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The map label for this gene is hemA

Identifier: 46445981

GI number: 46445981

Start: 471768

End: 472790

Strand: Reverse

Name: hemA

Synonym: pc0347

Alternate gene names: 46445981

Gene position: 472790-471768 (Counterclockwise)

Preceding gene: 46445983

Following gene: 46445978

Centisome position: 19.58

GC content: 35.48

Gene sequence:

>1023_bases
ATGCGTATTGGCGTTATTGGCATTAATCACAAACTAGCAGATTTAAAATTAAGAGACGCACTTGCCAAAGCTTGTCAAAA
GCGATTTGGAGCTAATCAATCTGTTCATGATCAACACCACTTTATCTTACTTTCTACCTGTAATCGCACCGAAGTTTATT
TTAGTTCCCATGATCTTACAGCTACCCATTCCTATTTATTAAGTATTTTACGACAAGATGTAAAAGAAGACTTTGATCAT
AAACTTTACTCTTTTTTTGGTATGGATTGTTTTAGCCATCTTACACGTGTGACGTCCGGACTTGATAGCGCTATCGTCGC
CGAAACAGAAATTCAAGGCCAAGTAAAAAATGCGTACAATCTGGCAACAACCTTTCTTTGTCTGCCAAAAGAACTTCATT
TTCTCTTTCAAAAATCAATGGGAATTGCTAAAAGAATACGATCTGAGCTACACTTAGGAAGAGGGTTGCCTAATTTAGAA
CATGCAATCCTTCAAACTGGAAAATATTTTTTTAGGAATACTCAACAACCAAAAATTCTTTTTGTAGGTGCCTCAGAAAT
CAACCGAAAAATTCTACATTTTTTGAAATCCAAACAATATTCAGATATGACGATTTGCAATCGTTCAGAAATTCGCTCCA
AAGAATTAGCTATTCTATATGGATTGCATCTTCTTCCGTGGTGCCAACTCGATTCATGGCATCAGTATGATTGGATTATA
TTTGGAACAAAGTCTTCCGAATATTTAATTAAACCTGAAAAGAACTTTATCCCAGCTGATAATGATAAACTGATTATGGA
TTTATGCGTTCCACGCAATGTAGAGCCAAAACTTGGCCAAAATGCCAAAATAACTTTATTAAATATTGATCAAATTAATC
GCCTTCTTAAGATTCGTCATCGTGGCATGACACAAGCTCTCATTGAAGCTGAAAATCGCGTTAACTTGGCGACTTATGAA
CATACTAACCGATACAGGCAAAAAGAAGATTCTAAAATCACAATTTTTGCAGCATCTGCCTAA

Upstream 100 bases:

>100_bases
AAAGTGTATTTGCAATAATTAACGTTTTTCTTATAAAGATGCGCAACGATATTTGACTTCCCTAGAATGTAAAATTGAAA
CTGGGAAAAGGAGCAAAAGA

Downstream 100 bases:

>100_bases
AAATACTTTCTTTTGGGAGGTAAAAAAACTGTCTAAACGATAAGCACGAATGGATTTATTTGTTAAAAATTTGCAAGTTT
TTGATTTCTTGCAAATTTTC

Product: putative glutamyl tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRIGVIGINHKLADLKLRDALAKACQKRFGANQSVHDQHHFILLSTCNRTEVYFSSHDLTATHSYLLSILRQDVKEDFDH
KLYSFFGMDCFSHLTRVTSGLDSAIVAETEIQGQVKNAYNLATTFLCLPKELHFLFQKSMGIAKRIRSELHLGRGLPNLE
HAILQTGKYFFRNTQQPKILFVGASEINRKILHFLKSKQYSDMTICNRSEIRSKELAILYGLHLLPWCQLDSWHQYDWII
FGTKSSEYLIKPEKNFIPADNDKLIMDLCVPRNVEPKLGQNAKITLLNIDQINRLLKIRHRGMTQALIEAENRVNLATYE
HTNRYRQKEDSKITIFAASA

Sequences:

>Translated_340_residues
MRIGVIGINHKLADLKLRDALAKACQKRFGANQSVHDQHHFILLSTCNRTEVYFSSHDLTATHSYLLSILRQDVKEDFDH
KLYSFFGMDCFSHLTRVTSGLDSAIVAETEIQGQVKNAYNLATTFLCLPKELHFLFQKSMGIAKRIRSELHLGRGLPNLE
HAILQTGKYFFRNTQQPKILFVGASEINRKILHFLKSKQYSDMTICNRSEIRSKELAILYGLHLLPWCQLDSWHQYDWII
FGTKSSEYLIKPEKNFIPADNDKLIMDLCVPRNVEPKLGQNAKITLLNIDQINRLLKIRHRGMTQALIEAENRVNLATYE
HTNRYRQKEDSKITIFAASA
>Mature_340_residues
MRIGVIGINHKLADLKLRDALAKACQKRFGANQSVHDQHHFILLSTCNRTEVYFSSHDLTATHSYLLSILRQDVKEDFDH
KLYSFFGMDCFSHLTRVTSGLDSAIVAETEIQGQVKNAYNLATTFLCLPKELHFLFQKSMGIAKRIRSELHLGRGLPNLE
HAILQTGKYFFRNTQQPKILFVGASEINRKILHFLKSKQYSDMTICNRSEIRSKELAILYGLHLLPWCQLDSWHQYDWII
FGTKSSEYLIKPEKNFIPADNDKLIMDLCVPRNVEPKLGQNAKITLLNIDQINRLLKIRHRGMTQALIEAENRVNLATYE
HTNRYRQKEDSKITIFAASA

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=336, Percent_Identity=30.6547619047619, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PARUW (Q6MEC8)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007346.1
- ProteinModelPortal:   Q6MEC8
- SMR:   Q6MEC8
- STRING:   Q6MEC8
- GeneID:   2779718
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0347
- NMPDR:   fig|264201.1.peg.347
- eggNOG:   COG0373
- HOGENOM:   HBG413932
- OMA:   RIRSELH
- PhylomeDB:   Q6MEC8
- ProtClustDB:   CLSK2762142
- BioCyc:   CPRO264201:PC0347-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 39233; Mature: 39233

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 47-47 BINDING 103-103 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVIGINHKLADLKLRDALAKACQKRFGANQSVHDQHHFILLSTCNRTEVYFSSHDLT
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCCH
ATHSYLLSILRQDVKEDFDHKLYSFFGMDCFSHLTRVTSGLDSAIVAETEIQGQVKNAYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCHHHHHHH
LATTFLCLPKELHFLFQKSMGIAKRIRSELHLGRGLPNLEHAILQTGKYFFRNTQQPKIL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHCCCCCCEEE
FVGASEINRKILHFLKSKQYSDMTICNRSEIRSKELAILYGLHLLPWCQLDSWHQYDWII
EEEHHHHHHHHHHHHHCCCCCCCEECCHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEE
FGTKSSEYLIKPEKNFIPADNDKLIMDLCVPRNVEPKLGQNAKITLLNIDQINRLLKIRH
EECCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RGMTQALIEAENRVNLATYEHTNRYRQKEDSKITIFAASA
CCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MRIGVIGINHKLADLKLRDALAKACQKRFGANQSVHDQHHFILLSTCNRTEVYFSSHDLT
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCCH
ATHSYLLSILRQDVKEDFDHKLYSFFGMDCFSHLTRVTSGLDSAIVAETEIQGQVKNAYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCHHHHHHH
LATTFLCLPKELHFLFQKSMGIAKRIRSELHLGRGLPNLEHAILQTGKYFFRNTQQPKIL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHCCCCCCEEE
FVGASEINRKILHFLKSKQYSDMTICNRSEIRSKELAILYGLHLLPWCQLDSWHQYDWII
EEEHHHHHHHHHHHHHCCCCCCCEECCHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEE
FGTKSSEYLIKPEKNFIPADNDKLIMDLCVPRNVEPKLGQNAKITLLNIDQINRLLKIRH
EECCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RGMTQALIEAENRVNLATYEHTNRYRQKEDSKITIFAASA
CCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA