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The map label for this gene is cpdB [H]

Identifier: 50843325

GI number: 50843325

Start: 2025228

End: 2027174

Strand: Direct

Name: cpdB [H]

Synonym: PPA1871

Alternate gene names: 50843325

Gene position: 2025228-2027174 (Clockwise)

Preceding gene: 50843324

Following gene: 50843326

Centisome position: 79.1

GC content: 59.53

Gene sequence:

>1947_bases
ATGCATGACAACCCCCTTGGTACGAACCTGTCGCGCCGCGCCCTGCTGGCCGGCTCGCTGGGAGCTGGACTCACCATGAC
AGCAGTTGACCGCTCCCTCGCATCACCGACCTCCACAGTTTCAGACTCCACGTTCAGCACGGCGGCGCTAACAGTGTTGG
CGACGACCGATATCCACGGTCATGTCTTCGACTGGGATTACTTCGCTGACGCTGCCTTTCCGCCTTCGGATAAGGGGCGT
TCCTCGGCTCCCTTGGGTGTAAGCCGCGTGGCCACGATCGCGAAACAGGTCCGCGCGGAGCAAGGCGCCGACTCTGTCGT
CATGCTCGACAACGGCGACACCATCCAGGGCACCCCGCTGACATACCTTTCAGCGAAGCAACCCGAAAAGCTCGGTCACG
ATGAGGTCATGGCTCGCGCCTTCAACCTGGTAGGATATGACGCTGCAAATATCGGCAATCATGAGTTCAATTACGGGGTC
GCAGAACTGTTCCGCTACCACAACGACCTCAAGGCCCCGCTGCTATGCGCCAACGTCATTGATGTCAAAACCGGCAAGCC
CCTCACCCAGGGCAGCCTCATGCTGACCAAAAACGTTGCCGGTCACGAGGTGAAGGTTGGCATAGTCGCGGTCACTACCC
CCGGCTCAATGGTGTGGGACAAGGCAAACCTGGTCGGCAAGGTCGATATCGCTGATCCAGTCAAGTCCGCCGCTCGATAC
TCAGTACGTCTTCGCAAAGATGGTGCCGACGTCGTCGTCGTGCTCATTCATGCCGGGCTCTCCGAGGTTCAGGCTGCCCC
GGTTTACCACGGGTTGCCCGAGAATAACGCCACCGTGTTGGCAAAGTCTGTTCCCGAGGTTGACCTGGTTGTCATCGGTC
ACACCCATCAGGACGACCCCGTTGAGATTGTTGACGGCATTTCAGGGCACAAGGTCGTCATCACTCAGCCCGACTACTGG
GCTCGTTCGGTATCTCAAGTGACGATTCCGCTGAACTTCTCCGCCACCAAGGCCACGATCCGCCACGATCAGATCACGGT
CAGGCCGCGTTACACCCGCGATGTTGAGGAGGACACAGAGTTCGCCTCCGACTCCCAACTACAGACCGACCACAAGGCCA
CCGTCAGGTACGTCAACTCAGTTGTTGCCACCTCGACGGAGACGCTGACAACTGAGCGTTCGATGGTCGAAGACACCCCG
ATCCTCGACTTCATCGGCAAGGTCGAGGCCGACACCGTTGCCAAGGCGATCAAGGGCGGCACATATAACGGCATCCCGGT
CATCGCCCAGGTGTCACCGTTCTCCCGCACTGCGGCCTTCCCGAAAGGTGACGTCAAGATCAAGGACATCGCCGGGCTGT
ACGTCTTTGACAACACGTTGGCCGGAATCCTGCTTACCGGTAAGCAGCTCAAGGACTACCTGGAGTACTCCGCGAAGTAC
TTCAAGCAGGTCAAGAAAGGGGCCGCCGTCAATCCGGCTCCGGCCAGCGAAGGCGGCGACACTCAGGCCGATTACCAGGG
CAAGCCGGTATGGGATTACAACTATGACGCCGTTACTGGGGTCACGTACTCCATCGATATTTCCCGGCCGGTCGGCGCGC
GTATCCTGGGCTTGTCGTGGCAGGGTAGGCCGGTCGCTCATGACCAGAGGTTCGTGCTGGCCATCAATAACTATCGCATG
AGCGGTGGCGGGGATTACCCGCACGTGACCGAAGCTCCAGTCGTCTGGGACGAGATCCTCGAGATTCGCCAGCTACTCAT
CGATACTGCCATGGCAATGAAGACGATCGATCCGAAGGACTTTTTCGATCGCAACTGGTTCCTCACCACGACCGGCGAGA
CATGGCCAAGCAGCGGCAAGCCAGGTGACGGCGGCACATCTGGTGGGTCCCAACCGGGATCTGGCTCTCCCAATCATCCG
ACAACCCTGCCCGGCACTGGCGTCTGA

Upstream 100 bases:

>100_bases
AGACAGTGTTGCCGACAAAAATCCATCGATTTGTTCCCCAACGCTCACCTCATTCGGTAACGATGGTGTCGCTTCCCAAC
CCGTTGGAAAGACGCCATCT

Downstream 100 bases:

>100_bases
CTACGTGTGAACATTGTTAAGCCTCGGCCCACCTCAAAGGTAGGCCGAGGCTCTTCATTATCCGGGCAACGTGGAAGAGT
GCGATCATGGCAGGTAAAGA

Product: 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MHDNPLGTNLSRRALLAGSLGAGLTMTAVDRSLASPTSTVSDSTFSTAALTVLATTDIHGHVFDWDYFADAAFPPSDKGR
SSAPLGVSRVATIAKQVRAEQGADSVVMLDNGDTIQGTPLTYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGV
AELFRYHNDLKAPLLCANVIDVKTGKPLTQGSLMLTKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVKSAARY
SVRLRKDGADVVVVLIHAGLSEVQAAPVYHGLPENNATVLAKSVPEVDLVVIGHTHQDDPVEIVDGISGHKVVITQPDYW
ARSVSQVTIPLNFSATKATIRHDQITVRPRYTRDVEEDTEFASDSQLQTDHKATVRYVNSVVATSTETLTTERSMVEDTP
ILDFIGKVEADTVAKAIKGGTYNGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKY
FKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSWQGRPVAHDQRFVLAINNYRM
SGGGDYPHVTEAPVVWDEILEIRQLLIDTAMAMKTIDPKDFFDRNWFLTTTGETWPSSGKPGDGGTSGGSQPGSGSPNHP
TTLPGTGV

Sequences:

>Translated_648_residues
MHDNPLGTNLSRRALLAGSLGAGLTMTAVDRSLASPTSTVSDSTFSTAALTVLATTDIHGHVFDWDYFADAAFPPSDKGR
SSAPLGVSRVATIAKQVRAEQGADSVVMLDNGDTIQGTPLTYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGV
AELFRYHNDLKAPLLCANVIDVKTGKPLTQGSLMLTKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVKSAARY
SVRLRKDGADVVVVLIHAGLSEVQAAPVYHGLPENNATVLAKSVPEVDLVVIGHTHQDDPVEIVDGISGHKVVITQPDYW
ARSVSQVTIPLNFSATKATIRHDQITVRPRYTRDVEEDTEFASDSQLQTDHKATVRYVNSVVATSTETLTTERSMVEDTP
ILDFIGKVEADTVAKAIKGGTYNGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKY
FKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSWQGRPVAHDQRFVLAINNYRM
SGGGDYPHVTEAPVVWDEILEIRQLLIDTAMAMKTIDPKDFFDRNWFLTTTGETWPSSGKPGDGGTSGGSQPGSGSPNHP
TTLPGTGV
>Mature_648_residues
MHDNPLGTNLSRRALLAGSLGAGLTMTAVDRSLASPTSTVSDSTFSTAALTVLATTDIHGHVFDWDYFADAAFPPSDKGR
SSAPLGVSRVATIAKQVRAEQGADSVVMLDNGDTIQGTPLTYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGV
AELFRYHNDLKAPLLCANVIDVKTGKPLTQGSLMLTKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVKSAARY
SVRLRKDGADVVVVLIHAGLSEVQAAPVYHGLPENNATVLAKSVPEVDLVVIGHTHQDDPVEIVDGISGHKVVITQPDYW
ARSVSQVTIPLNFSATKATIRHDQITVRPRYTRDVEEDTEFASDSQLQTDHKATVRYVNSVVATSTETLTTERSMVEDTP
ILDFIGKVEADTVAKAIKGGTYNGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKY
FKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSWQGRPVAHDQRFVLAINNYRM
SGGGDYPHVTEAPVVWDEILEIRQLLIDTAMAMKTIDPKDFFDRNWFLTTTGETWPSSGKPGDGGTSGGSQPGSGSPNHP
TTLPGTGV

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=559, Percent_Identity=29.8747763864043, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786687, Length=576, Percent_Identity=22.9166666666667, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922446, Length=250, Percent_Identity=26.4, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654424, Length=250, Percent_Identity=26.4, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922444, Length=295, Percent_Identity=26.1016949152542, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641187, Length=524, Percent_Identity=21.1832061068702, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076508, Length=455, Percent_Identity=20.6593406593407, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24652512, Length=455, Percent_Identity=20.6593406593407, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19921980, Length=455, Percent_Identity=20.6593406593407, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 69504; Mature: 69504

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDNPLGTNLSRRALLAGSLGAGLTMTAVDRSLASPTSTVSDSTFSTAALTVLATTDIHG
CCCCCCCCCCHHHEEEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCC
HVFDWDYFADAAFPPSDKGRSSAPLGVSRVATIAKQVRAEQGADSVVMLDNGDTIQGTPL
EEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
TYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGVAELFRYHNDLKAPLLCANVI
EEECCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEE
DVKTGKPLTQGSLMLTKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVKSAARY
EECCCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHE
SVRLRKDGADVVVVLIHAGLSEVQAAPVYHGLPENNATVLAKSVPEVDLVVIGHTHQDDP
EEEEECCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCC
VEIVDGISGHKVVITQPDYWARSVSQVTIPLNFSATKATIRHDQITVRPRYTRDVEEDTE
HHHHCCCCCCEEEEECCCHHHCCCEEEEEEEECCCCEEEEECCEEEECCCCCCCCHHHHH
FASDSQLQTDHKATVRYVNSVVATSTETLTTERSMVEDTPILDFIGKVEADTVAKAIKGG
HCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCC
TYNGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKY
CCCCCEEEEEECCCHHHCCCCCCCEEEEEEEEEEEECCCCEEEEEECHHHHHHHHHHHHH
FKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSW
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECEEEEEECCCCCCCEEEEECC
QGRPVAHDQRFVLAINNYRMSGGGDYPHVTEAPVVWDEILEIRQLLIDTAMAMKTIDPKD
CCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
FFDRNWFLTTTGETWPSSGKPGDGGTSGGSQPGSGSPNHPTTLPGTGV
HHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHDNPLGTNLSRRALLAGSLGAGLTMTAVDRSLASPTSTVSDSTFSTAALTVLATTDIHG
CCCCCCCCCCHHHEEEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCC
HVFDWDYFADAAFPPSDKGRSSAPLGVSRVATIAKQVRAEQGADSVVMLDNGDTIQGTPL
EEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
TYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGVAELFRYHNDLKAPLLCANVI
EEECCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEE
DVKTGKPLTQGSLMLTKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVKSAARY
EECCCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEECCCCEEEEECCHHHHHHHHE
SVRLRKDGADVVVVLIHAGLSEVQAAPVYHGLPENNATVLAKSVPEVDLVVIGHTHQDDP
EEEEECCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCC
VEIVDGISGHKVVITQPDYWARSVSQVTIPLNFSATKATIRHDQITVRPRYTRDVEEDTE
HHHHCCCCCCEEEEECCCHHHCCCEEEEEEEECCCCEEEEECCEEEECCCCCCCCHHHHH
FASDSQLQTDHKATVRYVNSVVATSTETLTTERSMVEDTPILDFIGKVEADTVAKAIKGG
HCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCC
TYNGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKY
CCCCCEEEEEECCCHHHCCCCCCCEEEEEEEEEEEECCCCEEEEEECHHHHHHHHHHHHH
FKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSW
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECEEEEEECCCCCCCEEEEECC
QGRPVAHDQRFVLAINNYRMSGGGDYPHVTEAPVVWDEILEIRQLLIDTAMAMKTIDPKD
CCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
FFDRNWFLTTTGETWPSSGKPGDGGTSGGSQPGSGSPNHPTTLPGTGV
HHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]