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The map label for this gene is parC [H]

Identifier: 49475728

GI number: 49475728

Start: 1071815

End: 1074064

Strand: Reverse

Name: parC [H]

Synonym: BH09780

Alternate gene names: 49475728

Gene position: 1074064-1071815 (Counterclockwise)

Preceding gene: 49475729

Following gene: 49475717

Centisome position: 55.62

GC content: 38.93

Gene sequence:

>2250_bases
ATGTCTGATAAAATGAATTTACCTTTTGATAAAGAACATATTGAGTCAATAGAATTACGTTCTGCTTTACAAGAGCGTTA
TTTGGCTTATGCGCTTTCTACTATTACGCACCGTGCGTTGCCTGATGTGCGTGATGGTTTGAAACCTGTGCATAGGCGTA
TTGTTCACGCTATGCGTTTACTCAAACTTAATCCAGGACATTCTTATGCGAAATGCGCAAGGATTGTTGGGGATGTCATG
GGAAAATTTCATCCACATGGTGATGCATCTATTTATGATGCATTAGTGCGCTTGGCTCAGAATTTTGCTGTCCGTTATCC
ATTGGTTGATGGACAAGGCAATTTTGGGAATATTGATGGTGATAATGCTGCTGCTATGCGTTATACGGAAGCACGCATGA
CTGAAGTAGCTGCATTGCTGCTTGAAGGAATTAATGAAAACGCTATTGATTTTCGTTTAACCTATAATGAGGAAGATGAA
GAACCGATCGTTTTACCTGGAGCTTTTCCTAATCTTTTAGCAAATGGTTCATCAGGTATTGCTGTTGGTATGGCAACATC
TATTCCACCCCATAATGTTTCTGAACTTTGTGATGCGGCGCTTCATTTGATTGCGCATCCCAATGCCCGTGATGAGGAAT
TAAATCACTTTGTGCTTGGACCTGATTTTCCAACAGGTGGCATTTTAGTTGAACCTAAAAAGAGTATTGAGGAATCTTAT
CGTGTTGGGCGTGGTTTTTTTCGGTTGCGTTCGCGTTGGCATCAGGAAACCGGTAACCGTGGTTCTTATGTGCTTGTTGT
GACTGAAATTCCCTATCAAGTTCAAAAGTCACGACTTATTGAAAAAACAGCAGAATTATTGCTTGCACGGCGGTTACCAA
TGCTTGAAGATATTCGTGATGAGTCAGCAGAAGATATTCGCATTGTACTTATTCCTAAAAATCGTACCGTCGATCCTGAG
ATTCTTATGGAGTCTCTTTTTAAATTGACTGATTTTGAAATAAGATTTCCTCTCAATCTTAATGTTTTGTCTTTTGGAAA
AGTACCGAATGTTCTTTCTTTGCGGGAAAGTTTAAAACAATGGCTTGAACATCGTCAAGAGGTGCTTATTCGCCGTTCTC
GTTATCAGCTTGACGAAATTGAACGACGGTTGGAAATCCTCCATGGATATCTTATCACATATTTGAATCTTGATGAGGTG
ATCCAGATTATTCGGGAAGAGGATGAACCAAAAAAAAAGCTTATCGATCGTTTTGAATTAACAGAAAATCAAGCTGAAGC
TATTCTTAATATGCGCTTGCGTTCTTTACGTAAACTTGAGGAATTTGAAATTCGTAAAGAATTTGAAACCTTGAGGGCTG
AAAAAGAAAAACTGCAAAATTTGTTAGATTCTCGGACAAAGCAATGGAAAATAATTTCAGAGGAAATCATAAAAGTTCGT
AAAGTTTTTGGTCCTCATACTCTCTTAGGGAAAAGGCGTACAACATTTGAAGAAGCACCAAGACATGATTTTGATGATAT
TTATCAGGCAATGATTGAAAAAGAACCAGTTACTATTGTTATTTCTGAAAAGGGTTGGATGCGTGCTTTGAAGGGGCATT
TGAGTGATTACAATGCACTTTCTTTCAAAGAAGGGGATTGTTTGAAATTAGCATTTCCAGCGTTTACTACAGATAAAATT
GTGGTGATAAGTACTGGCGGAAAGTTTTTTGCTATTGCTGCAAATAGTTTGCCGGGAGGACGGGGGCATGGGGAACCCAT
TCGTATTTTAGTTGATATGGATGACGAGCATGATCTCCTGACAGCTTTTGTGCATCATACACAGGAAAAACTTCTCTTAG
TTTCATCTCATGGAAATGGTTTTATTGTACCTGCAACTGAAGTGATTGCTAATACACGAAAAGGCAAGCAAGTTATGAAT
GTGAAATTTCCTGATAAGGTAAAACTTTGTGTTCCAGTAAAAGGTGATCATGTTGCAGTGGTTGGTGAAAACCGTAAAAT
GCTCATTTTTGCCATTGAACAAATACCAGAAATGAGTCGTGGTAAAGGTGTTCGTTTACAACGTTACAAACAAGGGGGAG
TTGTTGATGTCAAAACTTTTAATTTATCAGAAGGTTTAAGTTGGCAAGATACAGCTGAACGTTGCTTTAACCGCCAAGCG
AGTGATCTCATTGAGTGGATGGGAGTACGTTCTGGGGTAGGGCGTGTGGTTCCGAAAGGCTTTCCAAAATCAGGGAAATT
TACCAATTAA

Upstream 100 bases:

>100_bases
AGTCAGTTTTTAATAAAAATAGTTGATTTACAAAAGGTCGCACTGAAAAAAATCTTATAAAATAATTGCTCATTATTTTG
GGAATTGTTGTCCTAATACT

Downstream 100 bases:

>100_bases
ACTGTGTTCCATATTTAATTCTTAAGTTTTGTGTTTTAAGTCAAGATTTGAAAAAAGGTGGAGTGCTGGTAATATTCCAT
TTGTAAAGAACAGGAATTTT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVM
GKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDE
EPIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY
RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPE
ILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEV
IQIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR
KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKI
VVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMN
VKFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA
SDLIEWMGVRSGVGRVVPKGFPKSGKFTN

Sequences:

>Translated_749_residues
MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVM
GKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDE
EPIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY
RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPE
ILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEV
IQIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR
KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKI
VVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMN
VKFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA
SDLIEWMGVRSGVGRVVPKGFPKSGKFTN
>Mature_748_residues
SDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVMG
KFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEE
PIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESYR
VGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPEI
LMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVI
QIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVRK
VFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKIV
VISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNV
KFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQAS
DLIEWMGVRSGVGRVVPKGFPKSGKFTN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1789396, Length=680, Percent_Identity=38.9705882352941, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1788562, Length=661, Percent_Identity=35.8547655068079, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324241, Length=371, Percent_Identity=27.7628032345013, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136538, Length=227, Percent_Identity=28.6343612334802, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85236; Mature: 85105

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKLNPGHSYAKCARIVGDVMGKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCC
DNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEEPIVLPGAFPNLLANGSSGI
CCCHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCHHHHCCCCCCE
AVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY
EEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHH
RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRD
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
ESAEDIRIVLIPKNRTVDPEILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQ
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECEECCEEECCCCCCHHHHHHHHHH
WLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVIQIIREEDEPKKKLIDRFEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHC
TENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNAL
HHCCCHHHHCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC
SFKEGDCLKLAFPAFTTDKIVVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLL
CCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHH
TAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNVKFPDKVKLCVPVKGDHVAV
HHHHHHCCCEEEEEEECCCEEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCEEEE
VGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA
EECCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCH
SDLIEWMGVRSGVGRVVPKGFPKSGKFTN
HHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKLNPGHSYAKCARIVGDVMGKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCC
DNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEEPIVLPGAFPNLLANGSSGI
CCCHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCHHHHCCCCCCE
AVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY
EEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHH
RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRD
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
ESAEDIRIVLIPKNRTVDPEILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQ
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECEECCEEECCCCCCHHHHHHHHHH
WLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVIQIIREEDEPKKKLIDRFEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHC
TENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNAL
HHCCCHHHHCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC
SFKEGDCLKLAFPAFTTDKIVVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLL
CCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHH
TAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNVKFPDKVKLCVPVKGDHVAV
HHHHHHCCCEEEEEEECCCEEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCEEEE
VGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA
EECCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCH
SDLIEWMGVRSGVGRVVPKGFPKSGKFTN
HHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]