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The map label for this gene is sucD [H]

Identifier: 50843214

GI number: 50843214

Start: 1915508

End: 1916401

Strand: Reverse

Name: sucD [H]

Synonym: PPA1754

Alternate gene names: 50843214

Gene position: 1916401-1915508 (Counterclockwise)

Preceding gene: 50843215

Following gene: 50843213

Centisome position: 74.85

GC content: 62.64

Gene sequence:

>894_bases
ATGGCGATCATTCTCGACCAGAACTCCAAAATCATCGTTCAGGGCATGACCGGCTCGGAGGGCATGAAGCACACCCAGCG
CATGCTCGACTCCGGTACTGCCGTCGTCGGCGGCGTCAACCCGCGCAAGGCCGGTACCACCGTTGACTTCAACGGTGGCA
CTACCGTCCCCGTCTACGGCAGCGTCAAGCAGGCCGTTGAGGCTACCGGCGCCAACGTGTCCGTCATCTTCGTCCCGGCC
AAGTTCACCAAGTCGGCCGTTATGGAGGCCATCGAGGCCGAGATGCCATTGGTGGTCTGTATCACCGAGGGTGTACCGGT
CAAGGACACCGCGGAGTTCTTCACCGCTGCCCAGCGCTCCGGCAAGACTCGTATCATCGGCCCGAACTGCCCGGGCATCA
TTAGCCCCGGGAAGTCCAATGCCGGCATCGTCCCGGCCGACATCACTGGCCCCGGTCGTGTGGGCCTGGTGTCGAAGTCG
GGCACCCTGACCTACCAGCTCATGTACGAGGTGCGTGACCTGGGTATCTCGACGGCAATTGGCATCGGTGGTGACCCGAT
CATCGGCACCACCCACATCGATGCCCTACAGGCCTTCCAGGATGACCCGGAGACAGACATCATCGTCATGATCGGTGAGA
TCGGTGGTGACGCTGAGGAGCGTGCCGCTAAATACATCTCTGAGCACATCACCAAACCGGTAGTTGCTTATGTAGCTGGG
TTCACCGCTCCTGAGGGCAAGACGATGGGCCACGCCGGCGCCATCGTGTCTGGGTCCTCGGGTACCGCGGCTGCCAAGAA
GGAGGCCCTTGAGGCCGTCGGCGTCCGCGTTGGCAAGACCCCGACTGAGACCGCCCGGCTGGCCCACGAGGCGATGGAGT
CCCTCAAGAAGTGA

Upstream 100 bases:

>100_bases
GATTCTCGAGGAATTCAACTACCCGCTCGTGACCATGGTCTCGACCATGGACGAGGCCGCCAGCAAGGCCGCCGAGCTCG
CATCCAAGGAGGCCTGAGAC

Downstream 100 bases:

>100_bases
CGCCTTGACCGTCTGAATGCATGGAGCCCGGTCCCACGTGGGACCGGGCTCCATGCATTCAGACGGCCCTGGTGTGGTAA
CCGAAAAAGTTGTTGGTGGA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTTVDFNGGTTVPVYGSVKQAVEATGANVSVIFVPA
KFTKSAVMEAIEAEMPLVVCITEGVPVKDTAEFFTAAQRSGKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKS
GTLTYQLMYEVRDLGISTAIGIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAG
FTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK

Sequences:

>Translated_297_residues
MAIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTTVDFNGGTTVPVYGSVKQAVEATGANVSVIFVPA
KFTKSAVMEAIEAEMPLVVCITEGVPVKDTAEFFTAAQRSGKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKS
GTLTYQLMYEVRDLGISTAIGIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAG
FTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK
>Mature_296_residues
AIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTTVDFNGGTTVPVYGSVKQAVEATGANVSVIFVPAK
FTKSAVMEAIEAEMPLVVCITEGVPVKDTAEFFTAAQRSGKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKSG
TLTYQLMYEVRDLGISTAIGIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAGF
TAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=300, Percent_Identity=47.3333333333333, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI38569423, Length=318, Percent_Identity=29.2452830188679, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI38569421, Length=318, Percent_Identity=29.2452830188679, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786949, Length=298, Percent_Identity=51.3422818791946, Blast_Score=288, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=49.1228070175439, Blast_Score=248, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17553126, Length=296, Percent_Identity=43.9189189189189, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17557344, Length=321, Percent_Identity=28.9719626168224, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=300, Percent_Identity=29.3333333333333, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=289, Percent_Identity=46.0207612456747, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21356559, Length=298, Percent_Identity=44.9664429530201, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574296, Length=299, Percent_Identity=45.819397993311, Blast_Score=230, Evalue=8e-61,
Organism=Drosophila melanogaster, GI281363477, Length=320, Percent_Identity=28.75, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363475, Length=320, Percent_Identity=28.75, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281363473, Length=320, Percent_Identity=28.75, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30581; Mature: 30450

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTTVDFNGGTTVPVYG
CEEEEECCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCCEEEECC
SVKQAVEATGANVSVIFVPAKFTKSAVMEAIEAEMPLVVCITEGVPVKDTAEFFTAAQRS
CHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHC
GKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKSGTLTYQLMYEVRDLGISTAI
CCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEE
GIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAG
CCCCCCCEECHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
FTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK
CCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTTVDFNGGTTVPVYG
EEEEECCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCCEEEECC
SVKQAVEATGANVSVIFVPAKFTKSAVMEAIEAEMPLVVCITEGVPVKDTAEFFTAAQRS
CHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHC
GKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKSGTLTYQLMYEVRDLGISTAI
CCEEEECCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEE
GIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAG
CCCCCCCEECHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
FTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK
CCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]