BacMap

Definition	Bartonella henselae str. Houston-1, complete genome.
Accession	NC_005956
Length	1,931,047

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The map label for this gene is hmuV

Identifier: 49475288

GI number: 49475288

Start: 576455

End: 577255

Strand: Reverse

Name: hmuV

Synonym: BH04930

Alternate gene names: 49475288

Gene position: 577255-576455 (Counterclockwise)

Preceding gene: 49475289

Following gene: 49475286

Centisome position: 29.89

GC content: 39.95

Gene sequence:

>801_bases
ATGATTGAAGCAGTTGATATCTGCGTTCAACGCGGAAAAAAACAGATCCTCAAACATGTTGACCTCCAAGCAAAAAATGG
TGCTATAACCGTCATTATCGGTCCTAATGGATCTGGGAAAAGTACTTTTGTCAAAGCACTGAGTGGAGAAATTCCCTACA
GTGGAAAAATGACTCTAAATGGTCATGATGTTACCCAAACAAAAACTTCTAAAATGGCAACAATGCGTGCGGTGCTCCCA
CAGTCAACAACGTTAGCATTTCCATTCTTAGTCCATGAAGTCGTAGAACTTGGTCTCTCCATAAACAAATTTACTATTGC
AAAAAAACAATTCCAAAATCTTCCTCAAAAAACTTTAGAACGCGTTGGACTAGCTGACTATGGTCACCGACTCTATCACC
AATTATCAGGTGGAGAACAAGCTAGAGTACAACTTGCCCGTGTGCTTTGTCAAATCTGGGAACCTATTTGTAATAAAATC
CCTCGTTGGATGATATTAGATGAGCCTATTGCTAGCCTTGATATCCAACATCAACTTGTTGTTATGAATATTGCTAGAAA
TTTTGCCCATCGTGGCGGTGGCGTTCTTGCTATTCTTCATGATCTCAATCTTGCCGCACATTATGCAGATAAAATGATAT
TGCTAAAGCAGGGAAAAGTTTATTGTGAAGGAAGTGCCTCTACCGTTTTGACAACGCAAAATCTGCGCGATGTTTATTCT
TGTTCGTTAAACGTTTCTGAATTGCCTCAAGCAGACATCCCTTTTATTTTGCCACAAACAGCGCAGCCCCTAATGAAATA
G

Upstream 100 bases:

>100_bases
TTGTAGCCCCAGCAGAATTACCAATCGGAATTGTTACAGCACTTTTTGGTGCACCTTTTTTCCTTTGGATTCTTATATGC
AAACGAGGAATAAATTTTTC

Downstream 100 bases:

>100_bases
CGTATTTTTTAGAATAACTATTTGCTTAAATCAAAAAAACAAGTCGTATGACAAATTAAAATACGCAAATATGGTGAGAA
GTTTTTTTGTTTTTAATTAA

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MIEAVDICVQRGKKQILKHVDLQAKNGAITVIIGPNGSGKSTFVKALSGEIPYSGKMTLNGHDVTQTKTSKMATMRAVLP
QSTTLAFPFLVHEVVELGLSINKFTIAKKQFQNLPQKTLERVGLADYGHRLYHQLSGGEQARVQLARVLCQIWEPICNKI
PRWMILDEPIASLDIQHQLVVMNIARNFAHRGGGVLAILHDLNLAAHYADKMILLKQGKVYCEGSASTVLTTQNLRDVYS
CSLNVSELPQADIPFILPQTAQPLMK

Sequences:

>Translated_266_residues
MIEAVDICVQRGKKQILKHVDLQAKNGAITVIIGPNGSGKSTFVKALSGEIPYSGKMTLNGHDVTQTKTSKMATMRAVLP
QSTTLAFPFLVHEVVELGLSINKFTIAKKQFQNLPQKTLERVGLADYGHRLYHQLSGGEQARVQLARVLCQIWEPICNKI
PRWMILDEPIASLDIQHQLVVMNIARNFAHRGGGVLAILHDLNLAAHYADKMILLKQGKVYCEGSASTVLTTQNLRDVYS
CSLNVSELPQADIPFILPQTAQPLMK
>Mature_266_residues
MIEAVDICVQRGKKQILKHVDLQAKNGAITVIIGPNGSGKSTFVKALSGEIPYSGKMTLNGHDVTQTKTSKMATMRAVLP
QSTTLAFPFLVHEVVELGLSINKFTIAKKQFQNLPQKTLERVGLADYGHRLYHQLSGGEQARVQLARVLCQIWEPICNKI
PRWMILDEPIASLDIQHQLVVMNIARNFAHRGGGVLAILHDLNLAAHYADKMILLKQGKVYCEGSASTVLTTQNLRDVYS
CSLNVSELPQADIPFILPQTAQPLMK

