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The map label for this gene is mutA [H]

Identifier: 50842081

GI number: 50842081

Start: 657197

End: 659107

Strand: Direct

Name: mutA [H]

Synonym: PPA0595

Alternate gene names: 50842081

Gene position: 657197-659107 (Clockwise)

Preceding gene: 50842078

Following gene: 50842082

Centisome position: 25.67

GC content: 61.17

Gene sequence:

>1911_bases
ATGACTGATCCTGACAACCTCGCATCCAAGTCCGTCGAGGACAGGATGCCTGAGGAGTTGAGCCTGGCCGGGGACTTCCC
GAAGGTCACCCACGAGCAGTGGGAGGAGGCGGTCCTTAAGGTTCTGAACCGGGGTCGTCCCGAGGGCAAGGAACTCAACA
TCGAGCAGGGAATGAAGCGCCTCGAGCCGACTACGGTCGACGGCATCCAGATCGAGCCGATGTACCGGCGTCAGGATGCC
CCCGAGAAGCTCGGTGTTCCGGGCGTGCCGCCGTTCACTCGTGGTACCACGATCCGTGAAGGCGGCATGGATGCATGGGA
TGTCCGGGCCCTTCATGAGGATCCCGATGTCGCGTTCACTAAAAAGGCCGTTATCGCCGACCTTGAGCGTGGCGTGACGT
CCCTGTGGCTGCGGGTCGGGGCTGACGCCATTAAGCCCGAGGACATTGCGGGTGACCTCAAGGATGTGTTGCTCGACCTG
GCCAAGGTTGAGGTCTCTAGCCGTGATGACCAGGAGGCCGCTGCTCAGGCTCTCCTTGATGTTTACATTGAGTCCAAGAT
CGATGCTGACAAGCTGTCGTTTAACCTCGGTCTGGACCCCATCGGTTTTGCGGCCCTTAATGGCGGTAACCCAGACTTGT
CCGGGATGGCCGAGTGGGTCAAGAAGACCGAGAATTACAAGAACTCCCGCCCCTTCGTCGTTGACGCCACGATCTACCAC
AACGCCGGTGCTGGCGACGTGCACGAACTCGCGTGGGCTGTCGCGACCGGCGTTGAGTACGTCCGAGCTTTCATTGAGCA
GGGGCTGACAGCTGAGCAGGCCTTCGATTCCATCAACTTCCGCGTCACGGCCACCCACGACGAGTTCCTCACTATTTCCC
GTCTGCGTGCCCTACGTACCTTGTGGAACCGTGTTGGCGAGGTCTTCGAGGTACCGGCTGCTAAGCGTGGTGCCCGTCAA
GAAGCGGTCACCAGCTGGCGCGAGCTCACTCGCGACGATCCTTACGTCAATATCCTTCGTGGCACGATCGCAACCTTCGG
TGCTGCTGTCGGTGGCGCTGAGGCGGTCACGACCTTGCCTTTCGACGCCGCTATTGGTTTACCGAAGAGTGACTTCTCTC
GTCGTATCGCTCGCAACACCGGCATCATTCTCGCTGAAGAGTCGAATATTGGTCGCGCTAATGATCCAGCTGGTGGCTCC
TTCTATGTCGAGGCACTCACCAAGAAGTTGGAGGATGCCGGTTGGGCCGAGTTCCAGGCCGTCGAGGCTGCTGGTGGCAT
GGCTGCCGCCCTCACCGGCGACCATGTCCGCACCGAGCTCGACAAGCTCAACACCGAGCGTGCCAAGCGTCTTGCCACTC
GCAAGCAGCCGATTACGGCCGTCAGTGAGTTCCCGCTGCTCGATGCCAAGTCCGTCGAGACCAAACCGTATCCAGCAGCC
CCGGCCCGTGAGGGTCTGGAATGGCACCGTGACGCCGAGGTCTTCGAGGCCCTCGTTGATCGCTCTGCCACTTGCCCTGA
GCGTCCAAAAGTGTTCCTGGCCTGCCTGGGAACCCGCCGTGACTTTGGCCCGCGCGAGGGATTCTCCGCCCCGGTATGGC
ACATCGCCGGCATGGAAACCCCCGAGTGTGAGGGGGGCACCACCGAGGAGGTCGTGAAGGCCTTTAAGGAGTCTGGTGCT
GATATCGCCGACCTGTGCTCGAACGCCAAGACCTACGCGGCTCAAGGTCTCGAGGTCGCCAAGGCCCTCAAGGAGGCTGG
CGCCAAGCTGGTTTACCTGTCAGGTGCCTTCAAGGAATTCGGTGATGATGCCGCCGAGGCCGAGAAGGTCATCGACGGGC
GCATCTACCTCGGGATGGACGTCGTGGACGTCCTGACCGCCACTCTGGACACGTTGGGAGTTGCCAAGTGA

Upstream 100 bases:

>100_bases
GCCAGAGCGTGTGGTGCACTACGCGTGTACCACAGCGTCCGAGGTCTCGAGGGCCGACCGAGGTCGTCCAACCATCCACA
GCGGAGCAGGAGTCTAACGA

Downstream 100 bases:

