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The map label for this gene is 50842172

Identifier: 50842172

GI number: 50842172

Start: 752060

End: 754375

Strand: Reverse

Name: 50842172

Synonym: PPA0685

Alternate gene names: NA

Gene position: 754375-752060 (Counterclockwise)

Preceding gene: 50842173

Following gene: 50842171

Centisome position: 29.46

GC content: 59.2

Gene sequence:

>2316_bases
ATGACTATTACTGATACTTATACCGAGGAATTGGCGATTGACCTCACTGGGAGCGCCTTGCTGCCGGCCCGAAAGGGCAT
GGACGTGCAACGAATCGACGGCGAGGACGGCTCACTTCTCGTGGAATTCAGCGCAACGTCCTCCGGATGCCTGTTCGAGC
TTGTCGGAAAGAACGGACGGTTATCAGTCGATGTGGATGAAGACCGCTTGCTTGGCCGTATAGATCTGAACGGAGAATCT
CGCAGTCTCGACGCCGAGGATGCGCTGGGCATGGCAGATGGCACGATTCACTCCGTCGGACTCACCGCCGATGAAACTGG
GACGCATTTGTTTGCAGACGGTTACGAAACATTCTCCGCCACATTGCGGGTATGGTGCCAGGATCTGGGAGCAACCAATA
TTGTCATCAATCCGTCGGGCGTCCTCGACGTACGGCGATTCAAGATGTGGAACTCAGCCCTGTCCTTGCAAGCTATGGCG
GCCAAGGCGCCGACGGCAACACCGTTCGTCGAGTTCGCTGGTTCTGAGCTGTCGGCCCGCGACGCACGCCGTATCGGAGA
ACTCGCTCATGGCGCGCTCCGAGCAAGGACCCGCCTTCGTGGCAAAGGCCAGGGTGGAACCGTCCTCGCAGCCCAAGGGA
GCGCCGGTGAACTGTCCTTCGAGATCGTCAACGGCGACCTGCTCCTGCACGTGGAAGTGGACGATGAACCCATCGCCCAC
GTGCGCGCTCCAGGCAAGTGGGACGACGGAAACTGGCATGACCTGGTAGCAATCAGTGGCCGGGGTGCCATTGATCTCTA
TGTTGACGGTTTCCTCGTGGCTCACGAGCCTGGTGAGGCATTCTTTGCCGATCTTGGCAAGGTGGAAAGGGTGACCGTCG
GGAAGGACCTCGAAGGAGCACGGCTATTCGGGGAAGCGCAGACGGCGTCCATCTTCAGCAGTGCGCTAACCGACGCCCAA
GTCAAACGCCTAGCCAACGTGGCTCCTCTACGTACCCAAGCTCTCTTCGACACGGGATATCTGGGCTCGAAAAGTTACCG
GATCCCATCGCTCATCAGACTTGATTCCGGAAGCTTCATCGCCGGGGCAGACCAACGTGTCAGCATTGCCAACGACAGCC
CCAACGACATCAATTTCGTCATCCGTCGCAGCGAAGACGGTCGTCGGTGGGACGAGGCCCAGATAGTCCTCGAGTATCCC
GGCGAGGGCGCCCTCGGAGCATCGGTTATCGACTCAGTTCTGTTCCAAGACCACAACTCGGGGCGCGTGTTCTGCTTGAT
CGACCAGTTCCCGGGTGGCGTGGGGCAGCCTAACGCCGAACCAGGGTCGGGCTTCGATGAGCAAGGTCGGCAGCTTCTGT
TCGATCGCGATGCAACCGCCTACGTCATCGATGCAGAAGGCATCGTAACAACCGAGTCGGGGGAACCCACGGACTACACC
GTTGACGAAACCGGAAACGTCTTCGCAGCCGGTGCCCCCGCCGGCAATATCCACTTGGCCACCGGAGTGGACCCCCACGA
GTCCCTGCTGACCCTACGGACCTGCAACCTCATCCTCATCCACAGTGATGACGACGGACGGACATGGTCACGACCTATCA
ACCTGAACCCGGCTCTCAAGCAGCCTTGGATGCGGTTCCTCGGTACGTCACCGGGCAACGGAATTCAGTTGGAACACGGG
ACGCACCGAGGCCGACTCCTGGCACCGGTCTACTACAACCACGAGGAGGGAAAAACCTTTTCATGTGCCGCGGTGTACAG
CGATGACGGGGGCCAGACATGGAACCTCGGTAAGTCACCGAATGACGAGCGCGAACTTTTCGGAAAGATCGTCAGTTCTC
GAAATCTCAACGATGATCGCGGCTCGACCCATGAGTCAGCGTTAGTAGAAACCCCTGACGGGGTCGTGCACTCCTTCATG
CGCAACCAACATCCCTCCGGACGGGTGGCGCACGCGGCCAGCGTCGACGGCGGCGAAACATGGGGCGAGGTGACGTTCGT
CGAGCAACTGACCGAAATCTTCTCCCAGCCCAATGCCATTTCTGTCCGGGATGAGCTTGGAACCGAATCGGTGGTCTTTG
CCAATGCGTCGATGATGCTCCCGTTCCGGGGTTGTGGTGTGCTGCGTCAAAGTTTCGACGGAGGCAAGACCTGGCCGCAC
AACCGCGTGCTCAACCCTCGCCATCATGTGTACCAATGCATGACTCAGCAAGACGAACAGACCCTGCTCGTATTGTGGGA
ACGGGAGTGGCAAGGCTTGTTCCTGACAGAGGTCCCGTTGTCATGGCTTACCACTTCGCGCAGCACGCTGGAGTGA