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI31657092, Length=215, Percent_Identity=26.9767441860465, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI45446740, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI47078218, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786803, Length=251, Percent_Identity=29.8804780876494, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786345, Length=256, Percent_Identity=29.6875, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790739, Length=264, Percent_Identity=31.0606060606061, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787029, Length=233, Percent_Identity=28.755364806867, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788002, Length=221, Percent_Identity=31.2217194570136, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786872, Length=193, Percent_Identity=32.1243523316062, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789672, Length=214, Percent_Identity=28.0373831775701, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790544, Length=235, Percent_Identity=30.6382978723404, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787370, Length=219, Percent_Identity=28.310502283105, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789873, Length=214, Percent_Identity=29.9065420560748, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787089, Length=229, Percent_Identity=27.9475982532751, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788225, Length=227, Percent_Identity=27.3127753303965, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786563, Length=223, Percent_Identity=29.5964125560538, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789032, Length=227, Percent_Identity=28.1938325991189, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788644, Length=240, Percent_Identity=27.9166666666667, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=236, Percent_Identity=25.8474576271186, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082268, Length=255, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081791, Length=240, Percent_Identity=30, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788761, Length=228, Percent_Identity=27.6315789473684, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789991, Length=226, Percent_Identity=29.2035398230088, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787105, Length=209, Percent_Identity=29.1866028708134, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788165, Length=231, Percent_Identity=29.004329004329, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081709, Length=228, Percent_Identity=25, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788450, Length=234, Percent_Identity=25.2136752136752, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788506, Length=224, Percent_Identity=26.7857142857143, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787547, Length=228, Percent_Identity=26.7543859649123, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786703, Length=218, Percent_Identity=33.0275229357798, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787758, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789593, Length=228, Percent_Identity=23.2456140350877, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789962, Length=239, Percent_Identity=25.5230125523013, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789963, Length=233, Percent_Identity=27.0386266094421, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787164, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786319, Length=223, Percent_Identity=24.6636771300448, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786253, Length=214, Percent_Identity=26.6355140186916, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787712, Length=229, Percent_Identity=25.3275109170306, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786398, Length=222, Percent_Identity=24.7747747747748, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789864, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790467, Length=213, Percent_Identity=29.1079812206573, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI48995001, Length=209, Percent_Identity=26.7942583732057, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787500, Length=226, Percent_Identity=24.7787610619469, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994883, Length=233, Percent_Identity=24.4635193133047, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789586, Length=241, Percent_Identity=26.5560165975104, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1789891, Length=220, Percent_Identity=26.8181818181818, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17569145, Length=238, Percent_Identity=26.890756302521, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539902, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=238, Percent_Identity=24.7899159663866, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=238, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=225, Percent_Identity=27.1111111111111, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=222, Percent_Identity=31.5315315315315, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076682, Length=223, Percent_Identity=29.5964125560538, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076684, Length=221, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581617, Length=221, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581615, Length=221, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666092, Length=215, Percent_Identity=27.4418604651163, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574744, Length=228, Percent_Identity=28.5087719298246, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221512771, Length=216, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724864, Length=231, Percent_Identity=27.7056277056277, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24580555, Length=231, Percent_Identity=27.7056277056277, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281363262, Length=223, Percent_Identity=29.1479820627803, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI85816269, Length=232, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24580553, Length=232, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMUV_BARHE (Q6G475)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033329.1
- HSSP:   P06611
- ProteinModelPortal:   Q6G475
- GeneID:   2865356
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH04930
- NMPDR:   fig|283166.1.peg.457
- HOGENOM:   HBG758042
- OMA:   FPFLVHE
- PhylomeDB:   Q6G475
- ProtClustDB:   PRK13548
- BioCyc:   BHEN283166:BH04930-MONOMER
- HAMAP:   MF_01718
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 29375; Mature: 29375

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51261 HMUV

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEAVDICVQRGKKQILKHVDLQAKNGAITVIIGPNGSGKSTFVKALSGEIPYSGKMTLN
CCHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEC
GHDVTQTKTSKMATMRAVLPQSTTLAFPFLVHEVVELGLSINKFTIAKKQFQNLPQKTLE
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHH
RVGLADYGHRLYHQLSGGEQARVQLARVLCQIWEPICNKIPRWMILDEPIASLDIQHQLV
HCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCHHHH
VMNIARNFAHRGGGVLAILHDLNLAAHYADKMILLKQGKVYCEGSASTVLTTQNLRDVYS
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCEEEEECCCEEECCCCCEEEEHHHHHHHHH
CSLNVSELPQADIPFILPQTAQPLMK
CCCCHHHCCCCCCCEECCCCCHHHCC
>Mature Secondary Structure
MIEAVDICVQRGKKQILKHVDLQAKNGAITVIIGPNGSGKSTFVKALSGEIPYSGKMTLN
CCHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEC
GHDVTQTKTSKMATMRAVLPQSTTLAFPFLVHEVVELGLSINKFTIAKKQFQNLPQKTLE
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHH
RVGLADYGHRLYHQLSGGEQARVQLARVLCQIWEPICNKIPRWMILDEPIASLDIQHQLV
HCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCHHHH
VMNIARNFAHRGGGVLAILHDLNLAAHYADKMILLKQGKVYCEGSASTVLTTQNLRDVYS
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCEEEEECCCEEECCCCCEEEEHHHHHHHHH
CSLNVSELPQADIPFILPQTAQPLMK
CCCCHHHCCCCCCCEECCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA