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The map label for this gene is ubiB [C]

Identifier: 50085496

GI number: 50085496

Start: 2369436

End: 2370743

Strand: Reverse

Name: ubiB [C]

Synonym: ACIAD2409

Alternate gene names: 50085496

Gene position: 2370743-2369436 (Counterclockwise)

Preceding gene: 50085497

Following gene: 50085495

Centisome position: 65.88

GC content: 39.53

Gene sequence:

>1308_bases
TTGAATCATATGAAAAAAAATATACTGTTTGATGGGCTACGATCTGTTGCACGTATTGGTGAAACTGCTTTTGTCGCGGC
AAGAGCAGGCATCAAGTATGCAACTGAAAAACCAAGCAACGCCAAGCTAATGCGAGAAACTTTTGAATCACTCGGTTCGA
CTTACATTAAACTCGGTCAGTTTATTGCGAGCACGCCATCTTTATTTCCACGCGAATATGTTGAAGAATTTCAGGGTTGT
TTAGATCAAACGCCTACTTTGCCTTTTAGCTATATTCAGGAAGTACTTGCTGAAGAATTTGAAGGCCGTGATTTGAATCA
GATTTTTGCATCGATTGATGAAACACCTCTAGCTTCTGCCTCGATTGCACAGGTTCATGCTGCGCGATTAACAACCGGCG
AAGACGTTGTGATTAAAGTTCAAAAGCCAGGTGTAGAAACGATTCTATATACAGACCTCAATGTTGTTCATTGGGCGACA
AAGATGCTTGAAAAAGCAATTCCTAAAGTGAAGTTTGCTTCTCTTTCAGAAATTGTAGAAGAAATTAAGATCCGTATGGT
TCGTGAAGTAGATTTTATTGAAGAAGCTCAGAATCTTGATGATTTTGTTGAATATCTAAAAATTACCAACAATCAGGCAG
CCACTGCACCTAAAGTCTATCATCAGTTTTCCACACGCCGTATTTTAACGATGGAGCGTTTGTATGGGGTATCACTGACC
GATTTTGATATTGTTAAAAAGTTTGCCAAAGATCCATCTCAAGTTCTGATTACAGCCATGAATACTTGGTTTGGTAGTCT
GATGCTATGTAAAAGTTTTCATGCAGATTTACACGCAGGGAATTTAATGCTGCTTGAAGATGGTCGAATCGGTTTTATTG
ACTTTGGTATTGTTGGTCAACTGAATCCACAAGTCTGGACAGCTTGTCTGGCATTTATGGATGCCTTACAAAAAACTGAC
TACACTGCTATGGCTGAAAACATGCTGAAAATGGGGATGACCAAAACCCAGATTGATACACAGGTTTTAGCTCAGGATTT
AGAACGTTTGTTTAGCGGCGTCTTACTTGCAGATCCACAGGAAATTCTAGCCTCAAAACCGTCAGATCTTAATGATATTA
TGCTGGACATGGTGGCCGTTGGTGAGCGTCATGGCATTAAATTTCCTCGTGATTTTGCCTTGTTGTTCAAACAAATGCTT
TATTTCGATCGTTTTATGCGCGTACTTGCACCTTATACCGATATTTATGCAGACCAACGTTTGAAAATGGTTCAAACTAT
AGAGCCTCAGTCGTTGTTAAAGCATTAA

Upstream 100 bases:

>100_bases
TTTTACATTTTGAAAAAGATACAAATTGTTCAACTTGTCAGGCAAGTTTATCGGTAAACTCGGTGAAGTTTGATACACTG
CCACAATGAGTTAAACCATA

Downstream 100 bases:

>100_bases
TTGTCGAGTTAGATCATTATGGATGCCATTGTTATTGAAGGTTTAAAAGTCAATACAGTTGTAGGATGTTTTAATTGGGA
ACGCCAAATTACTCAGCCGT

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNHMKKNILFDGLRSVARIGETAFVAARAGIKYATEKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGC
LDQTPTLPFSYIQEVLAEEFEGRDLNQIFASIDETPLASASIAQVHAARLTTGEDVVIKVQKPGVETILYTDLNVVHWAT
KMLEKAIPKVKFASLSEIVEEIKIRMVREVDFIEEAQNLDDFVEYLKITNNQAATAPKVYHQFSTRRILTMERLYGVSLT
DFDIVKKFAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLNPQVWTACLAFMDALQKTD
YTAMAENMLKMGMTKTQIDTQVLAQDLERLFSGVLLADPQEILASKPSDLNDIMLDMVAVGERHGIKFPRDFALLFKQML
YFDRFMRVLAPYTDIYADQRLKMVQTIEPQSLLKH

Sequences:

>Translated_435_residues
MNHMKKNILFDGLRSVARIGETAFVAARAGIKYATEKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGC
LDQTPTLPFSYIQEVLAEEFEGRDLNQIFASIDETPLASASIAQVHAARLTTGEDVVIKVQKPGVETILYTDLNVVHWAT
KMLEKAIPKVKFASLSEIVEEIKIRMVREVDFIEEAQNLDDFVEYLKITNNQAATAPKVYHQFSTRRILTMERLYGVSLT
DFDIVKKFAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLNPQVWTACLAFMDALQKTD
YTAMAENMLKMGMTKTQIDTQVLAQDLERLFSGVLLADPQEILASKPSDLNDIMLDMVAVGERHGIKFPRDFALLFKQML
YFDRFMRVLAPYTDIYADQRLKMVQTIEPQSLLKH
>Mature_435_residues
MNHMKKNILFDGLRSVARIGETAFVAARAGIKYATEKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGC
LDQTPTLPFSYIQEVLAEEFEGRDLNQIFASIDETPLASASIAQVHAARLTTGEDVVIKVQKPGVETILYTDLNVVHWAT
KMLEKAIPKVKFASLSEIVEEIKIRMVREVDFIEEAQNLDDFVEYLKITNNQAATAPKVYHQFSTRRILTMERLYGVSLT
DFDIVKKFAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLNPQVWTACLAFMDALQKTD
YTAMAENMLKMGMTKTQIDTQVLAQDLERLFSGVLLADPQEILASKPSDLNDIMLDMVAVGERHGIKFPRDFALLFKQML
YFDRFMRVLAPYTDIYADQRLKMVQTIEPQSLLKH

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=312, Percent_Identity=25.9615384615385, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI41393593, Length=256, Percent_Identity=26.5625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI217035081, Length=260, Percent_Identity=25.3846153846154, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI27363457, Length=202, Percent_Identity=29.2079207920792, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI217416386, Length=153, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367309, Length=381, Percent_Identity=24.9343832020997, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17559152, Length=365, Percent_Identity=25.7534246575342, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=200, Percent_Identity=29.5, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=442, Percent_Identity=24.2081447963801, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323282, Length=244, Percent_Identity=27.8688524590164, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=205, Percent_Identity=28.780487804878, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI22024280, Length=339, Percent_Identity=27.7286135693215, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=24.3589743589744, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859849, Length=262, Percent_Identity=25.5725190839695, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49275; Mature: 49275

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHMKKNILFDGLRSVARIGETAFVAARAGIKYATEKPSNAKLMRETFESLGSTYIKLGQ
CCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
FIASTPSLFPREYVEEFQGCLDQTPTLPFSYIQEVLAEEFEGRDLNQIFASIDETPLASA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCH
SIAQVHAARLTTGEDVVIKVQKPGVETILYTDLNVVHWATKMLEKAIPKVKFASLSEIVE
HHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
EIKIRMVREVDFIEEAQNLDDFVEYLKITNNQAATAPKVYHQFSTRRILTMERLYGVSLT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DFDIVKKFAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCC
LNPQVWTACLAFMDALQKTDYTAMAENMLKMGMTKTQIDTQVLAQDLERLFSGVLLADPQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EILASKPSDLNDIMLDMVAVGERHGIKFPRDFALLFKQMLYFDRFMRVLAPYTDIYADQR
HHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKMVQTIEPQSLLKH
HHHHHHCCHHHHHCC
>Mature Secondary Structure
MNHMKKNILFDGLRSVARIGETAFVAARAGIKYATEKPSNAKLMRETFESLGSTYIKLGQ
CCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
FIASTPSLFPREYVEEFQGCLDQTPTLPFSYIQEVLAEEFEGRDLNQIFASIDETPLASA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCH
SIAQVHAARLTTGEDVVIKVQKPGVETILYTDLNVVHWATKMLEKAIPKVKFASLSEIVE
HHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
EIKIRMVREVDFIEEAQNLDDFVEYLKITNNQAATAPKVYHQFSTRRILTMERLYGVSLT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DFDIVKKFAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCC
LNPQVWTACLAFMDALQKTDYTAMAENMLKMGMTKTQIDTQVLAQDLERLFSGVLLADPQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EILASKPSDLNDIMLDMVAVGERHGIKFPRDFALLFKQMLYFDRFMRVLAPYTDIYADQR
HHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKMVQTIEPQSLLKH
HHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]