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The map label for this gene is bioF [H]

Identifier: 50843320

GI number: 50843320

Start: 2018260

End: 2020221

Strand: Direct

Name: bioF [H]

Synonym: PPA1866

Alternate gene names: 50843320

Gene position: 2018260-2020221 (Clockwise)

Preceding gene: 50843292

Following gene: 50843324

Centisome position: 78.83

GC content: 62.39

Gene sequence:

>1962_bases
ATGTTATCGCAAAACCCCACAACTGTGGCCTGGTGGAGTGTGCGCATGAGAGCCACTGGGACCCTCGATGACGAGCCCTA
TCACGTCAGCGGAGCCGAGTCACTCGTTGCACCGGGAATGATCGAGCAGACCGTGGCCGGTCTAACACAACGTGCCCTTG
CGCCGGGGCATACCGTCAAAGCCCGGCAGGTGCGAGTCAGTCTGGATCAACTCGACGTCGAGCCCACCATCATTCCTGCT
CTTCCCACTGAGCTTAAGGAATGTCCTGATCCCGTGGCGGCTCGCCAGTACTTTGTCGACGTCTTATCCCGCTTCGTCCC
CCATCCTGCCGAAGCACTGCGTGTTCTCACCGAAGGCCCAACCATGCGAGGAGCTGCCATGGTTGAAGCGGGAACTGACC
GTCGGTTAGAAGCCGACCCTCTGCGTGGGGTGCGAGTTACGAAGTTCGGAGATCTCACCGAATCGGCCCCGGGAGCGTCT
TTGGCACACAAGAAACACCATCATGAAGCCGTGTTGTTGGCTAGCAAAGTCGCAGCCGCACCAGGAGTACTGGCGGAATT
CTGCATTTCCGACGACCCCCATTACACCCGCGGCTACGTTTGTGTCGACGGGGTCTACACGACGGTGACCAACGTCAAAG
CTGACGGCGACCCCAATGGTGGACGCGTCATCCTCGTCGATACGGCACGTGCCGACCCGACCACGATCACCACGTGGCTC
GAAAACCACCCCGTTCTTATCGGCCCTGCCACGGCCAGCAGCCAGAAAGCGACCTCCTGGCATGGTCACCTCTGCGGCCG
TCTCAACGCATGGCGCGCTGCTGGCCTCGAGCGCCGTCCCCGCACCTTCTGTTCTGCCCAGGATCCTGACGCCGTCACAA
CCGACGGGCCTGCCTTGCTGTTCTCCTCATCGGACTACCTCGGCCTGTCGACCGAGCCTAAGGTTCAGCAGGCTATGAAC
AACACTGTCAGAAGGCTCGGGAGTAGTTCGGGTGGCTCTCGCCTCACGACGGGCACTTCCGTAGCTCACCACCAGGCTGA
ACATGAGATCGCCGCATGGTTGGGATACCCGCAGGCCGTGTTCATGGCCAGCGGCTACCAGGCCAACATCGCGACCATAC
AGTTGCTTGCCGACCCTCACGTCACCGTCATTTCCGATGCTGAGAACCATGCCAGCCTGATCGACGGGTGCCGCTTGGCG
CGAGCGCGCACCGTCGTCGTCCCCCACGCCGACCTCGACGCTATCGACACAGCCCTTGATTGCGTCACGACCGACAGGGC
GCTCGTACTCACCGAAGGCGTCTACTCCATGGGCGGCGACGTCGCCCCTGTCGGCGAGCTCGTCGAGATTGCCCACCGCC
ATGGTGCTCTGGTTGTCGTCGACGATGCTCATGGGATTGGTACGGTCGGGCCTACTGGCCGCGGCGCGACCGAAGAACTC
CCGGCATCACAACGACCCGACGTCTTGTTGGGAACAGCAAGCAAAGCTCTCGGAGTCGAGGGTGGTTTCGCATGCGTCGA
CGAGACTCTGGCTACCCTGATGCGCAACTGCGCACGAGGGTACGTGTTTTCCAGCGCCCCTTCCCCTGTCGTCGCGGCAG
GCGTGGCCGCAGCCGTGGAGTACCTACGAACTGACACACGTCGGGTCTGTAGTCTTCAAGCTAACGTCGCCCAGGCACGT
CTCCTCCTGGCCGAAGCTGACCTCATCCCGCCCTCGGCCGCCCATGATCGCGGCCCGATTATCCGGATCCCCGTGGGACC
GGAATCTCGTGCTGTCGCAGCTCAGGAAGAGCTGGCTCGTCGCGGCCTCATGGTCGGTGCAATCCGCTACCCCGCAGTCG
CGAGGGGCGACGCCATCCTGCGTATTTGTCTCACGGCACGTCACACTGACGAGCACATTCGGATTCTCGTCACGTCCCTC
CGCGAAGTCCTTGACGGTGCTCTCAGCGACGCACCACGGTGA

