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The map label for this gene is uvrC [H]

Identifier: 50364916

GI number: 50364916

Start: 127478

End: 129244

Strand: Direct

Name: uvrC [H]

Synonym: Mfl101

Alternate gene names: 50364916

Gene position: 127478-129244 (Clockwise)

Preceding gene: 50364915

Following gene: 50364917

Centisome position: 16.07

GC content: 25.58

Gene sequence:

>1767_bases
ATGGAATTAAAAAATAAAGTTAGTAATTTACCAAGTAAACCTGGTTGTTATTTATATTTAAATAAAGACAAACACGTAAT
TTACGTAGGGAAAGCAAAGAATCTTAAAAAGAGAGTTTCATCTTATTTTGATAGAGCACAAAATTTAAAAACTACTAGGC
TAGTTCGTGAAATTGCTGATCTTGAATATTTTGTTGTATCAAATGAAAAAGAATCGTTACTATTAGAAGAAAACTTAATT
AAAAAATATAGACCAAAATACAATGTTTTATTGAATGATGACAAAGCTTATCCTTATATTATTATCACAAATGAAAAAGA
CCCAACTTATAAATATGTTAGAAAACTAGATAAAAAGGCATTCAGAAGTTTTGGCCCATTACCAATTGGTTCTAATGCAA
GAGAAACATTAATAACACTACAAAGACTCTTTCCTTTAAGAAGATGCAAAGGAAATTTGGGAAAACCTTGTCTACATTAT
TTTATTGGTCAGTGTAGTGGTGCTTGTTTTAAAGAAGTTAACAAGGAATATTATCAAGAACAAATTAAGAGAGTTGACAA
TTTCTTTAAGGGTAATATAAATGAAGTTAAAACATTATTAACAAATCAAATGCATAAAGCTGCAGAAAATTTACAATTTG
AAGAAGCTCAGAGAATAAAAGAACAAATCATAAGTCTTGATTTTACTACAACAAAACAAAACGTTGAATTTAAAAGTCAA
ACTGATGTTGATGTGATAAGTTATTTTATTGAAGATGAAAAAATTGCTATTGTTACTTTATTCTATAGATCTGGTAAATT
ACTTTTTAAAGATGAACATATACAGTTATATTTTGAGCAAGACATAACAGATTTAATTGATTCATTCATGTCTCAAATTT
ATGATAAAAATATTCTTCCAGATAAAATTATTGTTGATAATGAAGTAGAACTGTTTGATTTAAATGAAAAATATAAATCT
ATATCAACACATCCGATAAAAGAAGATGAAAAAATAATTTATAAATTAGCAACTGAAAATGCACAAGAGGCAATTAGGAA
ATCTAAAATATCAACAACAATAAATATAGGTAATGAAAATGAATTATTGTTAGAGCTGCAAGAAAAAGCAAATTTACAAA
AAGAACCGTACAGACTTGAGATGTTTGACATTTCAAATATAGGTAATGAATTTATTGTTGGAAGTTGTGTTGTTTATATT
AATGGAAAACCAGCAAGAAATGAATTTAGAAAATATAATATTGAAAGTAAATTTACATCAGATTATGATAGATTAAAAGA
AATGTTATATAGAAGGTTTCAAAAAGCACTAATTGAAAAAAGAATGTTACCAGATTTAATAATAATGGACGGTGGTATCA
TTCAAATTCATGCTGCTAAAGAAATAATAAATGCTTTAGGACTATCAGAAATACAAGTAATAGGTTTAGTTAAAGATGAA
CATCATAATACATCTTTTTTAATTGATACTAATGAAGAACAAGTAATCATTAAGGATAAACCAAAATTGTTTAACTGATT
AAGTAGCATTCAAGTTAGGGTAGATGAATATGCTAAGTCAGGGTTTAGAAAAAAACAAAATAATTCTTTCTTAAAATCTG
ATTTAGAACAAATTGAGGGATTAGGTAAAAAAAGAATACAAGATCTTTTCAAAAAGTTCAATACAATAAATGAAATTGAA
AGTGCCGACCAAGAAGAACTCTTCAAAATTTTAAAAAATAAGAAAGCTTTAGACAACCTGAACATATATTTAAAGAACAG
AAAATAG

Upstream 100 bases:

