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The map label for this gene is fsr [H]

Identifier: 50084244

GI number: 50084244

Start: 1032731

End: 1033945

Strand: Direct

Name: fsr [H]

Synonym: ACIAD1042

Alternate gene names: 50084244

Gene position: 1032731-1033945 (Clockwise)

Preceding gene: 50084242

Following gene: 50084245

Centisome position: 28.7

GC content: 42.88

Gene sequence:

>1215_bases
TTGAAAGACAAAATCGGAGATGAGCGAAATTCATCTAGTCAACCGCAGAAAATGATTATCCAGATTGTAGGTGCAGTTGC
GATTGCACATTTGCTTAATGATCTGATACAAGCCGTATTACCTGCGATTTATCCAATGCTCAAAGCAAATTTTGCTTTAA
GCTTTGCCCAGGTTGGACTCATTTCCTTTGTCTATCAAATTACAGGTTCATTGCTACAACCGTGGATCGGACTGTATACA
GATAAATATCCTAAACCTTACCTGCTTCCTATTGGGGCAGCCGTCACGCTATGCGGTGTTCTGTTATTGGCATTTTCACC
AAGCTTTATGGTTCTGCTGCTTGCCTCTGCATTAATTGGCGTGGGTTCTGCAACATTTCATCCTGAAGCTTCACGAGTTG
CCCGTCTCGCTTCAGGTGGACGTTTTGGTACAGCTCAATCGACATTTCAGGTCGGTGGAAATACTGGAACGGCTATTGGA
CCTTTACTGGCGGCTTTAATTATTGTGCCTTTTGGTCAGCACGCTGTGGCTTGGCTGGTGGCATTTAGCTTACTTGCGAT
CTGGATTTTATCTAAAGTAAGTCAATGGTCGATTGAGCATGCCAAAACTCAAATGGCCTCAAAAATCAGTGTTGGAATGC
ACAAGCTGCATGGCCGTGAATTGATCATGGCTATAGGCACAATATGTGTTTTGATGTTTGCCAAATTTACCTATATTGCC
AGTATTAGTAATTACTTTACCTTTTATCTCATTCATAAATTTCATGTCAGTTTGGCCACTGCACAATTACATCTGTTTGC
GTTTTTAGCCGCAGTTGCGGTAGGAACCTTTGCAGGTGGACCAATCGGTGACAAAATCGGACGAAAAGCTGTCATTTGGG
TATCTTTTGTCGGGATGGCACCATTTGCCTTGCTGATGCCTTATGCTGACTTATTCTGGACCACAGTACTTTCGATCATT
GCAGGCTTAGTTTTATCATCTGCATTTGCTGCTATGGTGGTGTATGCACAAGAGGCTGTGCCAGGACGTGTGGGAATGAT
TTCAGGTTTAATGTTTGGCTTAATGTTCGGTGTGAGTGGGATTGCTGCGGCAGGACTGGGTTATTTGGCAGATATTAATG
GAATTGAATGGGTATTCAAGTTGTGTTCATTTTTGCCATTGTTAGGTGTGGCAGCAGTTTTTCTACCTAAAAACAGAGCT
GTATCCAAGCTATAA

Upstream 100 bases:

>100_bases
CACTTTCACAATGATTATTGGAAGATAACTGCATAATAGACATTTTACAATGATGTTTCATTAGAAATATTGGAGTTTGA
GGATGACGTCTTCAATACAG

Downstream 100 bases:

>100_bases
GTCGAATAAATATAAATTGATGCCCATTTTGACTAAATCATATTTGGGCATCAATGAGACAGGACGTGAGCCTGCTTGGT
TCAATTCAAACTTGACCATA

Product: major facilitator superfamily fosmidomycin/multidrug transport protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKDKIGDERNSSSQPQKMIIQIVGAVAIAHLLNDLIQAVLPAIYPMLKANFALSFAQVGLISFVYQITGSLLQPWIGLYT
DKYPKPYLLPIGAAVTLCGVLLLAFSPSFMVLLLASALIGVGSATFHPEASRVARLASGGRFGTAQSTFQVGGNTGTAIG
PLLAALIIVPFGQHAVAWLVAFSLLAIWILSKVSQWSIEHAKTQMASKISVGMHKLHGRELIMAIGTICVLMFAKFTYIA
SISNYFTFYLIHKFHVSLATAQLHLFAFLAAVAVGTFAGGPIGDKIGRKAVIWVSFVGMAPFALLMPYADLFWTTVLSII
AGLVLSSAFAAMVVYAQEAVPGRVGMISGLMFGLMFGVSGIAAAGLGYLADINGIEWVFKLCSFLPLLGVAAVFLPKNRA
VSKL

Sequences:

>Translated_404_residues
MKDKIGDERNSSSQPQKMIIQIVGAVAIAHLLNDLIQAVLPAIYPMLKANFALSFAQVGLISFVYQITGSLLQPWIGLYT
DKYPKPYLLPIGAAVTLCGVLLLAFSPSFMVLLLASALIGVGSATFHPEASRVARLASGGRFGTAQSTFQVGGNTGTAIG
PLLAALIIVPFGQHAVAWLVAFSLLAIWILSKVSQWSIEHAKTQMASKISVGMHKLHGRELIMAIGTICVLMFAKFTYIA
SISNYFTFYLIHKFHVSLATAQLHLFAFLAAVAVGTFAGGPIGDKIGRKAVIWVSFVGMAPFALLMPYADLFWTTVLSII
AGLVLSSAFAAMVVYAQEAVPGRVGMISGLMFGLMFGVSGIAAAGLGYLADINGIEWVFKLCSFLPLLGVAAVFLPKNRA
VSKL
>Mature_404_residues
MKDKIGDERNSSSQPQKMIIQIVGAVAIAHLLNDLIQAVLPAIYPMLKANFALSFAQVGLISFVYQITGSLLQPWIGLYT
DKYPKPYLLPIGAAVTLCGVLLLAFSPSFMVLLLASALIGVGSATFHPEASRVARLASGGRFGTAQSTFQVGGNTGTAIG
PLLAALIIVPFGQHAVAWLVAFSLLAIWILSKVSQWSIEHAKTQMASKISVGMHKLHGRELIMAIGTICVLMFAKFTYIA
SISNYFTFYLIHKFHVSLATAQLHLFAFLAAVAVGTFAGGPIGDKIGRKAVIWVSFVGMAPFALLMPYADLFWTTVLSII
AGLVLSSAFAAMVVYAQEAVPGRVGMISGLMFGLMFGVSGIAAAGLGYLADINGIEWVFKLCSFLPLLGVAAVFLPKNRA
VSKL

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=390, Percent_Identity=53.8461538461538, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43005; Mature: 43005

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKIGDERNSSSQPQKMIIQIVGAVAIAHLLNDLIQAVLPAIYPMLKANFALSFAQVGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISFVYQITGSLLQPWIGLYTDKYPKPYLLPIGAAVTLCGVLLLAFSPSFMVLLLASALIG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VGSATFHPEASRVARLASGGRFGTAQSTFQVGGNTGTAIGPLLAALIIVPFGQHAVAWLV
CCCCCCCCCHHHHHHHHCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCHHHHHHHH
AFSLLAIWILSKVSQWSIEHAKTQMASKISVGMHKLHGRELIMAIGTICVLMFAKFTYIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISNYFTFYLIHKFHVSLATAQLHLFAFLAAVAVGTFAGGPIGDKIGRKAVIWVSFVGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
PFALLMPYADLFWTTVLSIIAGLVLSSAFAAMVVYAQEAVPGRVGMISGLMFGLMFGVSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IAAAGLGYLADINGIEWVFKLCSFLPLLGVAAVFLPKNRAVSKL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MKDKIGDERNSSSQPQKMIIQIVGAVAIAHLLNDLIQAVLPAIYPMLKANFALSFAQVGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISFVYQITGSLLQPWIGLYTDKYPKPYLLPIGAAVTLCGVLLLAFSPSFMVLLLASALIG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VGSATFHPEASRVARLASGGRFGTAQSTFQVGGNTGTAIGPLLAALIIVPFGQHAVAWLV
CCCCCCCCCHHHHHHHHCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCHHHHHHHH
AFSLLAIWILSKVSQWSIEHAKTQMASKISVGMHKLHGRELIMAIGTICVLMFAKFTYIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISNYFTFYLIHKFHVSLATAQLHLFAFLAAVAVGTFAGGPIGDKIGRKAVIWVSFVGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
PFALLMPYADLFWTTVLSIIAGLVLSSAFAAMVVYAQEAVPGRVGMISGLMFGLMFGVSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IAAAGLGYLADINGIEWVFKLCSFLPLLGVAAVFLPKNRAVSKL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]