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The map label for this gene is folB [H]

Identifier: 50085495

GI number: 50085495

Start: 2369037

End: 2369417

Strand: Reverse

Name: folB [H]

Synonym: ACIAD2408

Alternate gene names: 50085495

Gene position: 2369417-2369037 (Counterclockwise)

Preceding gene: 50085496

Following gene: 50085494

Centisome position: 65.84

GC content: 40.42

Gene sequence:

>381_bases
ATGGATGCCATTGTTATTGAAGGTTTAAAAGTCAATACAGTTGTAGGATGTTTTAATTGGGAACGCCAAATTACTCAGCC
GTTATTACTTGATCTAACGATCCATAATGATCTGCAAAAAGCTGCATGTTCAGATGAGCTGGAAGATACGCTAAATTACG
CCCAGATTTGTGAATTGGCGGCGCAGTCCATTCAGACAGTTCAACCCAAACTTATTGAGCACGCTGCGCATTTGGTTCTG
AAAATACTGTTTGAAACTTTTCCCACGATTGAGTCTATTATTATTACCATTCGTAAGCCTGCCATTATTGCAGAAGCTCA
TTCTGTAGGAATTCGACTTGAACGCCAACGCCACAATTTTTGCACTCGCACTTTCGAGTAA

Upstream 100 bases:

>100_bases
TGCACCTTATACCGATATTTATGCAGACCAACGTTTGAAAATGGTTCAAACTATAGAGCCTCAGTCGTTGTTAAAGCATT
AATTGTCGAGTTAGATCATT

Downstream 100 bases:

>100_bases
CTTAAATCAAAAGCAACATTTTGAAATGGCTTATCGACAAATTCAGTCATGGGGAGATGTGCAGTTTTCAAATGTGTATA
AAATTCCATGTCGTGATGGG

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAAQSIQTVQPKLIEHAAHLVL
KILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNFCTRTFE

Sequences:

>Translated_126_residues
MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAAQSIQTVQPKLIEHAAHLVL
KILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNFCTRTFE
>Mature_126_residues
MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELAAQSIQTVQPKLIEHAAHLVL
KILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNFCTRTFE

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=118, Percent_Identity=34.7457627118644, Blast_Score=76, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 14292; Mature: 14292

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA
CCCEEECCEEEEEEEEECCCHHHHCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHCEEEEHHHCCH
CTRTFE
HCCCCC
>Mature Secondary Structure
MDAIVIEGLKVNTVVGCFNWERQITQPLLLDLTIHNDLQKAACSDELEDTLNYAQICELA
CCCEEECCEEEEEEEEECCCHHHHCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSIQTVQPKLIEHAAHLVLKILFETFPTIESIIITIRKPAIIAEAHSVGIRLERQRHNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHCEEEEHHHCCH
CTRTFE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]