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The map label for this gene is glnS [H]

Identifier: 50843324

GI number: 50843324

Start: 2023428

End: 2025125

Strand: Direct

Name: glnS [H]

Synonym: PPA1870

Alternate gene names: 50843324

Gene position: 2023428-2025125 (Clockwise)

Preceding gene: 50843320

Following gene: 50843325

Centisome position: 79.03

GC content: 60.54

Gene sequence:

>1698_bases
ATGGCAGAACCTACTGGAAACCCGGCTGAGTCCAGCTCGGACTTCATTCATCAGGTTGTTCGCGCGGACATCCAACAGGA
CACCTACGGCGGGCGCGTCCAGACCCGGTTCCCACCTGAGCCTAACGGCTACCTCCACATTGGCCACGCGAAGGCCATCG
TCACCGATTTCGGCGTTGCCGAGGATTTCGGCGGCACCTGCAACCTGAGACTTGATGATACTAATCCAGGCACCGAGGAA
ACCGAGTATGTCGAGTCGATCATTGCAGACATTGAGTGGTTAGGCTACTCCCCGGCCCACGTTGTCCACGCGTCGGACTA
TTTCGAGCAGCTTTACGAGTGGGCGAAATACCTCGTACGTGAGGGACTGGCCTACGTTGACGACCAGTCCCCCGAAACTA
TCCGTGAGCAACGCGGCGGCTACGGTAAGCCGGGCATTGAAAGTCCCTATCGCAACCGTCCTGCCGAAGAATCCCTTAAC
CTGTTGAGGCGGATGCGTGCCGGGGAATTCCCCGACGGTTCCCGCTGCCTGCGCGCCCGCATCGATATGCAGGCCGAAAA
TATGTGGCTGCGCGACCCAGTCATGTACCGGATCCGCCACCAAGCCCACCACTCCACCGGTACCGAGTGGTGCATCTACC
CCACGTATGACTGGGCACATGGTCAGTCTGACGCTATTGAGGGCGTGACTCACTCGTTGTGCTCCCTAGAATTCAACAGT
CATCGTCCGCTCTACGACTGGTTCCTTTCCCACTTGCCTCTGGACGGCCCTGCCCCCAAGCAGCGCGAATTTGCCCGTCT
CGAGTTGACCCACACCATCACCTCGAAGCGCCGGCTCAAGTCCCTAGTAACCAACAACATCGTTGACGGATGGGATGATC
CGCGCATGCCCACCCTGCGCGGTATGCGTCGCCGTGGATACCCAGCAGCCGCCATTCGAGCCTTCTGCCAGGCCGTCGGC
ACTACCAAGAACAACTCGGTCAAGGCCATTGAGGAGTTTGAGTCCTTCGTGCGCCGCGAGCTCAACGCCACCGCTCAGCG
GCGCATGGCTGTGTTGCACCCCCTCAAGCTTGTCCTTGACGGCTGGCCGACTGACGACGACGGCAACCCGGTGGTGGAAT
GGTTCCAGCTGGTCAATAATCCGGAGAATCCTGACGACGGCACCCGTCGCGTCCCCTTCACCGGAGAGCTCTGGATTGAG
GCCGATGATTTCCGCGAGGACCCTCCCCGCAAATTCTTCCGCCTCTCCCCCGGACATGAGGTGCGCCTGCGCGGCGCCTA
TCTGGTGACAGCCACCGACGTCGTCAAAAATCCTGACGGAACTATTGCTGAGGTTCACGCCAGTTACGACCCGCAATCGC
GCGGCGGAACCGCCCCTGACGGCCGCAAGGTGAAGTCGACGATGCACTGGGTTTCGGCTGGCCATGCCATTCCCGTGACA
GCCAACCTGTACGACCGCTTATTCAGCGCTGAGATTCCTGGGTCGCAGACCGGGGAAGCCCTTGACGATCTCAACCCACA
TTCCCGCGAAACACTCACCGAGGTCATGGCCGAACCGGCCCTGGCCAATGTGGCTCCGGGCGAGGTAGTGCAATTCGAGA
GACTGGGATACTTCGCTGCAGATCACGACACCGCCGTGTTCCATCGCACCGTCGGTCTGCGTGACGAATGGGCCCAGCTA
CAAAAGCGCCAGGCCTGA

Upstream 100 bases:

>100_bases
GTGGGCGAGGGGGCAACGCGCGTGCGCGCGGGATGCAAATCAGTCATGATGACACGAAGTCTATCGGGATCCGCTGACAG
ACTCCGGTAAAGTTCCCGCC

Downstream 100 bases:

>100_bases
CCAGACAGTGTTGCCGACAAAAATCCATCGATTTGTTCCCCAACGCTCACCTCATTCGGTAACGATGGTGTCGCTTCCCA
ACCCGTTGGAAAGACGCCAT

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MAEPTGNPAESSSDFIHQVVRADIQQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVAEDFGGTCNLRLDDTNPGTEE
TEYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVREGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLN
LLRRMRAGEFPDGSRCLRARIDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWAHGQSDAIEGVTHSLCSLEFNS
HRPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRLKSLVTNNIVDGWDDPRMPTLRGMRRRGYPAAAIRAFCQAVG
TTKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLDGWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIE
ADDFREDPPRKFFRLSPGHEVRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVT
ANLYDRLFSAEIPGSQTGEALDDLNPHSRETLTEVMAEPALANVAPGEVVQFERLGYFAADHDTAVFHRTVGLRDEWAQL
QKRQA

Sequences:

>Translated_565_residues
MAEPTGNPAESSSDFIHQVVRADIQQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVAEDFGGTCNLRLDDTNPGTEE
TEYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVREGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLN
LLRRMRAGEFPDGSRCLRARIDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWAHGQSDAIEGVTHSLCSLEFNS
HRPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRLKSLVTNNIVDGWDDPRMPTLRGMRRRGYPAAAIRAFCQAVG
TTKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLDGWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIE
ADDFREDPPRKFFRLSPGHEVRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVT
ANLYDRLFSAEIPGSQTGEALDDLNPHSRETLTEVMAEPALANVAPGEVVQFERLGYFAADHDTAVFHRTVGLRDEWAQL
QKRQA
>Mature_564_residues
AEPTGNPAESSSDFIHQVVRADIQQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVAEDFGGTCNLRLDDTNPGTEET
EYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVREGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLNL
LRRMRAGEFPDGSRCLRARIDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWAHGQSDAIEGVTHSLCSLEFNSH
RPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRLKSLVTNNIVDGWDDPRMPTLRGMRRRGYPAAAIRAFCQAVGT
TKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLDGWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIEA
DDFREDPPRKFFRLSPGHEVRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVTA
NLYDRLFSAEIPGSQTGEALDDLNPHSRETLTEVMAEPALANVAPGEVVQFERLGYFAADHDTAVFHRTVGLRDEWAQLQ
KRQA

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4826960, Length=535, Percent_Identity=41.8691588785047, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI62241042, Length=515, Percent_Identity=31.8446601941748, Blast_Score=271, Evalue=9e-73,
Organism=Escherichia coli, GI1786895, Length=567, Percent_Identity=49.3827160493827, Blast_Score=561, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17543332, Length=539, Percent_Identity=39.8886827458256, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17511007, Length=528, Percent_Identity=30.8712121212121, Blast_Score=239, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324742, Length=566, Percent_Identity=37.2791519434629, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321192, Length=519, Percent_Identity=33.140655105973, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17864488, Length=536, Percent_Identity=41.4179104477612, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24649466, Length=518, Percent_Identity=31.4671814671815, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.18 [H]

Molecular weight: Translated: 63844; Mature: 63713

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00435 PEROXIDASE_1 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPTGNPAESSSDFIHQVVRADIQQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCHHHHHHHCCCH
EDFGGTCNLRLDDTNPGTEETEYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVR
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHH
EGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLNLLRRMRAGEFPDGSRCLRAR
CCCHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
IDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWAHGQSDAIEGVTHSLCSLEFNS
HCCHHCCEECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHEECCC
HRPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRLKSLVTNNIVDGWDDPRMPTLR
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
GMRRRGYPAAAIRAFCQAVGTTKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLD
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIEADDFREDPPRKFFRLSPGHE
CCCCCCCCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCCCCHHHEECCCCCE
VRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVT
EEEEEEEEEEEHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
ANLYDRLFSAEIPGSQTGEALDDLNPHSRETLTEVMAEPALANVAPGEVVQFERLGYFAA
HHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHEEHHHHCCEEC
DHDTAVFHRTVGLRDEWAQLQKRQA
CCCCCHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AEPTGNPAESSSDFIHQVVRADIQQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVA
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCHHHHHHHCCCH
EDFGGTCNLRLDDTNPGTEETEYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVR
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHH
EGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLNLLRRMRAGEFPDGSRCLRAR
CCCHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
IDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWAHGQSDAIEGVTHSLCSLEFNS
HCCHHCCEECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHEECCC
HRPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRLKSLVTNNIVDGWDDPRMPTLR
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
GMRRRGYPAAAIRAFCQAVGTTKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLD
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIEADDFREDPPRKFFRLSPGHE
CCCCCCCCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEEECCCCCCCCCHHHEECCCCCE
VRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVT
EEEEEEEEEEEHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
ANLYDRLFSAEIPGSQTGEALDDLNPHSRETLTEVMAEPALANVAPGEVVQFERLGYFAA
HHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHEEHHHHCCEEC
DHDTAVFHRTVGLRDEWAQLQKRQA
CCCCCHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]