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The map label for this gene is pyrD

Identifier: 50842485

GI number: 50842485

Start: 1086957

End: 1087880

Strand: Direct

Name: pyrD

Synonym: PPA1002

Alternate gene names: 50842485

Gene position: 1086957-1087880 (Clockwise)

Preceding gene: 50842484

Following gene: 50842486

Centisome position: 42.45

GC content: 59.63

Gene sequence:

>924_bases
ATGACTAGATTGGCCGTGTCCCTTCCGGGCCTGAACCTTAAGAACCCGATCATGCCCGCCAGCGGGTGTTTTGGTTTTGG
CGCCGAGTATGCGGAGTACTACGACCTGTCGGTGCTTGGGTCGATCATGGTCAAGGCGACCACCCTCGAGCCTCGCCGTG
GCAATCCGGTTATTCGGGTGGCCGAAACCCCAGGAGGCATGCTCAACGCCATCGGCCTGCAAAATCCTGGCCTCGACGTC
GTCATGGCCGAGAAGCTGCCGTGGTTGGCTGAGCACTTTCCGGACCTGCCCATCATCGCAAACGTCGCCGGTTACACCAC
CGAGGACTACGTCAGGGTCTGCGAGGTCATCTCGACGGCCCCCAATGTGGCCGCTGTGGAGATTAACATCTCTTGTCCCA
ACGTCAAGCGCGGTGGAATTACTTTCGGCACTAATGTGACCGCAGCCCATGACCTGACGCAGGCCGTCGTCGCAGCCGCT
AGTGTGCCTGTCTACGTCAAGTTGTCGCCCAATGTCACCGACATTACCGAGATCGCGCGTGCGACCGCCGATGCCGGTGC
CGACGGTCTAACCCTCATCAACACTCTCACCGGGATGAGGATCAACCTGGCACGGCGTACGCCTGTTATTGCTAACGCCA
CCGGTGGTCTGTCTGGACCAGCCGTTCTGCCTATCGCGGTGAGGATGATTGACGCCGTTACCCGGGTCGTCGACATCCCC
GTCATCGGTATGGGCGGCGTGATGACAAGTGCTGACGCCCTCGAACTCATGATGGCTGGGGCTTCGGCAGTTGGCGTCGG
GACCGCTAATTTCACCGATCCGTTGGCCTGCCCCAAGATCATTAACGGTCTTGAGCCTCTCATGGACGACTTAAGCATTG
CCAGCCTTGAGGACCTTCGGACTCAGGTTAGGCAGTCTCGTTGA

Upstream 100 bases:

>100_bases
GCGCGTGCTACGCCTGCGTCGTCGGTGATGCCCGAGACCCCGATCACCAGTTTCGGGTGTGCTTCGACGGTCCCGTGCTC
GCGGCCGAGGAGGTTCTGCT

Downstream 100 bases:

>100_bases
TCCGACCACCACTCAAGGAGTTCATATGGACATCACCCGCCCGATTATCGCTCTCGATCTTCCTAGCGCCGAGGCAGCTC
TTGACTTCGTAGGTCGATTC

Product: dihydroorotate dehydrogenase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRVAETPGGMLNAIGLQNPGLDV
VMAEKLPWLAEHFPDLPIIANVAGYTTEDYVRVCEVISTAPNVAAVEINISCPNVKRGGITFGTNVTAAHDLTQAVVAAA
SVPVYVKLSPNVTDITEIARATADAGADGLTLINTLTGMRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIP
VIGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLSIASLEDLRTQVRQSR

Sequences:

>Translated_307_residues
MTRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRVAETPGGMLNAIGLQNPGLDV
VMAEKLPWLAEHFPDLPIIANVAGYTTEDYVRVCEVISTAPNVAAVEINISCPNVKRGGITFGTNVTAAHDLTQAVVAAA
SVPVYVKLSPNVTDITEIARATADAGADGLTLINTLTGMRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIP
VIGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLSIASLEDLRTQVRQSR
>Mature_306_residues
TRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRVAETPGGMLNAIGLQNPGLDVV
MAEKLPWLAEHFPDLPIIANVAGYTTEDYVRVCEVISTAPNVAAVEINISCPNVKRGGITFGTNVTAAHDLTQAVVAAAS
VPVYVKLSPNVTDITEIARATADAGADGLTLINTLTGMRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIPV
IGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLSIASLEDLRTQVRQSR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=231, Percent_Identity=31.1688311688312, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=27.6729559748428, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI87082059, Length=285, Percent_Identity=28.4210526315789, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71984108, Length=154, Percent_Identity=33.1168831168831, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=299, Percent_Identity=27.4247491638796, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640763, Length=192, Percent_Identity=32.2916666666667, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18858217, Length=192, Percent_Identity=32.2916666666667, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PROAC (Q6A912)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055712.1
- HSSP:   P54322
- ProteinModelPortal:   Q6A912
- SMR:   Q6A912
- GeneID:   2932792
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1002
- NMPDR:   fig|267747.1.peg.989
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   CLSK2763661
- BioCyc:   PACN267747:PPA1002-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 31977; Mature: 31845

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRV
CCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEE
AETPGGMLNAIGLQNPGLDVVMAEKLPWLAEHFPDLPIIANVAGYTTEDYVRVCEVISTA
ECCCCCEEEECCCCCCCCCEEECCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCC
PNVAAVEINISCPNVKRGGITFGTNVTAAHDLTQAVVAAASVPVYVKLSPNVTDITEIAR
CCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
ATADAGADGLTLINTLTGMRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIP
HHHCCCCCCHHHHHHHCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VIGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLSIASLEDLR
EECCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQVRQSR
HHHHHCC
>Mature Secondary Structure 
TRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRV
CEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEE
AETPGGMLNAIGLQNPGLDVVMAEKLPWLAEHFPDLPIIANVAGYTTEDYVRVCEVISTA
ECCCCCEEEECCCCCCCCCEEECCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCC
PNVAAVEINISCPNVKRGGITFGTNVTAAHDLTQAVVAAASVPVYVKLSPNVTDITEIAR
CCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
ATADAGADGLTLINTLTGMRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIP
HHHCCCCCCHHHHHHHCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VIGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLSIASLEDLR
EECCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQVRQSR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA