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The map label for this gene is ubiE

Identifier: 49474866

GI number: 49474866

Start: 52554

End: 53336

Strand: Reverse

Name: ubiE

Synonym: BH00400

Alternate gene names: 49474866

Gene position: 53336-52554 (Counterclockwise)

Preceding gene: 49474867

Following gene: 49474865

Centisome position: 2.76

GC content: 40.1

Gene sequence:

>783_bases
ATGACAGCTGAAACAGAACGTATAGGAGTCAAAGGAGGTATGGAATATTCTTTTGGCTTTACAAAAATTGATGAAGCGCA
AAAGCAATCCATGGTTGATGGTGTCTTTCACTCTGTCGCTGAAAACTATGATAAGATGAATGACATTTTGTCTCTTGGAT
TACACCGTATGTGGAAAAACTCCATGGTCGCATGGCTTTCTCCACCAGCAGTTTTTCATTGGAAAGTTTTGGATGTAGCT
GGGGGTACTGGTGATATCGCTTTTCGCATTCTTAACGCTTCACGCCAAAAAGCCCATGCTACAGTGCTTGATATTAATGG
TTCGATGCTTAGCGTTGGAAAAAAACGCGCAGAAAAAAATGGTCTTGCCCCTCTGATTGACTTTGTTGAAGCAAATGCAG
AACATTTGCCTTTTGAAGACCAAAGTTTTGATGCTTATACTATTGCCTTTGGAATTCGCAATGTCCCTCATATTGATCAA
GCTCTTAGGGAAGCTTTTCGTGTTTTAAAACCGGGAGGGCGTTTTTTATGTTTAGAATTTTCAAATGTTGAGATGCCTCT
ACTTGATAAAATTTACGATCTTTGGTCTTTTCATGCTATCCCTAAGCTTGGTCAACTCATTGCAAATGATGGTGATGCTT
ATCGTTATTTGGTTGAATCTATTCGCAAATTTCCTAAGCAAGATGATTTTGCCCATATGATCAATCATGTAGGTTTTTCG
CGAGTATCATACCGCAACCTCACGGGTGCAATCGCAGCGCTGCATTCAGCCTGGAAGATTTAA

Upstream 100 bases:

>100_bases
GCTGTATAAACGTCGTGGTTTTATAGAGGGCTTTTGCATATTTGAACATTCCTTCTACACTTCATTTACGACAAAAGAAA
AAATAAGGAAGGTCACGCAT

Downstream 100 bases:

>100_bases
AAAATGGTGCAAATTTCCACTTACTTTCAATTAATACGTACTGGATGGGTTTTAGCACGTGAAGGCGTTTTGAGTGCTTT
GCCTCACGATGATCTTCAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTAETERIGVKGGMEYSFGFTKIDEAQKQSMVDGVFHSVAENYDKMNDILSLGLHRMWKNSMVAWLSPPAVFHWKVLDVA
GGTGDIAFRILNASRQKAHATVLDINGSMLSVGKKRAEKNGLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQ
ALREAFRVLKPGGRFLCLEFSNVEMPLLDKIYDLWSFHAIPKLGQLIANDGDAYRYLVESIRKFPKQDDFAHMINHVGFS
RVSYRNLTGAIAALHSAWKI

Sequences:

>Translated_260_residues
MTAETERIGVKGGMEYSFGFTKIDEAQKQSMVDGVFHSVAENYDKMNDILSLGLHRMWKNSMVAWLSPPAVFHWKVLDVA
GGTGDIAFRILNASRQKAHATVLDINGSMLSVGKKRAEKNGLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQ
ALREAFRVLKPGGRFLCLEFSNVEMPLLDKIYDLWSFHAIPKLGQLIANDGDAYRYLVESIRKFPKQDDFAHMINHVGFS
RVSYRNLTGAIAALHSAWKI
>Mature_259_residues
TAETERIGVKGGMEYSFGFTKIDEAQKQSMVDGVFHSVAENYDKMNDILSLGLHRMWKNSMVAWLSPPAVFHWKVLDVAG
GTGDIAFRILNASRQKAHATVLDINGSMLSVGKKRAEKNGLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQA
LREAFRVLKPGGRFLCLEFSNVEMPLLDKIYDLWSFHAIPKLGQLIANDGDAYRYLVESIRKFPKQDDFAHMINHVGFSR
VSYRNLTGAIAALHSAWKI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=284, Percent_Identity=48.2394366197183, Blast_Score=257, Evalue=9e-69,
Organism=Escherichia coli, GI48994983, Length=242, Percent_Identity=46.6942148760331, Blast_Score=230, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17557039, Length=249, Percent_Identity=52.6104417670683, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=44.140625, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24641702, Length=256, Percent_Identity=49.21875, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_BARHE (Q6G577)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_032907.1
- ProteinModelPortal:   Q6G577
- GeneID:   2864848
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH00400
- NMPDR:   fig|283166.1.peg.35
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- PhylomeDB:   Q6G577
- ProtClustDB:   PRK00216
- BioCyc:   BHEN283166:BH00400-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 29203; Mature: 29072

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAETERIGVKGGMEYSFGFTKIDEAQKQSMVDGVFHSVAENYDKMNDILSLGLHRMWKN
CCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVAWLSPPAVFHWKVLDVAGGTGDIAFRILNASRQKAHATVLDINGSMLSVGKKRAEKN
CEEEEECCCCEEEEEEEEECCCCCHHHHEEHHHHHHHHCEEEEECCCCHHHHHHHHHHHC
GLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQALREAFRVLKPGGRFLCLEF
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEE
SNVEMPLLDKIYDLWSFHAIPKLGQLIANDGDAYRYLVESIRKFPKQDDFAHMINHVGFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHH
RVSYRNLTGAIAALHSAWKI
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAETERIGVKGGMEYSFGFTKIDEAQKQSMVDGVFHSVAENYDKMNDILSLGLHRMWKN
CCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVAWLSPPAVFHWKVLDVAGGTGDIAFRILNASRQKAHATVLDINGSMLSVGKKRAEKN
CEEEEECCCCEEEEEEEEECCCCCHHHHEEHHHHHHHHCEEEEECCCCHHHHHHHHHHHC
GLAPLIDFVEANAEHLPFEDQSFDAYTIAFGIRNVPHIDQALREAFRVLKPGGRFLCLEF
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEE
SNVEMPLLDKIYDLWSFHAIPKLGQLIANDGDAYRYLVESIRKFPKQDDFAHMINHVGFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHH
RVSYRNLTGAIAALHSAWKI
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA