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The map label for this gene is inhA [H]

Identifier: 50843010

GI number: 50843010

Start: 1653180

End: 1653953

Strand: Reverse

Name: inhA [H]

Synonym: PPA1532

Alternate gene names: 50843010

Gene position: 1653953-1653180 (Counterclockwise)

Preceding gene: 50843011

Following gene: 50843008

Centisome position: 64.6

GC content: 60.59

Gene sequence:

>774_bases
ATGGGACTTCTTGAAGGACGTACCGTCCTCGTCACAGGCGTGACGATGCACACCTCTATCGCTTTTAAGGCGGCCCAGAT
TGCCCAGGATGAGGGCGCCCGGGTTATTGTTTCGAACCTGCCGCGTGCCGTCGGCGTCACCCGTCGAGCTGTTCGCAAAC
TCGATCCGGTGCCGGAGGTACTCGAACTCGATGTCACCGACGCCGACCAGCTGGCTGCCCTGCCTCAGCAACTGCGCGAC
CTCGGAGTGGAAAAGCTTGATGGTGTCGTTCACGCCATCGCCTTCGCTAACCCCAAGACGGCCCTGGGGGGCAAGTTTCT
CGAAACGGAATGGGATGACGTCTCGGTCGCTGTCCACACCTCCACGTATTCTTATGTCTCCTTGATGACCGCCCTTGTCG
ACATCCTCGCCGAGCATGCTTCGGTCGTCGGTCTGACCTTTGACGCCACCGTCTCCTGGCCCTTCTACGACTGGATGGGA
GTGGCCAAGGCGGGACTGGAATCGGCCAATCGCTACCTGGCTCGATACCTGGGCCCCAAAGGTGTGCGCTGCAACCTAGT
GTCCGCTGGTCCGCTGGACACCATGGCTAAAACAGCTATTCCGGGCGCTGATGCCTTTAATGATGTGTGGGGGGAGCGTG
CCCCGCTTGGCTGGGACACCAAGGACACCACGCCCGCGGCCAAGGGAATTGTTGCCCTCTTGTCTGACTGGTTCCCAGCC
ACTACCGGCGAGATAATCCACGTCGATGGCGGTATGGGTTCGACCGGAGCTTGA

Upstream 100 bases:

>100_bases
GCCAGCTACGTCTCTGGGGCTGTGATCCCTGTCGACGGAGGACTCGGCATGGGCCACTGACACCATCACATCCATCCACA
TCGACCGGAAGGACATCACT

Downstream 100 bases:

>100_bases
TCCACTTAGGTCAGTGGCCACGACGTGGCTGCGGTAACAGCTTGGGAGGCGGCGTTGCGCAGTTGGCGCAGCGCCGTTTC
TCGTGTCTGTGCTCCGTAGG

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MGLLEGRTVLVTGVTMHTSIAFKAAQIAQDEGARVIVSNLPRAVGVTRRAVRKLDPVPEVLELDVTDADQLAALPQQLRD
LGVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHTSTYSYVSLMTALVDILAEHASVVGLTFDATVSWPFYDWMG
VAKAGLESANRYLARYLGPKGVRCNLVSAGPLDTMAKTAIPGADAFNDVWGERAPLGWDTKDTTPAAKGIVALLSDWFPA
TTGEIIHVDGGMGSTGA

Sequences:

>Translated_257_residues
MGLLEGRTVLVTGVTMHTSIAFKAAQIAQDEGARVIVSNLPRAVGVTRRAVRKLDPVPEVLELDVTDADQLAALPQQLRD
LGVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHTSTYSYVSLMTALVDILAEHASVVGLTFDATVSWPFYDWMG
VAKAGLESANRYLARYLGPKGVRCNLVSAGPLDTMAKTAIPGADAFNDVWGERAPLGWDTKDTTPAAKGIVALLSDWFPA
TTGEIIHVDGGMGSTGA
>Mature_256_residues
GLLEGRTVLVTGVTMHTSIAFKAAQIAQDEGARVIVSNLPRAVGVTRRAVRKLDPVPEVLELDVTDADQLAALPQQLRDL
GVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHTSTYSYVSLMTALVDILAEHASVVGLTFDATVSWPFYDWMGV
AKAGLESANRYLARYLGPKGVRCNLVSAGPLDTMAKTAIPGADAFNDVWGERAPLGWDTKDTTPAAKGIVALLSDWFPAT
TGEIIHVDGGMGSTGA

Specific function: Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide [H]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=32.8185328185328, Blast_Score=106, Evalue=1e-24,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR016040 [H]

Pfam domain/function: NA

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27231; Mature: 27100

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLEGRTVLVTGVTMHTSIAFKAAQIAQDEGARVIVSNLPRAVGVTRRAVRKLDPVPEV
CCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHCCCCCHH
LELDVTDADQLAALPQQLRDLGVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHT
HEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCCEECCCCCCEEEEEEE
STYSYVSLMTALVDILAEHASVVGLTFDATVSWPFYDWMGVAKAGLESANRYLARYLGPK
CHHHHHHHHHHHHHHHHHHHHEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVRCNLVSAGPLDTMAKTAIPGADAFNDVWGERAPLGWDTKDTTPAAKGIVALLSDWFPA
CCEEEEEECCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TTGEIIHVDGGMGSTGA
CCCCEEEECCCCCCCCC
>Mature Secondary Structure 
GLLEGRTVLVTGVTMHTSIAFKAAQIAQDEGARVIVSNLPRAVGVTRRAVRKLDPVPEV
CCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHCCCCCHH
LELDVTDADQLAALPQQLRDLGVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHT
HEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHCCCCEECCCCCCEEEEEEE
STYSYVSLMTALVDILAEHASVVGLTFDATVSWPFYDWMGVAKAGLESANRYLARYLGPK
CHHHHHHHHHHHHHHHHHHHHEEEEEEECEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVRCNLVSAGPLDTMAKTAIPGADAFNDVWGERAPLGWDTKDTTPAAKGIVALLSDWFPA
CCEEEEEECCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TTGEIIHVDGGMGSTGA
CCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8284673 [H]