>100_bases
TGGGCCTAAAAATGGTTCAAGACCAAGAGAAGTATTAGTTAAAAAATAAAACCCTCAGTTTAGGGTTTTATTTTTCTAAG
AGAATAGAAAGGAAAGCTAT

Downstream 100 bases:

>100_bases
ATACAAATTTAAGAACAAATAATATATAATTAAAAAGTTAATGAATTAGGAGACAAACATGGCAAAAGAAATAATCTTAA
CTCAAGAAGGTATTGAGGAA

Product: repair endonuclease subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MELKNKVSNLPSKPGCYLYLNKDKHVIYVGKAKNLKKRVSSYFDRAQNLKTTRLVREIADLEYFVVSNEKESLLLEENLI
KKYRPKYNVLLNDDKAYPYIIITNEKDPTYKYVRKLDKKAFRSFGPLPIGSNARETLITLQRLFPLRRCKGNLGKPCLHY
FIGQCSGACFKEVNKEYYQEQIKRVDNFFKGNINEVKTLLTNQMHKAAENLQFEEAQRIKEQIISLDFTTTKQNVEFKSQ
TDVDVISYFIEDEKIAIVTLFYRSGKLLFKDEHIQLYFEQDITDLIDSFMSQIYDKNILPDKIIVDNEVELFDLNEKYKS
ISTHPIKEDEKIIYKLATENAQEAIRKSKISTTINIGNENELLLELQEKANLQKEPYRLEMFDISNIGNEFIVGSCVVYI
NGKPARNEFRKYNIESKFTSDYDRLKEMLYRRFQKALIEKRMLPDLIIMDGGIIQIHAAKEIINALGLSEIQVIGLVKDE
HHNTSFLIDTNEEQVIIKDKPKLFNWLSSIQVRVDEYAKSGFRKKQNNSFLKSDLEQIEGLGKKRIQDLFKKFNTINEIE
SADQEELFKILKNKKALDNLNIYLKNRK

Sequences:

>Translated_588_residues
MELKNKVSNLPSKPGCYLYLNKDKHVIYVGKAKNLKKRVSSYFDRAQNLKTTRLVREIADLEYFVVSNEKESLLLEENLI
KKYRPKYNVLLNDDKAYPYIIITNEKDPTYKYVRKLDKKAFRSFGPLPIGSNARETLITLQRLFPLRRCKGNLGKPCLHY
FIGQCSGACFKEVNKEYYQEQIKRVDNFFKGNINEVKTLLTNQMHKAAENLQFEEAQRIKEQIISLDFTTTKQNVEFKSQ
TDVDVISYFIEDEKIAIVTLFYRSGKLLFKDEHIQLYFEQDITDLIDSFMSQIYDKNILPDKIIVDNEVELFDLNEKYKS
ISTHPIKEDEKIIYKLATENAQEAIRKSKISTTINIGNENELLLELQEKANLQKEPYRLEMFDISNIGNEFIVGSCVVYI
NGKPARNEFRKYNIESKFTSDYDRLKEMLYRRFQKALIEKRMLPDLIIMDGGIIQIHAAKEIINALGLSEIQVIGLVKDE
HHNTSFLIDTNEEQVIIKDKPKLFN*LSSIQVRVDEYAKSGFRKKQNNSFLKSDLEQIEGLGKKRIQDLFKKFNTINEIE
SADQEELFKILKNKKALDNLNIYLKNRK
>Mature_588_residues
MELKNKVSNLPSKPGCYLYLNKDKHVIYVGKAKNLKKRVSSYFDRAQNLKTTRLVREIADLEYFVVSNEKESLLLEENLI
KKYRPKYNVLLNDDKAYPYIIITNEKDPTYKYVRKLDKKAFRSFGPLPIGSNARETLITLQRLFPLRRCKGNLGKPCLHY
FIGQCSGACFKEVNKEYYQEQIKRVDNFFKGNINEVKTLLTNQMHKAAENLQFEEAQRIKEQIISLDFTTTKQNVEFKSQ
TDVDVISYFIEDEKIAIVTLFYRSGKLLFKDEHIQLYFEQDITDLIDSFMSQIYDKNILPDKIIVDNEVELFDLNEKYKS
ISTHPIKEDEKIIYKLATENAQEAIRKSKISTTINIGNENELLLELQEKANLQKEPYRLEMFDISNIGNEFIVGSCVVYI
NGKPARNEFRKYNIESKFTSDYDRLKEMLYRRFQKALIEKRMLPDLIIMDGGIIQIHAAKEIINALGLSEIQVIGLVKDE
HHNTSFLIDTNEEQVIIKDKPKLFN*LSSIQVRVDEYAKSGFRKKQNNSFLKSDLEQIEGLGKKRIQDLFKKFNTINEIE
SADQEELFKILKNKKALDNLNIYLKNRK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=588, Percent_Identity=34.3537414965986, Blast_Score=297, Evalue=2e-81,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=28.4974093264249, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68725; Mature: 68725

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKNKVSNLPSKPGCYLYLNKDKHVIYVGKAKNLKKRVSSYFDRAQNLKTTRLVREIAD
CCCHHHHHCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LEYFVVSNEKESLLLEENLIKKYRPKYNVLLNDDKAYPYIIITNEKDPTYKYVRKLDKKA
CEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHH
FRSFGPLPIGSNARETLITLQRLFPLRRCKGNLGKPCLHYFIGQCSGACFKEVNKEYYQE
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
QIKRVDNFFKGNINEVKTLLTNQMHKAAENLQFEEAQRIKEQIISLDFTTTKQNVEFKSQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCCCCCC
TDVDVISYFIEDEKIAIVTLFYRSGKLLFKDEHIQLYFEQDITDLIDSFMSQIYDKNILP
CCHHHHHHHHCCCCEEEEEEEEECCEEEEEECCEEEEEHHHHHHHHHHHHHHHHCCCCCC
DKIIVDNEVELFDLNEKYKSISTHPIKEDEKIIYKLATENAQEAIRKSKISTTINIGNEN
CCEEECCCEEEEECCHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCEEEEECCCC
ELLLELQEKANLQKEPYRLEMFDISNIGNEFIVGSCVVYINGKPARNEFRKYNIESKFTS
CEEEEEHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHCCCCCCCCC
DYDRLKEMLYRRFQKALIEKRMLPDLIIMDGGIIQIHAAKEIINALGLSEIQVIGLVKDE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHHCCCCEEEEEEEECC
HHNTSFLIDTNEEQVIIKDKPKLFNLSSIQVRVDEYAKSGFRKKQNNSFLKSDLEQIEGL
CCCCEEEEECCCCEEEEECCCCEECCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHCC
GKKRIQDLFKKFNTINEIESADQEELFKILKNKKALDNLNIYLKNRK
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCC
>Mature Secondary Structure
MELKNKVSNLPSKPGCYLYLNKDKHVIYVGKAKNLKKRVSSYFDRAQNLKTTRLVREIAD
CCCHHHHHCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LEYFVVSNEKESLLLEENLIKKYRPKYNVLLNDDKAYPYIIITNEKDPTYKYVRKLDKKA
CEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHH
FRSFGPLPIGSNARETLITLQRLFPLRRCKGNLGKPCLHYFIGQCSGACFKEVNKEYYQE
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
QIKRVDNFFKGNINEVKTLLTNQMHKAAENLQFEEAQRIKEQIISLDFTTTKQNVEFKSQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCCCCCC
TDVDVISYFIEDEKIAIVTLFYRSGKLLFKDEHIQLYFEQDITDLIDSFMSQIYDKNILP
CCHHHHHHHHCCCCEEEEEEEEECCEEEEEECCEEEEEHHHHHHHHHHHHHHHHCCCCCC
DKIIVDNEVELFDLNEKYKSISTHPIKEDEKIIYKLATENAQEAIRKSKISTTINIGNEN
CCEEECCCEEEEECCHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCEEEEECCCC
ELLLELQEKANLQKEPYRLEMFDISNIGNEFIVGSCVVYINGKPARNEFRKYNIESKFTS
CEEEEEHHHCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHCCCCCCCCC
DYDRLKEMLYRRFQKALIEKRMLPDLIIMDGGIIQIHAAKEIINALGLSEIQVIGLVKDE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHHCCCCEEEEEEEECC
HHNTSFLIDTNEEQVIIKDKPKLFNLSSIQVRVDEYAKSGFRKKQNNSFLKSDLEQIEGL
CCCCEEEEECCCCEEEEECCCCEECCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHCC
GKKRIQDLFKKFNTINEIESADQEELFKILKNKKALDNLNIYLKNRK
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA