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The map label for this gene is hemH2

Identifier: 49184095

GI number: 49184095

Start: 1128032

End: 1128991

Strand: Direct

Name: hemH2

Synonym: BAS1075

Alternate gene names: 49184095

Gene position: 1128032-1128991 (Clockwise)

Preceding gene: 49184094

Following gene: 49184096

Centisome position: 21.57

GC content: 36.88

Gene sequence:

>960_bases
ATGAAAAAGAAAAAAATAGGTTTACTCGTAATGGCGTATGGAACGCCGGATTCATTAGATGAAGTAGAGGCATATTATAC
ACATATTCGTCATGGGCGTAAGCCATCCGAAGAAGCGCTCCAAGATTTAATTGGGCGCTATAAAGCAATTGGCGGAATTT
CACCGCTTGCAAAAATTACGAAAGAGCAAGCGCATAAATTAACAGACTCAATGAATAATATGTTTACAGAGTATGAATTT
AATTGTTACTTAGGCTTAAAACATACTGCTCCGTTTATAGAAGATGCAGTAGAAGAGATGAAGCGCGATGGAATTGAGCA
AGCGATTAGTATCGTATTAGCGCCGCATTATTCTACCTTTAGCATTAAGGCATATAACGAGCGTGCAATTCGTCTTTCGG
AGGAAATAGGTGGTCCTGTTATTAAGCCGATTGACCAATGGTACGATGAACCGAAGTTTATTTCGTATTGGGCAGATCAA
ATAAAAGAAACATTTACAAAAATTGAAGATAAAGAGAAAGCGGTCGTAATTTTTTCAGCGCATAGTTTACCAGAAAAAAT
TATTGCAGCAGGTGACCCTTATGTGGAGCAATTGCAACATACAGCGGATTTAATCGCAGCAGCTGCAAACATCCAAAACT
ATACAATTGGTTGGCAAAGTGCCGGAAATACACCTGATCCATGGATTGGACCGGATGTGCAAGATTTAACGAGAGATTTA
TTTGAAGAGTATAGATATGAATCTTTCATATATTGCCCAGTCGGTTTTGTGGCAGAGCATTTAGAAGTTTTATATGACAA
CGATTACGAGTGTAAAGTTGTGACGGATGAATTAAATGCTGCGTATTTTAGACCAAATATGCCGAATGCGCAATCTACAT
TTATTGATTGTTTAGCTACAATTGTTTCCAGAAAAATGAAAGAAATAGTTGACAAAGAACTAATTTTGAATAATAATTAA

Upstream 100 bases:

>100_bases
TTTAGAATAATTATCTTTACGTACTTATTATTAGTTGTTATAATTGGAAACAAATGTTCTTGAAAAAGATTCTCATTTAT
AAAATTGAGGTGTTATATAG

Downstream 100 bases:

>100_bases
TTTATAATAATTTTAAATAAATAATAATTACTACGAAAGAAAGAGGAGGATCCCCCTAGATGAATCCAAATAATCGCTTA
ACAACAAACCAAGGTGCTCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEYRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN

Sequences:

>Translated_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEYRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN
>Mature_319_residues
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNMFTEYEF
NCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSIKAYNERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQ
IKETFTKIEDKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
FEEYRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLATIVSRKMKEIVDKELILNNN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=343, Percent_Identity=28.5714285714286, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI60499021, Length=342, Percent_Identity=28.6549707602339, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1786681, Length=283, Percent_Identity=23.321554770318, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=23.1707317073171, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=28.0966767371601, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=27.6264591439689, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=32.5443786982249, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH2_BACAN (Q81TU9)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843640.1
- RefSeq:   YP_017774.1
- RefSeq:   YP_027347.1
- ProteinModelPortal:   Q81TU9
- SMR:   Q81TU9
- IntAct:   Q81TU9
- EnsemblBacteria:   EBBACT00000010545
- EnsemblBacteria:   EBBACT00000016912
- EnsemblBacteria:   EBBACT00000022666
- GeneID:   1084775
- GeneID:   2816522
- GeneID:   2852557
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1158
- KEGG:   bar:GBAA_1158
- KEGG:   bat:BAS1075
- TIGR:   BA_1158
- TIGR:   GBAA_1158
- GeneTree:   EBGT00050000002085
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK12435
- BioCyc:   BANT260799:BAS1075-MONOMER
- BioCyc:   BANT261594:GBAA1158-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36367; Mature: 36367

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQIKETFTKIEDKEKAVVIFSA
EEEECCCHHEEEHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEYRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKMKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKKIGLLVMAYGTPDSLDEVEAYYTHIRHGRKPSEEALQDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNMFTEYEFNCYLGLKHTAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
SIKAYNERAIRLSEEIGGPVIKPIDQWYDEPKFISYWADQIKETFTKIEDKEKAVVIFSA
EEEECCCHHEEEHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HSLPEKIIAAGDPYVEQLQHTADLIAAAANIQNYTIGWQSAGNTPDPWIGPDVQDLTRDL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHH
FEEYRYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAAYFRPNMPNAQSTFIDCLAT
HHHHCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSRKMKEIVDKELILNNN
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629