Upstream 100 bases:

>100_bases
CAAACCAGCAAGGCAAATCAGGACCGTCAGACCCCAACAACGACTCGGCAATTGAATGGTGTTCAATTGTTATCCGGTTG
CCAACGCCGAGGAGTCGCCA

Downstream 100 bases:

>100_bases
CGTTCTTCGGGAGGTCGTAATACTGATGAAGGCGGGCCTCGGTGGATCCACGGCGGCCCGCATAGTCGGGCAACCAGTCT
GGGGCGGGCAGCGCCTTCGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MLSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVKARQVRVSLDQLDVEPTIIPA
LPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGPTMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGAS
LAHKKHHHEAVLLASKVAAAPGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWL
ENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALLFSSSDYLGLSTEPKVQQAMN
NTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAVFMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLA
RARTVVVPHADLDAIDTALDCVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEEL
PASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVEYLRTDTRRVCSLQANVAQAR
LLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELARRGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSL
REVLDGALSDAPR

Sequences:

>Translated_653_residues
MLSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVKARQVRVSLDQLDVEPTIIPA
LPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGPTMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGAS
LAHKKHHHEAVLLASKVAAAPGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWL
ENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALLFSSSDYLGLSTEPKVQQAMN
NTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAVFMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLA
RARTVVVPHADLDAIDTALDCVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEEL
PASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVEYLRTDTRRVCSLQANVAQAR
LLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELARRGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSL
REVLDGALSDAPR
>Mature_653_residues
MLSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVKARQVRVSLDQLDVEPTIIPA
LPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGPTMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGAS
LAHKKHHHEAVLLASKVAAAPGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWL
ENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALLFSSSDYLGLSTEPKVQQAMN
NTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAVFMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLA
RARTVVVPHADLDAIDTALDCVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEEL
PASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVEYLRTDTRRVCSLQANVAQAR
LLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELARRGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSL
REVLDGALSDAPR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=34.1772151898734, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=34.180790960452, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=33.4285714285714, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=33.0459770114943, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=33.4285714285714, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4502025, Length=447, Percent_Identity=30.2013422818792, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI40316939, Length=447, Percent_Identity=30.2013422818792, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI4758668, Length=359, Percent_Identity=26.7409470752089, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=26.5927977839335, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI5454084, Length=241, Percent_Identity=23.2365145228216, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1790046, Length=379, Percent_Identity=31.6622691292876, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=34.453781512605, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=31.1688311688312, Blast_Score=194, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=27.9891304347826, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=351, Percent_Identity=27.6353276353276, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=351, Percent_Identity=27.6353276353276, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=271, Percent_Identity=23.6162361623616, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=271, Percent_Identity=23.6162361623616, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=29.4906166219839, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=371, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=265, Percent_Identity=22.2641509433962, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24662918, Length=380, Percent_Identity=30, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI17137420, Length=361, Percent_Identity=32.9639889196676, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=25.3369272237197, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=22.0216606498195, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=22.0216606498195, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=22.0216606498195, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 69154; Mature: 69154

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVK
CCCCCCCEEEEEEEEEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCCEE
ARQVRVSLDQLDVEPTIIPALPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGP
EEEEEEEHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
TMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGASLAHKKHHHEAVLLASKVAAA
CCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCC
PGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWL
CCHHHHHHCCCCCCCCCCEEEECCEEEEEEEEECCCCCCCCEEEEEECCCCCCCEEEEEE
ENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALL
CCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCCEEE
FSSSDYLGLSTEPKVQQAMNNTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAV
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHE
FMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLARARTVVVPHADLDAIDTALD
EEECCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHH
CVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEEL
HHCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCC
PASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVE
CCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHH
YLRTDTRRVCSLQANVAQARLLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
RGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSLREVLDGALSDAPR
CCCEEEEEECCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVK
CCCCCCCEEEEEEEEEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCCEE
ARQVRVSLDQLDVEPTIIPALPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGP
EEEEEEEHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
TMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGASLAHKKHHHEAVLLASKVAAA
CCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCC
PGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWL
CCHHHHHHCCCCCCCCCCEEEECCEEEEEEEEECCCCCCCCEEEEEECCCCCCCEEEEEE
ENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALL
CCCCEEEECCCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCCEEE
FSSSDYLGLSTEPKVQQAMNNTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAV
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHE
FMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLARARTVVVPHADLDAIDTALD
EEECCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHH
CVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEEL
HHCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCC
PASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVE
CCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHH
YLRTDTRRVCSLQANVAQARLLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
RGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSLREVLDGALSDAPR
CCCEEEEEECCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA