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The map label for this gene is acoD [H]

Identifier: 50084222

GI number: 50084222

Start: 1011671

End: 1013077

Strand: Direct

Name: acoD [H]

Synonym: ACIAD1020

Alternate gene names: 50084222

Gene position: 1011671-1013077 (Clockwise)

Preceding gene: 50084221

Following gene: 50084223

Centisome position: 28.11

GC content: 45.84

Gene sequence:

>1407_bases
ATGAGCATGTCAGACACACAATTTGACCTTGTGGTGATTGGTGCTGGTCCTGGAGGCTATGTGGCTGCGATTCGAGCAGC
CCAACTGGGTCTAAAAACCGCGATTGTCGAAGCGACTCATCTGGGAGGAATTTGTTTGAATTGGGGGTGTATACCGACCA
AGGCATTACTGGCGGGTGCTGAGCTTGCGCATCAATTTAAACATGCGTCGCAGTTTGGATTTGAGCTAGGAGATATCAAT
TTTGATTTATCTAAACTGGTTCAACATAGTCGTCAGGTTTCAGCGCAATTGGTGCAGGGGATTGAGCACTTACTTCGTAA
AAATCAGGTCAGCGTATTTTATGCAAAAGCCAGATTTATTGCCAAAGAGCGCTTAGAGCTGGTCGATGCGCAACAGCAGA
AACAGATGATTCGTGCCCCGCATATTATTGTGGCAACAGGTGCACATGCGGCTTCACTTCCTCAGATTCCAGTAGATGGT
GATTACGTTTGGTCTTATAAGGAAGCATTGCAACCCAAGCAACTTCCCAAGTCTTTACTGGTCATTGGTTCTGGTGCCAT
AGGCAGTGAATTTGCGAGCCTGTATCAGGATTTGGGAAGTCAGGTCACACTGCTCGATCTTGCCAGGCAGATTTTACCCA
CCGAAGATCATGAAGTTGCACAGTATGTACGAAAGCAGTTTGAACAAAAGGGCATGCGTATTCTGACAGAAAGTACCGTA
CAGCATTTAGAAGTTTGTGAGGGAAAGGTACATTGTGAAATACACGATCCTTCTGGAGTTCAATCCCTAAGCTTTGATCA
TGTGCTCTCAGCCGTGGGGGTTAAACCCAATACACAGAATTTGGGTCTGGAACAATTGGGTGTGGCATTGACAAATGGAT
TCATCCAGACAGATGAATGGTGTCGAACCAATGTCGTCGGCATTTATGCGATTGGCGATGTTGCTGGCGCGCCTTGTCTG
GCACACAAAGCCAGCCATGAAGCCATATTATGTGTAGAGAAAATTGCGGGTATTGCAGATGTACATCCACTCAATCGGCT
ACAAATTCCAGGTTGCATCTTTACCCACCCTCAGGTTGCCAGTATTGGATTGACTGAGCAGCAAGCCAAAGCAGAAGGCA
AACAGATTCATATTGGGAAATTTCCAATGTCTGCCAACGGCAAAGCGATTGCACTTGGGCAAACCGCCGGTTTTGTTAAA
ACCATTGTTGATGTGGAATCTGGTGAGTTATTGGGTGCTCATATGGTCGGTCATGAAGTAACAGAGCAAATACAAGGTTA
TGCAATTGCACAGGCACTTGAAGCAACGGATGAGCATCTGGCACAAGTCATTTTTCCTCATCCAACTTTGTCTGAAGCAA
TGCATGAGTCTATTCTGGCATCTATGCAACGGGCGATTCATATATAA

Upstream 100 bases:

>100_bases
TCTTGTGATCATCGAGTCATTGATGGTGCTTTGGGAGCCAAGTTTTTGGCGAGTTTCAAACAGTTTGTCGAAAACCCAGC
TTTGATTTTGGTGTAGGAGG

Downstream 100 bases:

