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The map label for this gene is ung

Identifier: 50085443

GI number: 50085443

Start: 2313666

End: 2314379

Strand: Reverse

Name: ung

Synonym: ACIAD2352

Alternate gene names: 50085443

Gene position: 2314379-2313666 (Counterclockwise)

Preceding gene: 50085444

Following gene: 50085442

Centisome position: 64.31

GC content: 40.06

Gene sequence:

>714_bases
ATGCAGTTGACTGAGCAACAACACGATAAACTCAGTAAAGTTCAATTGGATGAAAGTTGGAAACATTCTCTTGCGGAGTT
TTTAGTCAGCTCGCGTATGGATGAATTACGTCAGTTTTTAATAGAACAAAAAAATCAAGATAAAGTCATTTATCCACCCA
GTAAGCAAATTTTTAATGCACTTAATACCACGCCACTATCTGCTGTTAAAGTTGTTATCCTGGGGCAAGATCCCTATCAT
GGCCCAAATCAGGCCAATGGCTTGAGTTTTTCTGTGCAAAAGGGAATTGTATTACCACCATCGCTGCGTAATATTTTTCA
TGAGTTAAATACAGATCTTGGAATACCTGTTCCCAAACATGGTGATTTAACCAAATGGGCAGATCAAGGTGTTTTGTTGC
TGAACAGTGTATTGACTGTTGAAGCTGGGCAGCCAACTTCGCATCAAAAGCGTGGTTGGGAGCAGTTTACAGACAGTATC
ATTGATGTATTAAATGAACAGCGTGAGCATGTGGTTTTTATCCTGTGGGGTGCTTATGCACAGCGTAAAGGGCAACGAAT
TGATCGTGAAAAACATCTCGTATTAAAAGCAGCACATCCATCCCCATTAGCCGCAAATCGTGGCGGTTTTTTTGGTTGTA
AAGTTTTTTCCAAAACAAATAATTATCTGAAACAACATGGCATTGAGCCTATAGATTGGCAGCTGGACGCATGA

Upstream 100 bases:

>100_bases
GAGATAAGTTCTCCAATCCGCAAGTGGAATTGCAAGTTCATATTTAATCTATGATTTTAATATATTATTAAGATAGGCCA
AAAGCGTTTAGGATGAAAAA

Downstream 100 bases:

>100_bases
CTAACTCTCCCAATGTAACAAGTTATCATCCTGATCTAATTGTAGAAGAGGCAAAAAACGGCTGGCGTATCATACGTCTT
AACCGCCCGAAGTCTTTGCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNALNTTPLSAVKVVILGQDPYH
GPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKHGDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSI
IDVLNEQREHVVFILWGAYAQRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA

Sequences:

>Translated_237_residues
MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNALNTTPLSAVKVVILGQDPYH
GPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKHGDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSI
IDVLNEQREHVVFILWGAYAQRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA
>Mature_237_residues
MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNALNTTPLSAVKVVILGQDPYH
GPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKHGDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSI
IDVLNEQREHVVFILWGAYAQRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=222, Percent_Identity=53.6036036036036, Blast_Score=237, Evalue=8e-63,
Organism=Homo sapiens, GI6224979, Length=222, Percent_Identity=53.6036036036036, Blast_Score=236, Evalue=1e-62,
Organism=Escherichia coli, GI1788934, Length=216, Percent_Identity=54.6296296296296, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17556304, Length=235, Percent_Identity=45.531914893617, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=40.9282700421941, Blast_Score=166, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_ACIAD (Q6F9Y2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046953.1
- ProteinModelPortal:   Q6F9Y2
- SMR:   Q6F9Y2
- STRING:   Q6F9Y2
- GeneID:   2880808
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2352
- NMPDR:   fig|62977.3.peg.2240
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q6F9Y2
- ProtClustDB:   PRK05254
- BioCyc:   ASP62977:ACIAD2352-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26843; Mature: 26843

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 77-77

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
LNTTPLSAVKVVILGQDPYHGPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKH
HCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHCCCCCCCCCCC
GDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSIIDVLNEQREHVVFILWGAYA
CCCHHHHHCCCEEEHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
QRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA
HHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MQLTEQQHDKLSKVQLDESWKHSLAEFLVSSRMDELRQFLIEQKNQDKVIYPPSKQIFNA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
LNTTPLSAVKVVILGQDPYHGPNQANGLSFSVQKGIVLPPSLRNIFHELNTDLGIPVPKH
HCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHCCCCCCCCCCC
GDLTKWADQGVLLLNSVLTVEAGQPTSHQKRGWEQFTDSIIDVLNEQREHVVFILWGAYA
CCCHHHHHCCCEEEHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
QRKGQRIDREKHLVLKAAHPSPLAANRGGFFGCKVFSKTNNYLKQHGIEPIDWQLDA
HHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA