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The map label for this gene is tdh [H]

Identifier: 50842108

GI number: 50842108

Start: 686124

End: 687173

Strand: Reverse

Name: tdh [H]

Synonym: PPA0621

Alternate gene names: 50842108

Gene position: 687173-686124 (Counterclockwise)

Preceding gene: 50842110

Following gene: 50842106

Centisome position: 26.84

GC content: 62.67

Gene sequence:

>1050_bases
ATGACGCACACCATGCCAGCTCTAGTTCTCAATGGCCCCGGAGACGTCCAGGTAGCCGAAAAACCCATACCCACGCCTGG
TCCCGGAGAGGTCGTGCTGGCCGTCGAGGCGACGACAATCTGCGGCACCGACCTACGCATCATTTCCGGTGAGAAAACCG
CCGGGGTGCGCCCCGGGGTCACCCTCGGTCACGAGATCGCCGGAAGGATCGCCTCCCTCGGCGAGGGGGTGGAAGGACTG
GTTGTCGGGCAACAGGCAACTATCTCCATCGTCGTCTCCTGCGGCACCTGCCGGGCTTGCCTCGCAGGACGGGAGCACTT
ATGTAGCCACTGCGAGCTCGTCGGTTACGGCCTTGATGGTGGCCTCGCGCCGTGGTTGTGTGTGCCAGCCCAAGCGGTCT
CTCGCGGCAACATCATCCCGGTAGCTACGGAGATACCAGCTACGCGGCTGGCCCTGGCGGAACCTCTCTCCTGTGTTCTT
AACGGACATCGCCGTCATGGCGGGGTGAACCCTGGGGAGACTGTTGTCATCATCGGCGGCGGGGCTATCGGCCTGCTTCA
TACCGCGCTCAACCTGGCATGCGGGGCTGGGCGAGTCATCCTGTGTGAGAAGCACGCGGATCGACGCGACCGCGCCGCAG
CCATGGGAGCGGTGACGACCTGTCCGGAACACCTTTCCGAGGTTGTCACCGAGCACACCGGCGGATACGGGGCCGAGCTT
GTCATCGTCGCTATCGGTCGTAACGAATTGACCGAGGAATCCCTTAACCTCGCGGCCCCGGGCGGACGCGTGAGCTGGTT
TGCTGGTTTCCCCAAAGGATCAACGACGACCATCACCCCCAATACGGTGCATTACCAAGAGCTGACGATCTCCGGAGGAT
CGAATGCCAGTCGAGCAGACGTTCACCGGGCGGTCGACATGCTCGGACGGGGAAATATCGACGAAACCCCCATTGTCACT
CACACTTTTGGCCTGTCCCAGTGGACCGAAGCTGTTGACGCCGTGCGCGGTCACGTCGGTGTCAAGATCGCTATCGATCC
CCGCCGTTAA

Upstream 100 bases:

>100_bases
ATCGTCGATGGTGTTTTCCCCATGTCACATGGTAATTGGCGCCTGCGCAGCCTGCCCGACGTAACAGAAATGCGACACTA
GAACTGACGAAGGAGATCAC

Downstream 100 bases:

>100_bases
GTCGCACCCCGTCACGCAGCGACTGCCGCCTCACAATCTCACCGAGAGGACCCCAGCATCCGGGTTGCCGAATCGGTGCG
CTGTCATCGAGACCGACTGC

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTHTMPALVLNGPGDVQVAEKPIPTPGPGEVVLAVEATTICGTDLRIISGEKTAGVRPGVTLGHEIAGRIASLGEGVEGL
VVGQQATISIVVSCGTCRACLAGREHLCSHCELVGYGLDGGLAPWLCVPAQAVSRGNIIPVATEIPATRLALAEPLSCVL
NGHRRHGGVNPGETVVIIGGGAIGLLHTALNLACGAGRVILCEKHADRRDRAAAMGAVTTCPEHLSEVVTEHTGGYGAEL
VIVAIGRNELTEESLNLAAPGGRVSWFAGFPKGSTTTITPNTVHYQELTISGGSNASRADVHRAVDMLGRGNIDETPIVT
HTFGLSQWTEAVDAVRGHVGVKIAIDPRR

Sequences:

>Translated_349_residues
MTHTMPALVLNGPGDVQVAEKPIPTPGPGEVVLAVEATTICGTDLRIISGEKTAGVRPGVTLGHEIAGRIASLGEGVEGL
VVGQQATISIVVSCGTCRACLAGREHLCSHCELVGYGLDGGLAPWLCVPAQAVSRGNIIPVATEIPATRLALAEPLSCVL
NGHRRHGGVNPGETVVIIGGGAIGLLHTALNLACGAGRVILCEKHADRRDRAAAMGAVTTCPEHLSEVVTEHTGGYGAEL
VIVAIGRNELTEESLNLAAPGGRVSWFAGFPKGSTTTITPNTVHYQELTISGGSNASRADVHRAVDMLGRGNIDETPIVT
HTFGLSQWTEAVDAVRGHVGVKIAIDPRR
>Mature_348_residues
THTMPALVLNGPGDVQVAEKPIPTPGPGEVVLAVEATTICGTDLRIISGEKTAGVRPGVTLGHEIAGRIASLGEGVEGLV
VGQQATISIVVSCGTCRACLAGREHLCSHCELVGYGLDGGLAPWLCVPAQAVSRGNIIPVATEIPATRLALAEPLSCVLN
GHRRHGGVNPGETVVIIGGGAIGLLHTALNLACGAGRVILCEKHADRRDRAAAMGAVTTCPEHLSEVVTEHTGGYGAELV
IVAIGRNELTEESLNLAAPGGRVSWFAGFPKGSTTTITPNTVHYQELTISGGSNASRADVHRAVDMLGRGNIDETPIVTH
TFGLSQWTEAVDAVRGHVGVKIAIDPRR

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI262073058, Length=346, Percent_Identity=25.4335260115607, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71743840, Length=346, Percent_Identity=25.4335260115607, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565154, Length=267, Percent_Identity=28.8389513108614, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4501929, Length=351, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=30.03003003003, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787863, Length=332, Percent_Identity=28.6144578313253, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1790045, Length=326, Percent_Identity=26.0736196319018, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=27.9778393351801, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788407, Length=358, Percent_Identity=26.2569832402235, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=334, Percent_Identity=24.8502994011976, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=272, Percent_Identity=27.9411764705882, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=27.1293375394322, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082125, Length=346, Percent_Identity=24.8554913294798, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=321, Percent_Identity=27.7258566978193, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=245, Percent_Identity=26.1224489795918, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=318, Percent_Identity=26.7295597484277, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=223, Percent_Identity=28.6995515695067, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=317, Percent_Identity=25.2365930599369, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=26.8361581920904, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=26.5536723163842, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=354, Percent_Identity=25.9887005649718, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=352, Percent_Identity=23.0113636363636, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=247, Percent_Identity=29.1497975708502, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=347, Percent_Identity=25.3602305475504, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=347, Percent_Identity=25.6484149855908, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=324, Percent_Identity=26.2345679012346, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=247, Percent_Identity=28.7449392712551, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737897, Length=364, Percent_Identity=26.6483516483516, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137530, Length=358, Percent_Identity=26.536312849162, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36000; Mature: 35868

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTMPALVLNGPGDVQVAEKPIPTPGPGEVVLAVEATTICGTDLRIISGEKTAGVRPGV
CCCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCC
TLGHEIAGRIASLGEGVEGLVVGQQATISIVVSCGTCRACLAGREHLCSHCELVGYGLDG
CCCHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCHHHHHHCHHHHHCCCEEEEECCCC
GLAPWLCVPAQAVSRGNIIPVATEIPATRLALAEPLSCVLNGHRRHGGVNPGETVVIIGG
CCCCCEECCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEECC
GAIGLLHTALNLACGAGRVILCEKHADRRDRAAAMGAVTTCPEHLSEVVTEHTGGYGAEL
CHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
VIVAIGRNELTEESLNLAAPGGRVSWFAGFPKGSTTTITPNTVHYQELTISGGSNASRAD
EEEEECCCCCCHHHCCEECCCCCEEEEECCCCCCCEEECCCEEEEEEEEEECCCCCCHHH
VHRAVDMLGRGNIDETPIVTHTFGLSQWTEAVDAVRGHVGVKIAIDPRR
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure 
THTMPALVLNGPGDVQVAEKPIPTPGPGEVVLAVEATTICGTDLRIISGEKTAGVRPGV
CCCCCEEEECCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCCCC
TLGHEIAGRIASLGEGVEGLVVGQQATISIVVSCGTCRACLAGREHLCSHCELVGYGLDG
CCCHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCHHHHHHCHHHHHCCCEEEEECCCC
GLAPWLCVPAQAVSRGNIIPVATEIPATRLALAEPLSCVLNGHRRHGGVNPGETVVIIGG
CCCCCEECCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEECC
GAIGLLHTALNLACGAGRVILCEKHADRRDRAAAMGAVTTCPEHLSEVVTEHTGGYGAEL
CHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
VIVAIGRNELTEESLNLAAPGGRVSWFAGFPKGSTTTITPNTVHYQELTISGGSNASRAD
EEEEECCCCCCHHHCCEECCCCCEEEEECCCCCCCEEECCCEEEEEEEEEECCCCCCHHH
VHRAVDMLGRGNIDETPIVTHTFGLSQWTEAVDAVRGHVGVKIAIDPRR
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]