADLAAERGAYPMFEGSGWSRGMVPVDTLAVLERDRGIPVDVDRTTRMDWDALRAKVRTGMRNATLMAIAP TASIGLIAGTTPGLDPQFSQMFSRTTSAGKFLEVNRNLVADLKDLGLWETIREELLRRQGDPSEIEAIPAPLRRLYRTSF TLDPMAYLNVAARAQKWVDQAISRNIYLASRSVGDMEDLYTAAWRMGVKTTYYLHMLPRHTAEQSTVAVNKAAGRRNGPR RGFATAVRRASGAATIRKPVTETLNASVEPVVSLDLIDGASCPVDPQERQQCESCQ >Mature_855_residues SADPISTIRVRKRDGSLAPYDGNEVAASIMDSARGLDDAVARATLLQAEVEITLFDGMTTDALDEAVIQVALGNAKDDPA FDTIASRIAVKKLYKEVFGDTHDDLGDVDPERVQDLHRNYFPRTIAKLVADGHLDERLGRDFDLETLAAALDPTRDDLIG FMGVRTMINRYLLRTPDKQALEVPQYFWMRVAMGLSLTEDDPTSSALALYDSMSNLRHLAAGSTLVNAGTPSAQLSNCFV MRTEDNLEHIAQTIRDVMWITKGTGGIGLSMSDLRCEGSPIRSDNTASTGPIPFIHTFDSTLRAVSRGGKKLGALCFYLE NWHMDFPQFLDLRQNSGDPYRRTRTADTAVWISDEFMKRVAKDEDWYLFDPAETPDLTELTGSDFSKRYAQYVEQAEAGK IKRFRRTTAREQFRAILVSLQTTSHPWLTWKDSINTRALNSNTGTIHSSNLCTEICLPQDRDHTAVCNLASVNLAAHLAG PRGKRRLDWDQLAATTRLAVRHLDNLVDITASAVPQAQRSNEENRAIGLGVMGLTDMLEQIRVPYDSPDACEIVDRVVEF ISWHAIDTSADLAAERGAYPMFEGSGWSRGMVPVDTLAVLERDRGIPVDVDRTTRMDWDALRAKVRTGMRNATLMAIAPT ASIGLIAGTTPGLDPQFSQMFSRTTSAGKFLEVNRNLVADLKDLGLWETIREELLRRQGDPSEIEAIPAPLRRLYRTSFT LDPMAYLNVAARAQKWVDQAISRNIYLASRSVGDMEDLYTAAWRMGVKTTYYLHMLPRHTAEQSTVAVNKAAGRRNGPRR GFATAVRRASGAATIRKPVTETLNASVEPVVSLDLIDGASCPVDPQERQQCESCQ
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 3 ATP-cone domains [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=792, Percent_Identity=33.9646464646465, Blast_Score=425, Evalue=1e-118, Organism=Escherichia coli, GI2367133, Length=798, Percent_Identity=25.8145363408521, Blast_Score=249, Evalue=8e-67, Organism=Escherichia coli, GI1789030, Length=684, Percent_Identity=27.9239766081871, Blast_Score=205, Evalue=9e-54, Organism=Caenorhabditis elegans, GI17555242, Length=788, Percent_Identity=33.6294416243655, Blast_Score=411, Evalue=1e-115, Organism=Saccharomyces cerevisiae, GI6320914, Length=836, Percent_Identity=32.7751196172249, Blast_Score=397, Evalue=1e-111, Organism=Saccharomyces cerevisiae, GI6322123, Length=789, Percent_Identity=32.9531051964512, Blast_Score=394, Evalue=1e-110, Organism=Drosophila melanogaster, GI17352481, Length=800, Percent_Identity=31.625, Blast_Score=399, Evalue=1e-111,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 94959; Mature: 94828
Theoretical pI: Translated: 5.51; Mature: 5.51
Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSADPISTIRVRKRDGSLAPYDGNEVAASIMDSARGLDDAVARATLLQAEVEITLFDGMT CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEECCCC TDALDEAVIQVALGNAKDDPAFDTIASRIAVKKLYKEVFGDTHDDLGDVDPERVQDLHRN HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH YFPRTIAKLVADGHLDERLGRDFDLETLAAALDPTRDDLIGFMGVRTMINRYLLRTPDKQ CCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHH ALEVPQYFWMRVAMGLSLTEDDPTSSALALYDSMSNLRHLAAGSTLVNAGTPSAQLSNCF HHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCEE VMRTEDNLEHIAQTIRDVMWITKGTGGIGLSMSDLRCEGSPIRSDNTASTGPIPFIHTFD EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEHHH STLRAVSRGGKKLGALCFYLENWHMDFPQFLDLRQNSGDPYRRTRTADTAVWISDEFMKR HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCCEEEECHHHHHH VAKDEDWYLFDPAETPDLTELTGSDFSKRYAQYVEQAEAGKIKRFRRTTAREQFRAILVS HHCCCCEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LQTTSHPWLTWKDSINTRALNSNTGTIHSSNLCTEICLPQDRDHTAVCNLASVNLAAHLA HCCCCCCCEEECCCCCCEEECCCCCCEECCCCHHHHCCCCCCCCHHEEEHHHHHHHHEEC GPRGKRRLDWDQLAATTRLAVRHLDNLVDITASAVPQAQRSNEENRAIGLGVMGLTDMLE CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEHHHHHHHHH QIRVPYDSPDACEIVDRVVEFISWHAIDTSADLAAERGAYPMFEGSGWSRGMVPVDTLAV HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH LERDRGIPVDVDRTTRMDWDALRAKVRTGMRNATLMAIAPTASIGLIAGTTPGLDPQFSQ HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHH MFSRTTSAGKFLEVNRNLVADLKDLGLWETIREELLRRQGDPSEIEAIPAPLRRLYRTSF HHHHHCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCC TLDPMAYLNVAARAQKWVDQAISRNIYLASRSVGDMEDLYTAAWRMGVKTTYYLHMLPRH CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC TAEQSTVAVNKAAGRRNGPRRGFATAVRRASGAATIRKPVTETLNASVEPVVSLDLIDGA CCCHHHEEEEHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCC SCPVDPQERQQCESCQ CCCCCHHHHHHHHCCC >Mature Secondary Structure SADPISTIRVRKRDGSLAPYDGNEVAASIMDSARGLDDAVARATLLQAEVEITLFDGMT CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEECCCC TDALDEAVIQVALGNAKDDPAFDTIASRIAVKKLYKEVFGDTHDDLGDVDPERVQDLHRN HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH YFPRTIAKLVADGHLDERLGRDFDLETLAAALDPTRDDLIGFMGVRTMINRYLLRTPDKQ CCHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHH ALEVPQYFWMRVAMGLSLTEDDPTSSALALYDSMSNLRHLAAGSTLVNAGTPSAQLSNCF HHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCEE VMRTEDNLEHIAQTIRDVMWITKGTGGIGLSMSDLRCEGSPIRSDNTASTGPIPFIHTFD EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEHHH STLRAVSRGGKKLGALCFYLENWHMDFPQFLDLRQNSGDPYRRTRTADTAVWISDEFMKR HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCCEEEECHHHHHH VAKDEDWYLFDPAETPDLTELTGSDFSKRYAQYVEQAEAGKIKRFRRTTAREQFRAILVS HHCCCCEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LQTTSHPWLTWKDSINTRALNSNTGTIHSSNLCTEICLPQDRDHTAVCNLASVNLAAHLA HCCCCCCCEEECCCCCCEEECCCCCCEECCCCHHHHCCCCCCCCHHEEEHHHHHHHHEEC GPRGKRRLDWDQLAATTRLAVRHLDNLVDITASAVPQAQRSNEENRAIGLGVMGLTDMLE CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEHHHHHHHHH QIRVPYDSPDACEIVDRVVEFISWHAIDTSADLAAERGAYPMFEGSGWSRGMVPVDTLAV HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH LERDRGIPVDVDRTTRMDWDALRAKVRTGMRNATLMAIAPTASIGLIAGTTPGLDPQFSQ HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHH MFSRTTSAGKFLEVNRNLVADLKDLGLWETIREELLRRQGDPSEIEAIPAPLRRLYRTSF HHHHHCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCC TLDPMAYLNVAARAQKWVDQAISRNIYLASRSVGDMEDLYTAAWRMGVKTTYYLHMLPRH CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCC TAEQSTVAVNKAAGRRNGPRRGFATAVRRASGAATIRKPVTETLNASVEPVVSLDLIDGA CCCHHHEEEEHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCC SCPVDPQERQQCESCQ CCCCCHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]