>100_bases
CCACCCTGCCTCGTTTCGATTCCATTAACCTCGGGGATTCCCCGGTTCCCGCAGATGCGCAGGAGCAGTTCGCCAGATTG
GCTGCGGCCGCCGGTGAGCA

Product: methylmalonyl-CoA mutase small subunit

Products: NA

Alternate protein names: MCB-beta [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MTDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKRLEPTTVDGIQIEPMYRRQDA
PEKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFTKKAVIADLERGVTSLWLRVGADAIKPEDIAGDLKDVLLDL
AKVEVSSRDDQEAAAQALLDVYIESKIDADKLSFNLGLDPIGFAALNGGNPDLSGMAEWVKKTENYKNSRPFVVDATIYH
NAGAGDVHELAWAVATGVEYVRAFIEQGLTAEQAFDSINFRVTATHDEFLTISRLRALRTLWNRVGEVFEVPAAKRGARQ
EAVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLPFDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGS
FYVEALTKKLEDAGWAEFQAVEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAA
PAREGLEWHRDAEVFEALVDRSATCPERPKVFLACLGTRRDFGPREGFSAPVWHIAGMETPECEGGTTEEVVKAFKESGA
DIADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEFGDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK

Sequences:

>Translated_636_residues
MTDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKRLEPTTVDGIQIEPMYRRQDA
PEKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFTKKAVIADLERGVTSLWLRVGADAIKPEDIAGDLKDVLLDL
AKVEVSSRDDQEAAAQALLDVYIESKIDADKLSFNLGLDPIGFAALNGGNPDLSGMAEWVKKTENYKNSRPFVVDATIYH
NAGAGDVHELAWAVATGVEYVRAFIEQGLTAEQAFDSINFRVTATHDEFLTISRLRALRTLWNRVGEVFEVPAAKRGARQ
EAVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLPFDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGS
FYVEALTKKLEDAGWAEFQAVEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAA
PAREGLEWHRDAEVFEALVDRSATCPERPKVFLACLGTRRDFGPREGFSAPVWHIAGMETPECEGGTTEEVVKAFKESGA
DIADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEFGDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK
>Mature_635_residues
TDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKRLEPTTVDGIQIEPMYRRQDAP
EKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFTKKAVIADLERGVTSLWLRVGADAIKPEDIAGDLKDVLLDLA
KVEVSSRDDQEAAAQALLDVYIESKIDADKLSFNLGLDPIGFAALNGGNPDLSGMAEWVKKTENYKNSRPFVVDATIYHN
AGAGDVHELAWAVATGVEYVRAFIEQGLTAEQAFDSINFRVTATHDEFLTISRLRALRTLWNRVGEVFEVPAAKRGARQE
AVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLPFDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGSF
YVEALTKKLEDAGWAEFQAVEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAAP
AREGLEWHRDAEVFEALVDRSATCPERPKVFLACLGTRRDFGPREGFSAPVWHIAGMETPECEGGTTEEVVKAFKESGAD
IADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEFGDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=450, Percent_Identity=29.3333333333333, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1789284, Length=471, Percent_Identity=30.9978768577495, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI25144500, Length=458, Percent_Identity=27.5109170305677, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 69086; Mature: 68955

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKR
CCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHH
LEPTTVDGIQIEPMYRRQDAPEKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFT
CCCCCCCCEEECCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHH
KKAVIADLERGVTSLWLRVGADAIKPEDIAGDLKDVLLDLAKVEVSSRDDQEAAAQALLD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VYIESKIDADKLSFNLGLDPIGFAALNGGNPDLSGMAEWVKKTENYKNSRPFVVDATIYH
HHHHCCCCHHHEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEE
NAGAGDVHELAWAVATGVEYVRAFIEQGLTAEQAFDSINFRVTATHDEFLTISRLRALRT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LWNRVGEVFEVPAAKRGARQEAVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLP
HHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHEEECC
FDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGSFYVEALTKKLEDAGWAEFQA
CHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
VEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAA
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
PAREGLEWHRDAEVFEALVDRSATCPERPKVFLACLGTRRDFGPREGFSAPVWHIAGMET
CHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCC
PECEGGTTEEVVKAFKESGADIADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEF
CCCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHH
GDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK
CCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKR
CCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHH
LEPTTVDGIQIEPMYRRQDAPEKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFT
CCCCCCCCEEECCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHH
KKAVIADLERGVTSLWLRVGADAIKPEDIAGDLKDVLLDLAKVEVSSRDDQEAAAQALLD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VYIESKIDADKLSFNLGLDPIGFAALNGGNPDLSGMAEWVKKTENYKNSRPFVVDATIYH
HHHHCCCCHHHEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEE
NAGAGDVHELAWAVATGVEYVRAFIEQGLTAEQAFDSINFRVTATHDEFLTISRLRALRT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LWNRVGEVFEVPAAKRGARQEAVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLP
HHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHEEECC
FDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGSFYVEALTKKLEDAGWAEFQA
CHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
VEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAA
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
PAREGLEWHRDAEVFEALVDRSATCPERPKVFLACLGTRRDFGPREGFSAPVWHIAGMET
CHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCC
PECEGGTTEEVVKAFKESGADIADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEF
CCCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHH
GDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK
CCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2569861; 2569860; 8805541; 9655823 [H]