>100_bases
AAATATGACCTTTACCACTGTGTAAGGTCATACAGTTTAAAGGGTTTCAACAAAGTTTTAAAAGGAAGATAACAATGAAA
GCAGCACGTTTTTATGATCG

Product: dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes)

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSMSDTQFDLVVIGAGPGGYVAAIRAAQLGLKTAIVEATHLGGICLNWGCIPTKALLAGAELAHQFKHASQFGFELGDIN
FDLSKLVQHSRQVSAQLVQGIEHLLRKNQVSVFYAKARFIAKERLELVDAQQQKQMIRAPHIIVATGAHAASLPQIPVDG
DYVWSYKEALQPKQLPKSLLVIGSGAIGSEFASLYQDLGSQVTLLDLARQILPTEDHEVAQYVRKQFEQKGMRILTESTV
QHLEVCEGKVHCEIHDPSGVQSLSFDHVLSAVGVKPNTQNLGLEQLGVALTNGFIQTDEWCRTNVVGIYAIGDVAGAPCL
AHKASHEAILCVEKIAGIADVHPLNRLQIPGCIFTHPQVASIGLTEQQAKAEGKQIHIGKFPMSANGKAIALGQTAGFVK
TIVDVESGELLGAHMVGHEVTEQIQGYAIAQALEATDEHLAQVIFPHPTLSEAMHESILASMQRAIHI

Sequences:

>Translated_468_residues
MSMSDTQFDLVVIGAGPGGYVAAIRAAQLGLKTAIVEATHLGGICLNWGCIPTKALLAGAELAHQFKHASQFGFELGDIN
FDLSKLVQHSRQVSAQLVQGIEHLLRKNQVSVFYAKARFIAKERLELVDAQQQKQMIRAPHIIVATGAHAASLPQIPVDG
DYVWSYKEALQPKQLPKSLLVIGSGAIGSEFASLYQDLGSQVTLLDLARQILPTEDHEVAQYVRKQFEQKGMRILTESTV
QHLEVCEGKVHCEIHDPSGVQSLSFDHVLSAVGVKPNTQNLGLEQLGVALTNGFIQTDEWCRTNVVGIYAIGDVAGAPCL
AHKASHEAILCVEKIAGIADVHPLNRLQIPGCIFTHPQVASIGLTEQQAKAEGKQIHIGKFPMSANGKAIALGQTAGFVK
TIVDVESGELLGAHMVGHEVTEQIQGYAIAQALEATDEHLAQVIFPHPTLSEAMHESILASMQRAIHI
>Mature_467_residues
SMSDTQFDLVVIGAGPGGYVAAIRAAQLGLKTAIVEATHLGGICLNWGCIPTKALLAGAELAHQFKHASQFGFELGDINF
DLSKLVQHSRQVSAQLVQGIEHLLRKNQVSVFYAKARFIAKERLELVDAQQQKQMIRAPHIIVATGAHAASLPQIPVDGD
YVWSYKEALQPKQLPKSLLVIGSGAIGSEFASLYQDLGSQVTLLDLARQILPTEDHEVAQYVRKQFEQKGMRILTESTVQ
HLEVCEGKVHCEIHDPSGVQSLSFDHVLSAVGVKPNTQNLGLEQLGVALTNGFIQTDEWCRTNVVGIYAIGDVAGAPCLA
HKASHEAILCVEKIAGIADVHPLNRLQIPGCIFTHPQVASIGLTEQQAKAEGKQIHIGKFPMSANGKAIALGQTAGFVKT
IVDVESGELLGAHMVGHEVTEQIQGYAIAQALEATDEHLAQVIFPHPTLSEAMHESILASMQRAIHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=37.4458874458874, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=27.4298056155508, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22035672, Length=454, Percent_Identity=28.6343612334802, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=25.4901960784314, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148277065, Length=471, Percent_Identity=23.3545647558386, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33519430, Length=471, Percent_Identity=23.3545647558386, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI33519428, Length=471, Percent_Identity=23.3545647558386, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI33519426, Length=471, Percent_Identity=23.3545647558386, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI148277071, Length=471, Percent_Identity=23.3545647558386, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI291045268, Length=454, Percent_Identity=24.0088105726872, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=35.4625550660793, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082354, Length=468, Percent_Identity=27.1367521367521, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=27.6255707762557, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=28.5087719298246, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788892, Length=185, Percent_Identity=31.3513513513514, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=37.4732334047109, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=27.0833333333333, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=458, Percent_Identity=25.764192139738, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=458, Percent_Identity=25.764192139738, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=25.2066115702479, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=231, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=37.2093023255814, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=27.1186440677966, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=27.906976744186, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21358499, Length=466, Percent_Identity=35.4077253218884, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=25.9656652360515, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=25.9656652360515, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640551, Length=466, Percent_Identity=25.9656652360515, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=24.7357293868922, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50457; Mature: 50325

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSDTQFDLVVIGAGPGGYVAAIRAAQLGLKTAIVEATHLGGICLNWGCIPTKALLAGA
CCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
ELAHQFKHASQFGFELGDINFDLSKLVQHSRQVSAQLVQGIEHLLRKNQVSVFYAKARFI
HHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
AKERLELVDAQQQKQMIRAPHIIVATGAHAASLPQIPVDGDYVWSYKEALQPKQLPKSLL
HHHHHHHHCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECHHHHCCHHHCCCEEE
VIGSGAIGSEFASLYQDLGSQVTLLDLARQILPTEDHEVAQYVRKQFEQKGMRILTESTV
EEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QHLEVCEGKVHCEIHDPSGVQSLSFDHVLSAVGVKPNTQNLGLEQLGVALTNGFIQTDEW
HHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCH
CRTNVVGIYAIGDVAGAPCLAHKASHEAILCVEKIAGIADVHPLNRLQIPGCIFTHPQVA
HHHCCEEEEEECCCCCCCHHHHCCCCCCEEEHHHHCCCCCCCCCCCCCCCCEEECCCCHH
SIGLTEQQAKAEGKQIHIGKFPMSANGKAIALGQTAGFVKTIVDVESGELLGAHMVGHEV
CCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCCCEEHHHHHHHHH
TEQIQGYAIAQALEATDEHLAQVIFPHPTLSEAMHESILASMQRAIHI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMSDTQFDLVVIGAGPGGYVAAIRAAQLGLKTAIVEATHLGGICLNWGCIPTKALLAGA
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
ELAHQFKHASQFGFELGDINFDLSKLVQHSRQVSAQLVQGIEHLLRKNQVSVFYAKARFI
HHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
AKERLELVDAQQQKQMIRAPHIIVATGAHAASLPQIPVDGDYVWSYKEALQPKQLPKSLL
HHHHHHHHCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECHHHHCCHHHCCCEEE
VIGSGAIGSEFASLYQDLGSQVTLLDLARQILPTEDHEVAQYVRKQFEQKGMRILTESTV
EEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QHLEVCEGKVHCEIHDPSGVQSLSFDHVLSAVGVKPNTQNLGLEQLGVALTNGFIQTDEW
HHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCH
CRTNVVGIYAIGDVAGAPCLAHKASHEAILCVEKIAGIADVHPLNRLQIPGCIFTHPQVA
HHHCCEEEEEECCCCCCCHHHHCCCCCCEEEHHHHCCCCCCCCCCCCCCCCEEECCCCHH
SIGLTEQQAKAEGKQIHIGKFPMSANGKAIALGQTAGFVKTIVDVESGELLGAHMVGHEV
CCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCCCEEHHHHHHHHH
TEQIQGYAIAQALEATDEHLAQVIFPHPTLSEAMHESILASMQRAIHI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]