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The map label for this gene is putP [H]

Identifier: 46447349

GI number: 46447349

Start: 2053532

End: 2054962

Strand: Direct

Name: putP [H]

Synonym: pc1715

Alternate gene names: 46447349

Gene position: 2053532-2054962 (Clockwise)

Preceding gene: 46447348

Following gene: 46447350

Centisome position: 85.05

GC content: 34.94

Gene sequence:

>1431_bases
ATGCAAATTCAAGTCATTTTAGCATTTATTGCTTATTTTAGTTTACTTCTTCTCATTGGCCTTGTTTGTCATAAAAAACA
AACAACCTCCTCTGATTTTATTATGGGCAACCGATCACTCAATTTCTGGCTGGTGGCTCTTTCTGCTCACGCAAGTGATA
TGAGTGCTTGGCTTTTTATGGCATTTCCTATGACAATTTTCGTATTGGGACTTCCCTATATTTGGATTGCACTAGGACTT
TTATTGGGAATGTTTTTCAACTGGCAATTCGTAGCCCCAAAATTACGCTCTATGACTGAAAGCTATGACACCTATACATT
ATCTTCATTTTTTGAGAAAAGATTTAAAGACACTTCTGGATACATAAGGATTTTAAGTGCTATTATTATGCTTATTTTTC
TTACTCATTATCTTTCAGCAGGTCTAATCGCAATGGGTTACTTGCTTGAATCATTATTTGGCCTTAACTACTACTTTGGT
TTATCTGTTGCTATGTTGGTGGTAGTCGTCTACACATTTATTGGTGGATTTACAACAGTTGCTTGGACAGATTTGTTTCA
AGGTGCTTTTCTTCTCCTAATGATTATTTTAGTTCCTACCATAGCAATGACAAAGATTGATAGCTGGCAAACCATTTCGC
ATATGGCTCATCAAAAAAAAATTTCTTTATCTCTGTTTGGTGATAGTAGTCTGGACTCCTTTATCAAAATTTCTTCCTTG
GCCTTGGGATGGGGACTTGGTTATTTTGGGATGCCTCATATTATCACTAAATTTATGGGTATTAAAGATGTCAATGAAAT
GCACAAATCTAAATGGCTTGGCATGACATGGCAATTTGTTACTTTAGGAGCTGCTGCAGTCGTCGGCTTAATTGGAATTG
CTTATTTTCCAAACGGCTTAGCTAAACCAGAAATGGTTTTTGTTGAAATGGTAAAGGATCTTTTTAATCCTTTTACAGCA
GGCTTTATTTTATGTGCTGTGGTTGCGGCTAATATGTCAACAATGGATTCTCAAATCCTTGTTTGCGGTTCTATTTTAAG
CGAAGATCTTTATAAATATTTTTATAAACAAACACCATCCGATCAAAAAATCCTTTGGGTTTCTAAAATGAGCGTTGTCA
CGGTAGCTTTGATCGCTTTATTACTAGCATTCAATAAAAGTAATACAATTTTAGATACGGTTTTATATTCATGGTCAGGT
CTTGGAAGTGCTTTTGGCCCATTAGTTTTAATGAGTTTATATTCTAAACAAACAAATCGTTATGGGGCAATTGCAGGAAT
GATCACCGGAACTTTCGTCGTTGTGGTATGGCCTAGTTTAAACCCTCTATTATTTCGATATGAATTATTACCAATGATTC
CTGGTTTTTTCACAAGTTTGACTGCCATTTATTTAGCTTCAAAATACACTCGAAAAAATTCTTTGAATTAA

Upstream 100 bases:

>100_bases
CAGGGATAAGTAGCAAAGAAATTTTCGGGCAAAAAAGATCAATTTCACCATCAAGAATTTTAATAACGAAATGCGAACAT
CATAAAACAGAGACGTAACT

Downstream 100 bases:

>100_bases
ATCAGTACACTTATCAAATCTTCCTGAAAACTTCATTTCAGTATCAAATCTCTCCAACCAAAGAATTTTCATGATTTTGT
TGGGGAGTTGGCTGTCTTTA

Product: sodium/proline symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MQIQVILAFIAYFSLLLLIGLVCHKKQTTSSDFIMGNRSLNFWLVALSAHASDMSAWLFMAFPMTIFVLGLPYIWIALGL
LLGMFFNWQFVAPKLRSMTESYDTYTLSSFFEKRFKDTSGYIRILSAIIMLIFLTHYLSAGLIAMGYLLESLFGLNYYFG
LSVAMLVVVVYTFIGGFTTVAWTDLFQGAFLLLMIILVPTIAMTKIDSWQTISHMAHQKKISLSLFGDSSLDSFIKISSL
ALGWGLGYFGMPHIITKFMGIKDVNEMHKSKWLGMTWQFVTLGAAAVVGLIGIAYFPNGLAKPEMVFVEMVKDLFNPFTA
GFILCAVVAANMSTMDSQILVCGSILSEDLYKYFYKQTPSDQKILWVSKMSVVTVALIALLLAFNKSNTILDTVLYSWSG
LGSAFGPLVLMSLYSKQTNRYGAIAGMITGTFVVVVWPSLNPLLFRYELLPMIPGFFTSLTAIYLASKYTRKNSLN

Sequences:

>Translated_476_residues
MQIQVILAFIAYFSLLLLIGLVCHKKQTTSSDFIMGNRSLNFWLVALSAHASDMSAWLFMAFPMTIFVLGLPYIWIALGL
LLGMFFNWQFVAPKLRSMTESYDTYTLSSFFEKRFKDTSGYIRILSAIIMLIFLTHYLSAGLIAMGYLLESLFGLNYYFG
LSVAMLVVVVYTFIGGFTTVAWTDLFQGAFLLLMIILVPTIAMTKIDSWQTISHMAHQKKISLSLFGDSSLDSFIKISSL
ALGWGLGYFGMPHIITKFMGIKDVNEMHKSKWLGMTWQFVTLGAAAVVGLIGIAYFPNGLAKPEMVFVEMVKDLFNPFTA
GFILCAVVAANMSTMDSQILVCGSILSEDLYKYFYKQTPSDQKILWVSKMSVVTVALIALLLAFNKSNTILDTVLYSWSG
LGSAFGPLVLMSLYSKQTNRYGAIAGMITGTFVVVVWPSLNPLLFRYELLPMIPGFFTSLTAIYLASKYTRKNSLN
>Mature_476_residues
MQIQVILAFIAYFSLLLLIGLVCHKKQTTSSDFIMGNRSLNFWLVALSAHASDMSAWLFMAFPMTIFVLGLPYIWIALGL
LLGMFFNWQFVAPKLRSMTESYDTYTLSSFFEKRFKDTSGYIRILSAIIMLIFLTHYLSAGLIAMGYLLESLFGLNYYFG
LSVAMLVVVVYTFIGGFTTVAWTDLFQGAFLLLMIILVPTIAMTKIDSWQTISHMAHQKKISLSLFGDSSLDSFIKISSL
ALGWGLGYFGMPHIITKFMGIKDVNEMHKSKWLGMTWQFVTLGAAAVVGLIGIAYFPNGLAKPEMVFVEMVKDLFNPFTA
GFILCAVVAANMSTMDSQILVCGSILSEDLYKYFYKQTPSDQKILWVSKMSVVTVALIALLLAFNKSNTILDTVLYSWSG
LGSAFGPLVLMSLYSKQTNRYGAIAGMITGTFVVVVWPSLNPLLFRYELLPMIPGFFTSLTAIYLASKYTRKNSLN

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=477, Percent_Identity=41.0901467505241, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI11141885, Length=497, Percent_Identity=23.3400402414487, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI256985183, Length=430, Percent_Identity=21.1627906976744, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507035, Length=382, Percent_Identity=22.2513089005236, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787251, Length=465, Percent_Identity=39.7849462365591, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI87082237, Length=478, Percent_Identity=24.4769874476987, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1790503, Length=470, Percent_Identity=25.9574468085106, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28573698, Length=475, Percent_Identity=21.2631578947368, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221459584, Length=376, Percent_Identity=19.6808510638298, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53170; Mature: 53170

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIQVILAFIAYFSLLLLIGLVCHKKQTTSSDFIMGNRSLNFWLVALSAHASDMSAWLFM
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEEEECCCCHHHHHHHH
AFPMTIFVLGLPYIWIALGLLLGMFFNWQFVAPKLRSMTESYDTYTLSSFFEKRFKDTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHCHHHHHHHHHHHHCCCHH
YIRILSAIIMLIFLTHYLSAGLIAMGYLLESLFGLNYYFGLSVAMLVVVVYTFIGGFTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWTDLFQGAFLLLMIILVPTIAMTKIDSWQTISHMAHQKKISLSLFGDSSLDSFIKISSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
ALGWGLGYFGMPHIITKFMGIKDVNEMHKSKWLGMTWQFVTLGAAAVVGLIGIAYFPNGL
HHHHCCHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AKPEMVFVEMVKDLFNPFTAGFILCAVVAANMSTMDSQILVCGSILSEDLYKYFYKQTPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
DQKILWVSKMSVVTVALIALLLAFNKSNTILDTVLYSWSGLGSAFGPLVLMSLYSKQTNR
CCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
YGAIAGMITGTFVVVVWPSLNPLLFRYELLPMIPGFFTSLTAIYLASKYTRKNSLN
HHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQIQVILAFIAYFSLLLLIGLVCHKKQTTSSDFIMGNRSLNFWLVALSAHASDMSAWLFM
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEEEECCCCHHHHHHHH
AFPMTIFVLGLPYIWIALGLLLGMFFNWQFVAPKLRSMTESYDTYTLSSFFEKRFKDTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHCHHHHHHHHHHHHCCCHH
YIRILSAIIMLIFLTHYLSAGLIAMGYLLESLFGLNYYFGLSVAMLVVVVYTFIGGFTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWTDLFQGAFLLLMIILVPTIAMTKIDSWQTISHMAHQKKISLSLFGDSSLDSFIKISSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
ALGWGLGYFGMPHIITKFMGIKDVNEMHKSKWLGMTWQFVTLGAAAVVGLIGIAYFPNGL
HHHHCCHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AKPEMVFVEMVKDLFNPFTAGFILCAVVAANMSTMDSQILVCGSILSEDLYKYFYKQTPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
DQKILWVSKMSVVTVALIALLLAFNKSNTILDTVLYSWSGLGSAFGPLVLMSLYSKQTNR
CCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
YGAIAGMITGTFVVVVWPSLNPLLFRYELLPMIPGFFTSLTAIYLASKYTRKNSLN
HHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]