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The map label for this gene is acoC [H]

Identifier: 50084221

GI number: 50084221

Start: 1010125

End: 1011666

Strand: Direct

Name: acoC [H]

Synonym: ACIAD1019

Alternate gene names: 50084221

Gene position: 1010125-1011666 (Clockwise)

Preceding gene: 50084220

Following gene: 50084222

Centisome position: 28.07

GC content: 45.07

Gene sequence:

>1542_bases
ATGAGCGAAATTAAAACACTGGAAATCCCGAAATGGGGATTGTCCATGGAAGAAGGAACAGTCGCACAGTGGCTGATCGA
AGAAGGCACCAGTTTCAAAAAAGGCGATGAAATTTGTGAAATTGAAACCACTAAAATTGTAAACGTCCTCGAAGCGCCTT
TTGATGGTACTTTGCGTCAGATTCTGGCACATGCAGGAGATACGCTGCCTGTAGGTGGCTTGATTGCAATCTGTGCCGAA
GCTGATGTTTCTGATACCGAAATTCAAAATTTTGCTCAGAATTTAAACGGTACTCAGTCGTCTAATACTCCAGCAGACGC
TAAAGTAACAACAGTTCAAACGCCTGAAGTTGATCAATTAGCAGTAGCAAACAGTCAAGCTCAGTCTCAAGCGATTATCG
AAACCAAAGCACAGGTTTCAAAAGACGGTGTTGAGATTCCAGCAGCTTTGCAGGGCTTTAAGGCGTCAGATGCATTTACT
ACGCCGCATGCATTCAAACTTGCAGAGAAACATAATATTGATCTTTCCCAAGTTACTGGTACAGGCCGATTGGGGCGCAT
TAGTGTGCAAGATCTGCAATCTGCGGTACAGGCAGCAGGCGGTCAATGGGCAGAGATTAAACGTCAGGGCAGTAGCAAAG
CAATCAAGTCAACTGCCGATGATCGGCATATAGCTGCAACACCTGTCGCTCGACGTTTAGCCCAAACATGGGGTATTAAC
TTAAATGATTGCCGAGTTTCGGGTACTCGGGGGCGTGTCTGTAAAGAGGATGTTGAAGCGGTCTATTATCGTGAACATCC
TGTATCAGAAACTGCTTCAACCGCGAGTTGTGCTGATACGCCAGTTGAGCTAAATTCTGTCAAGCCTATTGCCATGAATG
CGATGCGTAAGGCCATTGCTTCAAGATTACAATTGGCGAAACGTAATGCACCACATTTTCGTTTGAGCATTGAAGTGAAT
GTTGAAGCTTTGCAAGCTTTACGTCAGCAGATCAACGATACGGTACCCCAGCTCAAGCTATCGATCAACGATATGTTGAT
TAAAGCGGCTGCGGCTGCGCTGATTAAAGTGCCAGAAGTCAATGTGCAATATGACGAACAAAAACAGCAGATTTTACAGT
TTAAAGATGCTGATATCTCGGTTGCAGTTGCCATTGAAAATGGACTAATTACACCGATTGTTAAAGCAGCCAATCAGAAA
TCGCTCGCCACAATTTCGAGTACGATGCGAGATCTGGCAACCCGAGCCAAAACAGGTAAGCTTCAGCCTGATGAGTTCCA
AGGTGGTAGCTTTAGCATTTCCAATTTGGGAATGCTCGGCATCAAAAACTTTGATGCGATTATTAATCCTCCACAAGGCG
CCATCATGGCACTGGGGCGTTCTGAGGCACGTGCTGTAGTTGAGCATGATCTCATTGTAATTCGGCAGATGATGACAGTC
ACACTCTCTTGTGATCATCGAGTCATTGATGGTGCTTTGGGAGCCAAGTTTTTGGCGAGTTTCAAACAGTTTGTCGAAAA
CCCAGCTTTGATTTTGGTGTAG

Upstream 100 bases:

>100_bases
CCACATACGCCTATTCCTTTTTCACCAGTACTTGAAAAAGAATGGATACCAAGTGTCGAGCGGATCGAACAAGCGGTCAG
AAAAATACTGGAGGCTTAGG

Downstream 100 bases:

>100_bases
GAGGATGAGCATGTCAGACACACAATTTGACCTTGTGGTGATTGGTGCTGGTCCTGGAGGCTATGTGGCTGCGATTCGAG
CAGCCCAACTGGGTCTAAAA

Product: dihydrolipoamide acetyltransferase

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSEIKTLEIPKWGLSMEEGTVAQWLIEEGTSFKKGDEICEIETTKIVNVLEAPFDGTLRQILAHAGDTLPVGGLIAICAE
ADVSDTEIQNFAQNLNGTQSSNTPADAKVTTVQTPEVDQLAVANSQAQSQAIIETKAQVSKDGVEIPAALQGFKASDAFT
TPHAFKLAEKHNIDLSQVTGTGRLGRISVQDLQSAVQAAGGQWAEIKRQGSSKAIKSTADDRHIAATPVARRLAQTWGIN
LNDCRVSGTRGRVCKEDVEAVYYREHPVSETASTASCADTPVELNSVKPIAMNAMRKAIASRLQLAKRNAPHFRLSIEVN
VEALQALRQQINDTVPQLKLSINDMLIKAAAAALIKVPEVNVQYDEQKQQILQFKDADISVAVAIENGLITPIVKAANQK
SLATISSTMRDLATRAKTGKLQPDEFQGGSFSISNLGMLGIKNFDAIINPPQGAIMALGRSEARAVVEHDLIVIRQMMTV
TLSCDHRVIDGALGAKFLASFKQFVENPALILV

Sequences:

>Translated_513_residues
MSEIKTLEIPKWGLSMEEGTVAQWLIEEGTSFKKGDEICEIETTKIVNVLEAPFDGTLRQILAHAGDTLPVGGLIAICAE
ADVSDTEIQNFAQNLNGTQSSNTPADAKVTTVQTPEVDQLAVANSQAQSQAIIETKAQVSKDGVEIPAALQGFKASDAFT
TPHAFKLAEKHNIDLSQVTGTGRLGRISVQDLQSAVQAAGGQWAEIKRQGSSKAIKSTADDRHIAATPVARRLAQTWGIN
LNDCRVSGTRGRVCKEDVEAVYYREHPVSETASTASCADTPVELNSVKPIAMNAMRKAIASRLQLAKRNAPHFRLSIEVN
VEALQALRQQINDTVPQLKLSINDMLIKAAAAALIKVPEVNVQYDEQKQQILQFKDADISVAVAIENGLITPIVKAANQK
SLATISSTMRDLATRAKTGKLQPDEFQGGSFSISNLGMLGIKNFDAIINPPQGAIMALGRSEARAVVEHDLIVIRQMMTV
TLSCDHRVIDGALGAKFLASFKQFVENPALILV
>Mature_512_residues
SEIKTLEIPKWGLSMEEGTVAQWLIEEGTSFKKGDEICEIETTKIVNVLEAPFDGTLRQILAHAGDTLPVGGLIAICAEA
DVSDTEIQNFAQNLNGTQSSNTPADAKVTTVQTPEVDQLAVANSQAQSQAIIETKAQVSKDGVEIPAALQGFKASDAFTT
PHAFKLAEKHNIDLSQVTGTGRLGRISVQDLQSAVQAAGGQWAEIKRQGSSKAIKSTADDRHIAATPVARRLAQTWGINL
NDCRVSGTRGRVCKEDVEAVYYREHPVSETASTASCADTPVELNSVKPIAMNAMRKAIASRLQLAKRNAPHFRLSIEVNV
EALQALRQQINDTVPQLKLSINDMLIKAAAAALIKVPEVNVQYDEQKQQILQFKDADISVAVAIENGLITPIVKAANQKS
LATISSTMRDLATRAKTGKLQPDEFQGGSFSISNLGMLGIKNFDAIINPPQGAIMALGRSEARAVVEHDLIVIRQMMTVT
LSCDHRVIDGALGAKFLASFKQFVENPALILV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=296, Percent_Identity=41.8918918918919, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI203098816, Length=513, Percent_Identity=33.9181286549708, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI203098753, Length=513, Percent_Identity=33.9181286549708, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI260898739, Length=162, Percent_Identity=46.9135802469136, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI19923748, Length=225, Percent_Identity=33.7777777777778, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI110671329, Length=316, Percent_Identity=30.379746835443, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1786305, Length=293, Percent_Identity=32.0819112627986, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1786946, Length=293, Percent_Identity=30.3754266211604, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560088, Length=298, Percent_Identity=40.6040268456376, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17538894, Length=317, Percent_Identity=33.7539432176656, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537937, Length=361, Percent_Identity=27.9778393351801, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25146366, Length=224, Percent_Identity=34.375, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324258, Length=312, Percent_Identity=35.8974358974359, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320352, Length=247, Percent_Identity=34.0080971659919, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24582497, Length=292, Percent_Identity=36.986301369863, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129315, Length=292, Percent_Identity=36.986301369863, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI18859875, Length=306, Percent_Identity=34.3137254901961, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645909, Length=227, Percent_Identity=33.920704845815, Blast_Score=116, Evalue=5e-26,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 912 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 55248; Mature: 55116

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIKTLEIPKWGLSMEEGTVAQWLIEEGTSFKKGDEICEIETTKIVNVLEAPFDGTLRQ
CCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCHHHHH
ILAHAGDTLPVGGLIAICAEADVSDTEIQNFAQNLNGTQSSNTPADAKVTTVQTPEVDQL
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHH
AVANSQAQSQAIIETKAQVSKDGVEIPAALQGFKASDAFTTPHAFKLAEKHNIDLSQVTG
HHCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHCCC
TGRLGRISVQDLQSAVQAAGGQWAEIKRQGSSKAIKSTADDRHIAATPVARRLAQTWGIN
CCCCCEEEHHHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCEEEHHHHHHHHHHHHCCC
LNDCRVSGTRGRVCKEDVEAVYYREHPVSETASTASCADTPVELNSVKPIAMNAMRKAIA
CCCEEECCCCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SRLQLAKRNAPHFRLSIEVNVEALQALRQQINDTVPQLKLSINDMLIKAAAAALIKVPEV
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCC
NVQYDEQKQQILQFKDADISVAVAIENGLITPIVKAANQKSLATISSTMRDLATRAKTGK
CCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
LQPDEFQGGSFSISNLGMLGIKNFDAIINPPQGAIMALGRSEARAVVEHDLIVIRQMMTV
CCCCCCCCCCEECCCCCEEEECCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
TLSCDHRVIDGALGAKFLASFKQFVENPALILV
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure 
SEIKTLEIPKWGLSMEEGTVAQWLIEEGTSFKKGDEICEIETTKIVNVLEAPFDGTLRQ
CCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCHHHHH
ILAHAGDTLPVGGLIAICAEADVSDTEIQNFAQNLNGTQSSNTPADAKVTTVQTPEVDQL
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHH
AVANSQAQSQAIIETKAQVSKDGVEIPAALQGFKASDAFTTPHAFKLAEKHNIDLSQVTG
HHCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHCCC
TGRLGRISVQDLQSAVQAAGGQWAEIKRQGSSKAIKSTADDRHIAATPVARRLAQTWGIN
CCCCCEEEHHHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCEEEHHHHHHHHHHHHCCC
LNDCRVSGTRGRVCKEDVEAVYYREHPVSETASTASCADTPVELNSVKPIAMNAMRKAIA
CCCEEECCCCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SRLQLAKRNAPHFRLSIEVNVEALQALRQQINDTVPQLKLSINDMLIKAAAAALIKVPEV
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCC
NVQYDEQKQQILQFKDADISVAVAIENGLITPIVKAANQKSLATISSTMRDLATRAKTGK
CCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
LQPDEFQGGSFSISNLGMLGIKNFDAIINPPQGAIMALGRSEARAVVEHDLIVIRQMMTV
CCCCCCCCCCEECCCCCEEEECCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
TLSCDHRVIDGALGAKFLASFKQFVENPALILV
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]