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The map label for this gene is murC

Identifier: 49475854

GI number: 49475854

Start: 1238208

End: 1239635

Strand: Reverse

Name: murC

Synonym: BH11230

Alternate gene names: 49475854

Gene position: 1239635-1238208 (Counterclockwise)

Preceding gene: 49475855

Following gene: 49475853

Centisome position: 64.19

GC content: 39.99

Gene sequence:

>1428_bases
ATGAAAATGCCGCTTAATATAGGCCTTATCCATTTTGTCGGAATCGGTGGAATTGGTATGAGTGGAATTGCTGAAGTTTT
TCATAATCTTGGTTATAAAGTTCAAGGATCTGATCAAATTGATAACGCTAATGTTAAACGTTTACAGGATAAAGGAATTC
AAGTTCATGTAGGGCATCATGCTGAAAATTTAGGAGATGCAGAATTTGTTGTCCTTTCTACTGCTATTAAAAAAACAAAT
CCTGAATATATTGCTGCAAAAGAGAGGCATTTACCACTTGTAAAGCGTGCCGAAATGTTGGCAGAGCTGATGCGTTTTCG
TCGGGCAATTGCTGTGGGTGGTACTCATGGGAAAACAACAACGACATCAATGATTGCAGCGCTTCTTGATGCCGGGAGTT
TTGATCCGATGGTAATTAATGGTGGTATTATCAATGCTTATGGTACGAATGCTCGTATGGGGGAGGGTGATTGGATGGTG
GTTGAGGCTGATGAAAGTGATGGTACTTTTTTAAAATTACCTGCTGATATTGCTGTTGTGACCAATATCGATCGTGAGCA
TTTAGACCATTATGGGAGTTTTGCTGCTGTGCGTGATGCTTTTCGCCAATTTGTAGAGAATGTTCCTTTTTATGGTTTTG
CTGTTTTGTGTATTGATCATCCAGAGGTTCAGTCATTGGCTAGTCGTATTGATGATCGTTGGGTGATTACTTATGGTGCA
AATCCACAAGCGGATATTCGTTTTCTTAATCTTTCTATGGATGGTCAAAAAACGTATTTTGATGTCTTTATGCGCTCGCG
GAAAACGGGTAGAGAGACTGAATTGAAAAATTTGGTTTTGCCAATGTCTGGGCAGCACAATGTTTCTAATGCAACTGCGG
CGATTGCCATTGCTCATGAACTTGGCATTTCAAATGAATCTATCAAAAAGGGCTTAGCAGGATTTGGTGGAGTAAAACGG
CGTTTTACGCAAATAGGAAGTTGGCGAGGCGTTGAAATATTCGATGATTATGGACATCATCCTGTCGAAATAAAAGCTGT
TTTATGTGCAGCGCGTGAGAGTGCAAAAGGGCGCGTGATAGCTATTGCACAACCCCATCGTTATTCACGTTTGTATCATT
TATTTGATGATTTTGCGGCTTGTTTTAATGATGCAGATATAGTGTTGATTGCTCCGGTTTATGCAGCCGGTGAAGAGCCA
ATTACTGGTTTTGGTGCTAGGGAATTGGTAGAACATATTCAAATGGCTGGTCATCGTGATGTGCGTTTGATTGATTGTTT
GGAAGATGTTGTTTCGATTGTCTCTACTTTTTCTAAATCTGGTGATTATGTTGTTTTTCTTGGTGCTGGCAATATCACAC
AATGGGCTTGTGCTTTGCCTAACCAATTGGCGGTATTTGATAACAATGATAAATTTTCAGCTGATTGA

Upstream 100 bases:

>100_bases
AAAAAAGTGGGGCAACCTTATGCAACTCGTCGTCTTGCTGATATGGCTGAAGCGTTGATTGTGGGGCGGTCGCTGTCAGA
TGTAAAGGAGGAGTTTTTTG

Downstream 100 bases:

>100_bases
TGGTGAGGCGCTGTTAGCGCGTTTACAACCGACGTTAGGTGGTATAAAGGGAAAACTTACGCCTAATATGGATATGCAGA
AGGTGACGTGGTTTCGCACT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKMPLNIGLIHFVGIGGIGMSGIAEVFHNLGYKVQGSDQIDNANVKRLQDKGIQVHVGHHAENLGDAEFVVLSTAIKKTN
PEYIAAKERHLPLVKRAEMLAELMRFRRAIAVGGTHGKTTTTSMIAALLDAGSFDPMVINGGIINAYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVVTNIDREHLDHYGSFAAVRDAFRQFVENVPFYGFAVLCIDHPEVQSLASRIDDRWVITYGA
NPQADIRFLNLSMDGQKTYFDVFMRSRKTGRETELKNLVLPMSGQHNVSNATAAIAIAHELGISNESIKKGLAGFGGVKR
RFTQIGSWRGVEIFDDYGHHPVEIKAVLCAARESAKGRVIAIAQPHRYSRLYHLFDDFAACFNDADIVLIAPVYAAGEEP
ITGFGARELVEHIQMAGHRDVRLIDCLEDVVSIVSTFSKSGDYVVFLGAGNITQWACALPNQLAVFDNNDKFSAD

Sequences:

>Translated_475_residues
MKMPLNIGLIHFVGIGGIGMSGIAEVFHNLGYKVQGSDQIDNANVKRLQDKGIQVHVGHHAENLGDAEFVVLSTAIKKTN
PEYIAAKERHLPLVKRAEMLAELMRFRRAIAVGGTHGKTTTTSMIAALLDAGSFDPMVINGGIINAYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVVTNIDREHLDHYGSFAAVRDAFRQFVENVPFYGFAVLCIDHPEVQSLASRIDDRWVITYGA
NPQADIRFLNLSMDGQKTYFDVFMRSRKTGRETELKNLVLPMSGQHNVSNATAAIAIAHELGISNESIKKGLAGFGGVKR
RFTQIGSWRGVEIFDDYGHHPVEIKAVLCAARESAKGRVIAIAQPHRYSRLYHLFDDFAACFNDADIVLIAPVYAAGEEP
ITGFGARELVEHIQMAGHRDVRLIDCLEDVVSIVSTFSKSGDYVVFLGAGNITQWACALPNQLAVFDNNDKFSAD
>Mature_475_residues
MKMPLNIGLIHFVGIGGIGMSGIAEVFHNLGYKVQGSDQIDNANVKRLQDKGIQVHVGHHAENLGDAEFVVLSTAIKKTN
PEYIAAKERHLPLVKRAEMLAELMRFRRAIAVGGTHGKTTTTSMIAALLDAGSFDPMVINGGIINAYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVVTNIDREHLDHYGSFAAVRDAFRQFVENVPFYGFAVLCIDHPEVQSLASRIDDRWVITYGA
NPQADIRFLNLSMDGQKTYFDVFMRSRKTGRETELKNLVLPMSGQHNVSNATAAIAIAHELGISNESIKKGLAGFGGVKR
RFTQIGSWRGVEIFDDYGHHPVEIKAVLCAARESAKGRVIAIAQPHRYSRLYHLFDDFAACFNDADIVLIAPVYAAGEEP
ITGFGARELVEHIQMAGHRDVRLIDCLEDVVSIVSTFSKSGDYVVFLGAGNITQWACALPNQLAVFDNNDKFSAD

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=40.997830802603, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI1790680, Length=464, Percent_Identity=28.2327586206897, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BARHE (Q6G2Q6)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033895.1
- ProteinModelPortal:   Q6G2Q6
- SMR:   Q6G2Q6
- GeneID:   2865363
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH11230
- NMPDR:   fig|283166.1.peg.1023
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- PhylomeDB:   Q6G2Q6
- ProtClustDB:   PRK00421
- BioCyc:   BHEN283166:BH11230-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52079; Mature: 52079

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPLNIGLIHFVGIGGIGMSGIAEVFHNLGYKVQGSDQIDNANVKRLQDKGIQVHVGHH
CCCCCEECEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCEEEECCC
AENLGDAEFVVLSTAIKKTNPEYIAAKERHLPLVKRAEMLAELMRFRRAIAVGGTHGKTT
CCCCCCCEEEEEEHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHH
TTSMIAALLDAGSFDPMVINGGIINAYGTNARMGEGDWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHCCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDREHLDHYGSFAAVRDAFRQFVENVPFYGFAVLCIDHPEVQSLASRIDDRWVITYGA
ECCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECC
NPQADIRFLNLSMDGQKTYFDVFMRSRKTGRETELKNLVLPMSGQHNVSNATAAIAIAHE
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCHHEEEEEHHH
LGISNESIKKGLAGFGGVKRRFTQIGSWRGVEIFDDYGHHPVEIKAVLCAARESAKGRVI
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCEEEHEEEEHHHHCCCCCEE
AIAQPHRYSRLYHLFDDFAACFNDADIVLIAPVYAAGEEPITGFGARELVEHIQMAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCC
VRLIDCLEDVVSIVSTFSKSGDYVVFLGAGNITQWACALPNQLAVFDNNDKFSAD
CHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKMPLNIGLIHFVGIGGIGMSGIAEVFHNLGYKVQGSDQIDNANVKRLQDKGIQVHVGHH
CCCCCEECEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCEEEECCC
AENLGDAEFVVLSTAIKKTNPEYIAAKERHLPLVKRAEMLAELMRFRRAIAVGGTHGKTT
CCCCCCCEEEEEEHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCHH
TTSMIAALLDAGSFDPMVINGGIINAYGTNARMGEGDWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHCCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDREHLDHYGSFAAVRDAFRQFVENVPFYGFAVLCIDHPEVQSLASRIDDRWVITYGA
ECCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECC
NPQADIRFLNLSMDGQKTYFDVFMRSRKTGRETELKNLVLPMSGQHNVSNATAAIAIAHE
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCHHEEEEEHHH
LGISNESIKKGLAGFGGVKRRFTQIGSWRGVEIFDDYGHHPVEIKAVLCAARESAKGRVI
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCEEEHEEEEHHHHCCCCCEE
AIAQPHRYSRLYHLFDDFAACFNDADIVLIAPVYAAGEEPITGFGARELVEHIQMAGHRD
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCC
VRLIDCLEDVVSIVSTFSKSGDYVVFLGAGNITQWACALPNQLAVFDNNDKFSAD
CHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA