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The map label for this gene is ubiB [C]

Identifier: 50083680

GI number: 50083680

Start: 423592

End: 424923

Strand: Reverse

Name: ubiB [C]

Synonym: ACIAD0426

Alternate gene names: 50083680

Gene position: 424923-423592 (Counterclockwise)

Preceding gene: 50083683

Following gene: 50083679

Centisome position: 11.81

GC content: 40.92

Gene sequence:

>1332_bases
CTGAAAAATCGCTATGCGAAGGTATCTAATATGGCAAAGAATGCGAGCTCACCGAGTCGACGTTTTATGAAGCTTGCAGG
CATGACGGCAAGTATTGCAACCAAAACGGTCTCCAACTCCATCCGTAATCTGACTGCCGATGATGAGCAAAAACTTGCCT
CAAAAACCAAACTTTTTCAGGATATTGGCATCCAGATTGCGGATACTCTGGGTGAAATGAAAGGCGCGGTCATGAAAGTG
GGGCAAATTGCCTCACAATATAAAGATATCTTCCCACCCGAAGTGGCCAAAGCCATCGCAAAATTACAGCGTCAGGCACC
AGCCGTTCCTTTCAGCGCAATTCAACAGCAAGTGGAAAAAGAGCTCGGTAAACCGCTACTCCAGGCCTTTCAGTCTTTTG
ATCAACAACCTTTTGCCGCAGCATCAATTGGTCAGGTACATCGGGCTGTTTTGCCAGACGGACAAGAAGTTGTGGTCAAA
GTACAATATCCTGGCGTTGATGAAGCCTGTGAAAGTGATCTAAAACAGGTTCGTCTTGCTTTACGCTTGATGGGTGTGAT
CAAGATTGATAAAAAACTTCAGGATCAACTTTTTACAGAAATTCAGGACAGTCTGTCTGACGAGCTAAACTATGAAATTG
AAGCTCAAAATCTTGAAGTCTTTAAAACGTTTCATCAACAACTAGATAATAAAATCATTATTCCGACTGTATACAAGAAC
TATTCTTCACGACGTATTCTGACATTGAGTCTGGAACGTGGCGATTCCATTGAAACTGCAAGTACTTGGCCTCTTGAAAC
TCGAAATCAAATTGGTCGACGTCTCATTCGTGCACTCGGACAAGAAATTTTTTACCTTAAACGTTTCCATTGTGACCCTC
ATCCTGGCAATTTTGCATTTCGTGAGGATGGTACTGTCATCATTTATGATTTTGGTGGTGTTAAAACATTAAGTAGCGAT
ATCGTTAGTCATTTTAAACATTTGGTACAAGCTGCTCGCCAGCAAGATATTACCGCCATTGAAAATCATCTGGATGCCTT
GCATTCGCTCTCGGATAAGGGATTATTCCCAGAAGAGCTTTATTTACAATGGTTAGAAGTGCTATTACGTCCTCTTACTA
CACATTACGATTTTGCTGAAAATTCAGCACATCATGATGGTGTAACACTTGTAAAAAAATCTTTAAAATACTGGGATGTA
TTCAAGCCTTCACCAGATACGCTGATGGTCAATCGAACTATTTCTGGTCATTACTGGAATCTGATTCATTTAAAAGTGCA
TGATGATTTAAGCGATTTGTTTGAAGAGTTGGTACCAACCACCATTAACTAA

Upstream 100 bases:

>100_bases
AGAAAATTGTATTTATTTAAGCTCTTGTTTACATTGTGGTATTAACAGCATCTAAACAATTTCAACTATGCAATCAATTT
AATGTCACCTATGATCAAAA

Downstream 100 bases:

>100_bases
TTGATACAGGTATCTGCATAGAGATCATTGACTATACAAAATGAAATAATATAACATTACATAGTTAGGCAAGAATAAAT
TTGAGGTTAATATGAGACAA

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKNRYAKVSNMAKNASSPSRRFMKLAGMTASIATKTVSNSIRNLTADDEQKLASKTKLFQDIGIQIADTLGEMKGAVMKV
GQIASQYKDIFPPEVAKAIAKLQRQAPAVPFSAIQQQVEKELGKPLLQAFQSFDQQPFAAASIGQVHRAVLPDGQEVVVK
VQYPGVDEACESDLKQVRLALRLMGVIKIDKKLQDQLFTEIQDSLSDELNYEIEAQNLEVFKTFHQQLDNKIIIPTVYKN
YSSRRILTLSLERGDSIETASTWPLETRNQIGRRLIRALGQEIFYLKRFHCDPHPGNFAFREDGTVIIYDFGGVKTLSSD
IVSHFKHLVQAARQQDITAIENHLDALHSLSDKGLFPEELYLQWLEVLLRPLTTHYDFAENSAHHDGVTLVKKSLKYWDV
FKPSPDTLMVNRTISGHYWNLIHLKVHDDLSDLFEELVPTTIN

Sequences:

>Translated_443_residues
MKNRYAKVSNMAKNASSPSRRFMKLAGMTASIATKTVSNSIRNLTADDEQKLASKTKLFQDIGIQIADTLGEMKGAVMKV
GQIASQYKDIFPPEVAKAIAKLQRQAPAVPFSAIQQQVEKELGKPLLQAFQSFDQQPFAAASIGQVHRAVLPDGQEVVVK
VQYPGVDEACESDLKQVRLALRLMGVIKIDKKLQDQLFTEIQDSLSDELNYEIEAQNLEVFKTFHQQLDNKIIIPTVYKN
YSSRRILTLSLERGDSIETASTWPLETRNQIGRRLIRALGQEIFYLKRFHCDPHPGNFAFREDGTVIIYDFGGVKTLSSD
IVSHFKHLVQAARQQDITAIENHLDALHSLSDKGLFPEELYLQWLEVLLRPLTTHYDFAENSAHHDGVTLVKKSLKYWDV
FKPSPDTLMVNRTISGHYWNLIHLKVHDDLSDLFEELVPTTIN
>Mature_443_residues
MKNRYAKVSNMAKNASSPSRRFMKLAGMTASIATKTVSNSIRNLTADDEQKLASKTKLFQDIGIQIADTLGEMKGAVMKV
GQIASQYKDIFPPEVAKAIAKLQRQAPAVPFSAIQQQVEKELGKPLLQAFQSFDQQPFAAASIGQVHRAVLPDGQEVVVK
VQYPGVDEACESDLKQVRLALRLMGVIKIDKKLQDQLFTEIQDSLSDELNYEIEAQNLEVFKTFHQQLDNKIIIPTVYKN
YSSRRILTLSLERGDSIETASTWPLETRNQIGRRLIRALGQEIFYLKRFHCDPHPGNFAFREDGTVIIYDFGGVKTLSSD
IVSHFKHLVQAARQQDITAIENHLDALHSLSDKGLFPEELYLQWLEVLLRPLTTHYDFAENSAHHDGVTLVKKSLKYWDV
FKPSPDTLMVNRTISGHYWNLIHLKVHDDLSDLFEELVPTTIN

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI27363457, Length=460, Percent_Identity=26.0869565217391, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI217416386, Length=378, Percent_Identity=26.984126984127, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI34147522, Length=447, Percent_Identity=23.9373601789709, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI40254938, Length=336, Percent_Identity=27.0833333333333, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI41393593, Length=247, Percent_Identity=31.1740890688259, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=29.7413793103448, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI2367309, Length=273, Percent_Identity=30.4029304029304, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32565180, Length=426, Percent_Identity=25.8215962441315, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17559152, Length=274, Percent_Identity=26.6423357664234, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=330, Percent_Identity=29.0909090909091, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323282, Length=239, Percent_Identity=30.5439330543933, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859849, Length=386, Percent_Identity=24.6113989637306, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24662575, Length=254, Percent_Identity=29.9212598425197, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI22024280, Length=331, Percent_Identity=28.3987915407855, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50133; Mature: 50133

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRYAKVSNMAKNASSPSRRFMKLAGMTASIATKTVSNSIRNLTADDEQKLASKTKLFQ
CCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DIGIQIADTLGEMKGAVMKVGQIASQYKDIFPPEVAKAIAKLQRQAPAVPFSAIQQQVEK
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ELGKPLLQAFQSFDQQPFAAASIGQVHRAVLPDGQEVVVKVQYPGVDEACESDLKQVRLA
HHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LRLMGVIKIDKKLQDQLFTEIQDSLSDELNYEIEAQNLEVFKTFHQQLDNKIIIPTVYKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCEEEEEHHHCC
YSSRRILTLSLERGDSIETASTWPLETRNQIGRRLIRALGQEIFYLKRFHCDPHPGNFAF
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
REDGTVIIYDFGGVKTLSSDIVSHFKHLVQAARQQDITAIENHLDALHSLSDKGLFPEEL
ECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHH
YLQWLEVLLRPLTTHYDFAENSAHHDGVTLVKKSLKYWDVFKPSPDTLMVNRTISGHYWN
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEE
LIHLKVHDDLSDLFEELVPTTIN
EEEEEECCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNRYAKVSNMAKNASSPSRRFMKLAGMTASIATKTVSNSIRNLTADDEQKLASKTKLFQ
CCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DIGIQIADTLGEMKGAVMKVGQIASQYKDIFPPEVAKAIAKLQRQAPAVPFSAIQQQVEK
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ELGKPLLQAFQSFDQQPFAAASIGQVHRAVLPDGQEVVVKVQYPGVDEACESDLKQVRLA
HHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LRLMGVIKIDKKLQDQLFTEIQDSLSDELNYEIEAQNLEVFKTFHQQLDNKIIIPTVYKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCEEEEEHHHCC
YSSRRILTLSLERGDSIETASTWPLETRNQIGRRLIRALGQEIFYLKRFHCDPHPGNFAF
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
REDGTVIIYDFGGVKTLSSDIVSHFKHLVQAARQQDITAIENHLDALHSLSDKGLFPEEL
ECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHH
YLQWLEVLLRPLTTHYDFAENSAHHDGVTLVKKSLKYWDVFKPSPDTLMVNRTISGHYWN
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEE
LIHLKVHDDLSDLFEELVPTTIN
EEEEEECCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]