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The map label for this gene is ahcY

Identifier: 49474859

GI number: 49474859

Start: 40432

End: 41829

Strand: Reverse

Name: ahcY

Synonym: BH00310

Alternate gene names: 49474859

Gene position: 41829-40432 (Counterclockwise)

Preceding gene: 49474860

Following gene: 49474858

Centisome position: 2.17

GC content: 41.06

Gene sequence:

>1398_bases
ATGACAGCTCAAGATTATGTTGTCAAAGATATCGCACTTGCTGCTTATGGTCGTAAAGAACTGGATATTGCTGAAACGGA
AATGCCCGGTTTGATGGCTTGTCGTGAGGAATTTTCTTCCAGCCAACCTTTGCGCGGAGCACGTATTTCTGGTTCATTGC
ACATGACCATTCAAACAGCTGTTTTGATTGAAACGCTCAAAGCAATTGGAGCCAATGTCCGGTGGAGTTCTAGCAATATT
TTCTCTACGCAAGATCACGCTGCAGCAGCTATTGCAGCCACTGGTACTCCTGTTTTTGCGGTTAAGGGTGAAACACTTGA
AGAATATTGGACTTATATAGATGCTATTTTCCAATGGCCTGATGGTAATCCCTCCAATCTTATCTTAGATGATGGAGCGG
ATGCTACAAACTATATTTTGATGGGAAGCCGTGCAGAAACAAATAAAGATATTCTGTCTCATCCCAAGACAGAAGAAGAG
GAACTTTTCTTCAAACAAATCCAAAGGCGTATGGAGGCTACACCAGGGTTTTTCACACGCCAGCGCGCAGCAATCAAAGG
TATAAGTGAAGAAACCACAACGGGTGTACACCGCCTTCATCAATTACAAAAGGAAGGGCTTCTGCCTTTTCCTGCTATTA
ATATCAATGATAGCGTCACTAAATCAAAATTTGATAATAAATATGGATGTAGAGAATCATTAGTAGACGGTATCAGACGC
GCAACAGACGTTATGATCGCTGGTAAAACAGCTATTGTTTGCGGTTATGGTGATGTGGGTAAAGGATCAGCAGCCTCTCT
TTCAGGTGCTGGAGCTCGTGTTAAAGTAACAGAAATTGACCCCATTTGTGCCCTTCAAGCAGCTATGGATGGCTATGAAG
TTGTTAATTTAGATGATGCAGCTTCCAGCGCTGATATTATTATCACAACAACGGGTAATAAAGATATTGTCCGTTTAGAT
CATATGCGGAAAGTCAAAGACATGTGTATTCTTGGAAATATTGGCCATTTTGATAATGAAATCCAAGTCGCAGCCTTGCA
AAATTTACCATGGACGAATATTAAACCACAAGTCGATATGATCACCTTTCCCGATGGAAAACGCATCATTTTGCTTTCTG
AAGGGCGTTTACTTAATCTCGGTAATGCCACGGGGCACCCTTCTTTTGTTATGTCGGCTTCATTTACCAATCAAGTTTTA
GCGCAAATTGAACTCTTTACTCGTTCAGGACACTACAAAAATGAAGTGACTGTTTTGCCAAAATACCTTGATGAAAAAGT
TGCCCGCCTTCACCTTGATCAGCTAGGAATAAAATTAACCACTTTATCACAAGAACAAGCTGCCTATATTGGAGTTACTC
CACAAGGACCTTATAAACCAGACCATTATCGTTATTAA

Upstream 100 bases:

>100_bases
GAATAAAGACTTTTTCCCAGAAAGAAGTGTTCCTATTAACTTGCATTTTTTTTTAATTTCTCCTACCGTTTTGCAAAAAT
TAATTTTGAAGGAATAAAGA

Downstream 100 bases:

>100_bases
ATGTTTCCTTGGGATAAAAGAAAAAGGAAAACGCATCGTGCTCAGCTTCGGTGACTATAACTCCAAAGAAAAAGCTCAAA
AAATGATCCGAATCTGTACT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTAQDYVVKDIALAAYGRKELDIAETEMPGLMACREEFSSSQPLRGARISGSLHMTIQTAVLIETLKAIGANVRWSSSNI
FSTQDHAAAAIAATGTPVFAVKGETLEEYWTYIDAIFQWPDGNPSNLILDDGADATNYILMGSRAETNKDILSHPKTEEE
ELFFKQIQRRMEATPGFFTRQRAAIKGISEETTTGVHRLHQLQKEGLLPFPAININDSVTKSKFDNKYGCRESLVDGIRR
ATDVMIAGKTAIVCGYGDVGKGSAASLSGAGARVKVTEIDPICALQAAMDGYEVVNLDDAASSADIIITTTGNKDIVRLD
HMRKVKDMCILGNIGHFDNEIQVAALQNLPWTNIKPQVDMITFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVL
AQIELFTRSGHYKNEVTVLPKYLDEKVARLHLDQLGIKLTTLSQEQAAYIGVTPQGPYKPDHYRY

Sequences:

>Translated_465_residues
MTAQDYVVKDIALAAYGRKELDIAETEMPGLMACREEFSSSQPLRGARISGSLHMTIQTAVLIETLKAIGANVRWSSSNI
FSTQDHAAAAIAATGTPVFAVKGETLEEYWTYIDAIFQWPDGNPSNLILDDGADATNYILMGSRAETNKDILSHPKTEEE
ELFFKQIQRRMEATPGFFTRQRAAIKGISEETTTGVHRLHQLQKEGLLPFPAININDSVTKSKFDNKYGCRESLVDGIRR
ATDVMIAGKTAIVCGYGDVGKGSAASLSGAGARVKVTEIDPICALQAAMDGYEVVNLDDAASSADIIITTTGNKDIVRLD
HMRKVKDMCILGNIGHFDNEIQVAALQNLPWTNIKPQVDMITFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVL
AQIELFTRSGHYKNEVTVLPKYLDEKVARLHLDQLGIKLTTLSQEQAAYIGVTPQGPYKPDHYRY
>Mature_464_residues
TAQDYVVKDIALAAYGRKELDIAETEMPGLMACREEFSSSQPLRGARISGSLHMTIQTAVLIETLKAIGANVRWSSSNIF
STQDHAAAAIAATGTPVFAVKGETLEEYWTYIDAIFQWPDGNPSNLILDDGADATNYILMGSRAETNKDILSHPKTEEEE
LFFKQIQRRMEATPGFFTRQRAAIKGISEETTTGVHRLHQLQKEGLLPFPAININDSVTKSKFDNKYGCRESLVDGIRRA
TDVMIAGKTAIVCGYGDVGKGSAASLSGAGARVKVTEIDPICALQAAMDGYEVVNLDDAASSADIIITTTGNKDIVRLDH
MRKVKDMCILGNIGHFDNEIQVAALQNLPWTNIKPQVDMITFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLA
QIELFTRSGHYKNEVTVLPKYLDEKVARLHLDQLGIKLTTLSQEQAAYIGVTPQGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=58.6580086580087, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=57.9545454545455, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI298286489, Length=466, Percent_Identity=48.2832618025751, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=466, Percent_Identity=48.4978540772532, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=466, Percent_Identity=48.4978540772532, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI24308043, Length=466, Percent_Identity=48.4978540772532, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=46.9957081545064, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=60, Blast_Score=522, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=482, Percent_Identity=55.6016597510373, Blast_Score=491, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=58.8865096359743, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=467, Percent_Identity=47.7516059957173, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=48.2758620689655, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=48.1641468682505, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_BARHE (Q6G584)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_032900.1
- ProteinModelPortal:   Q6G584
- SMR:   Q6G584
- GeneID:   2866066
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH00310
- NMPDR:   fig|283166.1.peg.28
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q6G584
- ProtClustDB:   PRK05476
- BioCyc:   BHEN283166:BH00310-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51030; Mature: 50898

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 56-56 BINDING 131-131 BINDING 191-191 BINDING 221-221 BINDING 225-225 BINDING 226-226 BINDING 278-278 BINDING 313-313 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQDYVVKDIALAAYGRKELDIAETEMPGLMACREEFSSSQPLRGARISGSLHMTIQTA
CCCCHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEEEEHHH
VLIETLKAIGANVRWSSSNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYIDAIFQWP
HHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHEECC
DGNPSNLILDDGADATNYILMGSRAETNKDILSHPKTEEEELFFKQIQRRMEATPGFFTR
CCCCCEEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
QRAAIKGISEETTTGVHRLHQLQKEGLLPFPAININDSVTKSKFDNKYGCRESLVDGIRR
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHH
ATDVMIAGKTAIVCGYGDVGKGSAASLSGAGARVKVTEIDPICALQAAMDGYEVVNLDDA
HHHEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEECCC
ASSADIIITTTGNKDIVRLDHMRKVKDMCILGNIGHFDNEIQVAALQNLPWTNIKPQVDM
CCCCCEEEEECCCCCEEEHHHHHHHHHEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEE
ITFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTRSGHYKNEVTVLP
EECCCCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCEEECH
KYLDEKVARLHLDQLGIKLTTLSQEQAAYIGVTPQGPYKPDHYRY
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TAQDYVVKDIALAAYGRKELDIAETEMPGLMACREEFSSSQPLRGARISGSLHMTIQTA
CCCHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCEEECCEEEEEEHHH
VLIETLKAIGANVRWSSSNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYIDAIFQWP
HHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHEECC
DGNPSNLILDDGADATNYILMGSRAETNKDILSHPKTEEEELFFKQIQRRMEATPGFFTR
CCCCCEEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
QRAAIKGISEETTTGVHRLHQLQKEGLLPFPAININDSVTKSKFDNKYGCRESLVDGIRR
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHH
ATDVMIAGKTAIVCGYGDVGKGSAASLSGAGARVKVTEIDPICALQAAMDGYEVVNLDDA
HHHEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCEEEEECCC
ASSADIIITTTGNKDIVRLDHMRKVKDMCILGNIGHFDNEIQVAALQNLPWTNIKPQVDM
CCCCCEEEEECCCCCEEEHHHHHHHHHEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEE
ITFPDGKRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTRSGHYKNEVTVLP
EECCCCCEEEEEECCCEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCEEECH
KYLDEKVARLHLDQLGIKLTTLSQEQAAYIGVTPQGPYKPDHYRY
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA