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The map label for this gene is hom

Identifier: 49481300

GI number: 49481300

Start: 5144883

End: 5146178

Strand: Reverse

Name: hom

Synonym: BT9727_5085

Alternate gene names: 49481300

Gene position: 5146178-5144883 (Counterclockwise)

Preceding gene: 49480444

Following gene: 49481301

Centisome position: 98.25

GC content: 38.12

Gene sequence:

>1296_bases
ATGAAAGAAATTCAAGTTGGTTTATTAGGTCTTGGGACGGTTGGTAGCGGTGTAGTTCGTATCATTACAGATCATCAAGA
GCGACTTATACACCAAGTAGGTTGTCCTGTGAAAGTAACGAAAGTACTAGTGCAAAATATTGAAAAAGAGAGAGAAGTAG
AGGTACCCTCTACTCTATTAACACAAGATGCACATGAAATTTTAGATAATCCAAATATTGACGTTGTCATCGAAGTAATG
GGTGGCATTGATGATGCAAAAGCATATATTCTGCAAGCTTTACAAAGTGGGAAGCACGTTGTGACTGCGAATAAAGATTT
AATGGCGTTGCACGGGGCGGAACTACTAGCGGTAGCAAAAGATAATAAAGCAGATTTATTTTACGAAGCAAGTGTAGCCG
GAGGGATTCCAATTTTACGAAGTATCGTAGAAGGGCTTTCTTCAGATCTTATTACGAAAGTAATGGGAATTGTAAATGGA
ACGACTAATTTTATTTTGACGAAAATGTCAGATGAAGGGAGAGCATATAACGACGTGTTAAAAGAAGCCCAGCAACTTGG
ATTTGCAGAAGCGGATCCAACATCAGATGTAGAAGGTTTAGATGCAGCAAGAAAAATGACAATATTGGCTACCCTTGGTT
TCTCTACAAATGTAGAGCTTGGAGATGTCAAGGTAAAAGGGATTACTTCTATTACAGAGGAAGATATCGAATACAGTAAG
AGTTTAGGGTACACGATTAAACTAATCGGTCTTGCGAAGCGAGATGGTGAAAAATTAGAGGTTACAGTTGAACCGACTTT
ACTTCCAAATACACATCCTCTTGCGGCCGTGCAAAACGAATATAACGCTGTATATGTGTATGGTGAAGCAGTTGGAGAAA
CGATGTTTTATGGACCAGGTGCAGGAAGCTTACCGACAGCAACAGCTGTTGTTTCCGATTTAGTAGCTGTAATGCAAAAT
ATTAGATTAGGGGTAACAGGAAATAGTGCTGTAGTCCCGCAATACCAAAAAGTATTAAAAGAGCCAGATGAAATTGTTGT
AAAGAAATTTTTAAGACTTCATGTAAAAGATGAAATTGGTGTATTTGCAAAAATTACTTCGTTATTCTCTGAGCGTGGTG
TTAGCTTTGAAAAGATTATTCAAATGCCGCTTGAAGAGAAAGGAAAGGCTGAAATTGTTATTGTAACGCACCGTGCTTCT
CTTGCTGATTATGATTATATTCTACATACGTTGCAAGGGTATGAAGAAATAGATTGTTTGAAAGCAAACTATCGAATTGA
AGGGGATGCAAAGTAG

Upstream 100 bases:

>100_bases
GTTAATCTATATTATTCCGAATGTTCGAAAAACATTGTTTTTCAGATTTTTTACTCATATAATTTCATCTAAACACAATT
TTTGAGGGGTGGACAGTATT

Downstream 100 bases:

>100_bases
TATCTCCACTAATAAAGAACCTATTAAGCGGCTTGCTTAATAGGTTCTTTTCTATTTAAACTGTGCGTGCCAACTTGAAT
AAATGCTTGAATAATCCAGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRAS
LADYDYILHTLQGYEEIDCLKANYRIEGDAK

Sequences:

>Translated_431_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRAS
LADYDYILHTLQGYEEIDCLKANYRIEGDAK
>Mature_431_residues
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLLTQDAHEILDNPNIDVVIEVM
GGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAKDNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYNDVLKEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVVPQYQKVLKEPDEIVVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRAS
LADYDYILHTLQGYEEIDCLKANYRIEGDAK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=265, Percent_Identity=25.6603773584906, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790376, Length=376, Percent_Identity=24.7340425531915, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=32.5581395348837, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46775; Mature: 46775

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLL
CCCEEEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
TQDAHEILDNPNIDVVIEVMGGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAK
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
DNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYNDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
KEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
HHHHHCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHH
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEECCCCCEEEEEECCEECCCCCCCHHCCCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVVPQYQKVLKEPDEIVVKKFLRLHVKDEIG
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGYEEIDCL
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHE
KANYRIEGDAK
ECCEEECCCCC
>Mature Secondary Structure
MKEIQVGLLGLGTVGSGVVRIITDHQERLIHQVGCPVKVTKVLVQNIEKEREVEVPSTLL
CCCEEEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
TQDAHEILDNPNIDVVIEVMGGIDDAKAYILQALQSGKHVVTANKDLMALHGAELLAVAK
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
DNKADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYNDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
KEAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIEYSK
HHHHHCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCEECCEEEECCCHHHHHHHHHHH
SLGYTIKLIGLAKRDGEKLEVTVEPTLLPNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEECCCCCEEEEEECCEECCCCCCCHHCCCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVVPQYQKVLKEPDEIVVKKFLRLHVKDEIG
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VFAKITSLFSERGVSFEKIIQMPLEEKGKAEIVIVTHRASLADYDYILHTLQGYEEIDCL
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHE
KANYRIEGDAK
ECCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]