Upstream 100 bases:

>100_bases
GAGCGAGTTTGCATCCAGCGAGTGCTAAATCGACAGCCAGAACACATATTCATATTCTCCAGCCAGAACGAGCCAGGGAA
GCCACGAGGAGACGTCAATC

Downstream 100 bases:

>100_bases
TTCACACAGCAACACCAGATATCGCCCATTCAATGTAATCACGCTACGGAAGACTTAACGTTTAGGGATTCAGCATGCAC
CAACGGATTTCACGCCGATC

Product: sialidase A precursor

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MTITDTYTEELAIDLTGSALLPARKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGRLSVDVDEDRLLGRIDLNGES
RSLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSATLRVWCQDLGATNIVINPSGVLDVRRFKMWNSALSLQAMA
AKAPTATPFVEFAGSELSARDARRIGELAHGALRARTRLRGKGQGGTVLAAQGSAGELSFEIVNGDLLLHVEVDDEPIAH
VRAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFFADLGKVERVTVGKDLEGARLFGEAQTASIFSSALTDAQ
VKRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFIAGADQRVSIANDSPNDINFVIRRSEDGRRWDEAQIVLEYP
GEGALGASVIDSVLFQDHNSGRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYT
VDETGNVFAAGAPAGNIHLATGVDPHESLLTLRTCNLILIHSDDDGRTWSRPINLNPALKQPWMRFLGTSPGNGIQLEHG
THRGRLLAPVYYNHEEGKTFSCAAVYSDDGGQTWNLGKSPNDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFM
RNQHPSGRVAHAASVDGGETWGEVTFVEQLTEIFSQPNAISVRDELGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPH
NRVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE

Sequences:

>Translated_771_residues
MTITDTYTEELAIDLTGSALLPARKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGRLSVDVDEDRLLGRIDLNGES
RSLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSATLRVWCQDLGATNIVINPSGVLDVRRFKMWNSALSLQAMA
AKAPTATPFVEFAGSELSARDARRIGELAHGALRARTRLRGKGQGGTVLAAQGSAGELSFEIVNGDLLLHVEVDDEPIAH
VRAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFFADLGKVERVTVGKDLEGARLFGEAQTASIFSSALTDAQ
VKRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFIAGADQRVSIANDSPNDINFVIRRSEDGRRWDEAQIVLEYP
GEGALGASVIDSVLFQDHNSGRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYT
VDETGNVFAAGAPAGNIHLATGVDPHESLLTLRTCNLILIHSDDDGRTWSRPINLNPALKQPWMRFLGTSPGNGIQLEHG
THRGRLLAPVYYNHEEGKTFSCAAVYSDDGGQTWNLGKSPNDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFM
RNQHPSGRVAHAASVDGGETWGEVTFVEQLTEIFSQPNAISVRDELGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPH
NRVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE
>Mature_770_residues
TITDTYTEELAIDLTGSALLPARKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGRLSVDVDEDRLLGRIDLNGESR
SLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSATLRVWCQDLGATNIVINPSGVLDVRRFKMWNSALSLQAMAA
KAPTATPFVEFAGSELSARDARRIGELAHGALRARTRLRGKGQGGTVLAAQGSAGELSFEIVNGDLLLHVEVDDEPIAHV
RAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFFADLGKVERVTVGKDLEGARLFGEAQTASIFSSALTDAQV
KRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFIAGADQRVSIANDSPNDINFVIRRSEDGRRWDEAQIVLEYPG
EGALGASVIDSVLFQDHNSGRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYTV
DETGNVFAAGAPAGNIHLATGVDPHESLLTLRTCNLILIHSDDDGRTWSRPINLNPALKQPWMRFLGTSPGNGIQLEHGT
HRGRLLAPVYYNHEEGKTFSCAAVYSDDGGQTWNLGKSPNDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFMR
NQHPSGRVAHAASVDGGETWGEVTFVEQLTEIFSQPNAISVRDELGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPHN
RVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE

Specific function: Sialidases have been suggested to be pathogenic factors in microbial infections [H]

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 F5/8 type C domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002860
- InterPro:   IPR000421
- InterPro:   IPR008985
- InterPro:   IPR013320
- InterPro:   IPR008979
- InterPro:   IPR004124
- InterPro:   IPR011040 [H]

Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF02973 Sialidase [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 83653; Mature: 83522

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITDTYTEELAIDLTGSALLPARKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGR
CCCCCCCCCEEEEEECCCEECCHHCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCE
LSVDVDEDRLLGRIDLNGESRSLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSA
EEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHH
TLRVWCQDLGATNIVINPSGVLDVRRFKMWNSALSLQAMAAKAPTATPFVEFAGSELSAR
HHHHHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHH
DARRIGELAHGALRARTRLRGKGQGGTVLAAQGSAGELSFEIVNGDLLLHVEVDDEPIAH
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEEEEEECCCCCEE
VRAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFFADLGKVERVTVGKDLEGA
EECCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCHHHHHHCCCEEEEEECCCCCCC
RLFGEAQTASIFSSALTDAQVKRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFI
EEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCCCCEEEEECCCCEE
AGADQRVSIANDSPNDINFVIRRSEDGRRWDEAQIVLEYPGEGALGASVIDSVLFQDHNS
ECCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
GRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYT
CEEEEEEECCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEEEEECCCEEECCCCCCCCEE
VDETGNVFAAGAPAGNIHLATGVDPHESLLTLRTCNLILIHSDDDGRTWSRPINLNPALK
ECCCCCEEEECCCCCCEEEEECCCHHHHEEEEEEEEEEEEECCCCCCEECCCCCCCHHHH
QPWMRFLGTSPGNGIQLEHGTHRGRLLAPVYYNHEEGKTFSCAAVYSDDGGQTWNLGKSP
HHHHHHHCCCCCCCEEECCCCCCCEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCCCC
NDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFMRNQHPSGRVAHAASVDGGET
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCC
WGEVTFVEQLTEIFSQPNAISVRDELGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPH
CCHHHHHHHHHHHHCCCCEEEEHHHCCCCEEEEECCEEEEEECCCHHHHHCCCCCCCCCC
NRVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE
CCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCHHHHHCCCCCCC
>Mature Secondary Structure 
TITDTYTEELAIDLTGSALLPARKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGR
CCCCCCCCEEEEEECCCEECCHHCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCE
LSVDVDEDRLLGRIDLNGESRSLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSA
EEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHH
TLRVWCQDLGATNIVINPSGVLDVRRFKMWNSALSLQAMAAKAPTATPFVEFAGSELSAR
HHHHHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHH
DARRIGELAHGALRARTRLRGKGQGGTVLAAQGSAGELSFEIVNGDLLLHVEVDDEPIAH
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEEEEEECCCCCEE
VRAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFFADLGKVERVTVGKDLEGA
EECCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCHHHHHHCCCEEEEEECCCCCCC
RLFGEAQTASIFSSALTDAQVKRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFI
EEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCCCCEEEEECCCCEE
AGADQRVSIANDSPNDINFVIRRSEDGRRWDEAQIVLEYPGEGALGASVIDSVLFQDHNS
ECCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
GRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYT
CEEEEEEECCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEEEEECCCEEECCCCCCCCEE
VDETGNVFAAGAPAGNIHLATGVDPHESLLTLRTCNLILIHSDDDGRTWSRPINLNPALK
ECCCCCEEEECCCCCCEEEEECCCHHHHEEEEEEEEEEEEECCCCCCEECCCCCCCHHHH
QPWMRFLGTSPGNGIQLEHGTHRGRLLAPVYYNHEEGKTFSCAAVYSDDGGQTWNLGKSP
HHHHHHHCCCCCCCEEECCCCCCCEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCCCC
NDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFMRNQHPSGRVAHAASVDGGET
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCC
WGEVTFVEQLTEIFSQPNAISVRDELGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPH
CCHHHHHHHHHHHHCCCCEEEEHHHCCCCEEEEECCEEEEEECCCHHHHHCCCCCCCCCC
NRVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE
CCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034213 [H]