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The map label for this gene is pyrC [H]

Identifier: 50842481

GI number: 50842481

Start: 1080538

End: 1081875

Strand: Direct

Name: pyrC [H]

Synonym: PPA0998

Alternate gene names: 50842481

Gene position: 1080538-1081875 (Clockwise)

Preceding gene: 50842480

Following gene: 50842482

Centisome position: 42.2

GC content: 64.57

Gene sequence:

>1338_bases
ATGAGCCGCCGGGTCCTCCTCACCGGGCTGACCATGCTGGTGGGAGCCACCCCGGTTTCCTCCCAGCTCCTCATCCGTGA
TGAGCGGATCGAGGCTATTTCACGAGGGCGGTCCAACGCCCTCGACGGGGCCGATGCTGAGGTCGTCGATCTTGGTGGGG
CTCTGGTGACTCCCGGGATGGTGGACCTGCACGTTCATCTGCGCGAGCCGGGTCAGGAACATAAGGAGACTATCGCCTCA
GGCACTGCGGCGGCCGCCCGAGGCGGCTGGACGACGATTTGTGCGATGCCCAATACTGTTCCTGACCCCCATAGCCCCGA
GCTCATGGCCGACCTCAACCGGAGGGTTGAGGAATCGGCCGTGGTGCGGGTGTTGCCCATCGCCCCCATCACTGTTGGAC
TGACGGGCAATGACCTTGTTGACGTTGAGGCCTTGACACGGGCCGGGGCAGTGGCCTTCTCCAATGACGGCAAGGGAGTG
CAGCTGGCCGGAGTCATGTACGACGCGATGCGGTCAGCCGCCGCGGTCGACCGTCCGATCGCTGCTCACGCCGAGGACGA
GTCCCTGGTGCGGGGCGGGGTGATCAACGACGGACGTCGGGCTAGGGAACTCGGCCTACCTCCCATGACTCGTCTTACCG
AGACTGTGCAGGTGGCCCGCGACGTCATGATCGCCGAGGAGACTGGTGCCCACTACCATCTGTGCCACGCCTCGACCCGG
CAGTCGATTCGTACTCTGCGTCGGGGCCGTGAGGACGGCGCGAATGTCACCGGTGAGGCGGCTCCGCACCATCTGCTGCT
GGCCGACGACGACATCCCCGACGATGATGGGTTCTACAAGATGAATCCGCCGCTGCGCACCCGTGACGACCTCAACGCTA
TGGTCGAGGGTCTGTGTGACGGGACCTTGACCTGTATCGCCACCGATAACGCCCCGCACGCGGCTGAAGAAAAGGCATGT
TCCTTCCGCGATGCCGCTTTTGGGGTCATCACTAACGAGCACACCTTTGCCCTGCTGTACACCAACTTTGTGCTTGACCG
GCGGTTCCGACTCGACCAGCTTGTCGACTGGCTCACCATCGGGCCGGCCGAGACCTTCGGGATACCGGAGGCCGGTCGGC
TGCGAGTGGGAGGACCGGCCGACCTGGCCGCTTTCGACTTGCGCACCGAGATGACGATTATTCCCGGGGACGGAGCCGGG
ATGGGGCGTAACACCCCCTTCGCTGGTCGTTCCGTCCGCGGTGACTGCGTGCTGACGATGGTCGGTGGCCAGACGGTTTA
CCGTCGCGGCCAGCCGATAGGGAAGACTGACGACCACGAGATGGGAGACCCGCAGTGA

Upstream 100 bases:

>100_bases
TCGTAGAGGCTCCCTCGTCTCGTATTTTTGAGCAGATGGGGAACGGAGTTATGGTGCGAATGGCTATTTTGGAACAGGTG
TTGCACGGCAGGGAGACAAA

Downstream 100 bases:

>100_bases
GCAGACGCACCCTGTTATTGGCCGACGGGACAAGCTACCAGGGCGAGGCTTTCGGGGCCGATCGTGAGGTGAGTGCCGAG
GTCGTCTTCACTACCGGCAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSRRVLLTGLTMLVGATPVSSQLLIRDERIEAISRGRSNALDGADAEVVDLGGALVTPGMVDLHVHLREPGQEHKETIAS
GTAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESAVVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGV
QLAGVMYDAMRSAAAVDRPIAAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTR
QSIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLNAMVEGLCDGTLTCIATDNAPHAAEEKAC
SFRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTIGPAETFGIPEAGRLRVGGPADLAAFDLRTEMTIIPGDGAG
MGRNTPFAGRSVRGDCVLTMVGGQTVYRRGQPIGKTDDHEMGDPQ

Sequences:

>Translated_445_residues
MSRRVLLTGLTMLVGATPVSSQLLIRDERIEAISRGRSNALDGADAEVVDLGGALVTPGMVDLHVHLREPGQEHKETIAS
GTAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESAVVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGV
QLAGVMYDAMRSAAAVDRPIAAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTR
QSIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLNAMVEGLCDGTLTCIATDNAPHAAEEKAC
SFRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTIGPAETFGIPEAGRLRVGGPADLAAFDLRTEMTIIPGDGAG
MGRNTPFAGRSVRGDCVLTMVGGQTVYRRGQPIGKTDDHEMGDPQ
>Mature_444_residues
SRRVLLTGLTMLVGATPVSSQLLIRDERIEAISRGRSNALDGADAEVVDLGGALVTPGMVDLHVHLREPGQEHKETIASG
TAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESAVVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGVQ
LAGVMYDAMRSAAAVDRPIAAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTRQ
SIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLNAMVEGLCDGTLTCIATDNAPHAAEEKACS
FRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTIGPAETFGIPEAGRLRVGGPADLAAFDLRTEMTIIPGDGAGM
GRNTPFAGRSVRGDCVLTMVGGQTVYRRGQPIGKTDDHEMGDPQ

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=386, Percent_Identity=30.5699481865285, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786722, Length=454, Percent_Identity=24.8898678414097, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=23.3995584988962, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=374, Percent_Identity=30.2139037433155, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322218, Length=425, Percent_Identity=25.4117647058824, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=28.1578947368421, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI18859883, Length=475, Percent_Identity=25.4736842105263, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47629; Mature: 47498

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVLLTGLTMLVGATPVSSQLLIRDERIEAISRGRSNALDGADAEVVDLGGALVTPGM
CCCEEEEHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCE
VDLHVHLREPGQEHKETIASGTAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESA
EEEEEEECCCCHHHHHHHHCCCHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
VVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGVQLAGVMYDAMRSAAAVDRPI
EEEEEECCEEEEECCCCCEEEHHHHHHCCEEEECCCCCCEEEHHHHHHHHHHHHHHCCCC
AAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTR
CCCCCCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCEEEEECHHHH
QSIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLNAMVEGLCD
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHCC
GTLTCIATDNAPHAAEEKACSFRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTI
CEEEEEEECCCCCHHHHHHCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GPAETFGIPEAGRLRVGGPADLAAFDLRTEMTIIPGDGAGMGRNTPFAGRSVRGDCVLTM
CCHHHCCCCCCCEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
VGGQTVYRRGQPIGKTDDHEMGDPQ
ECCCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRVLLTGLTMLVGATPVSSQLLIRDERIEAISRGRSNALDGADAEVVDLGGALVTPGM
CCEEEEHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCE
VDLHVHLREPGQEHKETIASGTAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESA
EEEEEEECCCCHHHHHHHHCCCHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
VVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGVQLAGVMYDAMRSAAAVDRPI
EEEEEECCEEEEECCCCCEEEHHHHHHCCEEEECCCCCCEEEHHHHHHHHHHHHHHCCCC
AAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTR
CCCCCCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCEEEEECHHHH
QSIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLNAMVEGLCD
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHCC
GTLTCIATDNAPHAAEEKACSFRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTI
CEEEEEEECCCCCHHHHHHCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GPAETFGIPEAGRLRVGGPADLAAFDLRTEMTIIPGDGAGMGRNTPFAGRSVRGDCVLTM
CCHHHCCCCCCCEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
VGGQTVYRRGQPIGKTDDHEMGDPQ
ECCCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA