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The map label for this gene is 50842084

Identifier: 50842084

GI number: 50842084

Start: 662715

End: 664187

Strand: Direct

Name: 50842084

Synonym: PPA0598

Alternate gene names: NA

Gene position: 662715-664187 (Clockwise)

Preceding gene: 50842083

Following gene: 50842090

Centisome position: 25.88

GC content: 60.83

Gene sequence:

>1473_bases
ATGGCACTACGCCGTACGTTGACCTTGATGCTCTGTGCGATCACCGGCGCATCACTTGTCGCGACCGCAGTCCCCAGCAG
CGCCGCTCCTGGCTTCACTATCTCACCGCTGCGCACTTCCGATTCTATACAGTCCACCAGCGGATTCGTCGTTCATCTTA
AGGACCGTTCGGCCTCTGCCCAGCGCGTTAGGACCGCTCATGCCGCCTCCGCGATGCAGGCAACCAGCACGTCTCTGCGA
GGGTTAGTGGATCGTGCTGCGAAGGTGCGAGGTGCCCACGTCACTGAGTCATTGGCGCGTGCCAACAACTCCATGTCGGT
TCAGGTTTCTCAAGGGCTCAATGCTACGGCGGCTAAGGCTTTTGCATCTGAGATCGAACGCAACCCGGAGGTGGAATCCG
TCGAGCCCGTCTTGCATATGACGATTAATGAGAACACCGGTGTCCATCCTGCTGCAGTGTCGTCGGCCCCGAACGACCAG
TATTGGAACCGTCAATGGGGCCTGAATTCTGAGAACGGGATTGACGCTCCCGGCGCATGGGCAACCAACACAGGATCCGG
AGTGACCGTGGCCGTCATCGACTCCGGCATCACCAAGCACCCGGATCTGGATGGCAAGGTCCTACCTGGCTACGACTTCA
TCTCTGATCGTTATGCCGCCGGCGATGGTAACGGTCGCGATTCGGATCCCTCCGATGAGGGCGATTGGACTCGTGCGGGG
GCCTGCACCCGGCGTGACGTGCCGTCGTCGTGGCATGGGACCCACGTGGCGGGCATTATTGGCGCTGCGACCAACAATGC
TAGGGGTGTCGCAGGAGCCGCCCCTGGCGCCAAGATCCTGCCGGTTCGAGCGCTAGGTCATTGCGGTGGGACCGACGTCG
ATATTGCCGACGGTATTACGTGGGCCTCTGGTGGCGAGGTTCCGGGTGTTCCCACTAACCACAACCCCGCTAAGGTCATT
AATCTGAGCCTCGGCGGTCCGTCTAACTACTGCCCGATCACGTATCAGCGAGCCATTGATGCGGCCGTCTCTCGCGGATC
CACCGTCGTTGTGGCAGCCGGTAACGAGGCGATGGACGTCCGTAAGTCGACACCCGGCAACTGCCGCAATGTGGTCGTTG
TCGGAGCTACCGGTGAGACTGGTGCCCAGTCGTACTTCTCGAATTACGGTTCGACCGTTGACGTGTCCGCTCCTGGCGGT
GACGACCGCACCGGTGACATGATCCTATCCACCCTGAATAACGGCGAAACGACTCCTGCGGCCCCGACCTACGGCTACAT
GGAGGGCACCTCCCAGGCTGCCCCGCACGTCTCCGCCGTTGTTGCTCTCATGATCGCGGCCAACCCGAACCTCACCCCCG
CGAGGATCAAGGAAATCCTCAAACAGTCGGTGAACCCGGCTAAATGCAAGACCGGTTGCGGTACGGGCATTGTTGATGCC
CGCAAGGCGGTCAAGGCTGCAAAATCGGCCTGA

Upstream 100 bases:

>100_bases
GTGCGAGACATTTATAGGCTGTGTCAGGCTATGTCTAAATAAATGACCCACTGTCATCCTAGGTTCGTTTCACCTTCAGC
AAACTGAGAGGAATGGACAT

Downstream 100 bases:

>100_bases
TTGCTAGGATTCTGTCAATGATGAGTGACCTGGGCCATATGGTTCAGGCCACTCGTCACGTTGATAGGTATGCGCGGTAT
CACCAGGGGACGTCAGGCTC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MALRRTLTLMLCAITGASLVATAVPSSAAPGFTISPLRTSDSIQSTSGFVVHLKDRSASAQRVRTAHAASAMQATSTSLR
GLVDRAAKVRGAHVTESLARANNSMSVQVSQGLNATAAKAFASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQ
YWNRQWGLNSENGIDAPGAWATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAG
ACTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGITWASGGEVPGVPTNHNPAKVI
NLSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDVRKSTPGNCRNVVVVGATGETGAQSYFSNYGSTVDVSAPGG
DDRTGDMILSTLNNGETTPAAPTYGYMEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGTGIVDA
RKAVKAAKSA

Sequences:

>Translated_490_residues
MALRRTLTLMLCAITGASLVATAVPSSAAPGFTISPLRTSDSIQSTSGFVVHLKDRSASAQRVRTAHAASAMQATSTSLR
GLVDRAAKVRGAHVTESLARANNSMSVQVSQGLNATAAKAFASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQ
YWNRQWGLNSENGIDAPGAWATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAG
ACTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGITWASGGEVPGVPTNHNPAKVI
NLSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDVRKSTPGNCRNVVVVGATGETGAQSYFSNYGSTVDVSAPGG
DDRTGDMILSTLNNGETTPAAPTYGYMEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGTGIVDA
RKAVKAAKSA
>Mature_489_residues
ALRRTLTLMLCAITGASLVATAVPSSAAPGFTISPLRTSDSIQSTSGFVVHLKDRSASAQRVRTAHAASAMQATSTSLRG
LVDRAAKVRGAHVTESLARANNSMSVQVSQGLNATAAKAFASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQY
WNRQWGLNSENGIDAPGAWATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAGA
CTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGITWASGGEVPGVPTNHNPAKVIN
LSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDVRKSTPGNCRNVVVVGATGETGAQSYFSNYGSTVDVSAPGGD
DRTGDMILSTLNNGETTPAAPTYGYMEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGTGIVDAR
KAVKAAKSA

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505577, Length=368, Percent_Identity=26.9021739130435, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI20336180, Length=368, Percent_Identity=26.9021739130435, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20336182, Length=368, Percent_Identity=26.9021739130435, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI27894285, Length=368, Percent_Identity=26.6304347826087, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4505579, Length=366, Percent_Identity=25.1366120218579, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20336184, Length=368, Percent_Identity=26.9021739130435, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20336190, Length=369, Percent_Identity=26.5582655826558, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI20336188, Length=368, Percent_Identity=26.6304347826087, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI20336186, Length=336, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=373, Percent_Identity=27.8820375335121, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25141268, Length=373, Percent_Identity=27.6139410187668, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324576, Length=321, Percent_Identity=28.9719626168224, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320775, Length=295, Percent_Identity=27.4576271186441, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319893, Length=285, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650056, Length=367, Percent_Identity=25.0681198910082, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650058, Length=367, Percent_Identity=25.0681198910082, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650060, Length=367, Percent_Identity=25.0681198910082, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553513, Length=367, Percent_Identity=25.0681198910082, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553515, Length=367, Percent_Identity=25.0681198910082, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17864552, Length=367, Percent_Identity=25.0681198910082, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007280
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 50175; Mature: 50044

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRRTLTLMLCAITGASLVATAVPSSAAPGFTISPLRTSDSIQSTSGFVVHLKDRSASA
CCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCHH
QRVRTAHAASAMQATSTSLRGLVDRAAKVRGAHVTESLARANNSMSVQVSQGLNATAAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
FASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQYWNRQWGLNSENGIDAPGAW
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAG
CCCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCCCC
ACTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGIT
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCEE
WASGGEVPGVPTNHNPAKVINLSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDV
ECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHH
RKSTPGNCRNVVVVGATGETGAQSYFSNYGSTVDVSAPGGDDRTGDMILSTLNNGETTPA
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHEEECCCCCCCCC
APTYGYMEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGTGIVDA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHH
RKAVKAAKSA
HHHHHHHHCC
>Mature Secondary Structure 
ALRRTLTLMLCAITGASLVATAVPSSAAPGFTISPLRTSDSIQSTSGFVVHLKDRSASA
CHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCHH
QRVRTAHAASAMQATSTSLRGLVDRAAKVRGAHVTESLARANNSMSVQVSQGLNATAAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
FASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQYWNRQWGLNSENGIDAPGAW
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAG
CCCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCCCC
ACTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGIT
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCEE
WASGGEVPGVPTNHNPAKVINLSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDV
ECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHH
RKSTPGNCRNVVVVGATGETGAQSYFSNYGSTVDVSAPGGDDRTGDMILSTLNNGETTPA
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHEEECCCCCCCCC
APTYGYMEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGTGIVDA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCHHHH
RKAVKAAKSA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2187155; 12024217 [H]