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The map label for this gene is nanT1 [H]

Identifier: 50842173

GI number: 50842173

Start: 754448

End: 755980

Strand: Reverse

Name: nanT1 [H]

Synonym: PPA0686

Alternate gene names: 50842173

Gene position: 755980-754448 (Counterclockwise)

Preceding gene: 50842175

Following gene: 50842172

Centisome position: 29.53

GC content: 56.29

Gene sequence:

>1533_bases
ATGGCCAGCTCAGACGACATCATCACCATCAAGGAGATGGGTGACAAGAGACGATGGTGGCAGTACTTAGACGCCACCAA
ATGGAAGCTCTTCATTGCAGCCCTTATTGGTGTCACCCTTGACGGCTACGACTTCGTGCTCATCACCTTGGCACTGCCAG
AGATCAAGGCGGCCTTTGGCCTCACCCTGGTACAAAGCGCAGCGTTGGTGTCAGCAGCCTTCATCACACGGTGGCTGGGC
GGACTAATCCTGGGCGGTGTTGGCGACAGGTTCGGACGCAAGCCAGCCATGATCATCGCAACCGTATTGTTCGCGATCGG
CTCGCTCCTCATGGGATTTTCGCCGAACTTCATGTTCCTGTTCATTATGCGCATGGTCGTCGGCTTCGCGATGGCGGGAG
AGTACGGGTCATCGGCAACATATGTCATCGAATCGTGGCACCCCCGAATCCGCGGCAAGGCATCGTCATTTCTGTTGTCA
GGCTATGCGATAGGCGCCATCCTGGCCGTCCAGGTCGACAAGTACTTAGTCCCATGGGTCGACAGTTGGCATGCCGGATG
GGGTTGGAGAGCCCTGTTCATCACCGGAATCGTGCCCATCGCAGTGGCACTGTACATGCGACGTCGCCTCCCCGAAGCTA
GCGACTGGGAAACGGCAAAGTCACGCGAGCGGGAAAAATCGTCCGAATCACGTGACGCTTTCCAGGTGCTGTTCAGCGGA
AGGCGCATGTCACTAAACATCACACTCGTCATCGCGGCAATGGCAGGTCTACTAGCCATCTTCGCCCTCAACATCCTGCC
TTTCTGGGGCGTCCTCGCCGTGGCCATAGCCTGTGGCGCCATCTTCGTGTGTCTCATCGTGCAATTTGATCCTCGACGCT
GGGTCATCGGCATCGGAATCATGATCGTTATCCTTTCTGCCTTCATGTATGGATGGCCCATCCTTGGACTCTTGCCTACA
TACCTCACGGGTGCAGGATATGCAGCTTCCACCGTCGCCAATCTGCTAACGATCGCACAATTCGGCAACATGATTGGTTA
CTTTGTCACAGGCTTCATGGGAGACTGGATAGGAATGCGAAAGTGGTACTTCACGAGCATTCTCATAGCGCAGATCATCG
TGTTTCCGCTATTCTTTGCGGGAATTAAGTCGGCATGGCTCATTGGGCTTCTACTGTTCTTCAACCAGTTGTTCGGCCAA
GGTGTTTCAGGGCTAGCCCCTCGGTGGGTGTCGAGCTATTTCCCCGTCGAGCAGCGAGCTGCCGGAGTGGGGTTCATCTA
CAATGTCGGAGCTCTCGGCGGTGCAATTGGACCATTTGTGGGCGCCTCGCTGGCTAAGAGCCACGGTCTGGGATCGGCTC
TAGGGGTGTTGTCCGTGGGCTTCGGCCTGATTGTTGTCCTTGGCGTTAGGCTGAATCTGCCACGCAAGCTACAGGCTCTC
GTCAACCCAGAGGCCGTCCGGCCCGAGGACGGAGATGACCGGTACATCAACAGCGTCGACCTTTCGAGCGAGTTTGCATC
CAGCGAGTGCTAA

Upstream 100 bases:

>100_bases
AGCGACCGGGAACATCGGCTTGCCAGCATATCGGCAACCACTTATCTTCAAAATGTTGGACGTCTAACGTACTTCCTGGA
TCAACGACGATTGGGGGCTC

Downstream 100 bases:

>100_bases
ATCGACAGCCAGAACACATATTCATATTCTCCAGCCAGAACGAGCCAGGGAAGCCACGAGGAGACGTCAATCATGACTAT
TACTGATACTTATACCGAGG

Product: putative sialic acid transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: Sialic acid permease 1 [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MASSDDIITIKEMGDKRRWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFGLTLVQSAALVSAAFITRWLG
GLILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFLFIMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLS
GYAIGAILAVQVDKYLVPWVDSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKSSESRDAFQVLFSG
RRMSLNITLVIAAMAGLLAIFALNILPFWGVLAVAIACGAIFVCLIVQFDPRRWVIGIGIMIVILSAFMYGWPILGLLPT
YLTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMRKWYFTSILIAQIIVFPLFFAGIKSAWLIGLLLFFNQLFGQ
GVSGLAPRWVSSYFPVEQRAAGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVRLNLPRKLQAL
VNPEAVRPEDGDDRYINSVDLSSEFASSEC

Sequences:

>Translated_510_residues
MASSDDIITIKEMGDKRRWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFGLTLVQSAALVSAAFITRWLG
GLILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFLFIMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLS
GYAIGAILAVQVDKYLVPWVDSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKSSESRDAFQVLFSG
RRMSLNITLVIAAMAGLLAIFALNILPFWGVLAVAIACGAIFVCLIVQFDPRRWVIGIGIMIVILSAFMYGWPILGLLPT
YLTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMRKWYFTSILIAQIIVFPLFFAGIKSAWLIGLLLFFNQLFGQ
GVSGLAPRWVSSYFPVEQRAAGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVRLNLPRKLQAL
VNPEAVRPEDGDDRYINSVDLSSEFASSEC
>Mature_509_residues
ASSDDIITIKEMGDKRRWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFGLTLVQSAALVSAAFITRWLGG
LILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFLFIMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLSG
YAIGAILAVQVDKYLVPWVDSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKSSESRDAFQVLFSGR
RMSLNITLVIAAMAGLLAIFALNILPFWGVLAVAIACGAIFVCLIVQFDPRRWVIGIGIMIVILSAFMYGWPILGLLPTY
LTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMRKWYFTSILIAQIIVFPLFFAGIKSAWLIGLLLFFNQLFGQG
VSGLAPRWVSSYFPVEQRAAGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVRLNLPRKLQALV
NPEAVRPEDGDDRYINSVDLSSEFASSEC

Specific function: May be a sugar-cation symporter involved in sialic acid uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Sialic acid transporter (TC 2.A.1.12.1) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082231, Length=476, Percent_Identity=46.6386554621849, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI87082404, Length=462, Percent_Identity=30.5194805194805, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1788292, Length=434, Percent_Identity=24.4239631336406, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788942, Length=236, Percent_Identity=28.3898305084746, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790550, Length=255, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789941, Length=220, Percent_Identity=28.1818181818182, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790463, Length=235, Percent_Identity=25.9574468085106, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786229, Length=189, Percent_Identity=25.3968253968254, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787880, Length=227, Percent_Identity=26.8722466960352, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI32564663, Length=220, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742
- InterPro:   IPR005828 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 55524; Mature: 55393

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSDDIITIKEMGDKRRWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFG
CCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHH
LTLVQSAALVSAAFITRWLGGLILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
FIMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLSGYAIGAILAVQVDKYLVPWV
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKSSESRDAFQVLFSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
RRMSLNITLVIAAMAGLLAIFALNILPFWGVLAVAIACGAIFVCLIVQFDPRRWVIGIGI
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHH
MIVILSAFMYGWPILGLLPTYLTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMR
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWYFTSILIAQIIVFPLFFAGIKSAWLIGLLLFFNQLFGQGVSGLAPRWVSSYFPVEQRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHC
AGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVRLNLPRKLQAL
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VNPEAVRPEDGDDRYINSVDLSSEFASSEC
CCCCCCCCCCCCCCEECCCCCCHHHCCCCC
>Mature Secondary Structure 
ASSDDIITIKEMGDKRRWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFG
CCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHH
LTLVQSAALVSAAFITRWLGGLILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
FIMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLSGYAIGAILAVQVDKYLVPWV
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKSSESRDAFQVLFSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
RRMSLNITLVIAAMAGLLAIFALNILPFWGVLAVAIACGAIFVCLIVQFDPRRWVIGIGI
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHH
MIVILSAFMYGWPILGLLPTYLTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMR
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWYFTSILIAQIIVFPLFFAGIKSAWLIGLLLFFNQLFGQGVSGLAPRWVSSYFPVEQRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHC
AGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVRLNLPRKLQAL
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VNPEAVRPEDGDDRYINSVDLSSEFASSEC
CCCCCCCCCCCCCCEECCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]