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The map label for this gene is map [H]

Identifier: 49475600

GI number: 49475600

Start: 940518

End: 941348

Strand: Reverse

Name: map [H]

Synonym: BH08350

Alternate gene names: 49475600

Gene position: 941348-940518 (Counterclockwise)

Preceding gene: 49475601

Following gene: 49475599

Centisome position: 48.75

GC content: 39.47

Gene sequence:

>831_bases
ATGACTGATTATATTGAATATTATAAAATACCCTTGAAATTTAACGGACAAATCCGCATTTTTGATGATTACGCTTTTGA
TAAAATGCGGAAAGTTGGTCGTATTGCTGCGGAATGTCTCGATGCACTTACGGATATTATTAAACCTGGTATTACTACGC
AAGAAATTGATGATTTTGTGTTTACTTTTGGTGCTGAGCGAGGAGCACTCCCTGCTGATCTGAATTATCATGGATATGGG
CACTCATGCTGTACATCCATCAATCACGTTGTTTGTCATGGTATCCCCAATAAGAGACCCTTGCAAGAAGGCGATATTGT
CAATGTTGATGTAACCTTTATTCTGGATGGCTGGCATGGTGATTCAAGCCGCATGTATCCTGTTGGAAAAATCAGACGTG
CTGCAGAACGCTTGCTAAAGATAACCTATGAAAGCCTTATGAGAGGAATTGCCGCAGTCAAACCCGGAGCAACCACAGGT
GATATTGGTGCAGCAATTCAGCGCTATGCGGAATCTGAACGGTGCTCAATTGTGAGAGACTTTTGTGGACATGGAATCGG
TCAGCTTTTTCATGATGCTCCGAATATTCTGCATTATGGAAACCCTGGAGAAGGAATAGAACTCAAACAAGGTATGATGT
TTACAATTGAACCGATGATTAATCTTGGTAAACCACAAGTTAAGATTTTATCTGATGGCTGGACTGCCGTTACACGTGAT
AGATCTCTTACTGCACAGTATGAACATACAATTGGTGTAACAAACGAAGGTTGCGAAATATTTACGCAATCTCCTAAAAA
TATTTTTTATATTTCAAATTCATATGTCTAA

Upstream 100 bases:

>100_bases
ATTTAGCATTAGAATCAGGGGTAGAATTTTATGCTATAAAATGTCAAGTAAGTGTAGAAGGTATTTTCCCAATTCAGCAA
GTGAAAATAGAAAACAGAAA

Downstream 100 bases:

>100_bases
ATAAATGTAGAAATGTCATGGCTAAAAAGTTAAGTAAAAAGGGAGATATTCAAAGAGATCATTTTGCATTAATCTCAAGT
TTCCCACTTAATCAAACACC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTDYIEYYKIPLKFNGQIRIFDDYAFDKMRKVGRIAAECLDALTDIIKPGITTQEIDDFVFTFGAERGALPADLNYHGYG
HSCCTSINHVVCHGIPNKRPLQEGDIVNVDVTFILDGWHGDSSRMYPVGKIRRAAERLLKITYESLMRGIAAVKPGATTG
DIGAAIQRYAESERCSIVRDFCGHGIGQLFHDAPNILHYGNPGEGIELKQGMMFTIEPMINLGKPQVKILSDGWTAVTRD
RSLTAQYEHTIGVTNEGCEIFTQSPKNIFYISNSYV

Sequences:

>Translated_276_residues
MTDYIEYYKIPLKFNGQIRIFDDYAFDKMRKVGRIAAECLDALTDIIKPGITTQEIDDFVFTFGAERGALPADLNYHGYG
HSCCTSINHVVCHGIPNKRPLQEGDIVNVDVTFILDGWHGDSSRMYPVGKIRRAAERLLKITYESLMRGIAAVKPGATTG
DIGAAIQRYAESERCSIVRDFCGHGIGQLFHDAPNILHYGNPGEGIELKQGMMFTIEPMINLGKPQVKILSDGWTAVTRD
RSLTAQYEHTIGVTNEGCEIFTQSPKNIFYISNSYV
>Mature_275_residues
TDYIEYYKIPLKFNGQIRIFDDYAFDKMRKVGRIAAECLDALTDIIKPGITTQEIDDFVFTFGAERGALPADLNYHGYGH
SCCTSINHVVCHGIPNKRPLQEGDIVNVDVTFILDGWHGDSSRMYPVGKIRRAAERLLKITYESLMRGIAAVKPGATTGD
IGAAIQRYAESERCSIVRDFCGHGIGQLFHDAPNILHYGNPGEGIELKQGMMFTIEPMINLGKPQVKILSDGWTAVTRDR
SLTAQYEHTIGVTNEGCEIFTQSPKNIFYISNSYV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=253, Percent_Identity=49.4071146245059, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI40385867, Length=263, Percent_Identity=36.1216730038023, Blast_Score=188, Evalue=5e-48,
Organism=Escherichia coli, GI1786364, Length=242, Percent_Identity=52.4793388429752, Blast_Score=257, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=43.0278884462151, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=42.741935483871, Blast_Score=213, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21355531, Length=252, Percent_Identity=43.6507936507937, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24583427, Length=248, Percent_Identity=41.5322580645161, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30808; Mature: 30676

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYIEYYKIPLKFNGQIRIFDDYAFDKMRKVGRIAAECLDALTDIIKPGITTQEIDDFV
CCCCEEEEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FTFGAERGALPADLNYHGYGHSCCTSINHVVCHGIPNKRPLQEGDIVNVDVTFILDGWHG
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
DSSRMYPVGKIRRAAERLLKITYESLMRGIAAVKPGATTGDIGAAIQRYAESERCSIVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHH
FCGHGIGQLFHDAPNILHYGNPGEGIELKQGMMFTIEPMINLGKPQVKILSDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEEEHHHCCCCCCEEEEECCCEEEECC
RSLTAQYEHTIGVTNEGCEIFTQSPKNIFYISNSYV
CCCEEEEHHEECCCCCCCEEEECCCCEEEEEECCCC
>Mature Secondary Structure 
TDYIEYYKIPLKFNGQIRIFDDYAFDKMRKVGRIAAECLDALTDIIKPGITTQEIDDFV
CCCEEEEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FTFGAERGALPADLNYHGYGHSCCTSINHVVCHGIPNKRPLQEGDIVNVDVTFILDGWHG
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
DSSRMYPVGKIRRAAERLLKITYESLMRGIAAVKPGATTGDIGAAIQRYAESERCSIVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHH
FCGHGIGQLFHDAPNILHYGNPGEGIELKQGMMFTIEPMINLGKPQVKILSDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEEEHHHCCCCCCEEEEECCCEEEECC
RSLTAQYEHTIGVTNEGCEIFTQSPKNIFYISNSYV
CCCEEEEHHEECCCCCCCEEEECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]