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The map label for this gene is bdhA [H]

Identifier: 50084223

GI number: 50084223

Start: 1013095

End: 1014210

Strand: Direct

Name: bdhA [H]

Synonym: ACIAD1021

Alternate gene names: 50084223

Gene position: 1013095-1014210 (Clockwise)

Preceding gene: 50084222

Following gene: 50084224

Centisome position: 28.15

GC content: 44.18

Gene sequence:

>1116_bases
CTGTGTAAGGTCATACAGTTTAAAGGGTTTCAACAAAGTTTTAAAAGGAAGATAACAATGAAAGCAGCACGTTTTTATGA
TCGTGGCGACATCCGTATTGAGGATATTCCTGAGCCTGAAGTAACGGCAGGAACAGTGGGCATACAGGTGGCGTGGTGTG
GGATCTGTGGAACAGATTTACACGAGTTTATGGAAGGCCCGATTTTTATTCCACCATGTGGACATCCGCATCCAATTTCG
GGAGAGTCAGCACCTATCACCATGGGCCATGAATTTTCGGGTGTGGTATACGCTGTGGGTGAAGGCGTAGATGATATTCA
GGTAGGCCAGCATGTGGTGGTCGAGCCATATATCGTGGCAGATGATGTTCCAACAGGTCCTGGTGAAAATTATCATCTTT
CTAAGAATATGAACTTTATTGGTCTGGGTGGTCGTGGTGGTGGCTTATCGGAAAAGATTGCAGTCCAGCGCCGTTGGGTA
CATCCAATTTCAGAAAATATTCCACTTGATCAAGCCGCATTAATTGAACCACTCTCTGTCGGACATCATGCCTATGTTCG
AAGTGGTGCGAAAGCAGGTGACGTGGCATTGGTGGGCGGCGCAGGCCCGATTGGTCTACTGCTCTCTGCAATTTTAAAGG
CCAAAGGTTTGACGGTTATCATTACCGAATTAAGCAGCAAGCGAAAAGAAAAAGCCAAAGAATCTGGCGTTGCGGACTAT
ATTCTCGATCCGACTCAAGTCGATGTGATTGCAGAAGTCATGAAAATTACGCAGGACAAAGGTGCAGACATTGCATTTGA
GTGCAGCAGTGTGAATAAAGTATTAGACACACTGGTTGCTTCAACAAAACCAACAGGTGTTATTGTCATTGTATCGATCT
GGAGCCACCCTGCAACCGTAAATGTACATAGTGTGGTGATGAAAGAGCTGGATATTCGCGGAACAATTGCCTATGTCAAT
GATCATCAGGAAACGATTAAACTGGTCGAACAAGGTAAAATTAATCTGGCGCCGTTTATTACGCAGCGCATTAAATTAGA
TGATCTGATTTCTCAAGGATTTGAGACATTGATCCATAACAATGAATCGGCTGTTAAAATTATTGTGCATCCTTAA

Upstream 100 bases:

>100_bases
AAGTCATTTTTCCTCATCCAACTTTGTCTGAAGCAATGCATGAGTCTATTCTGGCATCTATGCAACGGGCGATTCATATA
TAAAAATATGACCTTTACCA

Downstream 100 bases:

>100_bases
GTTGTACAATTGCATAGAAAGAATAGAAGGAAGAACAATATGCCAAAAGGATTAAAAGATAAAATTGCACTGATTACAGG
CGCTGGGCAAGGTATTGGCC

Product: (R,R)-butanediol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MCKVIQFKGFQQSFKRKITMKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPIS
GESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWV
HPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVIITELSSKRKEKAKESGVADY
ILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVN
DHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP

Sequences:

>Translated_371_residues
MCKVIQFKGFQQSFKRKITMKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPIS
GESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWV
HPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVIITELSSKRKEKAKESGVADY
ILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVN
DHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP
>Mature_371_residues
MCKVIQFKGFQQSFKRKITMKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDLHEFMEGPIFIPPCGHPHPIS
GESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVADDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWV
HPISENIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVIITELSSKRKEKAKESGVADY
ILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATVNVHSVVMKELDIRGTIAYVN
DHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHNNESAVKIIVHP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=30.8383233532934, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=27.5964391691395, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=28.2738095238095, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788407, Length=335, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787863, Length=314, Percent_Identity=29.9363057324841, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI226510992, Length=328, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=26.8292682926829, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=25.1612903225806, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=31.2312312312312, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=27.683615819209, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=379, Percent_Identity=34.5646437994723, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319257, Length=380, Percent_Identity=32.6315789473684, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323099, Length=363, Percent_Identity=30.0275482093664, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=30.2521008403361, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6322619, Length=357, Percent_Identity=30.2521008403361, Blast_Score=146, Evalue=6e-36,
Organism=Drosophila melanogaster, GI17737897, Length=348, Percent_Identity=29.0229885057471, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=28.2420749279539, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 40011; Mature: 40011

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKVIQFKGFQQSFKRKITMKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDL
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECEEEEEEEEECCCCHHH
HEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVA
HHHHCCCEEECCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEECCEEEE
DDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSV
CCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
GHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVIITELSSKRKEKAKESGVADY
CCHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCHHE
ILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATV
EECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEE
NVHSVVMKELDIRGTIAYVNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHN
EHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHCC
NESAVKIIVHP
CCCEEEEEEEC
>Mature Secondary Structure
MCKVIQFKGFQQSFKRKITMKAARFYDRGDIRIEDIPEPEVTAGTVGIQVAWCGICGTDL
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECEEEEEEEEECCCCHHH
HEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAVGEGVDDIQVGQHVVVEPYIVA
HHHHCCCEEECCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEECCEEEE
DDVPTGPGENYHLSKNMNFIGLGGRGGGLSEKIAVQRRWVHPISENIPLDQAALIEPLSV
CCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
GHHAYVRSGAKAGDVALVGGAGPIGLLLSAILKAKGLTVIITELSSKRKEKAKESGVADY
CCHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCHHE
ILDPTQVDVIAEVMKITQDKGADIAFECSSVNKVLDTLVASTKPTGVIVIVSIWSHPATV
EECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEE
NVHSVVMKELDIRGTIAYVNDHQETIKLVEQGKINLAPFITQRIKLDDLISQGFETLIHN
EHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHCC
NESAVKIIVHP
CCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]